raul fernando matano - Academia.edu (original) (raw)
Uploads
Papers by raul fernando matano
Revista de gastroenterología de México, 2016
Gastrointestinal Endoscopy, May 1, 2013
Revista de gastroenterología de México, 2019
Refractory gastric variceal bleeding treated through endoscopic ultrasound-guided coiling and N-b... more Refractory gastric variceal bleeding treated through endoscopic ultrasound-guided coiling and N-butyl-2-cyanoacrylate application
![Research paper thumbnail of [Endoscopic ultrasound-guided choledocho-duodenostomy in advanced pancreatic cancer with duodenal obstruction]](https://attachments.academia-assets.com/120892651/thumbnails/1.jpg)
](PubMed, 2015
Endoscopic retrograde cholangiopancreatography (ERCP) is considered the first-approach for biliar... more Endoscopic retrograde cholangiopancreatography (ERCP) is considered the first-approach for biliary drainage. In cases of ERCP failure, patients are usually referred for percutaneous transhepatic biliary drainage or surgical biliary bypass. In the last decade, the indications of endoscopic ultrasound (EUS) in the management of patients with pancreatic cancer have increased, and numerous cases of EUS-guided biliary drainage have been reported in patients with failures during the ERCP. Our goal is to report a patient with locally advanced pancreatic cancer who presented with painless jaundice and cholestasis with biliary and duodenal obstruction. A EUS-guided choledochoduodenostomy was performed by placement of a self-expanding metal stent.
Revista de gastroenterología de México, 2019
Revista de gastroenterología de México, 2017
Acta gastroenterologica Latinoamericana, Sep 27, 2021
Hamartoma gigante, resección endoscópica Karina Yonamine y col. diffuse glandular proliferation w... more Hamartoma gigante, resección endoscópica Karina Yonamine y col. diffuse glandular proliferation with thickening of the duodenal wall, and may be mistaken for a malignant neoplasm. Endoscopic resections of large Brunner's gland hamartomas in the duodenum is little reported in literature, due to its low incidence and diagnostic difficulty. The surgical approach is associated to greater morbidity compared to an endoscopic approach. The case of a 62-year-old patient is reported, who presented melena and symptomatic anemia, secondary to a giant polyp in the duodenal bulb. The polyp was successfully resected endoscopically without complications, which made it possible to avoid a more extensive surgical procedure. Histopathological examination of the whole specimen showed a Brunner's gland hamartoma. Conclusion: Brunner's gland hyperplasia or hamartoma is a benign neoplasm that rarely produces symptoms. Large lesions can become symptomatic and a high clinical-endoscopic suspicion and an evaluation of the extension are necessary before applying any therapeutic procedure, in order to avoid complex surgeries and favor a complete and safe endoscopic resection.
The American Journal of Gastroenterology, Oct 1, 2017
by RNA interference pancreatic cancer growth is significantly decreased. In addition, if the rece... more by RNA interference pancreatic cancer growth is significantly decreased. In addition, if the receptors are blocked with CCKR antagonists pancreatic cancer growth is inhibited. Method: In this investigation, we examined the effects of CCKR blockade or immune checkpoint blockade antibodies alone or in combination in two immune competent murine models of PDAC (Panc02 and mT3). Growth of orthotopic tumors and metastases were assessed in SCID mice and compare to immune competent mice. Next, mice bearing sc PDAC syngeneic tumors were treated with a CCKR antagonist (L364,718, 4 mg/kg tiw, ip or proglumide 30 mg/kg/d), or an immune checkpoint blockade ab (PD-1 antibody or CTLA-4 200ug ip q3d) or the combination of CCKR antagonist and immune checkpoint ab. Growth was assessed by tumor size and survival by Kaplan Meier analysis. Tumors were stained with selective antibodies for CD8, CD4, and Fox-P3 to identify lymphocyte populations by immune-histochemistry or flow cytometry. Fibrosis was assessed by Masson's trichrome stain and quantitative analysis. Results: Monotherapy with CCKR blockade significantly decreased tumor size and metastases in SCID mice with orthotopic PDAC. Mice that were treated with the combination of CCK receptor blockade and immune checkpoint blockade antibodies survived significantly longer and had smaller tumors. Tumor immuno-histochemical staining and flow cytometry demonstrated that the tumors of mice treated with the combination regimen had a significant reduction in Foxp3þ T-regulatory cells and an increase in CD4þ and CD8þ lymphocytes. Masson's trichrome stain analysis revealed 50% less fibrosis in the tumors of mice treated with CCKR antagonist compared to controls and compared to checkpoint antibody therapy. Discussion: Combination CCKR blockade and immune checkpoint antibody therapy represents a novel approach to improving survival of PDAC. The reduction in fibrosis is most likely due to inhibition of CCKRs on stellate cells or tumor associated fibroblasts. The mechanism by which this combination therapy improves survival of PDAC may be related to the decreased fibrosis of the tumor microenvironment and changing the signature of the tumor infiltrating lymphocytes. Conclusion: Given the poor prognosis of advanced pancreatic cancer, novel treatments such as the use of CCKR antagonists should be explored in the clinic.
Revista de gastroenterología de México, 2016
del tracto gastrointestinal. Su prevalencia oscila entre el 1 y el 2% de la población general. Pr... more del tracto gastrointestinal. Su prevalencia oscila entre el 1 y el 2% de la población general. Presentamos un paciente de 16 años con melena y descompensación hemodinámica que en la videocápsula endoscópica evidenció una lesión tumoral y en el Meckel-scan presentó un resultado falso negativo.
Hospital de Alta Complejidad en Red El Cruce Dr. Néstor C. Kirchner, Dec 10, 2020
Gastrointestinal Endoscopy, 2018
Lymphoma Acinar Other Weight Loss 0 2 (33.3) 2 (16.7) Jaundice 6 (50) 0 2 (16.7) Charlson Comorbi... more Lymphoma Acinar Other Weight Loss 0 2 (33.3) 2 (16.7) Jaundice 6 (50) 0 2 (16.7) Charlson Comorbidity Index -Median (IQR) 5 (3.75-6) 3 (1.25-4) 5 (3-8.25)
Trabajo presentado en la 13o Jornadas Cientificas y de Gestion realizada durante los dias 10 y 11... more Trabajo presentado en la 13o Jornadas Cientificas y de Gestion realizada durante los dias 10 y 11 de Diciembre de 2020, en el Auditorio Ramon Carrillo del Hospital de Alta Complejidad en Red El Cruce.
Presentacion en la 9o Jornadas Cientificas y de Gestion realizada durante los dias 3 y 4 de Novie... more Presentacion en la 9o Jornadas Cientificas y de Gestion realizada durante los dias 3 y 4 de Noviembre de 2016, en el Auditorio Ramon Carrillo del Hospital de Alta Complejidad en Red El Cruce
Revista de gastroenterología de México, 2016
Gastrointestinal Endoscopy, May 1, 2013
Revista de gastroenterología de México, 2019
Refractory gastric variceal bleeding treated through endoscopic ultrasound-guided coiling and N-b... more Refractory gastric variceal bleeding treated through endoscopic ultrasound-guided coiling and N-butyl-2-cyanoacrylate application
PubMed, 2015
Endoscopic retrograde cholangiopancreatography (ERCP) is considered the first-approach for biliar... more Endoscopic retrograde cholangiopancreatography (ERCP) is considered the first-approach for biliary drainage. In cases of ERCP failure, patients are usually referred for percutaneous transhepatic biliary drainage or surgical biliary bypass. In the last decade, the indications of endoscopic ultrasound (EUS) in the management of patients with pancreatic cancer have increased, and numerous cases of EUS-guided biliary drainage have been reported in patients with failures during the ERCP. Our goal is to report a patient with locally advanced pancreatic cancer who presented with painless jaundice and cholestasis with biliary and duodenal obstruction. A EUS-guided choledochoduodenostomy was performed by placement of a self-expanding metal stent.
Revista de gastroenterología de México, 2019
Revista de gastroenterología de México, 2017
Acta gastroenterologica Latinoamericana, Sep 27, 2021
Hamartoma gigante, resección endoscópica Karina Yonamine y col. diffuse glandular proliferation w... more Hamartoma gigante, resección endoscópica Karina Yonamine y col. diffuse glandular proliferation with thickening of the duodenal wall, and may be mistaken for a malignant neoplasm. Endoscopic resections of large Brunner's gland hamartomas in the duodenum is little reported in literature, due to its low incidence and diagnostic difficulty. The surgical approach is associated to greater morbidity compared to an endoscopic approach. The case of a 62-year-old patient is reported, who presented melena and symptomatic anemia, secondary to a giant polyp in the duodenal bulb. The polyp was successfully resected endoscopically without complications, which made it possible to avoid a more extensive surgical procedure. Histopathological examination of the whole specimen showed a Brunner's gland hamartoma. Conclusion: Brunner's gland hyperplasia or hamartoma is a benign neoplasm that rarely produces symptoms. Large lesions can become symptomatic and a high clinical-endoscopic suspicion and an evaluation of the extension are necessary before applying any therapeutic procedure, in order to avoid complex surgeries and favor a complete and safe endoscopic resection.
The American Journal of Gastroenterology, Oct 1, 2017
by RNA interference pancreatic cancer growth is significantly decreased. In addition, if the rece... more by RNA interference pancreatic cancer growth is significantly decreased. In addition, if the receptors are blocked with CCKR antagonists pancreatic cancer growth is inhibited. Method: In this investigation, we examined the effects of CCKR blockade or immune checkpoint blockade antibodies alone or in combination in two immune competent murine models of PDAC (Panc02 and mT3). Growth of orthotopic tumors and metastases were assessed in SCID mice and compare to immune competent mice. Next, mice bearing sc PDAC syngeneic tumors were treated with a CCKR antagonist (L364,718, 4 mg/kg tiw, ip or proglumide 30 mg/kg/d), or an immune checkpoint blockade ab (PD-1 antibody or CTLA-4 200ug ip q3d) or the combination of CCKR antagonist and immune checkpoint ab. Growth was assessed by tumor size and survival by Kaplan Meier analysis. Tumors were stained with selective antibodies for CD8, CD4, and Fox-P3 to identify lymphocyte populations by immune-histochemistry or flow cytometry. Fibrosis was assessed by Masson's trichrome stain and quantitative analysis. Results: Monotherapy with CCKR blockade significantly decreased tumor size and metastases in SCID mice with orthotopic PDAC. Mice that were treated with the combination of CCK receptor blockade and immune checkpoint blockade antibodies survived significantly longer and had smaller tumors. Tumor immuno-histochemical staining and flow cytometry demonstrated that the tumors of mice treated with the combination regimen had a significant reduction in Foxp3þ T-regulatory cells and an increase in CD4þ and CD8þ lymphocytes. Masson's trichrome stain analysis revealed 50% less fibrosis in the tumors of mice treated with CCKR antagonist compared to controls and compared to checkpoint antibody therapy. Discussion: Combination CCKR blockade and immune checkpoint antibody therapy represents a novel approach to improving survival of PDAC. The reduction in fibrosis is most likely due to inhibition of CCKRs on stellate cells or tumor associated fibroblasts. The mechanism by which this combination therapy improves survival of PDAC may be related to the decreased fibrosis of the tumor microenvironment and changing the signature of the tumor infiltrating lymphocytes. Conclusion: Given the poor prognosis of advanced pancreatic cancer, novel treatments such as the use of CCKR antagonists should be explored in the clinic.
Revista de gastroenterología de México, 2016
del tracto gastrointestinal. Su prevalencia oscila entre el 1 y el 2% de la población general. Pr... more del tracto gastrointestinal. Su prevalencia oscila entre el 1 y el 2% de la población general. Presentamos un paciente de 16 años con melena y descompensación hemodinámica que en la videocápsula endoscópica evidenció una lesión tumoral y en el Meckel-scan presentó un resultado falso negativo.
Hospital de Alta Complejidad en Red El Cruce Dr. Néstor C. Kirchner, Dec 10, 2020
Gastrointestinal Endoscopy, 2018
Lymphoma Acinar Other Weight Loss 0 2 (33.3) 2 (16.7) Jaundice 6 (50) 0 2 (16.7) Charlson Comorbi... more Lymphoma Acinar Other Weight Loss 0 2 (33.3) 2 (16.7) Jaundice 6 (50) 0 2 (16.7) Charlson Comorbidity Index -Median (IQR) 5 (3.75-6) 3 (1.25-4) 5 (3-8.25)
Trabajo presentado en la 13o Jornadas Cientificas y de Gestion realizada durante los dias 10 y 11... more Trabajo presentado en la 13o Jornadas Cientificas y de Gestion realizada durante los dias 10 y 11 de Diciembre de 2020, en el Auditorio Ramon Carrillo del Hospital de Alta Complejidad en Red El Cruce.
Presentacion en la 9o Jornadas Cientificas y de Gestion realizada durante los dias 3 y 4 de Novie... more Presentacion en la 9o Jornadas Cientificas y de Gestion realizada durante los dias 3 y 4 de Noviembre de 2016, en el Auditorio Ramon Carrillo del Hospital de Alta Complejidad en Red El Cruce