osvaldo contreras - Academia.edu (original) (raw)

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Papers by osvaldo contreras

Research paper thumbnail of Erratum for: Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies

Research paper thumbnail of Extracellular TGF-β downregulates the expression of Wnt transcription factor TCF7L2/TCF4 in mesenchymal stromal cells and fibroblasts

TGF-β signaling suppresses the expression of the Wnt transcription factor TCF7L2 and 3 compromise... more TGF-β signaling suppresses the expression of the Wnt transcription factor TCF7L2 and 3 compromises TCF7L2-dependent function in fibroblasts. 4 1 to initiate a signaling pathway that regulates the proteostasis of cytoplasmic β-catenin. In 1 the absence of canonical Wnt ligands, β-catenin is a target for the ubiquitin-proteasome 1 pathway-mediated degradation (Aberle et al., 1997). Once the canonical cascade starts, 1 the accumulation of β-catenin leads to its translocation to the nucleus, where it recognizes 1 and binds the T-cell factor (TCF) or Lymphoid enhancer (LEF) transcription factors (TFs) 1 but also recruits transcriptional partners and chromatin remodeling complexes which in 1 concert regulate the expression of Tcf/Lef target genes. Tcf/Lef TFs recognize Tcf/Lef-1 binding elements on its target genes to regulate the expression of thousands of genes 1

Research paper thumbnail of Near-Term Prospects for Semantic Technologies

IEEE Intelligent Systems, 2000

Tor the past few years, the Semantic Web has been enjoying significant investment, mostly through... more Tor the past few years, the Semantic Web has been enjoying significant investment, mostly through research but to a lesser extent through start-ups and commercial projects. A major topic of discussion is where we can see those investments' results, so I asked several experts to consider what semantic technology will accomplish in the near future. The experts are from academia,

Research paper thumbnail of Erratum for: Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies

Research paper thumbnail of Extracellular TGF-β downregulates the expression of Wnt transcription factor TCF7L2/TCF4 in mesenchymal stromal cells and fibroblasts

TGF-β signaling suppresses the expression of the Wnt transcription factor TCF7L2 and 3 compromise... more TGF-β signaling suppresses the expression of the Wnt transcription factor TCF7L2 and 3 compromises TCF7L2-dependent function in fibroblasts. 4 1 to initiate a signaling pathway that regulates the proteostasis of cytoplasmic β-catenin. In 1 the absence of canonical Wnt ligands, β-catenin is a target for the ubiquitin-proteasome 1 pathway-mediated degradation (Aberle et al., 1997). Once the canonical cascade starts, 1 the accumulation of β-catenin leads to its translocation to the nucleus, where it recognizes 1 and binds the T-cell factor (TCF) or Lymphoid enhancer (LEF) transcription factors (TFs) 1 but also recruits transcriptional partners and chromatin remodeling complexes which in 1 concert regulate the expression of Tcf/Lef target genes. Tcf/Lef TFs recognize Tcf/Lef-1 binding elements on its target genes to regulate the expression of thousands of genes 1

Research paper thumbnail of Near-Term Prospects for Semantic Technologies

IEEE Intelligent Systems, 2000

Tor the past few years, the Semantic Web has been enjoying significant investment, mostly through... more Tor the past few years, the Semantic Web has been enjoying significant investment, mostly through research but to a lesser extent through start-ups and commercial projects. A major topic of discussion is where we can see those investments' results, so I asked several experts to consider what semantic technology will accomplish in the near future. The experts are from academia,

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