orji ebele - Academia.edu (original) (raw)

Papers by orji ebele

For thousands of years, humans have relied on nature for their essential needs. These needs inclu... more For thousands of years, humans have relied on nature for their essential needs. These needs include food, clothing, shelter, means of transportation, flavours, fragrances and medicines. For thousands of years, plants have formed the basis of sophisticated traditional medicine. One of the earliest records of the use of plants dates back to 2600BC, in Mesopotamia. They used oils of Cedrus species (cedar) and Cupressus sempervirens (cypress), Commiphora species (myrrh) and Glycyrrhiza glabra (licorice) to cure illnesses ranging from coughs to colds to parasitic infections and inflammations, and all of these plants still function in present times in the treatment of the aforementioned ailments. 1 The African continent is made up of more than fifty (50) countries, eight hundred (800) languages and three thousand (3000) dialects, great biodiversity of tropical forests, savannahs and veldts, therefore, it is hardly surprising that it is a veritable treasure house of genetic materials, including medicinal plants. The unique environments of sub-Saharan Africa has presented native cultures with an immense variety of flora and as a consequence, a wealth of traditional knowledge about the use of plants for medicinal purposes. 2 According to the World Health Organization, 3 as many as 80% of the world's population depend on traditional medicine to meet their

Comparative clinical pathology, Feb 3, 2024

Tropical Journal of Natural Product Research, 2024

Identification of the phytochemical composition of plants is vital in new drug discovery and lead... more Identification of the phytochemical composition of plants is vital in new drug discovery and lead compound development for the management of infectious and non-infectious diseases. Lantana camara is an important medicinal essential oil-producing plant used in folklore medicine for the treatment of several diseases. This study evaluated the phytochemical composition and profiled the biologically active principles present in L. camara leaf extracts collected from Orba, Enugu State of Nigeria. The profiling of L. camara leaves methanol and aqueous extracts was done using qualitative and quantitative phytochemical and GC-MS techniques. The phytochemical screening showed the presence of alkaloids, terpenoids, flavonoids and other phenolic compounds. There were no significant differences (p > 0.05) in the steroids, saponins, terpenoids, glycosides and phenolic contents of methanol and aqueous extracts. The phenolic content in methanol (1563.85±0.07 mg/100g) and aqueous (1425.23±0.36 mg/100g) were significantly higher than other phytochemicals tested in this study. There was significantly (p < 0.05) higher alkaloids (506.74±5.52 mg/100g), flavonoids (372.04±8.39 mg/100g) and tannins (1426.43±7.43 mg/100g) in the methanol compared with the aqueous extracts with 349.92±13.10 mg/100g, 231.99±6.16 mg/100g and 1351.62±20.6 mg/100g respectively. The GC-MS analysis showed the presence of 39 biologically important compounds which included bis(2-ethylhexyl) phthalate, 9,19-cyclolanostan-3-ol-11-one acetate, 4H-1-benzopyran-4-one-5-hydroxy-2-(4-hydroxyphenyl), n-hexadecanoic acid, (Z)-7-hexadecenal, phytol acetate, phytol, 3,7,11,15-tetramethyl-2-hexadecen-1-ol and bicyclo [4.4.0] dec-2-ene-4-ol 2-methyl-9-(prop-1-en-3-ol-2-yl). The phytochemical analysis and the GC-MS profiling of the extracts of L. camara showed the presence of biologically important phytochemicals which could be responsible for the ethnomedicinal effects of L. camara.

In several parts of the world and cultural settings, herbs are used as medicine to treat various ... more In several parts of the world and cultural settings, herbs are used as medicine to treat various kinds of ailments. 1 This is due to the existence of phytochemicals also known as specialized metabolites in different parts of plants. 2 Phytochemicals are essential in the pharmaceutical industry for the production of drugs and other treatment agents. 1 The development of drugs begins with the identification of bioactive compounds and other active principles present in plants. 3 This can only be achieved by the screening of plant extracts. 4 Phytochemical screening of plant extract is the best method for finding curatively active principles in plant species. 5 When determining the concentration of certain active compounds in plants used in cosmetics, medicines, the food or pharmaceutical industries, the environment, or forensic applications, the GC-MS approach can be a useful tool.

Biomarkers, 2021

Sub-acute oral toxicity study of aqueous extract of tobacco leaves (Nicotiana tabacum L) on lipid... more Sub-acute oral toxicity study of aqueous extract of tobacco leaves (Nicotiana tabacum L) on lipid profile, the tissue, and serum of the liver and kidney of male Wistar rats

For thousands of years, humans have relied on nature for their essential needs. These needs inclu... more For thousands of years, humans have relied on nature for their essential needs. These needs include food, clothing, shelter, means of transportation, flavours, fragrances and medicines. For thousands of years, plants have formed the basis of sophisticated traditional medicine. One of the earliest records of the use of plants dates back to 2600BC, in Mesopotamia. They used oils of Cedrus species (cedar) and Cupressus sempervirens (cypress), Commiphora species (myrrh) and Glycyrrhiza glabra (licorice) to cure illnesses ranging from coughs to colds to parasitic infections and inflammations, and all of these plants still function in present times in the treatment of the aforementioned ailments. 1 The African continent is made up of more than fifty (50) countries, eight hundred (800) languages and three thousand (3000) dialects, great biodiversity of tropical forests, savannahs and veldts, therefore, it is hardly surprising that it is a veritable treasure house of genetic materials, including medicinal plants. The unique environments of sub-Saharan Africa has presented native cultures with an immense variety of flora and as a consequence, a wealth of traditional knowledge about the use of plants for medicinal purposes. 2 According to the World Health Organization, 3 as many as 80% of the world's population depend on traditional medicine to meet their

Comparative clinical pathology, Feb 3, 2024

Tropical Journal of Natural Product Research, 2024

Identification of the phytochemical composition of plants is vital in new drug discovery and lead... more Identification of the phytochemical composition of plants is vital in new drug discovery and lead compound development for the management of infectious and non-infectious diseases. Lantana camara is an important medicinal essential oil-producing plant used in folklore medicine for the treatment of several diseases. This study evaluated the phytochemical composition and profiled the biologically active principles present in L. camara leaf extracts collected from Orba, Enugu State of Nigeria. The profiling of L. camara leaves methanol and aqueous extracts was done using qualitative and quantitative phytochemical and GC-MS techniques. The phytochemical screening showed the presence of alkaloids, terpenoids, flavonoids and other phenolic compounds. There were no significant differences (p > 0.05) in the steroids, saponins, terpenoids, glycosides and phenolic contents of methanol and aqueous extracts. The phenolic content in methanol (1563.85±0.07 mg/100g) and aqueous (1425.23±0.36 mg/100g) were significantly higher than other phytochemicals tested in this study. There was significantly (p < 0.05) higher alkaloids (506.74±5.52 mg/100g), flavonoids (372.04±8.39 mg/100g) and tannins (1426.43±7.43 mg/100g) in the methanol compared with the aqueous extracts with 349.92±13.10 mg/100g, 231.99±6.16 mg/100g and 1351.62±20.6 mg/100g respectively. The GC-MS analysis showed the presence of 39 biologically important compounds which included bis(2-ethylhexyl) phthalate, 9,19-cyclolanostan-3-ol-11-one acetate, 4H-1-benzopyran-4-one-5-hydroxy-2-(4-hydroxyphenyl), n-hexadecanoic acid, (Z)-7-hexadecenal, phytol acetate, phytol, 3,7,11,15-tetramethyl-2-hexadecen-1-ol and bicyclo [4.4.0] dec-2-ene-4-ol 2-methyl-9-(prop-1-en-3-ol-2-yl). The phytochemical analysis and the GC-MS profiling of the extracts of L. camara showed the presence of biologically important phytochemicals which could be responsible for the ethnomedicinal effects of L. camara.

In several parts of the world and cultural settings, herbs are used as medicine to treat various ... more In several parts of the world and cultural settings, herbs are used as medicine to treat various kinds of ailments. 1 This is due to the existence of phytochemicals also known as specialized metabolites in different parts of plants. 2 Phytochemicals are essential in the pharmaceutical industry for the production of drugs and other treatment agents. 1 The development of drugs begins with the identification of bioactive compounds and other active principles present in plants. 3 This can only be achieved by the screening of plant extracts. 4 Phytochemical screening of plant extract is the best method for finding curatively active principles in plant species. 5 When determining the concentration of certain active compounds in plants used in cosmetics, medicines, the food or pharmaceutical industries, the environment, or forensic applications, the GC-MS approach can be a useful tool.

Biomarkers, 2021

Sub-acute oral toxicity study of aqueous extract of tobacco leaves (Nicotiana tabacum L) on lipid... more Sub-acute oral toxicity study of aqueous extract of tobacco leaves (Nicotiana tabacum L) on lipid profile, the tissue, and serum of the liver and kidney of male Wistar rats