ravi singh - Academia.edu (original) (raw)
Papers by ravi singh
Sensors International, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020
Background and aim: The current global challenge of COVID-19 pandemic has surpassed the provincia... more Background and aim: The current global challenge of COVID-19 pandemic has surpassed the provincial, radical, conceptual, spiritual, social, and pedagogical boundaries. Internet of Things (IoT) enabled healthcare system is useful for proper monitoring of COVID-19 patients, by employing an interconnected network. This technology helps to increase patient satisfaction and reduces readmission rate in the hospital. Methods: Searched the databases of Google Scholar, PubMed, SCOPUS and ResearchGate using the keywords "Internet of things" or "IoT" and "COVID-19". Further inputs are also taken from blogs and relevant reports. Results: IoT implementation impacts on reducing healthcare cost and improve treatment outcome of the infected patient. Therefore, this present study based research is attempted to explore, discuss, and highlight the overall applications of the well-proven IoT philosophy by offering a perspective roadmap to tackle the COVID-19 pandemic. Finally, twelve significant applications of IoT are identified and discussed. It has ultimately forced the researchers, academicians, and scientists to propose some productive solutions to overcome or confront this pandemic. Conclusions: IoT is helpful for an infected patient of COVID-19 to identify symptoms and provides better treatment rapidly. It is useful for patient, physician, surgeon and hospital management system.
Indian Journal of Child Health, 2020
N ephrotic syndrome (NS) is a disease that not only affects the obvious physical health but also ... more N ephrotic syndrome (NS) is a disease that not only affects the obvious physical health but also affects the family and psychology of the individual. NS is a common chronic disorder, characterized by alterations of the permeability of the glomerular capillary wall, resulting in its inability to restrict the urinary loss of protein. The proteinuria in childhood NS is relatively selective, constituted primarily by albumin. It is characterized by edema, nephrotic range proteinuria (>40 mg/m²/h), hyperlipidemia (hypercholesterolemia), and hypoalbuminemia [1]. During active disease, the loss of proteins required for various biologic functions can result in complications such as infections, thromboembolic incidence, and acute kidney injury (AKI) [2-5]. Nephrotic range proteinuria is said to be present if early morning urine protein is 3 + /4 + (heat coagulation test), spot urine protein/creatinine ratio >2, or urine albumin excretion >40 mg/m 2 /h [6]. The characteristics of the NS presenting in childhood age vary considerably in developing countries compared to the developed countries and are influenced by environmental factors, infection, and ethnic origin, which determine the histological expression of the disease [2]. NS commonly presents with generalized body swelling but can present with complicated form, especially atypical type. Hence, the importance of high clinical suspicion, diagnosis, and management comes into the picture. There is a lack of data on clinical profile and response to management in Central India, so in this study, we assessed the clinical presentation, investigation profile, associated complications, and therapeutic response in children with NS. MATERIALS AND METHODS This prospective observational hospital-based study was conducted in the department of pediatrics of a tertiary care center in Central India from March 2017 to June 2018. The study included children aged 1-14 years with newly diagnosed as well as previously diagnosed NS who presented with relapse. The study excluded patients whose parents did not give consent to participate in the study, who presented with comorbidities not related to complications of NS and known cases of steroidresistant NS (SRNS). Written informed consent from the parents/ guardians was obtained at the time of admission. Clearance from the Institutional Ethical Committee was taken before the start of the study. Selection of subjects was done according to the diagnostic criteria of NS with massive proteinuria-urine
Computer Architecture in Industrial, Biomechanical and Biomedical Engineering, 2019
The approach called as "graph theory and matrix approach" has been well employed in numerous rese... more The approach called as "graph theory and matrix approach" has been well employed in numerous research studies with a view to perform the decision-making while the situation is becoming perplexed type or where there is a very strong relative importance of one parameter over another. In such cases, the said graph theory and matrix method provides very suitable and fruitful solutions to make the decision to its final effective extent. The further improvements and the outcome enhancement can also be revealed through the use of combined practice of graph theory results along with some artificial intelligence-inspired logics and practices such as fuzzy logic, artificial neural network, etc. The significance and applicability of said method in vast fields of science, engineering, and research are also proved. Nowadays, our manufacturing sectors are getting up to date through the applications of artificial intelligence and several software-based directions. This is all to enhance the overall machine system performance with a view to improve desired performance characteristics of the process under the study. Few sections of this chapter has also elaborated the utility of the artificial intelligence-inspired fuzzy logic-based decision system which has already been a part of previous researches.
International Journal of Scientific and Research Publications (IJSRP), 2019
This paper presents the numerical simulations of low-Reynolds-number flow past an Eppler 387 airf... more This paper presents the numerical simulations of low-Reynolds-number flow past an Eppler 387 airfoil at Re=20,000, 30,000, 60,000, 100,000 and 300,000 where transition takes place through a laminar separation bubble. The analysis is carried out using ANSYS FUENT. Two turbulence models, trans-SST and k-kl-Ѡ models were used for investigation. The lift coefficient, drag coefficient, point of separation and the point of reattachment were established. The numerical results of the aerodynamic coefficients are validated against wind tunnel results available in the literature.
Journal of Nanomaterials, 2017
We investigated the effects of silver nanoparticle (AgNP) exposure in three ovarian cancer cell l... more We investigated the effects of silver nanoparticle (AgNP) exposure in three ovarian cancer cell lines (A2780, SKOV3, and OVCAR3). We found that AgNPs were highly cytotoxic toward A2780 and SKOV3 cells but OVCAR3 cells were less sensitive to AgNPs. In agreement with the cytotoxicity data, AgNPs caused DNA damage in A2780 and SKOV3 cells, but not in OVCAR3 cells. A2780 and SKOV3 showed higher levels of basal reactive oxygen species (ROS) relative to OVCAR3 cells. AgNP exposure increased ROS levels in both A2780 and SKOV3 cells, but not in OVCAR3 cells. We found that the heterogeneous cytotoxicity was specific to the uptake of intact particles and was not due to differences in sensitivity to silver ions. Furthermore, the combination of AgNPs and standard-of-care platinum therapy, cisplatin (cis-diamminedichloroplatinum(II), CDDP), was synergistic for treatment of A2780 and OVCAR3 cells and the combination of AgNPs and CDDP showed a favorable dose reduction in all cell lines tested. The...
Biochemistry, Sep 14, 2017
By classical competitive-antagonism, substrate and competitive-inhibitor must bind mutually exclu... more By classical competitive-antagonism, substrate and competitive-inhibitor must bind mutually exclusively to the active site. The competitive inhibition of O-acetyl serine sulfhydrylase (OASS) by C-terminal of serine acetyltransferase (SAT) presents a paradox, because the C-terminal of SAT binds to the active site of OASS with 4-6 log fold (104 -106) more affinity than that of the substrate. Therefore, we employed multiple approaches to understand how substrate gains access to OASS active site under physiological conditions. Single molecule and ensemble approaches showed that the active site bound high-affinity competitive inhibitor is actively dissociated by the substrate, not consistent with classical views of competitive-antagonism. We employed fast-flow kinetic approaches to demonstrate that substrate mediated dissociation of full length SAT-OASS (Cysteine Synthase Complex) follows a non-canonical "facilitated-dissociation" mechanism. To understand the mechanism by which...
Methods in molecular biology (Clifton, N.J.), 2017
Comparative sequence analysis is widely used for the reconstruction of phylogeny and for understa... more Comparative sequence analysis is widely used for the reconstruction of phylogeny and for understanding the evolutionary history of gene families. Here, we describe the methodologies to reconstruct the phylogenetic and evolutionary history of a gene family across genomes with a focus on the ARGONAUTE (AGO) family of proteins in plants. The method described here may easily be adapted for studying molecular evolution of a wide variety of gene families. We enlist methods as well as parameters for the collection of molecular data (nucleic acids and peptides), preparation of datasets, and selection of evolutionary models and various methods for the phylogenetic and evolutionary analysis, such as maximum likelihood and Bayesian inference.
Indian Journal of Physics, 2016
Reduced graphene oxide (RGO) and CeO2 nanocomposite fabricated by a facile hydrothermal method wa... more Reduced graphene oxide (RGO) and CeO2 nanocomposite fabricated by a facile hydrothermal method was studied as a photocatalyst for the degradation of methylene blue (MB) under natural sunlight. The reduction of graphene oxide and decoration of CeO2 nanocubes was accomplished simultaneously in one hydrothermal step. The structural, optical and photocatalytic properties of synthesized samples were probed by X-ray diffraction, Raman spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, UV–Vis diffuse reflectance spectra and photoluminescence spectra. RGO/CeO2 nanocomposite exhibited distinctive structural features comprising well-dispersed CeO2 nanocubes on the RGO surface without any agglomeration. RGO/CeO2 nanocomposite displayed a great MB absorptivity, significant band gap narrowing and photoluminescence quenching phenomenon concurrently, which was ascribed to unique properties of RGO sheets. The photocatalytic activity results revealed that there was a remarkable enhancement in reaction rate with RGO/CeO2 nanocomposite in comparison to its counterparts (Blank CeO2 and CNT/CeO2 nanocomposite). The degradation efficiency of RGO/CeO2, CNT/CeO2 and CeO2 was found to be 91.2, 75 and 64 % within 180 min respectively.
2015 IEEE Eindhoven PowerTech, 2015
This paper presents the construction of a Hardwarein-the-loop laboratory test setup designed to a... more This paper presents the construction of a Hardwarein-the-loop laboratory test setup designed to assess the time synchronization requirements of Phasor Measurement Units (PMUs). The test setup also allows to investigate the effects of signal phase shifts caused by current and voltage transformers, errors in timing source and the impact of these errors when determining time synchronization compliance of PMUs. The paper also describes the structure of an IRIG-B time-sync realtime implementation, which allowed real-time hardware-in-theloop simulation by providing a PMU with a high-accuracy timing source.
2015 IEEE Eindhoven PowerTech, 2015
This paper assesses time synchronization sources suitable for Phasor Measurement Unit (PMU) appli... more This paper assesses time synchronization sources suitable for Phasor Measurement Unit (PMU) applications in power systems. The paper investigates PMU phase error due to PMU timing inaccuracy and the presence of current and voltage transformers. This paper also shows that in practical on-field applications of commercial PMUs, the required accuracy of the time source should be better than the 31.8µs limit mentioned in the IEEE Standard for Synchrophasor Measurements for Power Systems C37.118.1-2011 and could be well in the sub-microsecond range. The laboratory test setup is discussed in brief.
The journal of physical chemistry. A, Jan 20, 2015
To gain qualitative and quantitative understanding of oxidation processes of large polycyclic aro... more To gain qualitative and quantitative understanding of oxidation processes of large polycyclic aromatics, soot particles, and graphene edges, a theoretical study is reported for the pyrenyl-O2 reaction system. First, possible reaction pathways and their energetics were investigated using high-level ab initio calculations. The results were utilized in RRKM-Mater-Equation calculations of rate coefficients and relative product yields at temperatures and pressures relevant to combustion. Finally, the deduced oxidation mechanisms of six- and five-member rings and the computed rate coefficients were employed in kinetic Monte-Carlo simulations of oxidation of a graphene "molecule" evolving in flame-like environments. Among the major findings from the latter simulations are the following. The oxidation system exhibits two basic pathways, thermal decomposition and regeneration of oxyradicals. Their competition is temperature dependent, with the former dominating at higher and the la...
Nucleic acids research, Jan 6, 2015
Genotoxic stress induces alternative splicing of the oncogene MDM2 generating MDM2-ALT1, an isofo... more Genotoxic stress induces alternative splicing of the oncogene MDM2 generating MDM2-ALT1, an isoform attributed with tumorigenic properties. However, the mechanisms underlying this event remain unclear. Here we explore MDM2 splicing regulation by utilizing a novel minigene that mimics endogenous MDM2 splicing in response to UV and cisplatinum-induced DNA damage. We report that exon 11 is necessary and sufficient for the damage-specific alternative splicing of the MDM2 minigene and that the splicing factor SRSF1 binds exon 11 at evolutionarily conserved sites. Interestingly, mutations disrupting this interaction proved sufficient to abolish the stress-induced alternative splicing of the MDM2 minigene. Furthermore, SRSF1 overexpression promoted exclusion of exon 11, while its siRNA-mediated knockdown prevented the stress-induced alternative splicing of endogenous MDM2. Additionally, we observed elevated SRSF1 levels under stress and in tumors correlating with the expression of MDM2-ALT...
Plant Disease, 2015
Stripe rust, caused by Puccinia striiformis f. sp. tritici W., is a devastating disease of wheat ... more Stripe rust, caused by Puccinia striiformis f. sp. tritici W., is a devastating disease of wheat worldwide. A new stripe rust resistance gene with moderate seedling and adult plant resistance was mapped using an F5 recombinant inbred line (RIL) population developed from the cross of the resistant parent ‘Almop’ with the susceptible parent ‘Avocet’. The parents and RILs were phenotyped for seedling stripe rust response variation in a greenhouse and in field trials at Toluca, Mexico for 2 years. Almop showed moderate levels of resistance at both seedling and adult plant stages compared with the highly susceptible response of Avocet. The distribution of homozygous resistant, homozygous susceptible, and segregating RILs conformed to segregation at a single locus. Seedlings and adult plant responses were correlated, indicating that the same gene conferred resistance at both stages. A bulk segregant analysis approach with widely distributed simple sequence repeat (SSR) markers mapped the ...
Lecture Notes in Computer Science, 2011
Prior work has shown that computer-supported homework can lead to better results over traditional... more Prior work has shown that computer-supported homework can lead to better results over traditional paper-and-pencil homework. This study about learning from homework involved the comparison of immediate-feedback with tutoring versus a control condition where students got feedback the next day in math class. After analyzing eighth grade students who participated in both conditions, it was found that they gained significantly more (effect size 0.40) with computer-supported homework. This result has practical significance as it suggests an effective improvement over the widely used paper-and-pencil homework. The main result is followed with a second set of studies to better understand this result: is it due to the timeliness of feedback or quality tutoring?
Fuzzy Information and Engineering, 2014
PloS one, 2014
MDM2 and MDMX are the chief negative regulators of the tumor-suppressor protein p53 and are essen... more MDM2 and MDMX are the chief negative regulators of the tumor-suppressor protein p53 and are essential for maintaining homeostasis within the cell. In response to genotoxic stress and also in several cancer types, MDM2 and MDMX are alternatively spliced. The splice variants MDM2-ALT1 and MDMX-ALT2 lack the p53-binding domain and are incapable of negatively regulating p53. However, they retain the RING domain that facilitates dimerization of the full-length MDM proteins. Concordantly, MDM2-ALT1 has been shown to lead to the stabilization of p53 through its interaction with and inactivation of full-length MDM2. The impact of MDM2-ALT1 expression on the p53 pathway and the nature of its interaction with MDMX remain unclear. Also, the role of the architecturally similar MDMX-ALT2 and its influence of the MDM2-MDMX-p53 axis are yet to be elucidated. We show here that MDM2-ALT1 is capable of binding full-length MDMX as well as full-length MDM2. Additionally, we demonstrate that MDMX-ALT2 i...
Sensors International, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020
Background and aim: The current global challenge of COVID-19 pandemic has surpassed the provincia... more Background and aim: The current global challenge of COVID-19 pandemic has surpassed the provincial, radical, conceptual, spiritual, social, and pedagogical boundaries. Internet of Things (IoT) enabled healthcare system is useful for proper monitoring of COVID-19 patients, by employing an interconnected network. This technology helps to increase patient satisfaction and reduces readmission rate in the hospital. Methods: Searched the databases of Google Scholar, PubMed, SCOPUS and ResearchGate using the keywords "Internet of things" or "IoT" and "COVID-19". Further inputs are also taken from blogs and relevant reports. Results: IoT implementation impacts on reducing healthcare cost and improve treatment outcome of the infected patient. Therefore, this present study based research is attempted to explore, discuss, and highlight the overall applications of the well-proven IoT philosophy by offering a perspective roadmap to tackle the COVID-19 pandemic. Finally, twelve significant applications of IoT are identified and discussed. It has ultimately forced the researchers, academicians, and scientists to propose some productive solutions to overcome or confront this pandemic. Conclusions: IoT is helpful for an infected patient of COVID-19 to identify symptoms and provides better treatment rapidly. It is useful for patient, physician, surgeon and hospital management system.
Indian Journal of Child Health, 2020
N ephrotic syndrome (NS) is a disease that not only affects the obvious physical health but also ... more N ephrotic syndrome (NS) is a disease that not only affects the obvious physical health but also affects the family and psychology of the individual. NS is a common chronic disorder, characterized by alterations of the permeability of the glomerular capillary wall, resulting in its inability to restrict the urinary loss of protein. The proteinuria in childhood NS is relatively selective, constituted primarily by albumin. It is characterized by edema, nephrotic range proteinuria (>40 mg/m²/h), hyperlipidemia (hypercholesterolemia), and hypoalbuminemia [1]. During active disease, the loss of proteins required for various biologic functions can result in complications such as infections, thromboembolic incidence, and acute kidney injury (AKI) [2-5]. Nephrotic range proteinuria is said to be present if early morning urine protein is 3 + /4 + (heat coagulation test), spot urine protein/creatinine ratio >2, or urine albumin excretion >40 mg/m 2 /h [6]. The characteristics of the NS presenting in childhood age vary considerably in developing countries compared to the developed countries and are influenced by environmental factors, infection, and ethnic origin, which determine the histological expression of the disease [2]. NS commonly presents with generalized body swelling but can present with complicated form, especially atypical type. Hence, the importance of high clinical suspicion, diagnosis, and management comes into the picture. There is a lack of data on clinical profile and response to management in Central India, so in this study, we assessed the clinical presentation, investigation profile, associated complications, and therapeutic response in children with NS. MATERIALS AND METHODS This prospective observational hospital-based study was conducted in the department of pediatrics of a tertiary care center in Central India from March 2017 to June 2018. The study included children aged 1-14 years with newly diagnosed as well as previously diagnosed NS who presented with relapse. The study excluded patients whose parents did not give consent to participate in the study, who presented with comorbidities not related to complications of NS and known cases of steroidresistant NS (SRNS). Written informed consent from the parents/ guardians was obtained at the time of admission. Clearance from the Institutional Ethical Committee was taken before the start of the study. Selection of subjects was done according to the diagnostic criteria of NS with massive proteinuria-urine
Computer Architecture in Industrial, Biomechanical and Biomedical Engineering, 2019
The approach called as "graph theory and matrix approach" has been well employed in numerous rese... more The approach called as "graph theory and matrix approach" has been well employed in numerous research studies with a view to perform the decision-making while the situation is becoming perplexed type or where there is a very strong relative importance of one parameter over another. In such cases, the said graph theory and matrix method provides very suitable and fruitful solutions to make the decision to its final effective extent. The further improvements and the outcome enhancement can also be revealed through the use of combined practice of graph theory results along with some artificial intelligence-inspired logics and practices such as fuzzy logic, artificial neural network, etc. The significance and applicability of said method in vast fields of science, engineering, and research are also proved. Nowadays, our manufacturing sectors are getting up to date through the applications of artificial intelligence and several software-based directions. This is all to enhance the overall machine system performance with a view to improve desired performance characteristics of the process under the study. Few sections of this chapter has also elaborated the utility of the artificial intelligence-inspired fuzzy logic-based decision system which has already been a part of previous researches.
International Journal of Scientific and Research Publications (IJSRP), 2019
This paper presents the numerical simulations of low-Reynolds-number flow past an Eppler 387 airf... more This paper presents the numerical simulations of low-Reynolds-number flow past an Eppler 387 airfoil at Re=20,000, 30,000, 60,000, 100,000 and 300,000 where transition takes place through a laminar separation bubble. The analysis is carried out using ANSYS FUENT. Two turbulence models, trans-SST and k-kl-Ѡ models were used for investigation. The lift coefficient, drag coefficient, point of separation and the point of reattachment were established. The numerical results of the aerodynamic coefficients are validated against wind tunnel results available in the literature.
Journal of Nanomaterials, 2017
We investigated the effects of silver nanoparticle (AgNP) exposure in three ovarian cancer cell l... more We investigated the effects of silver nanoparticle (AgNP) exposure in three ovarian cancer cell lines (A2780, SKOV3, and OVCAR3). We found that AgNPs were highly cytotoxic toward A2780 and SKOV3 cells but OVCAR3 cells were less sensitive to AgNPs. In agreement with the cytotoxicity data, AgNPs caused DNA damage in A2780 and SKOV3 cells, but not in OVCAR3 cells. A2780 and SKOV3 showed higher levels of basal reactive oxygen species (ROS) relative to OVCAR3 cells. AgNP exposure increased ROS levels in both A2780 and SKOV3 cells, but not in OVCAR3 cells. We found that the heterogeneous cytotoxicity was specific to the uptake of intact particles and was not due to differences in sensitivity to silver ions. Furthermore, the combination of AgNPs and standard-of-care platinum therapy, cisplatin (cis-diamminedichloroplatinum(II), CDDP), was synergistic for treatment of A2780 and OVCAR3 cells and the combination of AgNPs and CDDP showed a favorable dose reduction in all cell lines tested. The...
Biochemistry, Sep 14, 2017
By classical competitive-antagonism, substrate and competitive-inhibitor must bind mutually exclu... more By classical competitive-antagonism, substrate and competitive-inhibitor must bind mutually exclusively to the active site. The competitive inhibition of O-acetyl serine sulfhydrylase (OASS) by C-terminal of serine acetyltransferase (SAT) presents a paradox, because the C-terminal of SAT binds to the active site of OASS with 4-6 log fold (104 -106) more affinity than that of the substrate. Therefore, we employed multiple approaches to understand how substrate gains access to OASS active site under physiological conditions. Single molecule and ensemble approaches showed that the active site bound high-affinity competitive inhibitor is actively dissociated by the substrate, not consistent with classical views of competitive-antagonism. We employed fast-flow kinetic approaches to demonstrate that substrate mediated dissociation of full length SAT-OASS (Cysteine Synthase Complex) follows a non-canonical "facilitated-dissociation" mechanism. To understand the mechanism by which...
Methods in molecular biology (Clifton, N.J.), 2017
Comparative sequence analysis is widely used for the reconstruction of phylogeny and for understa... more Comparative sequence analysis is widely used for the reconstruction of phylogeny and for understanding the evolutionary history of gene families. Here, we describe the methodologies to reconstruct the phylogenetic and evolutionary history of a gene family across genomes with a focus on the ARGONAUTE (AGO) family of proteins in plants. The method described here may easily be adapted for studying molecular evolution of a wide variety of gene families. We enlist methods as well as parameters for the collection of molecular data (nucleic acids and peptides), preparation of datasets, and selection of evolutionary models and various methods for the phylogenetic and evolutionary analysis, such as maximum likelihood and Bayesian inference.
Indian Journal of Physics, 2016
Reduced graphene oxide (RGO) and CeO2 nanocomposite fabricated by a facile hydrothermal method wa... more Reduced graphene oxide (RGO) and CeO2 nanocomposite fabricated by a facile hydrothermal method was studied as a photocatalyst for the degradation of methylene blue (MB) under natural sunlight. The reduction of graphene oxide and decoration of CeO2 nanocubes was accomplished simultaneously in one hydrothermal step. The structural, optical and photocatalytic properties of synthesized samples were probed by X-ray diffraction, Raman spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, UV–Vis diffuse reflectance spectra and photoluminescence spectra. RGO/CeO2 nanocomposite exhibited distinctive structural features comprising well-dispersed CeO2 nanocubes on the RGO surface without any agglomeration. RGO/CeO2 nanocomposite displayed a great MB absorptivity, significant band gap narrowing and photoluminescence quenching phenomenon concurrently, which was ascribed to unique properties of RGO sheets. The photocatalytic activity results revealed that there was a remarkable enhancement in reaction rate with RGO/CeO2 nanocomposite in comparison to its counterparts (Blank CeO2 and CNT/CeO2 nanocomposite). The degradation efficiency of RGO/CeO2, CNT/CeO2 and CeO2 was found to be 91.2, 75 and 64 % within 180 min respectively.
2015 IEEE Eindhoven PowerTech, 2015
This paper presents the construction of a Hardwarein-the-loop laboratory test setup designed to a... more This paper presents the construction of a Hardwarein-the-loop laboratory test setup designed to assess the time synchronization requirements of Phasor Measurement Units (PMUs). The test setup also allows to investigate the effects of signal phase shifts caused by current and voltage transformers, errors in timing source and the impact of these errors when determining time synchronization compliance of PMUs. The paper also describes the structure of an IRIG-B time-sync realtime implementation, which allowed real-time hardware-in-theloop simulation by providing a PMU with a high-accuracy timing source.
2015 IEEE Eindhoven PowerTech, 2015
This paper assesses time synchronization sources suitable for Phasor Measurement Unit (PMU) appli... more This paper assesses time synchronization sources suitable for Phasor Measurement Unit (PMU) applications in power systems. The paper investigates PMU phase error due to PMU timing inaccuracy and the presence of current and voltage transformers. This paper also shows that in practical on-field applications of commercial PMUs, the required accuracy of the time source should be better than the 31.8µs limit mentioned in the IEEE Standard for Synchrophasor Measurements for Power Systems C37.118.1-2011 and could be well in the sub-microsecond range. The laboratory test setup is discussed in brief.
The journal of physical chemistry. A, Jan 20, 2015
To gain qualitative and quantitative understanding of oxidation processes of large polycyclic aro... more To gain qualitative and quantitative understanding of oxidation processes of large polycyclic aromatics, soot particles, and graphene edges, a theoretical study is reported for the pyrenyl-O2 reaction system. First, possible reaction pathways and their energetics were investigated using high-level ab initio calculations. The results were utilized in RRKM-Mater-Equation calculations of rate coefficients and relative product yields at temperatures and pressures relevant to combustion. Finally, the deduced oxidation mechanisms of six- and five-member rings and the computed rate coefficients were employed in kinetic Monte-Carlo simulations of oxidation of a graphene "molecule" evolving in flame-like environments. Among the major findings from the latter simulations are the following. The oxidation system exhibits two basic pathways, thermal decomposition and regeneration of oxyradicals. Their competition is temperature dependent, with the former dominating at higher and the la...
Nucleic acids research, Jan 6, 2015
Genotoxic stress induces alternative splicing of the oncogene MDM2 generating MDM2-ALT1, an isofo... more Genotoxic stress induces alternative splicing of the oncogene MDM2 generating MDM2-ALT1, an isoform attributed with tumorigenic properties. However, the mechanisms underlying this event remain unclear. Here we explore MDM2 splicing regulation by utilizing a novel minigene that mimics endogenous MDM2 splicing in response to UV and cisplatinum-induced DNA damage. We report that exon 11 is necessary and sufficient for the damage-specific alternative splicing of the MDM2 minigene and that the splicing factor SRSF1 binds exon 11 at evolutionarily conserved sites. Interestingly, mutations disrupting this interaction proved sufficient to abolish the stress-induced alternative splicing of the MDM2 minigene. Furthermore, SRSF1 overexpression promoted exclusion of exon 11, while its siRNA-mediated knockdown prevented the stress-induced alternative splicing of endogenous MDM2. Additionally, we observed elevated SRSF1 levels under stress and in tumors correlating with the expression of MDM2-ALT...
Plant Disease, 2015
Stripe rust, caused by Puccinia striiformis f. sp. tritici W., is a devastating disease of wheat ... more Stripe rust, caused by Puccinia striiformis f. sp. tritici W., is a devastating disease of wheat worldwide. A new stripe rust resistance gene with moderate seedling and adult plant resistance was mapped using an F5 recombinant inbred line (RIL) population developed from the cross of the resistant parent ‘Almop’ with the susceptible parent ‘Avocet’. The parents and RILs were phenotyped for seedling stripe rust response variation in a greenhouse and in field trials at Toluca, Mexico for 2 years. Almop showed moderate levels of resistance at both seedling and adult plant stages compared with the highly susceptible response of Avocet. The distribution of homozygous resistant, homozygous susceptible, and segregating RILs conformed to segregation at a single locus. Seedlings and adult plant responses were correlated, indicating that the same gene conferred resistance at both stages. A bulk segregant analysis approach with widely distributed simple sequence repeat (SSR) markers mapped the ...
Lecture Notes in Computer Science, 2011
Prior work has shown that computer-supported homework can lead to better results over traditional... more Prior work has shown that computer-supported homework can lead to better results over traditional paper-and-pencil homework. This study about learning from homework involved the comparison of immediate-feedback with tutoring versus a control condition where students got feedback the next day in math class. After analyzing eighth grade students who participated in both conditions, it was found that they gained significantly more (effect size 0.40) with computer-supported homework. This result has practical significance as it suggests an effective improvement over the widely used paper-and-pencil homework. The main result is followed with a second set of studies to better understand this result: is it due to the timeliness of feedback or quality tutoring?
Fuzzy Information and Engineering, 2014
PloS one, 2014
MDM2 and MDMX are the chief negative regulators of the tumor-suppressor protein p53 and are essen... more MDM2 and MDMX are the chief negative regulators of the tumor-suppressor protein p53 and are essential for maintaining homeostasis within the cell. In response to genotoxic stress and also in several cancer types, MDM2 and MDMX are alternatively spliced. The splice variants MDM2-ALT1 and MDMX-ALT2 lack the p53-binding domain and are incapable of negatively regulating p53. However, they retain the RING domain that facilitates dimerization of the full-length MDM proteins. Concordantly, MDM2-ALT1 has been shown to lead to the stabilization of p53 through its interaction with and inactivation of full-length MDM2. The impact of MDM2-ALT1 expression on the p53 pathway and the nature of its interaction with MDMX remain unclear. Also, the role of the architecturally similar MDMX-ALT2 and its influence of the MDM2-MDMX-p53 axis are yet to be elucidated. We show here that MDM2-ALT1 is capable of binding full-length MDMX as well as full-length MDM2. Additionally, we demonstrate that MDMX-ALT2 i...