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National Institute of Technology Rourkela

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Papers by asma pathan

International Journal of Chemical and Pharmaceutical Analysis, May 22, 2017

Journal of Drug Delivery, 2013

Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administ... more Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. It is highly lipophilic (log P 5.5) and a poorly water-soluble drug with absolute bioavailability of 26%. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate. Liquisolid compacts were prepared using Acrysol El 135 as a solvent, Avicel PH 102, Fujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios. The interaction between drug and excipients was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients. The powder characteristics were evaluated by different flow parameters to comply with pharmacopoeial limits. The dissolution studies for liquisolid compacts and conventional formulations ...

Aims: The present investigation concerns the preparation and characterization of Rufinamide HP-βc... more Aims: The present investigation concerns the preparation and characterization of Rufinamide HP-βcyclodextrin complexes prepared by the kneading method. Material & methods: Rufinamide was procured as a gift sample from Torrent Pharmaceuticals limited. HP-β-cyclodextrin (HP-β-CD) was purchased from Himedia, India. Methanol and Hydrochloric Acid were purchased from S. D. Fine Chem. Pvt. Ltd., India. kneading method was selected to prepare inclusion complexation of Rufinamide. Phase solubility study was performed to check formation of inclusion complex. Prepared complex were characterize by different methods like DSC study, FTIR study, X-RPD study & in-vitro dissolution study Results: It was found that there is a formation of 1:1 inclusion complex between HP-β-CD as stability constant was found to be 221.27 M-1. DSC study, FTIR study had given supporting data for formation of inclusion complex. Amorphous nature of the complex was confirmed from the X-RPD study. Conclusions: From in-vitr...

Itraconazole is a synthetic triazole antifungal agent. Itraconazole is formulated into several ph... more Itraconazole is a synthetic triazole antifungal agent. Itraconazole is formulated into several pharmaceutical forms available into market. Itraconazole capsules are used to treat fungal infection in the lungs that can spread throughout the body. Itraconazole is partially water soluble therefore methods available for assay of Itraconazole in pharmaceutical formulation use organic solvents thus available methods are not cost effective and difficult to routine use. In present work attempt has made to develop a more precise, simple and economical spectrophotometric method with combination of water and methanol as solvent with greater precision, accuracy and suitability for the quantitation of Itraconazole in capsule dosage form. UV spectroscopic determination was carried out at absorption maxima of 254 nm using Methanol: Water (40:60 % v/v) as solvent. In present UV spectroscopic method linearity over the concentration range of Itraconazole was found to be in between 50-150 µg/ml with a...