prof Hina chadha - Academia.edu (original) (raw)

Papers by prof Hina chadha

Epilepsy is getting common now a day but it is a serious brain disorder. It is universal, with an... more Epilepsy is getting common now a day but it is a serious brain disorder. It is universal, with any age, sex, geographical, social class or racial boundaries. Few of the most important mechanisms for handling it are via AMPA and GABA receptors. In same context while studying the treatment of epilepsy we found the significant effects of the derivatives of the quinazolinedione sulphonamide, this promotes us to study this moiety by the means of in-silico resources with antiepileptic/anticonvulsant effects. Results revealed that the major interacting amino acids for anticonvulsant action mediated via AMPA and GABA could be Ser277, Arg149, Tyr256 and GLn284. It was also found that between AMPA & GABA, possibly AMPA could results in better prospects for designed molecules against epilepsy.

Stroke is defined as brain injury which is caused by a sudden obstruction in the blood circulatio... more Stroke is defined as brain injury which is caused by a sudden obstruction in the blood circulation to the brain. When blood supply altered/arrested about two million brain cells die in each second, which can increase the risk of brain damage, disability and death. Present study focused on the fact that the combination of the hydro alcoholic extract of Eclipta alba and Centella asiatica can reverse MCAO induced brain stroke, protect brain form stroke and protect brain from other complication which are precipitated by brain stroke. In MCAO treated group MDA level was increased significantly and GSH was significantly decreased compare to control and SHAM group. These altered biochemical parameters were restored to normal values significantly respectively by administering hydro alcoholic extract of combination of Eclipta alba and Centella asiatica extract and melatonin. The results of present study suggest that the combination of eclipta alba and centella asiatica is more potent than in...

Leishmaniasis is found in every continent except Au stralia and Antarctica. Among all 90% of VL c... more Leishmaniasis is found in every continent except Au stralia and Antarctica. Among all 90% of VL cases have been found in Bangladesh, Brazil, India, Nepal and Sudan , where as CL was found more common in Afghanistan, Brazil, Iran, Peru, Saudi Arabia, Syria and the least commo n MCL was found prevalent in Bolivia, Brazil and P eru. Each year, approximately 0.7-1.2 million people sufferin g from CL and 0.2-0.4 million people suffering from VL. The resistance of leishmania parasites to antimonial dr ugs, especially pentavalent antimonials is one of t he main causes for rapid spread and exponential rise in number of cases which makes the situation more critical. With increasing international travel, leishmaniasis is being import ed into those areas where it was not previously see n and opportunistic infections are now being reported (pa rticularly in AIDS patients) [5]. Life cycle of leishmania parasite

Aim: The present paper modeled combination of three herbal extracts, extract from the seed of Car... more Aim: The present paper modeled combination of three herbal extracts, extract from the seed of Carica papaya, lyophilized water of Cocos nucifera, and extract from the stem of Ichnocarpus frutescens to evaluate their free radical scavenging activity, using Box-Behnken design response surface methodology (BBD-RSM), a statistical technique designed to optimize compositions that we applied in a novel manner to design combinations of herbal extracts for better antioxidant and antipsoriatic activity. Material and Methods: A BBD-RSM design using three factors and three levels were selected to optimize the ratio of three herbal extracts. Effect of three independent factors, that is, dry weight of C. papaya seed extract (ethanolic), dry weight of lyophilized coconut water, and dry weight of Ichnocarpus extract (hydroalcoholic) was studied on two dependent responses, that is, superoxide dismutase and 2,2-diphenyl-1-picrylhydrazyl activity. Results and Discussion: Combining herbal extracts in ...

Epigenetics, is the study of changes in gene expression but do not involve changes to the DNA seq... more Epigenetics, is the study of changes in gene expression but do not involve changes to the DNA sequence which in turn affects how cells read the genes. DNA methylation is also the process where the addition of a methyl group to part of the DNA molecule, which prevents certain genes from being expressed. Epigenetics also works through the histone modification, Acetylation of specific lysine residues on core histones is believed to result in uncoiling of the DNA. There are various diseases, including cancer, heart disease, diabetes, and mental illnesses are influenced by epigenetic mechanisms, and epigenetic therapy offers a potential way to influence them directly. When genes are silenced, their expression is reduced. Epigenetics play a major role against nephropathic and diabetic nephropathic conditions via epigenetical modifications in the specific genes.

The commonly using herb i.e. Eclipta alba (Linn.) Hassk [Synonym-Eclipta prostrate (Linn.), (Fami... more The commonly using herb i.e. Eclipta alba (Linn.) Hassk [Synonym-Eclipta prostrate (Linn.), (Family-Asteraceae)] is also said to be “Bhamgra” (Hindi), “Bhringarajah” (Sanskrit), “Kadiggagaraga” (Kannada). There are ten auspicious herbs in which Eclipta alba is one of the herb that constitute the group dasapuspam [1]. The herb is commonly moisture loving and creeping. Basically in India it is founded on roadsides and waste lands [2]. Throughout India the plant is distributed in moist or wet wasteland that is ascending up to 2000mt on the hills [3]. The Leaves of Eclipta alba are sessile to sub-sessile, opposite, 1.22.3cm wide usually oblong, 2.2-8.5cm long, sub-acute or acute and lanceolate having apprised hair on both surfaces [4]. The plant has been used for the treatment of Kapha and Vata imbalances in Ayurveda, [5]. Eclipta alba, a herb contains mainly demethyl wedelolactone, coumestans, i.e.wedelolactone, polyacetylenes, polypeptides, triterpenes, steroids, flavonoids,(luteolin, luteolin7-O-glucoside), derivatives of thiophene, alkaloid ecliptine and the ubiquitous stigmasterol [6]. The anticancer, analgesic, antileprotic, antianaphylactic and antioxidant properties are founded in all parts and chemical constituents of Eclipta alba [7]. Eclipta alba is also having the antihepatotoxic, antimyotoxic, antibacterial, antiviral, hypotensive, ovicidal, spasmogenic activity and the plant is a promoter for growth and blackening of hair [8]. The aqueous extract of E.alba was evaluated to possess significant hypolipidaemic activity [9]. The leaves of E. alba are grounded and mixed with water and should be drunk for constipation [10]. The herb is supplied to the problems of gastritis and the respiratory disorders, like cough [11]. And there are the other various pharmacological activities that are possessed by E. alba, such as general tonic, memory disorders treatment, edema, rheumatic joint pains treatment and fevers, hepatitis, digestion, enlarged spleen, skin disorders and antioxidant activity. E. alba is used as an antiseptic for wounds in cattle and externally for ulcers in Gujrat and Punjab, and in rural areas the plant is reported to treat many microbial infections [12]. The paste of Eclipta alba is also beneficial to control eczema and disease of skin. The herb is effective in anemic condition and having antihypertensive action and in case of jaundice, mushroom toxins [13] and the administration of aerial parts of the herb is done. Abstract

INDIAN DRUGS

Psoriasis is a chronic inflammatory skin disease resulting in red silvery skin patches, increased... more Psoriasis is a chronic inflammatory skin disease resulting in red silvery skin patches, increased dermal vascularity and keratinocyte hyper proliferation, particularly on extensor prominences and the scalp. There are some exogenous chemicals and endogenous sources which causes skin dysfunction due to the harmful generation of reactive oxygen species (ROS). Among them, the responsible exogenous chemicals are environmental toxins, chemotherapeutics, ionizing radiations, inflammatory cytokines, ultraviolet light, while the endogenous sources include cyt P-450, mitochondria, lipoxygenase, metabolic process, peroxisomes and various enzymatic and non-enzymatic defense mechanisms. It affects DNA, lipids and proteins, which are the cellular components of the skin. Modifications of plasma lipids, an expansion in the levels of biochemical markers of lipid peroxidation and subsequent inflammation suggest the interconnection between inflammation, oxidative damage and psoriasis. The review prese...

Journal of Bio Innovation

Website: www.dbtindia.gov.in, www.btisnet.gov.in 3) All India Council for Technical Education (AI... more Website: www.dbtindia.gov.in, www.btisnet.gov.in 3) All India Council for Technical Education (AICTE) 2020 November Edition |www.jbino.com |Innovative Association

Current Drug Therapy

Background: Coronaviruses (CoVs), having enveloped RNA of positive strand, are mainly responsible... more Background: Coronaviruses (CoVs), having enveloped RNA of positive strand, are mainly responsible for enzootic infections in mammals. The mortality of CoVs has been proved as they can cross the species barrier very easily and infect humans. Most recently, the outbreak of coronavirus induced COVID-19 emerged in the city of Wuhan, Hubei province of China and became the third highly pathogenic coronavirus infecting nearly 230 countries. Objective: To review the literature available about pathogenic Coronavirures with emphasis on pathogenesis of COVID19, and passive antibody therapy prospective. Method: This study reviewed relevant published literature to provide (1) structural similarities between coronaviruses and therapeutic methodologies used on SARS-CoV, MERS treatment which might help scientists in understanding novel COVID-19 infection, (2) understanding COVID-19 pathogenesis that may help in identification of appropriate therapeutic targets to develop specific and effective anti...

Indo Global Journal of Pharmaceutical Sciences

Indian Journal of Pharmaceutical Sciences

Ojha et al.: Development of Dimethyl Fumarate-loaded Chitosan Nanoparticles The aim of the presen... more Ojha et al.: Development of Dimethyl Fumarate-loaded Chitosan Nanoparticles The aim of the present study was to access the potential of dimethyl fumarate-loaded chitosan polymeric nanoparticles for the management of multiple sclerosis. Dimethyl fumarate-loaded chitosan nanoparticles were prepared by polyelectrolyte complex coaservation technique. The prepared nanoparticles were characterized and found to have an average particle size of 324 nm, zeta potential of-34.85 mV and a poly dispersity index of 0.367. The entrapment effi ciency was found to be 65.36 % and the drug loading was 28 %. The formulation's in vitro drug release profi le and stability parameters were also evaluated. Cumulative percent drug release was found to be 84 % up to 24 hours and the formulation was found to be stable at 28° for 90 days. In vitro neuroprotective effect of the nanoformulation was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human neuroblast SH-SY5Y cells and the treated cells showed improved cell viability under hydrogen peroxide-induced cell apoptosis. In vivo cuprizone model for multiple sclerosis in rodents also confi rmed these fi ndings by showing a signifi cant increase in locomotion score.

Epilepsy is getting common now a day but it is a serious brain disorder. It is universal, with an... more Epilepsy is getting common now a day but it is a serious brain disorder. It is universal, with any age, sex, geographical, social class or racial boundaries. Few of the most important mechanisms for handling it are via AMPA and GABA receptors. In same context while studying the treatment of epilepsy we found the significant effects of the derivatives of the quinazolinedione sulphonamide, this promotes us to study this moiety by the means of in-silico resources with antiepileptic/anticonvulsant effects. Results revealed that the major interacting amino acids for anticonvulsant action mediated via AMPA and GABA could be Ser277, Arg149, Tyr256 and GLn284. It was also found that between AMPA & GABA, possibly AMPA could results in better prospects for designed molecules against epilepsy.

Stroke is defined as brain injury which is caused by a sudden obstruction in the blood circulatio... more Stroke is defined as brain injury which is caused by a sudden obstruction in the blood circulation to the brain. When blood supply altered/arrested about two million brain cells die in each second, which can increase the risk of brain damage, disability and death. Present study focused on the fact that the combination of the hydro alcoholic extract of Eclipta alba and Centella asiatica can reverse MCAO induced brain stroke, protect brain form stroke and protect brain from other complication which are precipitated by brain stroke. In MCAO treated group MDA level was increased significantly and GSH was significantly decreased compare to control and SHAM group. These altered biochemical parameters were restored to normal values significantly respectively by administering hydro alcoholic extract of combination of Eclipta alba and Centella asiatica extract and melatonin. The results of present study suggest that the combination of eclipta alba and centella asiatica is more potent than in...

Leishmaniasis is found in every continent except Au stralia and Antarctica. Among all 90% of VL c... more Leishmaniasis is found in every continent except Au stralia and Antarctica. Among all 90% of VL cases have been found in Bangladesh, Brazil, India, Nepal and Sudan , where as CL was found more common in Afghanistan, Brazil, Iran, Peru, Saudi Arabia, Syria and the least commo n MCL was found prevalent in Bolivia, Brazil and P eru. Each year, approximately 0.7-1.2 million people sufferin g from CL and 0.2-0.4 million people suffering from VL. The resistance of leishmania parasites to antimonial dr ugs, especially pentavalent antimonials is one of t he main causes for rapid spread and exponential rise in number of cases which makes the situation more critical. With increasing international travel, leishmaniasis is being import ed into those areas where it was not previously see n and opportunistic infections are now being reported (pa rticularly in AIDS patients) [5]. Life cycle of leishmania parasite

Aim: The present paper modeled combination of three herbal extracts, extract from the seed of Car... more Aim: The present paper modeled combination of three herbal extracts, extract from the seed of Carica papaya, lyophilized water of Cocos nucifera, and extract from the stem of Ichnocarpus frutescens to evaluate their free radical scavenging activity, using Box-Behnken design response surface methodology (BBD-RSM), a statistical technique designed to optimize compositions that we applied in a novel manner to design combinations of herbal extracts for better antioxidant and antipsoriatic activity. Material and Methods: A BBD-RSM design using three factors and three levels were selected to optimize the ratio of three herbal extracts. Effect of three independent factors, that is, dry weight of C. papaya seed extract (ethanolic), dry weight of lyophilized coconut water, and dry weight of Ichnocarpus extract (hydroalcoholic) was studied on two dependent responses, that is, superoxide dismutase and 2,2-diphenyl-1-picrylhydrazyl activity. Results and Discussion: Combining herbal extracts in ...

Epigenetics, is the study of changes in gene expression but do not involve changes to the DNA seq... more Epigenetics, is the study of changes in gene expression but do not involve changes to the DNA sequence which in turn affects how cells read the genes. DNA methylation is also the process where the addition of a methyl group to part of the DNA molecule, which prevents certain genes from being expressed. Epigenetics also works through the histone modification, Acetylation of specific lysine residues on core histones is believed to result in uncoiling of the DNA. There are various diseases, including cancer, heart disease, diabetes, and mental illnesses are influenced by epigenetic mechanisms, and epigenetic therapy offers a potential way to influence them directly. When genes are silenced, their expression is reduced. Epigenetics play a major role against nephropathic and diabetic nephropathic conditions via epigenetical modifications in the specific genes.

The commonly using herb i.e. Eclipta alba (Linn.) Hassk [Synonym-Eclipta prostrate (Linn.), (Fami... more The commonly using herb i.e. Eclipta alba (Linn.) Hassk [Synonym-Eclipta prostrate (Linn.), (Family-Asteraceae)] is also said to be “Bhamgra” (Hindi), “Bhringarajah” (Sanskrit), “Kadiggagaraga” (Kannada). There are ten auspicious herbs in which Eclipta alba is one of the herb that constitute the group dasapuspam [1]. The herb is commonly moisture loving and creeping. Basically in India it is founded on roadsides and waste lands [2]. Throughout India the plant is distributed in moist or wet wasteland that is ascending up to 2000mt on the hills [3]. The Leaves of Eclipta alba are sessile to sub-sessile, opposite, 1.22.3cm wide usually oblong, 2.2-8.5cm long, sub-acute or acute and lanceolate having apprised hair on both surfaces [4]. The plant has been used for the treatment of Kapha and Vata imbalances in Ayurveda, [5]. Eclipta alba, a herb contains mainly demethyl wedelolactone, coumestans, i.e.wedelolactone, polyacetylenes, polypeptides, triterpenes, steroids, flavonoids,(luteolin, luteolin7-O-glucoside), derivatives of thiophene, alkaloid ecliptine and the ubiquitous stigmasterol [6]. The anticancer, analgesic, antileprotic, antianaphylactic and antioxidant properties are founded in all parts and chemical constituents of Eclipta alba [7]. Eclipta alba is also having the antihepatotoxic, antimyotoxic, antibacterial, antiviral, hypotensive, ovicidal, spasmogenic activity and the plant is a promoter for growth and blackening of hair [8]. The aqueous extract of E.alba was evaluated to possess significant hypolipidaemic activity [9]. The leaves of E. alba are grounded and mixed with water and should be drunk for constipation [10]. The herb is supplied to the problems of gastritis and the respiratory disorders, like cough [11]. And there are the other various pharmacological activities that are possessed by E. alba, such as general tonic, memory disorders treatment, edema, rheumatic joint pains treatment and fevers, hepatitis, digestion, enlarged spleen, skin disorders and antioxidant activity. E. alba is used as an antiseptic for wounds in cattle and externally for ulcers in Gujrat and Punjab, and in rural areas the plant is reported to treat many microbial infections [12]. The paste of Eclipta alba is also beneficial to control eczema and disease of skin. The herb is effective in anemic condition and having antihypertensive action and in case of jaundice, mushroom toxins [13] and the administration of aerial parts of the herb is done. Abstract

INDIAN DRUGS

Psoriasis is a chronic inflammatory skin disease resulting in red silvery skin patches, increased... more Psoriasis is a chronic inflammatory skin disease resulting in red silvery skin patches, increased dermal vascularity and keratinocyte hyper proliferation, particularly on extensor prominences and the scalp. There are some exogenous chemicals and endogenous sources which causes skin dysfunction due to the harmful generation of reactive oxygen species (ROS). Among them, the responsible exogenous chemicals are environmental toxins, chemotherapeutics, ionizing radiations, inflammatory cytokines, ultraviolet light, while the endogenous sources include cyt P-450, mitochondria, lipoxygenase, metabolic process, peroxisomes and various enzymatic and non-enzymatic defense mechanisms. It affects DNA, lipids and proteins, which are the cellular components of the skin. Modifications of plasma lipids, an expansion in the levels of biochemical markers of lipid peroxidation and subsequent inflammation suggest the interconnection between inflammation, oxidative damage and psoriasis. The review prese...

Journal of Bio Innovation

Website: www.dbtindia.gov.in, www.btisnet.gov.in 3) All India Council for Technical Education (AI... more Website: www.dbtindia.gov.in, www.btisnet.gov.in 3) All India Council for Technical Education (AICTE) 2020 November Edition |www.jbino.com |Innovative Association

Current Drug Therapy

Background: Coronaviruses (CoVs), having enveloped RNA of positive strand, are mainly responsible... more Background: Coronaviruses (CoVs), having enveloped RNA of positive strand, are mainly responsible for enzootic infections in mammals. The mortality of CoVs has been proved as they can cross the species barrier very easily and infect humans. Most recently, the outbreak of coronavirus induced COVID-19 emerged in the city of Wuhan, Hubei province of China and became the third highly pathogenic coronavirus infecting nearly 230 countries. Objective: To review the literature available about pathogenic Coronavirures with emphasis on pathogenesis of COVID19, and passive antibody therapy prospective. Method: This study reviewed relevant published literature to provide (1) structural similarities between coronaviruses and therapeutic methodologies used on SARS-CoV, MERS treatment which might help scientists in understanding novel COVID-19 infection, (2) understanding COVID-19 pathogenesis that may help in identification of appropriate therapeutic targets to develop specific and effective anti...

Indo Global Journal of Pharmaceutical Sciences

Indian Journal of Pharmaceutical Sciences

Ojha et al.: Development of Dimethyl Fumarate-loaded Chitosan Nanoparticles The aim of the presen... more Ojha et al.: Development of Dimethyl Fumarate-loaded Chitosan Nanoparticles The aim of the present study was to access the potential of dimethyl fumarate-loaded chitosan polymeric nanoparticles for the management of multiple sclerosis. Dimethyl fumarate-loaded chitosan nanoparticles were prepared by polyelectrolyte complex coaservation technique. The prepared nanoparticles were characterized and found to have an average particle size of 324 nm, zeta potential of-34.85 mV and a poly dispersity index of 0.367. The entrapment effi ciency was found to be 65.36 % and the drug loading was 28 %. The formulation's in vitro drug release profi le and stability parameters were also evaluated. Cumulative percent drug release was found to be 84 % up to 24 hours and the formulation was found to be stable at 28° for 90 days. In vitro neuroprotective effect of the nanoformulation was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human neuroblast SH-SY5Y cells and the treated cells showed improved cell viability under hydrogen peroxide-induced cell apoptosis. In vivo cuprizone model for multiple sclerosis in rodents also confi rmed these fi ndings by showing a signifi cant increase in locomotion score.