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Papers by rasaaq Oyesegun

African Journal of Urology, 2022

Background Globally, prostate cancer (PCa) is the commonest non-cutaneous male malignancy. It is ... more Background Globally, prostate cancer (PCa) is the commonest non-cutaneous male malignancy. It is more aggressive among black men with little known reasons as to the cause and continued trend among black men. This disproportionate pattern of PCa especially among black men of African ancestry resident in Africa calls for a closer look. Nigeria and South Africa, combined, have the highest cumulative risk incidence of PCa in Africa. The present study investigated the clinicopathologic behaviour of PCa among Nigerian and South African black men and the relationship between the disease and socio-demographic characteristics alongside medical co-morbidities. Methods A retrospective cross-sectional study was undertaken in which de-identified records of 234 black men with pathologically confirmed PCa between 2007 and 2017 from two tertiary hospitals, in Nigeria (National Hospital, Abuja) and South Africa (Tygerberg Hospital, Cape Town), were reviewed. Results Median age at presentation from b...

Pan African Medical Journal, 2022

ecancermedicalscience, 2020

JCO Global Oncology, 2020

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Journal of Clinical Oncology, 2019

6562 Background: Breast cancer is the most frequently diagnosed malignancy and the most common ca... more 6562 Background: Breast cancer is the most frequently diagnosed malignancy and the most common cause of cancer-related death in women in Ghana, Kenya, and Nigeria. We evaluated healthcare resource use and financial burden for patients treated at tertiary cancer centers in these countries. Methods: Records of breast cancer patients treated at the following government/private tertiary centers were included – Ghana: Korle-Bu Teaching Hospital and Sweden Ghana Medical Centre; Kenya: Kenyatta National Hospital and Aga Khan University Hospital; Nigeria: National Hospital Abuja and Lakeshore Cancer Center. Patients presenting within a prespecified 2-year period were followed until death or loss to follow-up. Results: The study included 299 patient records from Ghana, 314 from Kenya, and 249 from Nigeria. The use of common screening modalities (eg, mammogram, breast ultrasound) was < 45% in all 3 countries. Use of core needle biopsy was 76% in Kenya and Nigeria, but only 50% in Ghana. Ac...

Journal of Medical Genetics, 2005

Cancer Causes & Control, 2012

Purpose-The relationship between overall obesity and breast cancer risk has been well recognized,... more Purpose-The relationship between overall obesity and breast cancer risk has been well recognized, but the role of central obesity in breast cancer development is uncertain. Methods-Between 1998 and 2009, 1233 invasive breast cancer cases and 1101 community controls were recruited into the Nigerian Breast Cancer Study at Ibadan, Nigeria. Logistic regressions were used to calculate multivariate odds ratio (OR) and 95% confidence intervals (CI), adjusting for age, body mass index (BMI), and other known risk factors for breast cancer. Results-The OR for the highest quartile group of waist circumference relative to the lowest was 2.39 (95% CI: 1.59-3.60; P-trend<0.001). Comparing women with waist-hip ratio (WHR) in the lowest quartile group, the OR for women in the highest quartile category was 2.15 (95% CI: 1.61-2.85; P-trend<0.001). An inverse association was observed between hip circumference and breast cancer, with an OR of 0.36 for the highest quartile (95% CI: 0.24-0.55; P-trend<0.001). The effects of these three measures existed in both pre-and post-menopausal women. Of note, we found a significant interaction between WHR and BMI (P-interaction=0.016): the OR comparing the highest to lowest WHR quartile was 2.81 (95% CI: 1.90-4.16) for women with BMI<25 kg/m 2 and 1.70 (95% CI: 1.11-2.61) for women with BMI ≥25 kg/m 2. Conclusions-These results suggest that central adiposity, measured by waist circumference and waist-hip ratio, was an important risk factor for breast cancer in Nigerian women, and the effect of central adiposity was strong in normal weight women.

American Journal of Epidemiology, 2010

Previous studies have shown that weight is inversely associated with premenopausal breast cancer ... more Previous studies have shown that weight is inversely associated with premenopausal breast cancer and positively associated with postmenopausal disease. Height has been shown to be positively correlated with breast cancer risk, but the association was not conclusive for premenopausal women. These previous studies were conducted primarily in Western countries, where height is not limited by nutritional status during childhood. The authors assessed the association between breast cancer and anthropometric measures in the Nigerian Breast Cancer Study (Ibadan, Nigeria). Between 1998 and 2009, 1,233 invasive breast cancer cases and 1,101 controls were recruited. The multivariateadjusted odds ratio for the highest quartile group of height relative to the lowest was 2.03 (95% confidence interval (CI): 1.51, 2.72; P-trend < 0.001), with an odds ratio of 1.22 (95% CI: 1.14, 1.32) for each 5-cm increase, with no difference by menopausal status. Comparing women with a body mass index in the lowest quartile group, the adjusted odds ratio for women in the highest quartile category was 0.72 (95% CI: 0.54, 0.94; P-trend ¼ 0.009) for premenopausal and postmenopausal women. Influence of height on breast cancer risk was quite strong in this cohort of indigenous Africans, which suggests that energy intake during childhood may be important in breast cancer development.