oytun PORTAKAL - Academia.edu (original) (raw)
Papers by oytun PORTAKAL
Clinical Biochemistry, Mar 1, 2009
Journal of Obstetrics and Gynaecology Research, Mar 3, 2020
Aim: Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters ... more Aim: Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters of neutrophil, monocyte and lymphocyte, procalcitonin (PCT) and white blood cell count (WBC) during term and preterm labor to evaluate the impact of inflammation on the triggering mechanisms of uterine contractions. Methods: This study is consisted of 16 preterm and 60 term pregnancies at the beginning of the first stages of the labor. Leukocyte VCS parameters, PCT plasma levels and WBC count were evaluated. Results: We could not demonstrate statistically significant difference in between leukocyte VCS parameters in preterm and term deliveries (P > 0.050 for all). WBC counts were 10.6 and 11.8 × 10 3 /μL in the preterm and term groups respectively (P = 0.270). PCT levels were 0.04 and 0.03 ng/mL for preterm and term pregnancies (P = 0.062). Conclusion: Inflammation related markers such as leukocyte VCS parameters, PCT values and WBC count does not differentiate at the first stage of labor in preterm and term deliveries. These variables do not seem to have a prominent role at the biological events behind preterm contractions.
Early Human Development, 2012
Bone, Nov 1, 2012
We present a case with extremely high parathyroid hormone (PTH) concentrations in the order of hu... more We present a case with extremely high parathyroid hormone (PTH) concentrations in the order of hundred thousands accompanied by dermatological and hematological diseases. After several diagnostic interventions, no malignancy could be demonstrated except monoclonal gammopathy of unknown significance. The dermatological findings were taken to be manifestations of the hematological disease. Since the first serum intact PTH concentration of the patient was found to be higher than 2500 pg/ml, dilution study was performed and found to be 215,977 pg/ml. The high concentration of serum PTH was taken to be falsely high due to assay interference. This concentration was checked from three different paths; a test for linear dilution was performed, the test was repeated with another method and the sample was treated to remove or inhibit interfering substances. The results were compatible with endogenous antibody interference, presumed to be a result of monoclonal gammopathy. The extremely high PTH concentrations were not only due to assay interference, but also secondary hyperparathyroidism, which was evident by the decrease in PTH concentrations with calcium and vitamin D treatments.
Pediatric Blood & Cancer, 2003
We investigated the usefulness of serum cardiac Troponin T (cTnT) to detect doxorubicin related c... more We investigated the usefulness of serum cardiac Troponin T (cTnT) to detect doxorubicin related cardiotoxicity as a non-invasive and reliable method. Twenty-four patients who received doxorubicin for their solid tumors at cumulative doses of 400 mg/m(2) or higher, between June 1982 and August 2000, were included in this study. None of them had clinical signs or symptoms of cardiotoxicity. The age range was 3-31 years (median 14), and male to female ratio was 14/10. The systolic and diastolic cardiac functions were evaluated by two-dimensional, M-mode, and Doppler echocardiography. Serum cTnT levels were measured by a third generation immunoassay method and the lowest detectable level was 0.010 ng/ml. The cumulative doxorubicin doses were at the range of 400 and 840 mg/m(2) (median 480). The time past from the last doxorubicin dose was 1-168 months (median 12). All of the patients had normal chest X-rays, electrocardiograms, and nine patients (37.5%) had abnormal systolic or diastolic cardiac function parameters. The median cumulative doxorubicin doses of the patients with normal and abnormal echocardiographic parameters were 480 and 440 mg/m(2), respectively. Serum cTnT values of 21 patients were below the detection limit (< 0.010 ng/ml). There was no statistical difference between serum cTnT levels of the patients with normal and abnormal echocardiographic findings (P = 0.376). No correlation was found between serum cTnT values, cumulative doxorubicin doses, and systolic or diastolic cardiac functions. We can conclude that echocardiographic follow-up is more reliable than serum cTnT levels for detecting subclinical cardiac toxicity.
Klimik Dergisi/Klimik Journal
Objective: This study included participants from Hacettepe University 4th, 5th, and 6th-grade stu... more Objective: This study included participants from Hacettepe University 4th, 5th, and 6th-grade students of Medical School and 4th and 5th-grade students of Dental School; and aimed to evaluate the general health status, COVID-19 history, vaccination status, and SARS-CoV-2 antibody levels of the participants to support their physical and social health, during the pandemic period. Methods: A prospective cohort study was conducted with an integrated, matched, nested case-control study. Sociodemographic characteristics, life habits, COVID-19 history, vaccination status, compliance with mask-distance-hygiene rules, and risks (if any) for COVID-19 were inquired via online questionnaires. Physical examinations, complete blood count, biochemistry tests, and anti-SARS-CoV-2 anti-spike antibody tests were conducted for all consenting participants. All analyses were established using depersonalized data. Results: Of the 778 participants completing the baseline visit in June-July 2021, the perce...
Children with Attention Deficit Hyperactivity Disorder (ADHD) might have problems similar to auti... more Children with Attention Deficit Hyperactivity Disorder (ADHD) might have problems similar to autism spectrum disorders and show impairment in social behaviour. Also, there is a relationship between social relationship skills and ToM (Theory of Mind) skills in children with ADHD. Besides, ASD (Autism Spectrum Disorder) is associated with prenatal exposure to high levels of androgens, and oxytocin plays a role in the modulation of emotions, coping with stress, and social behaviour such as ASD. In this study, the relationship between autistic traits and serum oxytocin, testosterone, and androstenedione levels in prepubertal male drug naive children with ADHD has been investigated. Prepubertal children with ADHD have been included in the study. For the children included in the study, intelligence levels were evaluated with WISC-4 (Wechsler Intelligence Scale for Children-fourth edition) and autistic traits were measured with both social responsiveness scale and theory of mind tests. Ser...
Hepato-gastroenterology, 2010
The role of circulating tumor cells (CTCs) in the management of colorectal cancer has not yet est... more The role of circulating tumor cells (CTCs) in the management of colorectal cancer has not yet established. In present study, we aimed to investigate the relationship between clinicopathological characteristics and CTC levels in patients with colorectal carcinoma. The isolation of CTCs in blood was performed with the semi-automated CellSearch System (Veridex TM). Ninety-three patients were analyzed. Median age of patients at the time of diagnosis was 56 (24-78). Total number of blood samples collected for CTCs were 130. CTCs were detected in 46 patients (> or =1 per 7.5 mL), but only thirty (32%) patients were interpreted as positive (> or = 3/7.5 mL). In the 27 patients in whom 2 blood samples were taken, levels of CTCs were found to be decreased in 8 patients, increased in 14 patients and did not change in 5 patients after therapy. Although only 2 (25%) of 8 patients in whom CTCs decreased after therapy had disease progression, 13 (93%) of 14 patients with increased CTCs had ...
Taiwanese Journal of Obstetrics and Gynecology
OBJECTIVE To evaluate first trimester screening test parameters in epileptic patients using anti-... more OBJECTIVE To evaluate first trimester screening test parameters in epileptic patients using anti-epileptic drugs. MATERIALS AND METHODS We retrospectively evaluated first trimester screening test results of 23 epileptic pregnant women using anti-epileptic drugs with a control group consisting of 92 healthy pregnancies. The anti-epileptic drugs used in this study were carbamazepine, levatiracetam, valproic acid and lamotrigine. Single drug or multi-drug regimens were used according to the clinical conditions. Patients with any known chronic or acute disease and drug usage were excluded from the study. Comparisons were performed via Mann-Whitney U test. RESULTS First trimester screening test biochemical markers were compared and maternal serum PAPP-A MoM values were found to be similar in study and control groups while β-hCG MoM values were significantly higher in pregnancies using epileptic drugs (p: 0,737 and p < 0.001, respectively). CONCLUSION Biochemical first trimester screening test results may be affected by anti-epileptic drug usage, which may lead to misinterpretation of the risk level. Thus, validation of MoM values should be necessary in order to obtain optimal results.
Turkish Journal of Biochemistry
ObjectivesTo demonstrate immature granulocyte (IG) count and delta neutrophil index (DNI) values ... more ObjectivesTo demonstrate immature granulocyte (IG) count and delta neutrophil index (DNI) values (novel potential predictive marker for neonatal sepsis) for neonates.MethodsThis prospective controlled clinical study was consisted of 208 patients (77 in the study group and 131 in the control group) who were delivered between January 2016 and January 2018 at the Hacettepe University Neonatal Intensive Care Unit in Ankara, Turkey. In this study, we evaluated value of DNI in diagnosing neonatal sepsis by comparing the DNI values in culture positive septic neonates with healthy neonates.ResultsIn our study, the median interquartile range (IQR = 25–75%) DNI was 0.1% (0.0–0.3%) in the control group and 1.5% (1.0–2.45%) in the sepsis group (p
Clinical Laboratory
BACKGROUND Serial C-reactive protein (CRP) biomarker values are frequently recorded from patients... more BACKGROUND Serial C-reactive protein (CRP) biomarker values are frequently recorded from patients in adult intensive care units (ICU). The aim of this study was to assess the time-dependent diagnostic accuracy of repeated CRP measurements in predicting ICU mortality and determine the time-dependent cutoff values for this biomarker in mixed ICU population. METHODS Joint modeling was performed to model repeated CRP measurements and survival data. Time-dependent AUC (td-AUC) values were used to assess the diagnostic performances. Maximization of the product of sensitivity and specificity rule was applied to determine the time-dependent cutoff values. RESULTS Time-dependent diagnostic performance of serial CRP values were found as moderate in overall, observed to be higher in males than females, ranging from 0.603 to 0.624 in females and 0.639 to 0.690 in males. On the other hand, time-dependent cutoff values either remained constant or decreased through the 3rd day after the last measurement for both gender groups. CONCLUSIONS Newly proposed time-dependent cutoff values for CRP biomarker are suggested to be used in clinics to discriminate subjects who are at risk and who are not during the first three days after the last measurement. Furthermore, taking serial CRP values in predicting the risk of death at ICU is highly recommended, to be able to assess the change in longitudinal profiles of subjects throughout the follow-up period.
Turkish Journal of Biochemistry
Turkiye Klinikleri Journal of Biostatistics
C-Reaktif Protein (CRP), erişkin yoğun bakımda yatan hastalardan tekrarlı ölçümleri sıklıkla alın... more C-Reaktif Protein (CRP), erişkin yoğun bakımda yatan hastalardan tekrarlı ölçümleri sıklıkla alınan bir belirteçtir. Bu çalışmada söz konusu belirtecin tekrarlı ölçümlerinin, izlem süresi olarak belirlenen 30 günlük süre sonunda yoğun bakımda ölüm olgusunu kestirmedeki tanısal performansını etkileyen faktörlerin incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Hacettepe Üniversitesi Erişkin Yoğun Bakım Ünitesi'nde yatan hastalara ait tekrarlı CRP ölçümleri ile sağkalım sürelerinin eş zamanlı olarak modellenebilmesi için birleşik modelleme yaklaşımı kullanılmıştır. Bu yaklaşımdan yararlanılarak, belirteçlerin tanısal performanslarının belirlenebilmesi için zamana bağlı ROC Eğrisi altında kalan alan (zb-EAA) değerlendirilmiştir. Bulgular: Tekrarlı CRP ölçümlerinin izlem süresi sonunda yoğun bakımda ölümü kestirmedeki tanısal performansı orta düzeyde bulunmuştur. Bununla birlikte, sağkalım zamanına ait dağılım türünün ya da uzunlamasına veri bölümünde rassal etkiler kısmının daha detaylı olarak modellenmesinin tekrarlı CRP ölçümlerinin tanısal performansına etki etmediği saptanmış, en yüksek performansın standart birleşik model ile elde edildiği belirlenmiştir. Sonuç: Analiz sonuçlarına göre, optimum tanısal doğruluğun elde edilebilmesi için, standart birleşik modelin kullanılması önerilmekle birlikte, söz konusu modelin uzunlamasına bölümünde rassal eğim ve rassal kesim noktası modelinin; modelin sağkalım kısmında ise, parametrik bir dağılım olmasından dolayı Piecewise-Constant dağılımının kullanılması önerilmektedir. Anahtar Kelimeler: Zamana-bağlı ROC eğrileri; belirteç; zamana-bağlı eğri altında kalan alan; birleşik model; sağkalım zamanı; CRP ABSTRACT Objective: Serial C-Reactive Protein (CRP) measurements are frequently taken in Adult Intensive Care Units. In this study it's aimed to evaluate the factors affecting diagnostic accuracy of this biomarker's serial measurements in predicting the risk of death at Intensive Care Units (ICU) at the end of follow-up period, 30 days. Material and Methods: Joint Modelling Approach is used to model repeated CRP measurements taken from Hacettepe University Adult Intensive Care Units and survival times simultaneously. With the help of this model, time-dependent Area Under ROC Curve (td-AUC) values are calculated and assessed as diagnostic performance criteria. Results: Diagnostic performance of serial CRP values in predicting the risk of death is found as moderate. However, it's found that neither the distribution of survival times in survival sub-model nor utilizing more detailed function in random-effects part of longitudinal sub-model affect the diagnostic performance. Also it's determined that the highest diagnostic performance is obtained with standart standard joint model. Conclusion: To reach the highest diagnostic accuracy, standard joint model with Piecewise Constant Distribution in survival sub-model and random intercepts-random slope structure in longitudinal sub-model should be used.
The Turkish Journal of Pediatrics
Recent technological improvements have enabled automated hematology analyzers to determine the IG... more Recent technological improvements have enabled automated hematology analyzers to determine the IG count and fraction. The term IG is used to describe the myelocytes, promyelocytes and metamyelocytes (i.e., neutrophil precursors) that are found in the bone marrow but not in the peripheral blood
Journal of Obstetrics and Gynaecology Research
Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters of ne... more Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters of neutrophil, monocyte and lymphocyte, procalcitonin (PCT) and white blood cell count (WBC) during term and preterm labor to evaluate the impact of inflammation on the triggering mechanisms of uterine contractions.
Cukurova Medical Journal
Öz Purpose: Down syndrome screening with first trimester combined test is recommended for all pre... more Öz Purpose: Down syndrome screening with first trimester combined test is recommended for all pregnancies. It is unclear, whether thyroid stimulating hormone (TSH) affects secretion of free beta subunit human chorionic gonadotropin (fβ-hcg) and pregnancy-related plasma protein (PAPP-A). We aimed to investigate the effect of serum thyroid stimulating hormone (TSH) levels on the combined test results. Materials and Methods: First trimester TSH levels together with nuchal translucency (NT(fβ-hcg and PAPP-A results of 297 patients were included in this study. Patients were divided into four groups according to their TSH levels; Group 1 (<0.1 μL / ml), Group 2 (0.1-2.5 μlU / ml), Group 3 (2.5-3.5 μlU / ml) and Group 4 (> 3.5 μlU / ml). Groups were compared in terms of NT, PAPP-A and fβ-hcg levels. Results: The mean PAPP-A (MoM) value was found to be 0.99 in group 1, 1.12 in group 2, 1.03 in group 3, and 0.95 in group 4. Mean fβ-hcg (MoM) value was 1.36 in group 1, 1.29 in group 2, 1.05 in group 3, and 1.32 in group 4. The mean NT measurement was 1.27 ± 0.25, 1.33 ± 0.38, 1.34 ± 0.33 and 1.32 ± 0.37 mm, from group 1 to group 4, respectively. There was no statistically significant difference between groups in terms of PAPP-A, fβ-hcg and NT. Conclusion: The present study have shown that first trimester TSH levels do not affect combined test parameters. Prenatal screening by using NT, fβ-hCG and PAPP-A seems to be safe for pregnant women with hypothyroidism or hyperthyroidism.
Current Urology
Usage and distribution for commercial purposes as well as any distribution of modified material r... more Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. Urinary tract infection • Pregnancy • Uropathogens • Escherichia coli Background and Objectives: Our aim is to identify uropathogens that cause urinary tract infections (UTIs) that necessitate hospitalization, and analyze outcomes of gestational UTIs. Methods: This study consisted of 30 pregnant women who necessitate hospitalization because of UTI (7.8% of gestational UTIs during the same period of time). UTI that necessitates hospitalization is defined as clinical complaints, urination problems, urine analysis and culture positivity, fever and uterine discomfort. Patients with at least two positive cultures (≥ 100,000 cfu/ml) were included to this study. Antimicrobial susceptibility tests were obtained in all cases in order to determine antimicrobial resistance and to choose the ideal antibiotics for treatment. Results: In our study, we have found that Escherichia coli is the most common microorganism (56.7%). Enterococcus faecalis (13.3%) and Klebsiella pneumonia (10%) were other frequently observed microorganisms. In this series, mean gestational week at birth was 35 weeks 5 days (range 23-40 weeks). Mean birthweight was 2,656 g (range 500-3,700 g). Twenty-three cases (76.7%) were hospitalized before 37th gestational week and preterm delivery rate was 56.3%. Maternal risk factors and coexisting diseases were detected in 11 (36.7%) patients as follows: diabetes mellitus in 4, thrombophilia in 3, thyroid disorders in 3 and hydroureteronephrosis in 1 case. Cesarean section rate
Archives of Gynecology and Obstetrics
PurposePolycystic ovary syndrome (PCOS) is the most common endocrine disorder of women of reprodu... more PurposePolycystic ovary syndrome (PCOS) is the most common endocrine disorder of women of reproductive age. The aim of the current study was to assess muscle mechanical function in PCOS and its relationship with hormonal and metabolic features of the syndrome.MethodsThe study included 44 women with PCOS, all having clinical or biochemical hyperandrogenism, chronic oligo-anovulation and PCOM, and 32 age- and BMI-matched healthy women. Anthropometric, hormonal and biochemical measurements were performed. Muscle mechanical function including lower limb explosive strength and average power (AvP) was measured using isokinetic dynamometry, a valid and reliable instrument for measuring muscle strength.ResultsThe mean age and BMI of the women with PCOS and controls were 21.8 ± 3.2 versus 22.8 ± 3 years and 26.1 ± 5.4 versus 25.5 ± 5.7 kg/m2, respectively (p = NS for both). PCOS patients had higher androgen levels, whereas total and regional fat and lean body mass and insulin resistance parameters were similar between the groups. The peak muscle force output defined as the peak torque of knee extensor and flexor muscles was higher in normal weight women compared to overweight and obese (p < 0.05 for both) but did not differ in patients and controls. AvP determined by the time-averaged integrated area under the curve at 60°/s angular velocity was higher in the PCOS group for extension and flexion (50.3 ± 21.2 vs 42.1 ± 11.6 and 35.3 ± 27 vs 22.2 ± 11.1, respectively, p < 0.05 for both). These measurements were correlated with bioavailable testosterone (r = 0.29, p = 0.012, r = 0.36, p = 0.001, respectively).ConclusionMuscle mechanical function is altered in PCOS. Women with PCOS have increased average lower limb power that is associated with hyperandrogenism.
![Research paper thumbnail of Corrigendum to “Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects” [Respir. Med. (2016) 119 109–114]](https://attachments.academia-assets.com/82177273/thumbnails/1.jpg)
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Clinical Biochemistry, Mar 1, 2009
Journal of Obstetrics and Gynaecology Research, Mar 3, 2020
Aim: Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters ... more Aim: Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters of neutrophil, monocyte and lymphocyte, procalcitonin (PCT) and white blood cell count (WBC) during term and preterm labor to evaluate the impact of inflammation on the triggering mechanisms of uterine contractions. Methods: This study is consisted of 16 preterm and 60 term pregnancies at the beginning of the first stages of the labor. Leukocyte VCS parameters, PCT plasma levels and WBC count were evaluated. Results: We could not demonstrate statistically significant difference in between leukocyte VCS parameters in preterm and term deliveries (P > 0.050 for all). WBC counts were 10.6 and 11.8 × 10 3 /μL in the preterm and term groups respectively (P = 0.270). PCT levels were 0.04 and 0.03 ng/mL for preterm and term pregnancies (P = 0.062). Conclusion: Inflammation related markers such as leukocyte VCS parameters, PCT values and WBC count does not differentiate at the first stage of labor in preterm and term deliveries. These variables do not seem to have a prominent role at the biological events behind preterm contractions.
Early Human Development, 2012
Bone, Nov 1, 2012
We present a case with extremely high parathyroid hormone (PTH) concentrations in the order of hu... more We present a case with extremely high parathyroid hormone (PTH) concentrations in the order of hundred thousands accompanied by dermatological and hematological diseases. After several diagnostic interventions, no malignancy could be demonstrated except monoclonal gammopathy of unknown significance. The dermatological findings were taken to be manifestations of the hematological disease. Since the first serum intact PTH concentration of the patient was found to be higher than 2500 pg/ml, dilution study was performed and found to be 215,977 pg/ml. The high concentration of serum PTH was taken to be falsely high due to assay interference. This concentration was checked from three different paths; a test for linear dilution was performed, the test was repeated with another method and the sample was treated to remove or inhibit interfering substances. The results were compatible with endogenous antibody interference, presumed to be a result of monoclonal gammopathy. The extremely high PTH concentrations were not only due to assay interference, but also secondary hyperparathyroidism, which was evident by the decrease in PTH concentrations with calcium and vitamin D treatments.
Pediatric Blood & Cancer, 2003
We investigated the usefulness of serum cardiac Troponin T (cTnT) to detect doxorubicin related c... more We investigated the usefulness of serum cardiac Troponin T (cTnT) to detect doxorubicin related cardiotoxicity as a non-invasive and reliable method. Twenty-four patients who received doxorubicin for their solid tumors at cumulative doses of 400 mg/m(2) or higher, between June 1982 and August 2000, were included in this study. None of them had clinical signs or symptoms of cardiotoxicity. The age range was 3-31 years (median 14), and male to female ratio was 14/10. The systolic and diastolic cardiac functions were evaluated by two-dimensional, M-mode, and Doppler echocardiography. Serum cTnT levels were measured by a third generation immunoassay method and the lowest detectable level was 0.010 ng/ml. The cumulative doxorubicin doses were at the range of 400 and 840 mg/m(2) (median 480). The time past from the last doxorubicin dose was 1-168 months (median 12). All of the patients had normal chest X-rays, electrocardiograms, and nine patients (37.5%) had abnormal systolic or diastolic cardiac function parameters. The median cumulative doxorubicin doses of the patients with normal and abnormal echocardiographic parameters were 480 and 440 mg/m(2), respectively. Serum cTnT values of 21 patients were below the detection limit (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.010 ng/ml). There was no statistical difference between serum cTnT levels of the patients with normal and abnormal echocardiographic findings (P = 0.376). No correlation was found between serum cTnT values, cumulative doxorubicin doses, and systolic or diastolic cardiac functions. We can conclude that echocardiographic follow-up is more reliable than serum cTnT levels for detecting subclinical cardiac toxicity.
Klimik Dergisi/Klimik Journal
Objective: This study included participants from Hacettepe University 4th, 5th, and 6th-grade stu... more Objective: This study included participants from Hacettepe University 4th, 5th, and 6th-grade students of Medical School and 4th and 5th-grade students of Dental School; and aimed to evaluate the general health status, COVID-19 history, vaccination status, and SARS-CoV-2 antibody levels of the participants to support their physical and social health, during the pandemic period. Methods: A prospective cohort study was conducted with an integrated, matched, nested case-control study. Sociodemographic characteristics, life habits, COVID-19 history, vaccination status, compliance with mask-distance-hygiene rules, and risks (if any) for COVID-19 were inquired via online questionnaires. Physical examinations, complete blood count, biochemistry tests, and anti-SARS-CoV-2 anti-spike antibody tests were conducted for all consenting participants. All analyses were established using depersonalized data. Results: Of the 778 participants completing the baseline visit in June-July 2021, the perce...
Children with Attention Deficit Hyperactivity Disorder (ADHD) might have problems similar to auti... more Children with Attention Deficit Hyperactivity Disorder (ADHD) might have problems similar to autism spectrum disorders and show impairment in social behaviour. Also, there is a relationship between social relationship skills and ToM (Theory of Mind) skills in children with ADHD. Besides, ASD (Autism Spectrum Disorder) is associated with prenatal exposure to high levels of androgens, and oxytocin plays a role in the modulation of emotions, coping with stress, and social behaviour such as ASD. In this study, the relationship between autistic traits and serum oxytocin, testosterone, and androstenedione levels in prepubertal male drug naive children with ADHD has been investigated. Prepubertal children with ADHD have been included in the study. For the children included in the study, intelligence levels were evaluated with WISC-4 (Wechsler Intelligence Scale for Children-fourth edition) and autistic traits were measured with both social responsiveness scale and theory of mind tests. Ser...
Hepato-gastroenterology, 2010
The role of circulating tumor cells (CTCs) in the management of colorectal cancer has not yet est... more The role of circulating tumor cells (CTCs) in the management of colorectal cancer has not yet established. In present study, we aimed to investigate the relationship between clinicopathological characteristics and CTC levels in patients with colorectal carcinoma. The isolation of CTCs in blood was performed with the semi-automated CellSearch System (Veridex TM). Ninety-three patients were analyzed. Median age of patients at the time of diagnosis was 56 (24-78). Total number of blood samples collected for CTCs were 130. CTCs were detected in 46 patients (> or =1 per 7.5 mL), but only thirty (32%) patients were interpreted as positive (> or = 3/7.5 mL). In the 27 patients in whom 2 blood samples were taken, levels of CTCs were found to be decreased in 8 patients, increased in 14 patients and did not change in 5 patients after therapy. Although only 2 (25%) of 8 patients in whom CTCs decreased after therapy had disease progression, 13 (93%) of 14 patients with increased CTCs had ...
Taiwanese Journal of Obstetrics and Gynecology
OBJECTIVE To evaluate first trimester screening test parameters in epileptic patients using anti-... more OBJECTIVE To evaluate first trimester screening test parameters in epileptic patients using anti-epileptic drugs. MATERIALS AND METHODS We retrospectively evaluated first trimester screening test results of 23 epileptic pregnant women using anti-epileptic drugs with a control group consisting of 92 healthy pregnancies. The anti-epileptic drugs used in this study were carbamazepine, levatiracetam, valproic acid and lamotrigine. Single drug or multi-drug regimens were used according to the clinical conditions. Patients with any known chronic or acute disease and drug usage were excluded from the study. Comparisons were performed via Mann-Whitney U test. RESULTS First trimester screening test biochemical markers were compared and maternal serum PAPP-A MoM values were found to be similar in study and control groups while β-hCG MoM values were significantly higher in pregnancies using epileptic drugs (p: 0,737 and p < 0.001, respectively). CONCLUSION Biochemical first trimester screening test results may be affected by anti-epileptic drug usage, which may lead to misinterpretation of the risk level. Thus, validation of MoM values should be necessary in order to obtain optimal results.
Turkish Journal of Biochemistry
ObjectivesTo demonstrate immature granulocyte (IG) count and delta neutrophil index (DNI) values ... more ObjectivesTo demonstrate immature granulocyte (IG) count and delta neutrophil index (DNI) values (novel potential predictive marker for neonatal sepsis) for neonates.MethodsThis prospective controlled clinical study was consisted of 208 patients (77 in the study group and 131 in the control group) who were delivered between January 2016 and January 2018 at the Hacettepe University Neonatal Intensive Care Unit in Ankara, Turkey. In this study, we evaluated value of DNI in diagnosing neonatal sepsis by comparing the DNI values in culture positive septic neonates with healthy neonates.ResultsIn our study, the median interquartile range (IQR = 25–75%) DNI was 0.1% (0.0–0.3%) in the control group and 1.5% (1.0–2.45%) in the sepsis group (p
Clinical Laboratory
BACKGROUND Serial C-reactive protein (CRP) biomarker values are frequently recorded from patients... more BACKGROUND Serial C-reactive protein (CRP) biomarker values are frequently recorded from patients in adult intensive care units (ICU). The aim of this study was to assess the time-dependent diagnostic accuracy of repeated CRP measurements in predicting ICU mortality and determine the time-dependent cutoff values for this biomarker in mixed ICU population. METHODS Joint modeling was performed to model repeated CRP measurements and survival data. Time-dependent AUC (td-AUC) values were used to assess the diagnostic performances. Maximization of the product of sensitivity and specificity rule was applied to determine the time-dependent cutoff values. RESULTS Time-dependent diagnostic performance of serial CRP values were found as moderate in overall, observed to be higher in males than females, ranging from 0.603 to 0.624 in females and 0.639 to 0.690 in males. On the other hand, time-dependent cutoff values either remained constant or decreased through the 3rd day after the last measurement for both gender groups. CONCLUSIONS Newly proposed time-dependent cutoff values for CRP biomarker are suggested to be used in clinics to discriminate subjects who are at risk and who are not during the first three days after the last measurement. Furthermore, taking serial CRP values in predicting the risk of death at ICU is highly recommended, to be able to assess the change in longitudinal profiles of subjects throughout the follow-up period.
Turkish Journal of Biochemistry
Turkiye Klinikleri Journal of Biostatistics
C-Reaktif Protein (CRP), erişkin yoğun bakımda yatan hastalardan tekrarlı ölçümleri sıklıkla alın... more C-Reaktif Protein (CRP), erişkin yoğun bakımda yatan hastalardan tekrarlı ölçümleri sıklıkla alınan bir belirteçtir. Bu çalışmada söz konusu belirtecin tekrarlı ölçümlerinin, izlem süresi olarak belirlenen 30 günlük süre sonunda yoğun bakımda ölüm olgusunu kestirmedeki tanısal performansını etkileyen faktörlerin incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Hacettepe Üniversitesi Erişkin Yoğun Bakım Ünitesi'nde yatan hastalara ait tekrarlı CRP ölçümleri ile sağkalım sürelerinin eş zamanlı olarak modellenebilmesi için birleşik modelleme yaklaşımı kullanılmıştır. Bu yaklaşımdan yararlanılarak, belirteçlerin tanısal performanslarının belirlenebilmesi için zamana bağlı ROC Eğrisi altında kalan alan (zb-EAA) değerlendirilmiştir. Bulgular: Tekrarlı CRP ölçümlerinin izlem süresi sonunda yoğun bakımda ölümü kestirmedeki tanısal performansı orta düzeyde bulunmuştur. Bununla birlikte, sağkalım zamanına ait dağılım türünün ya da uzunlamasına veri bölümünde rassal etkiler kısmının daha detaylı olarak modellenmesinin tekrarlı CRP ölçümlerinin tanısal performansına etki etmediği saptanmış, en yüksek performansın standart birleşik model ile elde edildiği belirlenmiştir. Sonuç: Analiz sonuçlarına göre, optimum tanısal doğruluğun elde edilebilmesi için, standart birleşik modelin kullanılması önerilmekle birlikte, söz konusu modelin uzunlamasına bölümünde rassal eğim ve rassal kesim noktası modelinin; modelin sağkalım kısmında ise, parametrik bir dağılım olmasından dolayı Piecewise-Constant dağılımının kullanılması önerilmektedir. Anahtar Kelimeler: Zamana-bağlı ROC eğrileri; belirteç; zamana-bağlı eğri altında kalan alan; birleşik model; sağkalım zamanı; CRP ABSTRACT Objective: Serial C-Reactive Protein (CRP) measurements are frequently taken in Adult Intensive Care Units. In this study it's aimed to evaluate the factors affecting diagnostic accuracy of this biomarker's serial measurements in predicting the risk of death at Intensive Care Units (ICU) at the end of follow-up period, 30 days. Material and Methods: Joint Modelling Approach is used to model repeated CRP measurements taken from Hacettepe University Adult Intensive Care Units and survival times simultaneously. With the help of this model, time-dependent Area Under ROC Curve (td-AUC) values are calculated and assessed as diagnostic performance criteria. Results: Diagnostic performance of serial CRP values in predicting the risk of death is found as moderate. However, it's found that neither the distribution of survival times in survival sub-model nor utilizing more detailed function in random-effects part of longitudinal sub-model affect the diagnostic performance. Also it's determined that the highest diagnostic performance is obtained with standart standard joint model. Conclusion: To reach the highest diagnostic accuracy, standard joint model with Piecewise Constant Distribution in survival sub-model and random intercepts-random slope structure in longitudinal sub-model should be used.
The Turkish Journal of Pediatrics
Recent technological improvements have enabled automated hematology analyzers to determine the IG... more Recent technological improvements have enabled automated hematology analyzers to determine the IG count and fraction. The term IG is used to describe the myelocytes, promyelocytes and metamyelocytes (i.e., neutrophil precursors) that are found in the bone marrow but not in the peripheral blood
Journal of Obstetrics and Gynaecology Research
Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters of ne... more Comparison of mean channels of cell volume, conductivity and light scatter (VCS) parameters of neutrophil, monocyte and lymphocyte, procalcitonin (PCT) and white blood cell count (WBC) during term and preterm labor to evaluate the impact of inflammation on the triggering mechanisms of uterine contractions.
Cukurova Medical Journal
Öz Purpose: Down syndrome screening with first trimester combined test is recommended for all pre... more Öz Purpose: Down syndrome screening with first trimester combined test is recommended for all pregnancies. It is unclear, whether thyroid stimulating hormone (TSH) affects secretion of free beta subunit human chorionic gonadotropin (fβ-hcg) and pregnancy-related plasma protein (PAPP-A). We aimed to investigate the effect of serum thyroid stimulating hormone (TSH) levels on the combined test results. Materials and Methods: First trimester TSH levels together with nuchal translucency (NT(fβ-hcg and PAPP-A results of 297 patients were included in this study. Patients were divided into four groups according to their TSH levels; Group 1 (<0.1 μL / ml), Group 2 (0.1-2.5 μlU / ml), Group 3 (2.5-3.5 μlU / ml) and Group 4 (> 3.5 μlU / ml). Groups were compared in terms of NT, PAPP-A and fβ-hcg levels. Results: The mean PAPP-A (MoM) value was found to be 0.99 in group 1, 1.12 in group 2, 1.03 in group 3, and 0.95 in group 4. Mean fβ-hcg (MoM) value was 1.36 in group 1, 1.29 in group 2, 1.05 in group 3, and 1.32 in group 4. The mean NT measurement was 1.27 ± 0.25, 1.33 ± 0.38, 1.34 ± 0.33 and 1.32 ± 0.37 mm, from group 1 to group 4, respectively. There was no statistically significant difference between groups in terms of PAPP-A, fβ-hcg and NT. Conclusion: The present study have shown that first trimester TSH levels do not affect combined test parameters. Prenatal screening by using NT, fβ-hCG and PAPP-A seems to be safe for pregnant women with hypothyroidism or hyperthyroidism.
Current Urology
Usage and distribution for commercial purposes as well as any distribution of modified material r... more Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. Urinary tract infection • Pregnancy • Uropathogens • Escherichia coli Background and Objectives: Our aim is to identify uropathogens that cause urinary tract infections (UTIs) that necessitate hospitalization, and analyze outcomes of gestational UTIs. Methods: This study consisted of 30 pregnant women who necessitate hospitalization because of UTI (7.8% of gestational UTIs during the same period of time). UTI that necessitates hospitalization is defined as clinical complaints, urination problems, urine analysis and culture positivity, fever and uterine discomfort. Patients with at least two positive cultures (≥ 100,000 cfu/ml) were included to this study. Antimicrobial susceptibility tests were obtained in all cases in order to determine antimicrobial resistance and to choose the ideal antibiotics for treatment. Results: In our study, we have found that Escherichia coli is the most common microorganism (56.7%). Enterococcus faecalis (13.3%) and Klebsiella pneumonia (10%) were other frequently observed microorganisms. In this series, mean gestational week at birth was 35 weeks 5 days (range 23-40 weeks). Mean birthweight was 2,656 g (range 500-3,700 g). Twenty-three cases (76.7%) were hospitalized before 37th gestational week and preterm delivery rate was 56.3%. Maternal risk factors and coexisting diseases were detected in 11 (36.7%) patients as follows: diabetes mellitus in 4, thrombophilia in 3, thyroid disorders in 3 and hydroureteronephrosis in 1 case. Cesarean section rate
Archives of Gynecology and Obstetrics
PurposePolycystic ovary syndrome (PCOS) is the most common endocrine disorder of women of reprodu... more PurposePolycystic ovary syndrome (PCOS) is the most common endocrine disorder of women of reproductive age. The aim of the current study was to assess muscle mechanical function in PCOS and its relationship with hormonal and metabolic features of the syndrome.MethodsThe study included 44 women with PCOS, all having clinical or biochemical hyperandrogenism, chronic oligo-anovulation and PCOM, and 32 age- and BMI-matched healthy women. Anthropometric, hormonal and biochemical measurements were performed. Muscle mechanical function including lower limb explosive strength and average power (AvP) was measured using isokinetic dynamometry, a valid and reliable instrument for measuring muscle strength.ResultsThe mean age and BMI of the women with PCOS and controls were 21.8 ± 3.2 versus 22.8 ± 3 years and 26.1 ± 5.4 versus 25.5 ± 5.7 kg/m2, respectively (p = NS for both). PCOS patients had higher androgen levels, whereas total and regional fat and lean body mass and insulin resistance parameters were similar between the groups. The peak muscle force output defined as the peak torque of knee extensor and flexor muscles was higher in normal weight women compared to overweight and obese (p < 0.05 for both) but did not differ in patients and controls. AvP determined by the time-averaged integrated area under the curve at 60°/s angular velocity was higher in the PCOS group for extension and flexion (50.3 ± 21.2 vs 42.1 ± 11.6 and 35.3 ± 27 vs 22.2 ± 11.1, respectively, p < 0.05 for both). These measurements were correlated with bioavailable testosterone (r = 0.29, p = 0.012, r = 0.36, p = 0.001, respectively).ConclusionMuscle mechanical function is altered in PCOS. Women with PCOS have increased average lower limb power that is associated with hyperandrogenism.