ozlem çelebi erdivanli - Academia.edu (original) (raw)

Papers by ozlem çelebi erdivanli

Kafkas Journal of Medical Sciences, 2016

Nasal glioma is a rare congenital benign midline tumor consisting of heterotropic glial tissue. S... more Nasal glioma is a rare congenital benign midline tumor consisting of heterotropic glial tissue. Similarly, to the other intranasal tumors it causes symptoms like nasal obstruction, rhinorrhea, and bleeding. The only treatment option is surgical excision. Since the tumor recurrence is a very common condition the surgery should be performed very carefully. In addition, in cases with intracranial extension fatal postoperative meningitis may occur. In this report, we aimed to present clinical and therapeutic features of the two cases of nasal glioma patient which were both treated by transnasal surgery at the age of nine months and thirteen months old.

Turkiye Klinikleri Ear Nose and Throat - Special Topics, 2017

European Archives of Oto-rhino-laryngology, Mar 14, 2017

Clinical Otolaryngology, Jul 25, 2022

Medical science technology, Jan 18, 2016

Background: Allergic rhinitis (AR) is a common disease observed in otorhinolaryngology (ORL) prac... more Background: Allergic rhinitis (AR) is a common disease observed in otorhinolaryngology (ORL) practice. The aim of the study was to determine the rates of new asthma diagnosis in the patient population newly diagnosed with AR in otorhinolaryngology (ORL) practice in the Eastern Black Sea region. Material/Methods: This study retrospectively evaluated the files of patients admitted to an ORL outpatient clinic in Rize, Turkey between April 2011 and June 2012 and who were diagnosed with AR for the first time upon detection of aeroallergen sensitization in the prick test. Within this patient group, the files of patients who were also diagnosed with asthma in the same time period were examined. The files of patients who had previously been diagnosed with or treated for AR and/or asthma and with nasal polyposis and lower respiratory tract disease were excluded from the study. Results: There were 267 patients with a mean age of 37.5±14.9 (10–77 years) diagnosed with AR for the first time in the ORL outpatient clinic. The most common allergens were Dermatophagoides pteronyssinus (81.3% [217/267]), D. farinae (73.8% [197/267]), and grass mix (61.4% [164/267]). Of this patient group, 29.2% were diagnosed with asthma: 15% (40/267) with intermittent asthma, 13.9% (37/267) with mild persistent asthma, and 0.3% (1/267) with moderate persistent asthma. Conclusions: A rate of 29.2% for new asthma diagnoses in the Eastern Black Sea region in patients diagnosed with AR for the first time indicates a need to examine asthma complaints in all patients newly diagnosed with AR in ORL practices. © Med Sci Tech, 2016

Radiation and Environmental Biophysics, 2022

Radiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is... more Radiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is used together with other treatments such as surgery and chemotherapy in more advanced stages. However, exposure to ionizing radiation in association with radiotherapy affects several organs in the head and neck and can give rise to early and late side effects. Exposure to ionizing radiation used in radiotherapy is known to cause cell damage by leading to oxygen stress through the production of free oxygen radicals (such as superoxide radicals, hydroxyl radical, hydrogen peroxide, and singlet oxygen), depending on the total radiation dosage, the fractionation rate, radiosensitivity, and linear energy transfer. The purpose of the present study was to determine the potential protective role of a powerful and highly selective α2-adrenoreceptor agonist with a broad pharmacological spectrum against salivary gland damage induced by ionizing radiation exposure. Forty Sprague-Dawley rats were divided into five groups-control, ionizing radiation, ionizing radiation + dexmedetomidine (100 µg/kg), ionizing radiation + dexmedetomidine (200 µg/kg), and ionizing radiation + amifostine (200 mg/kg). Following exposure to ionizing radiation, we observed necrosis, fibrosis, and vascular congestions in parotid gland epithelial cells. We also observed increases in malondialdehyde (MDA) and cleaved Caspase-3 levels and a decrease in glutathione (GSH). In groups receiving dexmedetomidine, we observed necrotic epithelial cells, fibrosis and vascular congestion in parotid gland tissue, a decrease in MDA levels, and an increase in GSH. Dexmedetomidine may be a promising antioxidant agent for the prevention of oxidative damage following radiation exposure.

Journal of Experimental & Clinical Medicine, 2016

It was aimed to establish which identifiable variables for an idiopathic sudden sensorineural hea... more It was aimed to establish which identifiable variables for an idiopathic sudden sensorineural hearing loss (ISSHL) have a prognostic value in the hearing recovery. Patients hospitalized with diagnosis of ISSHL and treated in our clinic between 2009 and 2013 were evaluated retrospectively. Individuals received the same treatment were classified into two groups after a month from diagnosis by a pure tone audiogram regarding Siegel’s criteria. Effect of patient’s age, gender, side of ear, degree of hearing loss, patterns of initial pure-tone audiogram, comorbidities such as systemic diseases, time of initial treatment, contralateral ear hearing, presence of vestibular symptoms and tinnitus on the prognosis of ISSHL was evaluated in this study. Eighty two patients (46 male, 36 female, mean age 47.9, age ranging between 21 and 85) were included in this study. Hearing recovery was observed in 50 patients (61%). Recovery rate was significantly better in patients less than 60 years and rece...

European Archives of Oto-Rhino-Laryngology, 2021

Purpose While the use of cartilage graft for revision tympanoplasty is quite common, the data on ... more Purpose While the use of cartilage graft for revision tympanoplasty is quite common, the data on the revision of cartilage tympanoplasty are limited. Our study aims to present the results of our patients who underwent endoscopic butterfly inlay myringoplasty for the revision of cartilage tympanoplasty. Methods Demographic data, ear sides, perforation locations, graft success rates and hearing results of the patients who underwent endoscopic butterfly inlay myringoplasty for revision of cartilage tympanoplasty between Sep 2017 and Jan 2020 were evaluated. Results A total of 17 patients with 7 (41%) females and 10 (59%) males were included in our study. Eight of the ears (47%) were right and nine (53%) were left. Perforation locations included ten (59%) anterior, six (35%) inferior, and one (6%) posterior. The graft success rate of our study was 100%. No changes were observed in post-operative air conduction, bone conduction and air–bone gap values compared to the pre-operative period ( p > 0.05). Conclusions Endoscopic butterfly inlay myringoplasty for the revision of cartilage tympanoplasty is considered to be a safe surgical technique with satisfactory anatomical and hearing results.

ENT Updates, 2020

Objective: The purpose of the present study was to investigate the relationship between vertical ... more Objective: The purpose of the present study was to investigate the relationship between vertical facial development and angular and linear measurements of the face. Methods: Pretreatment cephalometric radiographs of subjects with class III malocclusion were divided into three groups according to vertical facial development as low, normal and high angle. Nine angular, three dimensional and one ratio measurements were performed with the analysis program (AudaxCeph ver. 5.2.0.3610, Audax Slovenia) on the cephalometric radiographs and compared between the vertical growth groups. Results: There was a significant negative correlation between the Sella-Nasion/Gonion-Menton (SN-GoMe) and Saddle-Nasion-A (SNA), Saddle-Nasion-B (SNB), Incisal Mandibular Plane Angle (IMPA) and Jarabak ratio measurements, whereas a significant positive correlation was found between the SN-GoMe and the Gonial and Saddle measurements. Conclusion: According to the results of the present study, we determined that anterior and posterior development of the face decreases with the increase in the vertical direction of the face. Also, an increase in vertical direction angles including Gonial and Saddle angles significantly correlated with the increase in SN-GoMe angle. Since vertical growth problems can cause complicated and long orthodontic treatment, factors that may affect vertical growth should be addressed, such as mouth breathing.

European Archives of Oto-Rhino-Laryngology, 2020

The aim of the present study was to evaluate the prognostic factors that may affect the success i... more The aim of the present study was to evaluate the prognostic factors that may affect the success in endoscopic cartilage tympanoplasty and determine the outcomes of endoscopic cartilage tympanoplasty. Methods This study included 312 patients who underwent transcanal endoscopic type I cartilage tympanoplasty. The effects of sex, the affected side, the size of the perforation, the location of the perforation, the absence of myringosclerosis, external ear canal protrusion, the condition of the contralateral ear, and surgical experience on the rate of graft success and hearing improvement were investigated. Results The affected side, sex, location of the perforation, myringosclerosis, the condition of contralateral ear, and surgical experience did not significantly affect the surgical success (p > 0.05). However, the size of perforation and ear canal wall protrusion were significantly related to both functional and anatomical success (p < 0.05). Conclusion Endoscopic transcanal type I cartilage tympanoplasty can be performed with a high anatomical and functional success rate. However, surgeons should be more careful and design a case-specific operation strategy in patients with external ear canal anterior wall protrusion and large perforations.

International Journal of Pediatric Otorhinolaryngology, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

American Journal of Otolaryngology, 2020

ENT Updates, 2018

Özet: Obstrüktif uyku apnesi tan›s›nda periferik arteriyel tonometrinin de¤erlendirilmesi Amaç: P... more Özet: Obstrüktif uyku apnesi tan›s›nda periferik arteriyel tonometrinin de¤erlendirilmesi Amaç: Periferik arteriyel tonometrinin (PAT), uyku monitörizasyonunda tafl›nabilir bir yöntem olarak kullan›m› k›smen yeni bir yöntemdir. Bu çal›flmada, PAT sonuçlar› ile polisomnografi (PSG) so-nuçlar›n›n karfl›laflt›r›lmas› ve obstrüktif uyku apnesi sendromu tan›-s›nda PAT'›n rolününün de¤erlendirilmesi amaçland›. Yöntem: Bu çal›flmaya KBB klini¤ine OSAS flikayetleri (gündüz uykululuk hali, horlama ve tan›kl› apne) ile baflvurmufl ve uyku monitörizasyonu PAT sistemi (WatchPAT 200 TM ; Itamar Medical Ltd., Caesarea, ‹srail) ile yap›lm›fl, daha sonra Gö¤üs Hastal›klar› Uyku La-boratuvar›nda kör olarak level 1 polisomnografi uygulanm›fl eriflkin hastalar dahil edildi. Bulgular: ‹ki farkl› zamanda yap›lm›fl uyku monitörizasyonunda apne hipopne indeksi (AHI) ve solunum bozuklu¤u indeksi (RDI) de¤erleri yüksek oranda korele idi (r=0.749, r=0.753; p<0.001). Oksijen desatürasyon indeksi (ODI) de¤eri ise çok yüksek oranda korele saptand› (r=0.861; p<0.001). Çal›flmaya dahil edilen hastalar›n AHI skorlar› PAT yöntemiyle ölçüldü¤ünde; hastalar›n %89.7'si OSAS için (AHI≥5) do¤ru tan› ald›; PAT testinde, RDI'ye göre yap›lan de¤erlendirmede (RDI≥5) OSAS tan›lar›n›n %100'ü do¤ru idi; PAT yöntemiyle yap›lan ölçümde AHI de¤eri için eflik de¤eri 15 olarak kabul edildi¤inde, duyarl›l›k %96.1 olarak oldukça yüksek bulundu. Sonuç: PAT ve PSG de¤erleri yüksek oranda korele idi. Bu durum PAT ile elde edilen sonuçlar›n tekrarlanabilirli¤inin de yüksek oldu-¤unu göstermifltir. Çal›flmam›z PAT'›n OSAS'da tarama testi olarak ve yüksek oranda OSAS flüphesi olan hasta grubunda kullan›labilece-¤ini göstermektedir.

European Archives of Oto-Rhino-Laryngology, 2019

Purpose Nowadays, the use of otoendoscopy is becoming increasingly popular in ear surgery. Data o... more Purpose Nowadays, the use of otoendoscopy is becoming increasingly popular in ear surgery. Data on endoscopic tympanoplasty are quite current but not yet sufficient. This study aims to present the anatomical and functional results of endoscopic butterfly inlay myringoplasty in large perforations. Methods The graft success rates and audiological outcomes of 26 ears of 23 patients who underwent endoscopic cartilage inlay myringoplasty due to large perforation (more than two-thirds of the area of tympanic membrane) from March 2016 to August 2018 were evaluated. Results The mean follow-up period was 13.3 ± 7.1 (6-32) months. Graft success rate was 96% (25/26 ears). The preoperative mean air-bone gap (ABG) was 21.4 dB and postoperative mean was 14.4 dB. Significant improvement was observed in postoperative air-bone gap values compared to preoperative period (p 0.005). Conclusions Endoscopic inlay butterfly myringoplasty is a safe surgical technique and has satisfactory anatomic and audiological outcomes in large tympanic perforations.

Indian Journal of Otology, 2017

Objective: The purpose of this study is to evaluate the effects of myringosclerosis (MS) localize... more Objective: The purpose of this study is to evaluate the effects of myringosclerosis (MS) localized to the tympanic membrane (TM) on the mechano-acoustics of hearing using wideband tympanometry (WBT). Materials and Methods: In this prospective case-controlled study, 86 ears of 54 patients who were found to have MS localized to the TM were compared to 40 healthy eardrums in 20 patients. Thirty-seven ears which had a MS ratio to the whole TM of <25% were classified as Group 1, 33 ears with a ratio of 25–50% were classified as Group 2, and 16 ears with a ratio of >50% were classified as Group 3. Peak acoustic compliance, resonant frequency (RF), and frequency-specific absorbance results of WBT were compared among the MS groups and the control group. Results: When the amplitudes of peak acoustic compliance of the MS groups and control group were compared, the MS groups were found to have lower amplitudes, and the difference was statistically significant (P < 0.05). There was no difference in frequency-specific absorbance values (250, 500, 1000, 2000, 4000, 8000, and 375–2000 Hz averaged absorbance) among the groups (P > 0.05). The RF of Groups 1, 2, and 3 were 1062, 1154, and 1166 Hz, respectively, and the RF of the control group was 1077 Hz. There was no significant difference among the groups with regard to resonant frequencies. Conclusion: This study showed that although MS localized to the TM decreased the amplitude of peak acoustic compliance of the tympanogram, it did not affect the RF or the wideband acoustic absorbance.

Evidence-Based Complementary and Alternative Medicine, 2017

We explored the effects of topical curcumin on the healing of nasal mucosal wounds. A total of 32... more We explored the effects of topical curcumin on the healing of nasal mucosal wounds. A total of 32 Sprague-Dawley Albino rats were randomized in equal numbers into four groups, and unilateral nasal wounds were created using an interdental brush. Group 1 (the sham-control group) contained untreated rats with traumatized right-side nasal cavities; Group 2 and 3 rats were similarly traumatized and treated with topical curcumin (5 and 10 mg/mL) dissolved in dimethyl sulfoxide daily for 7 days after trauma; Group 4 rats were treated with topical dimethyl sulfoxide only. All rats were decapitated on day 15 and the healing sites evaluated by blinded observers in terms of the presence of cellular hyperplasia, goblet cell hypertrophy and degeneration, leucocytic infiltration, ciliary loss and degeneration, edema, and vascular dilation. On histopathological evaluation, all of cellular hyperplasia, leukocytic infiltration, and edema were significantly reduced in Group 3 compared with Group 1 (p...

European Archives of Oto-Rhino-Laryngology, 2016

Thymoquinone has antioxidant properties. We hypothesized that thymoquinone may prevent or allevia... more Thymoquinone has antioxidant properties. We hypothesized that thymoquinone may prevent or alleviate hearing loss induced by acoustic trauma. We aimed to study thymoquinone's effect on hearing function with distortion-product otoacoustic emissions and auditory brainstem response. Thirty adult Spraque Dawley rats were randomized into four groups following exposure to acoustic trauma for 4 h. Control group (n = 7) did not receive further treatment. Thymoquinone-20 (n = 8) and Thymoquinone-40 (n = 8) received 20 and 40 mg/kg of intraperitoneal thymoquinone, respectively. Corn-oil group (n = 7) received 1 ml of corn oil intraperitoneally. Hearing function of both ears was tested with distortion-product otoacoustic emission and auditory brainstem response before, and shortly after acoustic trauma, and 96 h following acoustic trauma. Post-trauma signal/noise ratios and wave V amplitude/latencies of all groups were significantly low compared with pre-trauma values, which indicate no preventive effect of thymoquinone. Rats in Thymoquinone-20 showed a significantly improved distortion-product otoacoustic emission and auditory brainstem response results at 4000 frequency and above in post-treatment tests (p \ 0.05). Improvement in Thymoquinone-40 at the same frequencies was insignificantly inferior to Thymoquinone-20, yet superior to control and corn-oil groups (p \ 0.05). We conclude that thymoquinone may not prevent acoustic trauma-induced hearing loss, however, at 20 mg/kg for 96 h, may repair the damage.

Indian Journal of Otology, 2016

Objectives: To investigate possible sensorineural hearing loss created by the use of a cold light... more Objectives: To investigate possible sensorineural hearing loss created by the use of a cold light source in patients undergoing endoscopic tympanoplasty surgery. Materials and Methods: The medical records of 203 patients, who underwent endoscopic Type 1 tympanoplasty surgery in our ear, nose, and throat clinic between 2012 and 2015, were checked retrospectively. Ninety-one patients were male and 112 were female, and their mean age was 34.4 ± 11.2 years. Results of audiometric measurements performed during the preoperative period and repeated 1 and 3 months postsurgery were compared to each other. Results: The mean duration of the operations was determined to be 52.4 ± 9.1 min. In addition, average preoperative bone-conduction was 11.4 ± 7.4 dB nHL. However, it was 9.57 ± 7.1 dB nHL and 9.51 ± 7.4 dB nHL, respectively, in the 1st and 3rd postoperative months. Levels of postoperative average bone-conduction at the 1st and 3rd month, as well as the thresholds of bone-conduction at 500, 1000, and 2000 Hz, were significantly lower than the preoperative results (P < 0.05). However, there was not a remarkable difference at 4000 Hz (P > 0.05). Conclusion: Based on our findings, the increased heat generated by the use of a cold light source during an endoscopic tympanoplasty surgery is unlikely to cause the development of sensorineural hearing loss.

Turkiye Klinikleri Kulak Burun Bogaz Ozel Dergisi, 2013