rayan khan - Academia.edu (original) (raw)

Papers by rayan khan

2017 IEEE SENSORS, 2017

Inability to detect small concentration of cancer cells at the early stages of disease is a major... more Inability to detect small concentration of cancer cells at the early stages of disease is a major barrier for early diagnosis. Molecular bioelectricity, which recognizes how voltage gradients in nonexcitable cells coordinate morphogenesis, tissue development, repair, and cancer formation is shown here as a novel modality to detect cancerous behavior. The design, simulation and electrical characterization of an Ion Measuring Field Effect Transistors (IMFETs) are shown that detect cancer cells based on their molecular bioelectricity. IMFETs generate low impedance signals and consume low power because of the transistor properties. The small size of IMFETs can enable miniature diagnosis devices, allowing low sample requirements combined with a rapid response. IMFETs have the potential for selective detection of certain ions in complex samples efficiently and can open the way for low-cost lab-on-a-chip devices.

IEEE Access, 2018

The detection of small concentrations of cancer cells before cancer takes over the primary organ ... more The detection of small concentrations of cancer cells before cancer takes over the primary organ completely, or metastasizes to other areas of the body is important for early screening of cancer. One approach to address cancer early screening is through cell ion exchange bioelectricity, which characterizes voltage potential in non-neuronal cells to regulate shape changing, proliferation, differentiation, migration, and cancer formation. Herein, novel ion-sensitive field-effective transistor (ISFET) modality is shown to measure cell behavior during the change of cell properties at molecular levels. ISFETs produce low resistance signals and consume low power. The small size of ISFETs enables miniature diagnosis devices that can be affordably fabricated in a massive array format. A large number of cells can be measured in parallel. Therefore, ISFET allows the combination of low sample requirements and prompt response. ISFETs have the ability to measure the effect of ions from complex biological samples and can be used as affordable point of care devices. INDEX TERMS Cancer, biological interactions, cellular biophysics, biochemical analysis, diseases.

Computer methods and programs in biomedicine, 2018

Detection of metastatic tumor cells is important for early diagnosis and staging of cancer. Howev... more Detection of metastatic tumor cells is important for early diagnosis and staging of cancer. However, such cells are exceedingly difficult to detect from blood or biopsy samples at the disease onset. It is reported that cancer cells, and especially metastatic tumor cells, show very distinctive morphological behavior compared to their healthy counterparts on aptamer functionalized substrates. The ability to quickly analyze the data and quantify the cell morphology for an instant real-time feedback can certainly contribute to early cancer diagnosis. A supervised machine learning approach is presented for identification and classification of cancer cell gestures for early diagnosis. We quantified the morphologically distinct behavior of metastatic cells and their healthy counterparts captured on aptamer-functionalized glass substrates from time-lapse optical micrographs. As a proof of concept, the morphologies of human glioblastoma (hGBM) and astrocyte cells were used. The cells were ca...

2017 IEEE 12th Nanotechnology Materials and Devices Conference (NMDC), 2017

Poly lactic-co-glycolic acid (PLGA) microparticles are widely used for drug delivery. In a cancer... more Poly lactic-co-glycolic acid (PLGA) microparticles are widely used for drug delivery. In a cancer cell, ion channels have been recognized to play important roles in cancer pathology, as these regulate key events in cell proliferation and cancer initiation and progression. Ion channels are ideal drug targets as the respective small molecules may be effective from the extracellular space and do not need to enter the target cells. The development of cancer treatment using ion channel targeting compounds is still in early stages, although some studies have shown that some voltage-gated ion channel (VGIC) blockers can inhibit cell behaviors associated with metastasis. We developed a simple and effective method to control nanoporous formation, size, density and the surface functionalization of PLGA microparticles. PLGA microparticles were synthesized using water-in-oil-in-water (w/o/w) double emulsion method. The synthesis of nanoporous microparticles with this novel, rapid, inexpensive method and easily controllable properties can be useful for applications in targeting one or multiple VGIC in cancer patients.

2017 IEEE SENSORS, 2017

Inability to detect small concentration of cancer cells at the early stages of disease is a major... more Inability to detect small concentration of cancer cells at the early stages of disease is a major barrier for early diagnosis. Molecular bioelectricity, which recognizes how voltage gradients in nonexcitable cells coordinate morphogenesis, tissue development, repair, and cancer formation is shown here as a novel modality to detect cancerous behavior. The design, simulation and electrical characterization of an Ion Measuring Field Effect Transistors (IMFETs) are shown that detect cancer cells based on their molecular bioelectricity. IMFETs generate low impedance signals and consume low power because of the transistor properties. The small size of IMFETs can enable miniature diagnosis devices, allowing low sample requirements combined with a rapid response. IMFETs have the potential for selective detection of certain ions in complex samples efficiently and can open the way for low-cost lab-on-a-chip devices.

IEEE Access, 2018

The detection of small concentrations of cancer cells before cancer takes over the primary organ ... more The detection of small concentrations of cancer cells before cancer takes over the primary organ completely, or metastasizes to other areas of the body is important for early screening of cancer. One approach to address cancer early screening is through cell ion exchange bioelectricity, which characterizes voltage potential in non-neuronal cells to regulate shape changing, proliferation, differentiation, migration, and cancer formation. Herein, novel ion-sensitive field-effective transistor (ISFET) modality is shown to measure cell behavior during the change of cell properties at molecular levels. ISFETs produce low resistance signals and consume low power. The small size of ISFETs enables miniature diagnosis devices that can be affordably fabricated in a massive array format. A large number of cells can be measured in parallel. Therefore, ISFET allows the combination of low sample requirements and prompt response. ISFETs have the ability to measure the effect of ions from complex biological samples and can be used as affordable point of care devices. INDEX TERMS Cancer, biological interactions, cellular biophysics, biochemical analysis, diseases.

Computer methods and programs in biomedicine, 2018

Detection of metastatic tumor cells is important for early diagnosis and staging of cancer. Howev... more Detection of metastatic tumor cells is important for early diagnosis and staging of cancer. However, such cells are exceedingly difficult to detect from blood or biopsy samples at the disease onset. It is reported that cancer cells, and especially metastatic tumor cells, show very distinctive morphological behavior compared to their healthy counterparts on aptamer functionalized substrates. The ability to quickly analyze the data and quantify the cell morphology for an instant real-time feedback can certainly contribute to early cancer diagnosis. A supervised machine learning approach is presented for identification and classification of cancer cell gestures for early diagnosis. We quantified the morphologically distinct behavior of metastatic cells and their healthy counterparts captured on aptamer-functionalized glass substrates from time-lapse optical micrographs. As a proof of concept, the morphologies of human glioblastoma (hGBM) and astrocyte cells were used. The cells were ca...

2017 IEEE 12th Nanotechnology Materials and Devices Conference (NMDC), 2017

Poly lactic-co-glycolic acid (PLGA) microparticles are widely used for drug delivery. In a cancer... more Poly lactic-co-glycolic acid (PLGA) microparticles are widely used for drug delivery. In a cancer cell, ion channels have been recognized to play important roles in cancer pathology, as these regulate key events in cell proliferation and cancer initiation and progression. Ion channels are ideal drug targets as the respective small molecules may be effective from the extracellular space and do not need to enter the target cells. The development of cancer treatment using ion channel targeting compounds is still in early stages, although some studies have shown that some voltage-gated ion channel (VGIC) blockers can inhibit cell behaviors associated with metastasis. We developed a simple and effective method to control nanoporous formation, size, density and the surface functionalization of PLGA microparticles. PLGA microparticles were synthesized using water-in-oil-in-water (w/o/w) double emulsion method. The synthesis of nanoporous microparticles with this novel, rapid, inexpensive method and easily controllable properties can be useful for applications in targeting one or multiple VGIC in cancer patients.