prasad patil - Academia.edu (original) (raw)
Papers by prasad patil
AMIA Joint Summits on Translational Science proceedings AMIA Summit on Translational Science, 2012
Although a protocol aims to guide treatment management and optimize overall outcomes, the benefit... more Although a protocol aims to guide treatment management and optimize overall outcomes, the benefits and harms for each individual vary due to heterogeneity. Some protocols integrate clinical and genetic variation to provide treatment recommendation; it is not clear whether such integration is sufficient. If not, treatment outcomes may be sub-optimal for certain patient sub-populations. Unfortunately, running a clinical trial to examine such outcome responses is cost prohibitive and requires a significant amount of time to conduct the study. We propose a simulation approach to discover this knowledge from electronic medical records; a rapid method to reach this goal. We use the well-known drug warfarin as an example to examine whether patient characteristics, including race and the genes CYP2C9 and VKORC1, have been fully integrated into dosing protocols. The two genes mentioned above have been shown to be important in patient response to warfarin.
An approach to optimal individualized warfarin treatment through clinical trial simulations
… (CIBEC), 2010 5th …, 2010
Personalized medicine will depend on sophisticated tools, analyses, and molecular level data and ... more Personalized medicine will depend on sophisticated tools, analyses, and molecular level data and clinical information to provide optimized treatment based on each patient's individual characteristics such as health history, current health or disease status, and ...
BMC Bioinformatics, 2010
Background: Large comparative genomics studies and tools are becoming increasingly more compute-e... more Background: Large comparative genomics studies and tools are becoming increasingly more compute-expensive as the number of available genome sequences continues to rise. The capacity and cost of local computing infrastructures are likely to become prohibitive with the increase, especially as the breadth of questions continues to rise. Alternative computing architectures, in particular cloud computing environments, may help alleviate this increasing pressure and enable fast, large-scale, and cost-effective comparative genomics strategies going forward. To test this, we redesigned a typical comparative genomics algorithm, the reciprocal smallest distance algorithm (RSD), to run within Amazon's Elastic Computing Cloud (EC2). We then employed the RSD-cloud for ortholog calculations across a wide selection of fully sequenced genomes. Results: We ran more than 300,000 RSD-cloud processes within the EC2. These jobs were farmed simultaneously to 100 high capacity compute nodes using the Amazon Web Service Elastic Map Reduce and included a wide mix of large and small genomes. The total computation time took just under 70 hours and cost a total of $6,302 USD. Conclusions: The effort to transform existing comparative genomics algorithms from local compute infrastructures is not trivial. However, the speed and flexibility of cloud computing environments provides a substantial boost with manageable cost. The procedure designed to transform the RSD algorithm into a cloud-ready application is readily adaptable to similar comparative genomics problems.
ChemInform, 2015
Sulfamic acid has been found as an efficient and cost effective catalyst for one pot multicompone... more Sulfamic acid has been found as an efficient and cost effective catalyst for one pot multicomponent synthesis of some new densely functionalized piperidine derivatives using amines, aldehydes and β-keto esters. The meritorious aspects of this novel protocol are atom economic process, heterogeneous and easily accessible catalyst, good to excellent yield, convenient work up and eco-friendly route.
Synthesis of Novel Dibenzo-18-crown-6- ether-Functionalized Benzimidazoles and its Applications in Colorimetric Recognition to Hg 2+ and as Antifungal Agents
Journal of Heterocyclic Chemistry, 2014
ABSTRACT New crown ether-functionalized benzimidazoles was designed and synthesized via formylati... more ABSTRACT New crown ether-functionalized benzimidazoles was designed and synthesized via formylation of dibenzo-18-crown-6 followed by condensation with different o-phenylene diamines. The complexation properties of crown ether-functionalized benzimidazoles with various metals (K+, Ca2+, Ba2+, Co2+, Hg2+) were examined using UV–vis spectroscopy. Hg2+ showed a well-defined peculiar absorption maximum at 366 nm exclusively. All these newly synthesized compounds were screened for antifungal activity against Aspergillus niger and Aspergillus oryzae, respectively.
A series of novel crown ether complex cation ionic liquids (CECILs) have been synthesized and cha... more A series of novel crown ether complex cation ionic liquids (CECILs) have been synthesized and characterized by IR, 1 H NMR, 13 C NMR, and mass spectroscopy. Their catalytic applications in organic reactions along with recyclability without loss of catalytic activity have been studied.
Sequence Selective Michael Addition for Synthesis of Indeno-Pyridine and Indeno-Pyran Derivatives in One-Pot Reaction Using CuO Nanoparticles in Water
Journal of Heterocyclic Chemistry, 2014
ABSTRACT
Novel crown ether functionalized imidazolium-based acidic ionic liquid catalyzed synthesis of pyrazole derivatives under solvent-free conditions
Research on Chemical Intermediates, 2014
ABSTRACT An innovatively designed novel crown ether functionalized imidazolium-based reusable aci... more ABSTRACT An innovatively designed novel crown ether functionalized imidazolium-based reusable acidic ionic liquid [crown ether MIm] [HSO4] has been efficiently implemented for the synthesis of pyrazole derivatives using various substituted enaminones, hydrazine hydrate and phenyl hydrazine under solvent-free conditions. Structural novelty and task efficiency of the catalyst, high yields of desired products, greener approach attributing high atom economy and solvent-free conditions render this protocol suitable to cope with the current demand in contemporary organic chemistry. The inventive idea of utilizing crown ether functionalized ionic liquid as a catalyst was for the first time demonstrated in this protocol. Graphical Abstract
Proficient synthesis of quinoxaline and phthalazinetrione derivatives using [C8dabco]Br ionic liquid as catalyst in aqueous media
Journal of Molecular Liquids, 2013
ABSTRACT Relatively less toxic and biodegradable ionic liquid [C8dabco]Br has been successfully u... more ABSTRACT Relatively less toxic and biodegradable ionic liquid [C8dabco]Br has been successfully used for the synthesis of quinoxaline and phthalazinetrione derivatives in an aqueous media. Recyclability of catalyst, high yields, use of environmentally benign aqueous media as solvent, simple product isolation and high atom economy are the noteworthy aspects of the protocols.
Novel Brønsted Acidic Ionic Liquid ([CMIM][CF3COO]) Prompted Multicomponent Hantzsch Reaction for the Eco-Friendly Synthesis of Acridinediones: An Efficient and Recyclable Catalyst
Catalysis Letters, 2014
ABSTRACT Abstracts A novel, highly efficient and recyclable Brønsted acidic ionic liquid ([CMIM][... more ABSTRACT Abstracts A novel, highly efficient and recyclable Brønsted acidic ionic liquid ([CMIM][CF3COO]) has been successfully implemented for the synthesis of acridinediones in aqueous media. Recyclability of novel catalyst, high yields, use of environmentally benign aqueous media as solvent, simple product isolation, high atom economy and sidestep to column chromatography are the noteworthy features of this protocol. This protocol is competent for producing wide library of acridinediones in good to excellent yields. Furthermore, molecular structure and relative stereochemistry of 4c and 4s derivatives were confirmed by single-crystal X-ray diffraction. Graphical Abstract
Statistical Analysis and Data Mining: The ASA Data Science Journal, 2015
AMIA Joint Summits on Translational Science proceedings AMIA Summit on Translational Science, 2012
Although a protocol aims to guide treatment management and optimize overall outcomes, the benefit... more Although a protocol aims to guide treatment management and optimize overall outcomes, the benefits and harms for each individual vary due to heterogeneity. Some protocols integrate clinical and genetic variation to provide treatment recommendation; it is not clear whether such integration is sufficient. If not, treatment outcomes may be sub-optimal for certain patient sub-populations. Unfortunately, running a clinical trial to examine such outcome responses is cost prohibitive and requires a significant amount of time to conduct the study. We propose a simulation approach to discover this knowledge from electronic medical records; a rapid method to reach this goal. We use the well-known drug warfarin as an example to examine whether patient characteristics, including race and the genes CYP2C9 and VKORC1, have been fully integrated into dosing protocols. The two genes mentioned above have been shown to be important in patient response to warfarin.
An approach to optimal individualized warfarin treatment through clinical trial simulations
… (CIBEC), 2010 5th …, 2010
Personalized medicine will depend on sophisticated tools, analyses, and molecular level data and ... more Personalized medicine will depend on sophisticated tools, analyses, and molecular level data and clinical information to provide optimized treatment based on each patient's individual characteristics such as health history, current health or disease status, and ...
BMC Bioinformatics, 2010
Background: Large comparative genomics studies and tools are becoming increasingly more compute-e... more Background: Large comparative genomics studies and tools are becoming increasingly more compute-expensive as the number of available genome sequences continues to rise. The capacity and cost of local computing infrastructures are likely to become prohibitive with the increase, especially as the breadth of questions continues to rise. Alternative computing architectures, in particular cloud computing environments, may help alleviate this increasing pressure and enable fast, large-scale, and cost-effective comparative genomics strategies going forward. To test this, we redesigned a typical comparative genomics algorithm, the reciprocal smallest distance algorithm (RSD), to run within Amazon's Elastic Computing Cloud (EC2). We then employed the RSD-cloud for ortholog calculations across a wide selection of fully sequenced genomes. Results: We ran more than 300,000 RSD-cloud processes within the EC2. These jobs were farmed simultaneously to 100 high capacity compute nodes using the Amazon Web Service Elastic Map Reduce and included a wide mix of large and small genomes. The total computation time took just under 70 hours and cost a total of $6,302 USD. Conclusions: The effort to transform existing comparative genomics algorithms from local compute infrastructures is not trivial. However, the speed and flexibility of cloud computing environments provides a substantial boost with manageable cost. The procedure designed to transform the RSD algorithm into a cloud-ready application is readily adaptable to similar comparative genomics problems.
ChemInform, 2015
Sulfamic acid has been found as an efficient and cost effective catalyst for one pot multicompone... more Sulfamic acid has been found as an efficient and cost effective catalyst for one pot multicomponent synthesis of some new densely functionalized piperidine derivatives using amines, aldehydes and β-keto esters. The meritorious aspects of this novel protocol are atom economic process, heterogeneous and easily accessible catalyst, good to excellent yield, convenient work up and eco-friendly route.
Synthesis of Novel Dibenzo-18-crown-6- ether-Functionalized Benzimidazoles and its Applications in Colorimetric Recognition to Hg 2+ and as Antifungal Agents
Journal of Heterocyclic Chemistry, 2014
ABSTRACT New crown ether-functionalized benzimidazoles was designed and synthesized via formylati... more ABSTRACT New crown ether-functionalized benzimidazoles was designed and synthesized via formylation of dibenzo-18-crown-6 followed by condensation with different o-phenylene diamines. The complexation properties of crown ether-functionalized benzimidazoles with various metals (K+, Ca2+, Ba2+, Co2+, Hg2+) were examined using UV–vis spectroscopy. Hg2+ showed a well-defined peculiar absorption maximum at 366 nm exclusively. All these newly synthesized compounds were screened for antifungal activity against Aspergillus niger and Aspergillus oryzae, respectively.
A series of novel crown ether complex cation ionic liquids (CECILs) have been synthesized and cha... more A series of novel crown ether complex cation ionic liquids (CECILs) have been synthesized and characterized by IR, 1 H NMR, 13 C NMR, and mass spectroscopy. Their catalytic applications in organic reactions along with recyclability without loss of catalytic activity have been studied.
Sequence Selective Michael Addition for Synthesis of Indeno-Pyridine and Indeno-Pyran Derivatives in One-Pot Reaction Using CuO Nanoparticles in Water
Journal of Heterocyclic Chemistry, 2014
ABSTRACT
Novel crown ether functionalized imidazolium-based acidic ionic liquid catalyzed synthesis of pyrazole derivatives under solvent-free conditions
Research on Chemical Intermediates, 2014
ABSTRACT An innovatively designed novel crown ether functionalized imidazolium-based reusable aci... more ABSTRACT An innovatively designed novel crown ether functionalized imidazolium-based reusable acidic ionic liquid [crown ether MIm] [HSO4] has been efficiently implemented for the synthesis of pyrazole derivatives using various substituted enaminones, hydrazine hydrate and phenyl hydrazine under solvent-free conditions. Structural novelty and task efficiency of the catalyst, high yields of desired products, greener approach attributing high atom economy and solvent-free conditions render this protocol suitable to cope with the current demand in contemporary organic chemistry. The inventive idea of utilizing crown ether functionalized ionic liquid as a catalyst was for the first time demonstrated in this protocol. Graphical Abstract
Proficient synthesis of quinoxaline and phthalazinetrione derivatives using [C8dabco]Br ionic liquid as catalyst in aqueous media
Journal of Molecular Liquids, 2013
ABSTRACT Relatively less toxic and biodegradable ionic liquid [C8dabco]Br has been successfully u... more ABSTRACT Relatively less toxic and biodegradable ionic liquid [C8dabco]Br has been successfully used for the synthesis of quinoxaline and phthalazinetrione derivatives in an aqueous media. Recyclability of catalyst, high yields, use of environmentally benign aqueous media as solvent, simple product isolation and high atom economy are the noteworthy aspects of the protocols.
Novel Brønsted Acidic Ionic Liquid ([CMIM][CF3COO]) Prompted Multicomponent Hantzsch Reaction for the Eco-Friendly Synthesis of Acridinediones: An Efficient and Recyclable Catalyst
Catalysis Letters, 2014
ABSTRACT Abstracts A novel, highly efficient and recyclable Brønsted acidic ionic liquid ([CMIM][... more ABSTRACT Abstracts A novel, highly efficient and recyclable Brønsted acidic ionic liquid ([CMIM][CF3COO]) has been successfully implemented for the synthesis of acridinediones in aqueous media. Recyclability of novel catalyst, high yields, use of environmentally benign aqueous media as solvent, simple product isolation, high atom economy and sidestep to column chromatography are the noteworthy features of this protocol. This protocol is competent for producing wide library of acridinediones in good to excellent yields. Furthermore, molecular structure and relative stereochemistry of 4c and 4s derivatives were confirmed by single-crystal X-ray diffraction. Graphical Abstract
Statistical Analysis and Data Mining: The ASA Data Science Journal, 2015