Dr Purushothama R E D D Y Kudumula (original) (raw)

Papers by Dr Purushothama R E D D Y Kudumula

IOSR Journal of Dental and Medical Sciences, 2016

Introduction:Haemovigilance is a set of surveillance procedures covering the whole transfusion fr... more Introduction:Haemovigilance is a set of surveillance procedures covering the whole transfusion from collection of blood and its components to the follow up of its recepients.Haemovigilance programe of India was launched on 10 th December 2012. Objective:To identify and prevent occurence or recurrence of transfusion related unwanted events and to increase the safety ,efficacy and efficiency of blood transfusion. Materials And Methods:Transfusion reactions reported over a period of 3 months(march,april,may 2016)were reviewed and analysed. Results:A total of 2445 units of whole blood and components were transfused in this period.In this 1330 units of whole blood,950 units of packed cells,65 units of platelet rich plasma and 100 units of fresh frozen plasma were transfused.Acute transfusion reactions(ATR) encountered were 16(0.65%).Out of which ATRs with whole blood were(n= 7,p=0.13),with packed cells were(n= 2, p=0.19),with platelets were(n= 4,p=0.18)and with frozen plasma were (n=3,p=0.53).Allergic reactions were most common ATRs seen with whole blood transfusions.Febrile reactions were the second most ATRs.Least number of ATRs are seen with packed cells.Obstetrics and gynaecology department recieved most of blood transfusions(58.27%),while paediatric department stood second(8.6%). Conclusion:The overall incidence of ATRs in this hospital is 0.65%.Though there are no leucoreduction facilities, the ATRs are less due strict aseptic compatability testing.

www.ijpsr.com Patient counseling were intended to improve adherence and maintaining quality of li... more www.ijpsr.com Patient counseling were intended to improve adherence and maintaining quality of life. Antiretroviral adherence is the second strongest predictor of progression to AIDS and death, after CD4 count. Incomplete adherence to ART is common in all groups of treating individuals. The commonest cause of ART failure is poor adherence. Several factors associated with poor adherence include a poor patient-clinician relationship, high pill burden, forgetfulness, mental depression, lack of patient education, inability of patients to identify their medications, drug toxicity, beliefs about treatment and the impression of being too ill for treatment. Counseling steps include establishing the rapport between the patient and pharmacist, developing individual treatment plan and using of information sheets, compliance aids, leaflets can be helpful in better understanding about the ART regimen they are taking. The key to successful is educating the patient before the initiation of therapy...

Alzheimer Disease (AD) is a gradually progressive dementia affecting cognition, behavior, and fun... more Alzheimer Disease (AD) is a gradually progressive dementia affecting cognition, behavior, and functional status. It was discovered a century back (1907) characterized by defects in language use, visual-spatial perception, ability to learn, solve problems, perform mathematical calculations, thinking abstractly, and making appropriate judgments, affecting more than 4.5 million people in United States. 100,000 people die of AD every year, nevertheless hundred years have been passed after the discovery of AD but the appropriate pathology was not yet determined only it still floats in the hypotheses in contrast to the inventions in the medicine so far, hypothesis like amyloid cascades, neurofibrillary tangles, are well established but with incomplete benefits from them, in recent days the role of estrogen, cholesterol are also being included in AD pathology. Treatment lines are following just to improve the dementia but not able to concentrate in to the pathology, all these made the AD i...

A set of 35 germplasm lines of muskmelon (Cucumis melo L.) collected from Andhra Pradesh, India w... more A set of 35 germplasm lines of muskmelon (Cucumis melo L.) collected from Andhra Pradesh, India was evaluated in a randomized block design with three replications at the Experimental Farm, Vegetable Research Station, Rajendranagar, Hyderabad, Andhra Pradesh, India during late rabi season (November 2010 to February 2011). Eighteen morphological traits viz., vine length (cm), number of primary branches per vine, day of appearance of first staminate flower, day of appearance of first pistillate flower, node number of first pistillate flower, day of first fruit harvest, day of last fruit harvest, fruit length (cm), fruit diameter (cm), average fruit weight (g), number of fruits per vine, fruit cavity length (cm), fruit cavity width (cm), rind thickness (mm), pulp thickness (cm), total soluble solids (°Brix), seed yield (g fruit), and fruit yield (kg plant) were considered for multivariate analysis following Mahalanobis D statistics to determine the morphological diversity of the genotyp...

Key Words Metronidazole topical gel, Micro sponge formulation, Over-the-counter (OTC) Permeation ... more Key Words Metronidazole topical gel, Micro sponge formulation, Over-the-counter (OTC) Permeation enhancer Micro-sponge containing Metronidazole as active constituent with four different formulations by changing the proportions of drug (Metronidazole), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using emulsion solvent diffusion method. Metronidazole topical gel is used in the treatment of fungating tumours, rosacea. The drug was chosen because unavailable micro sponge dosage forms in the market in order to decrease the skin irritation by preventing excess accumulation of drug on epidermis. The size of the micro sponges can be varied, usually from 5-300 μm in diameter, depending upon the degree of smoothness or after-feel required for the end formula. The micro sponge system can also avoid unnecessary accumulation of ingredients within the epidermis and the dermis. Potentially, they can reduce considerably the irritation of effective drugs wit...

Adults aged ≥ 50 years are fastest segment of the population in many countries and often have mul... more Adults aged ≥ 50 years are fastest segment of the population in many countries and often have multiple medical conditions like hypertension (HTN), diabetes and arthritis etc. Increasing the medications leads to increase complexity and poor compliance. There are many interrelated factors like psychological, behavioral and treatment leading to cause nonadherence to medications in elders. Pharmacist contributions in the geriatric care can tremendously improve the compliance and adherence in geriatric patients. Patient education has been suggested as a primary means of improving patient compliance and has been shown to be successful in many c auses. Pharmacist involving geriatric patient care with proper motivation, education and support the elderly to overcome compliance difficulties. Pharmacy students should be encouraged to form a relationship with the elderly patients. Under the guidance of senior pharmacists the student pharmacists can able to learn and hand some of the problems el...

Journal of Evolution of medical and Dental Sciences, 2015

BACKGROUND: The term hysterectomy means surgical removal of uterus it can be either along with ce... more BACKGROUND: The term hysterectomy means surgical removal of uterus it can be either along with cervix or adnexae through different routes. The most commonly performed major elective gynecological surgery. The term Peripartum hysterectomy is used when performed either mostly by emergency as a maternal life saving measure within 24 hours after vaginal or abdominal delivery or as electively when indicated. OBJECTIVE: To study the incidence of peripartum hysterectomy; to analyze its causes, risk factors, complications and feto-maternal morbidity and mortality at newly established tertiary care teaching hospital.

Journal of Evolution of medical and Dental Sciences, 2015

BACKGROUND: Leiomyomas also called myomas or fibroids; are benign monoclonal uterine myometrial t... more BACKGROUND: Leiomyomas also called myomas or fibroids; are benign monoclonal uterine myometrial tumors. Uterine fibroids are the commonest benign tumours of female genital tract with a prevalence of 20 to 50% in women of reproductive age. Fibroids may be classified as submucous, intramural or sub-serous. It is often assumed that fibroids cause infertility since pregnancies do occur after myomectomy and other treatments where the fibroids are removed. The treatment of fibroids has historically been surgery, usually hysterectomy. Myomectomy is an option in women wishing to maintain fertility and for those desiring to keep their uterus. The position of the uterine fibroid plays important role in infertility. The presence of sub-mucous fibroid decreases the fertility rate. Subserosal fibroids do not affect the fertility rate but removing those does increase fertility. Surgical management is limited to non-pregnant uterus. Fibroid coexisting pregnancy, prevalence is 0.3-2.6%, can be asso...

TruScreen is a unique electro-optical technology that provides a direct means of tissue different... more TruScreen is a unique electro-optical technology that provides a direct means of tissue differentiation as a primary screening tool in the general population for cervical cancer and precancerous change (CIN). Objectives of the work are evaluation of sensitivity and specificity of the optoelectronic method in the detection of CIN and cervical cancer. The present study shows correlation between the pNOR number and sensitivity/specificity of the optoelectronic method. The study included 293 patients with abnormal cervical cytology result and the following examinations: examination with the use of the optoelectronic method-Truscreen, colposcopic examination, and histopathology biopsy. Specificity of the optoelectronic method for LGSIL was estimated at 65.70%, for HGSIL and squamous cell carcinoma ofcervix amounted to 90.38%. Specificity of the optoelectronic method used to confirm lack of cervical pathology was estimated at 78.89%.The field under the ROC curve for the optoelectronic method was estimated at 0.88 (95% CI, 0.84-0.92) which shows high diagnostic value of the test in the detection of HGSIL and squamous cell carcinoma. The optoelectronic method is characterized by high usefulness in the detection of CIN, present in the squamous epithelium and squamous cell carcinoma of cervix. In conclusion, we suggest that TruScreen holds the potential to detect lesions that might be missed by cytology alone and clarify unsatisfactory or ASCUS cytology results. With regard to patients, they can benefit from more rapid follow-up and early treatment. We also noticed that the women were happy with the real time results, which are now available using TruScreen. TruScreen technology seems to have a high potential to improve and standardize the screening of the cervical carcinoma.

actice, P. Rami reddy memorial college of pharmacy, Kadapa. AP

Journal of Evolution of Medical and Dental Sciences, 2015

Background: Truscreen is a portable system used to directly identify cancer or pre-cancerous cell... more Background: Truscreen is a portable system used to directly identify cancer or pre-cancerous cells in cervical tissue. Truscreen uses low levels of electric signals and light to examine the cervix by gently touching the surface of the cervix with a hand-held wand. The system comprises a hand piece, console and single use sensor (SUS).The hand piece uses advanced electro-optical biosensors to measure the response of cervical tissue to light together with tissue capacitance. Unlike cytology, Truscreen does not only examine surface epithelial cells. With the aim of to screen the Cervix with truscreen for detection of Pre cancerous and cancerous lesions of the cervix to minimize morbidity, mortality, to advance the health and to improve the quality of life of women. An ongoing pilot study was conducted at Govt. Maternity Hospital; Osmania Medical College, Hyderabad, Andhra Pradesh, with duration of 3 months (August to October 2008) by including 50 porous women were screened and within t...

Indian Journal of Pharmacy Practice, 2013

To evaluate the occurrence of Adverse Drug Reactions (ADRs) in the children who are hospitalized,... more To evaluate the occurrence of Adverse Drug Reactions (ADRs) in the children who are hospitalized, the follow-up processes resulting from it and to evaluate the reporting of ADRs by health care professionals. The occurrence of ADRs among hospitalized children has not been well established. As the clinical trials involving neonates, infants and children are absent or limited, the safety and tolerability of drugs are not well established among them hence the pharmacological actions of drugs are not similar to those identified for adults. A prospective observational study was conducted between June 2012 and March 2013 at Rajiv Gandhi Institute of Medical sciences (RIMS) an 800 bedded tertiary care teaching hospital, Kadapa. A total of 109 ADRs were identified. The most of the ADRs were mild(54.12%), severe were least (12.85%) and the moderate were between them (20.2%). Maximum of ADRs (89.91%, n-98) identified were predictable and least (10.09%, n-11) were non-predictable. Highest incid...

Thirty five genotypes of muskmelon (Cucumis melo L.) were evaluated in a randomized block design ... more Thirty five genotypes of muskmelon (Cucumis melo L.) were evaluated in a randomized block design with three replications at the Experimental Farm, Vegetable Research Station, Rajendranagar, Hyderabad, Andhra Pradesh, India during late rabi season (November 2010 to February 2011) for genetic diversity based on 18 morphological traits. Cluster analysis revealed distinct clustering pattern and grouping of genotypes into six distinct clusters. Cluster II was the largest (22 genotypes) followed by cluster I (8 genotypes) and cluster IV (2 genotypes), while cluster III, V and VI were solitary consisting of single genotypes. Intracluster D 2 values ranged from 0.00 (cluster III, V and VI) to 85.514 (cluster IV), while the intercluster D 2 values ranged from 94.56 (clusters I and II) to 753.29 (clusters I and VI). The genotype of the most divergent clusters I and VI (753.29), clusters IV and VI (590.55) and clusters II and IV (529.79) could be used in hybridization programmes. Total soluble...

European journal of clinical pharmacy: atención farmacéutica, 2016

Background: Clinical pharmacy services were started in 1997 in India, in contrast to developed co... more Background: Clinical pharmacy services were started in 1997 in India, in contrast to developed countries where the services were started in early 1960s. However 15 years have been passed out after the introduction of clinical pharmacy in India, but still the involvement of clinical pharmacist in the healthcare team is negligible. Objective: To elevate the clinical pharmacist role in the healthcare team, to justify the liaison between healthcare professionals and to promote better quality of life in chronic disease patients a prospective observational and interventional study was carried out. Setting: Rajiv Gandhi Institute of Medical Sciences, an 800 bedded tertiary care teaching hospital, Kadapa, India. Main Outcome: Progression of Quality of Life in chronic disease patients. Results: 200 patients were recruited belonging to age ≥40 years; they were divided into Observational Group (100) and Interventional Group (100). Each group consisted of 25 patients for Hypertension (25), Stro...

To evaluate the incidence of Hypertension in the geriatric patients attending a tertiary Care tea... more To evaluate the incidence of Hypertension in the geriatric patients attending a tertiary Care teaching hospital. A prospective observational study was conducted between July 2013 and June 2014 in Department of General Medicine at Rajiv Gandhi Institute of Medical sciences (RIMS) an 800 bedded hospital, Kadapa. A total of 462 patients were studied in one year, out of 462, male patients were 203 (43.93%) and female patients were 259 (56.06%), age group of 60-69 years were more (43.72%) and above 80 years were least (15.35%), most of the patients were identified as illiterate (85.06%). 5-10 years disease duration consists higher population (48.21%) and least (6.4%) was observed in 20 years and above of disease duration. Major risk factors were identified as sedentary life style, alcohol consumption, diet (excess salt intake), cigarette smoking and minor risk factor as hereditary. Target organ damage like stroke, myocardial infarction, heart failure, chronic kidney disease and periphera...

INTRODUCTION: Polycystic ovarian syndrome (PCOS) was originally described in 1935 by American gyn... more INTRODUCTION: Polycystic ovarian syndrome (PCOS) was originally described in 1935 by American gynaecologistsIrving F. Stein& Michael L. Leventhal from whom the original name of SteinLeventhal Syndrome is taken, as a syndrome manifested by amenorrhoea, hirsutism and obesity associated with enlarged polycystic ovaries. PCOS is one of the most common syndromes in the modern world in women during their reproductive age. It is now recognized as a common, heterogeneous, heritable disorder affecting women throughout their lifetime. PCOS is characterized by hyperandrogenism, ovulatory dysfunction& polycystic ovaries. However, there is considerable interindividual variation in presentation. Although not required for diagnosis, the presence of insulin resistance and hyper insulinaemia is common and places those affected at increased risk of diabetes and cardiovascular disease. PCOS is a condition in which a woman has an imbalance of sex hormones. This may lead to menstrual cycle changes, cyst...

Indo American Journal of Pharmaceutical Research, 2015

IOSR Journal of Dental and Medical Sciences, 2016

Introduction:Haemovigilance is a set of surveillance procedures covering the whole transfusion fr... more Introduction:Haemovigilance is a set of surveillance procedures covering the whole transfusion from collection of blood and its components to the follow up of its recepients.Haemovigilance programe of India was launched on 10 th December 2012. Objective:To identify and prevent occurence or recurrence of transfusion related unwanted events and to increase the safety ,efficacy and efficiency of blood transfusion. Materials And Methods:Transfusion reactions reported over a period of 3 months(march,april,may 2016)were reviewed and analysed. Results:A total of 2445 units of whole blood and components were transfused in this period.In this 1330 units of whole blood,950 units of packed cells,65 units of platelet rich plasma and 100 units of fresh frozen plasma were transfused.Acute transfusion reactions(ATR) encountered were 16(0.65%).Out of which ATRs with whole blood were(n= 7,p=0.13),with packed cells were(n= 2, p=0.19),with platelets were(n= 4,p=0.18)and with frozen plasma were (n=3,p=0.53).Allergic reactions were most common ATRs seen with whole blood transfusions.Febrile reactions were the second most ATRs.Least number of ATRs are seen with packed cells.Obstetrics and gynaecology department recieved most of blood transfusions(58.27%),while paediatric department stood second(8.6%). Conclusion:The overall incidence of ATRs in this hospital is 0.65%.Though there are no leucoreduction facilities, the ATRs are less due strict aseptic compatability testing.

www.ijpsr.com Patient counseling were intended to improve adherence and maintaining quality of li... more www.ijpsr.com Patient counseling were intended to improve adherence and maintaining quality of life. Antiretroviral adherence is the second strongest predictor of progression to AIDS and death, after CD4 count. Incomplete adherence to ART is common in all groups of treating individuals. The commonest cause of ART failure is poor adherence. Several factors associated with poor adherence include a poor patient-clinician relationship, high pill burden, forgetfulness, mental depression, lack of patient education, inability of patients to identify their medications, drug toxicity, beliefs about treatment and the impression of being too ill for treatment. Counseling steps include establishing the rapport between the patient and pharmacist, developing individual treatment plan and using of information sheets, compliance aids, leaflets can be helpful in better understanding about the ART regimen they are taking. The key to successful is educating the patient before the initiation of therapy...

Alzheimer Disease (AD) is a gradually progressive dementia affecting cognition, behavior, and fun... more Alzheimer Disease (AD) is a gradually progressive dementia affecting cognition, behavior, and functional status. It was discovered a century back (1907) characterized by defects in language use, visual-spatial perception, ability to learn, solve problems, perform mathematical calculations, thinking abstractly, and making appropriate judgments, affecting more than 4.5 million people in United States. 100,000 people die of AD every year, nevertheless hundred years have been passed after the discovery of AD but the appropriate pathology was not yet determined only it still floats in the hypotheses in contrast to the inventions in the medicine so far, hypothesis like amyloid cascades, neurofibrillary tangles, are well established but with incomplete benefits from them, in recent days the role of estrogen, cholesterol are also being included in AD pathology. Treatment lines are following just to improve the dementia but not able to concentrate in to the pathology, all these made the AD i...

A set of 35 germplasm lines of muskmelon (Cucumis melo L.) collected from Andhra Pradesh, India w... more A set of 35 germplasm lines of muskmelon (Cucumis melo L.) collected from Andhra Pradesh, India was evaluated in a randomized block design with three replications at the Experimental Farm, Vegetable Research Station, Rajendranagar, Hyderabad, Andhra Pradesh, India during late rabi season (November 2010 to February 2011). Eighteen morphological traits viz., vine length (cm), number of primary branches per vine, day of appearance of first staminate flower, day of appearance of first pistillate flower, node number of first pistillate flower, day of first fruit harvest, day of last fruit harvest, fruit length (cm), fruit diameter (cm), average fruit weight (g), number of fruits per vine, fruit cavity length (cm), fruit cavity width (cm), rind thickness (mm), pulp thickness (cm), total soluble solids (°Brix), seed yield (g fruit), and fruit yield (kg plant) were considered for multivariate analysis following Mahalanobis D statistics to determine the morphological diversity of the genotyp...

Key Words Metronidazole topical gel, Micro sponge formulation, Over-the-counter (OTC) Permeation ... more Key Words Metronidazole topical gel, Micro sponge formulation, Over-the-counter (OTC) Permeation enhancer Micro-sponge containing Metronidazole as active constituent with four different formulations by changing the proportions of drug (Metronidazole), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using emulsion solvent diffusion method. Metronidazole topical gel is used in the treatment of fungating tumours, rosacea. The drug was chosen because unavailable micro sponge dosage forms in the market in order to decrease the skin irritation by preventing excess accumulation of drug on epidermis. The size of the micro sponges can be varied, usually from 5-300 μm in diameter, depending upon the degree of smoothness or after-feel required for the end formula. The micro sponge system can also avoid unnecessary accumulation of ingredients within the epidermis and the dermis. Potentially, they can reduce considerably the irritation of effective drugs wit...

Adults aged ≥ 50 years are fastest segment of the population in many countries and often have mul... more Adults aged ≥ 50 years are fastest segment of the population in many countries and often have multiple medical conditions like hypertension (HTN), diabetes and arthritis etc. Increasing the medications leads to increase complexity and poor compliance. There are many interrelated factors like psychological, behavioral and treatment leading to cause nonadherence to medications in elders. Pharmacist contributions in the geriatric care can tremendously improve the compliance and adherence in geriatric patients. Patient education has been suggested as a primary means of improving patient compliance and has been shown to be successful in many c auses. Pharmacist involving geriatric patient care with proper motivation, education and support the elderly to overcome compliance difficulties. Pharmacy students should be encouraged to form a relationship with the elderly patients. Under the guidance of senior pharmacists the student pharmacists can able to learn and hand some of the problems el...

Journal of Evolution of medical and Dental Sciences, 2015

BACKGROUND: The term hysterectomy means surgical removal of uterus it can be either along with ce... more BACKGROUND: The term hysterectomy means surgical removal of uterus it can be either along with cervix or adnexae through different routes. The most commonly performed major elective gynecological surgery. The term Peripartum hysterectomy is used when performed either mostly by emergency as a maternal life saving measure within 24 hours after vaginal or abdominal delivery or as electively when indicated. OBJECTIVE: To study the incidence of peripartum hysterectomy; to analyze its causes, risk factors, complications and feto-maternal morbidity and mortality at newly established tertiary care teaching hospital.

Journal of Evolution of medical and Dental Sciences, 2015

BACKGROUND: Leiomyomas also called myomas or fibroids; are benign monoclonal uterine myometrial t... more BACKGROUND: Leiomyomas also called myomas or fibroids; are benign monoclonal uterine myometrial tumors. Uterine fibroids are the commonest benign tumours of female genital tract with a prevalence of 20 to 50% in women of reproductive age. Fibroids may be classified as submucous, intramural or sub-serous. It is often assumed that fibroids cause infertility since pregnancies do occur after myomectomy and other treatments where the fibroids are removed. The treatment of fibroids has historically been surgery, usually hysterectomy. Myomectomy is an option in women wishing to maintain fertility and for those desiring to keep their uterus. The position of the uterine fibroid plays important role in infertility. The presence of sub-mucous fibroid decreases the fertility rate. Subserosal fibroids do not affect the fertility rate but removing those does increase fertility. Surgical management is limited to non-pregnant uterus. Fibroid coexisting pregnancy, prevalence is 0.3-2.6%, can be asso...

TruScreen is a unique electro-optical technology that provides a direct means of tissue different... more TruScreen is a unique electro-optical technology that provides a direct means of tissue differentiation as a primary screening tool in the general population for cervical cancer and precancerous change (CIN). Objectives of the work are evaluation of sensitivity and specificity of the optoelectronic method in the detection of CIN and cervical cancer. The present study shows correlation between the pNOR number and sensitivity/specificity of the optoelectronic method. The study included 293 patients with abnormal cervical cytology result and the following examinations: examination with the use of the optoelectronic method-Truscreen, colposcopic examination, and histopathology biopsy. Specificity of the optoelectronic method for LGSIL was estimated at 65.70%, for HGSIL and squamous cell carcinoma ofcervix amounted to 90.38%. Specificity of the optoelectronic method used to confirm lack of cervical pathology was estimated at 78.89%.The field under the ROC curve for the optoelectronic method was estimated at 0.88 (95% CI, 0.84-0.92) which shows high diagnostic value of the test in the detection of HGSIL and squamous cell carcinoma. The optoelectronic method is characterized by high usefulness in the detection of CIN, present in the squamous epithelium and squamous cell carcinoma of cervix. In conclusion, we suggest that TruScreen holds the potential to detect lesions that might be missed by cytology alone and clarify unsatisfactory or ASCUS cytology results. With regard to patients, they can benefit from more rapid follow-up and early treatment. We also noticed that the women were happy with the real time results, which are now available using TruScreen. TruScreen technology seems to have a high potential to improve and standardize the screening of the cervical carcinoma.

actice, P. Rami reddy memorial college of pharmacy, Kadapa. AP

Journal of Evolution of Medical and Dental Sciences, 2015

Background: Truscreen is a portable system used to directly identify cancer or pre-cancerous cell... more Background: Truscreen is a portable system used to directly identify cancer or pre-cancerous cells in cervical tissue. Truscreen uses low levels of electric signals and light to examine the cervix by gently touching the surface of the cervix with a hand-held wand. The system comprises a hand piece, console and single use sensor (SUS).The hand piece uses advanced electro-optical biosensors to measure the response of cervical tissue to light together with tissue capacitance. Unlike cytology, Truscreen does not only examine surface epithelial cells. With the aim of to screen the Cervix with truscreen for detection of Pre cancerous and cancerous lesions of the cervix to minimize morbidity, mortality, to advance the health and to improve the quality of life of women. An ongoing pilot study was conducted at Govt. Maternity Hospital; Osmania Medical College, Hyderabad, Andhra Pradesh, with duration of 3 months (August to October 2008) by including 50 porous women were screened and within t...

Indian Journal of Pharmacy Practice, 2013

To evaluate the occurrence of Adverse Drug Reactions (ADRs) in the children who are hospitalized,... more To evaluate the occurrence of Adverse Drug Reactions (ADRs) in the children who are hospitalized, the follow-up processes resulting from it and to evaluate the reporting of ADRs by health care professionals. The occurrence of ADRs among hospitalized children has not been well established. As the clinical trials involving neonates, infants and children are absent or limited, the safety and tolerability of drugs are not well established among them hence the pharmacological actions of drugs are not similar to those identified for adults. A prospective observational study was conducted between June 2012 and March 2013 at Rajiv Gandhi Institute of Medical sciences (RIMS) an 800 bedded tertiary care teaching hospital, Kadapa. A total of 109 ADRs were identified. The most of the ADRs were mild(54.12%), severe were least (12.85%) and the moderate were between them (20.2%). Maximum of ADRs (89.91%, n-98) identified were predictable and least (10.09%, n-11) were non-predictable. Highest incid...

Thirty five genotypes of muskmelon (Cucumis melo L.) were evaluated in a randomized block design ... more Thirty five genotypes of muskmelon (Cucumis melo L.) were evaluated in a randomized block design with three replications at the Experimental Farm, Vegetable Research Station, Rajendranagar, Hyderabad, Andhra Pradesh, India during late rabi season (November 2010 to February 2011) for genetic diversity based on 18 morphological traits. Cluster analysis revealed distinct clustering pattern and grouping of genotypes into six distinct clusters. Cluster II was the largest (22 genotypes) followed by cluster I (8 genotypes) and cluster IV (2 genotypes), while cluster III, V and VI were solitary consisting of single genotypes. Intracluster D 2 values ranged from 0.00 (cluster III, V and VI) to 85.514 (cluster IV), while the intercluster D 2 values ranged from 94.56 (clusters I and II) to 753.29 (clusters I and VI). The genotype of the most divergent clusters I and VI (753.29), clusters IV and VI (590.55) and clusters II and IV (529.79) could be used in hybridization programmes. Total soluble...

European journal of clinical pharmacy: atención farmacéutica, 2016

Background: Clinical pharmacy services were started in 1997 in India, in contrast to developed co... more Background: Clinical pharmacy services were started in 1997 in India, in contrast to developed countries where the services were started in early 1960s. However 15 years have been passed out after the introduction of clinical pharmacy in India, but still the involvement of clinical pharmacist in the healthcare team is negligible. Objective: To elevate the clinical pharmacist role in the healthcare team, to justify the liaison between healthcare professionals and to promote better quality of life in chronic disease patients a prospective observational and interventional study was carried out. Setting: Rajiv Gandhi Institute of Medical Sciences, an 800 bedded tertiary care teaching hospital, Kadapa, India. Main Outcome: Progression of Quality of Life in chronic disease patients. Results: 200 patients were recruited belonging to age ≥40 years; they were divided into Observational Group (100) and Interventional Group (100). Each group consisted of 25 patients for Hypertension (25), Stro...

To evaluate the incidence of Hypertension in the geriatric patients attending a tertiary Care tea... more To evaluate the incidence of Hypertension in the geriatric patients attending a tertiary Care teaching hospital. A prospective observational study was conducted between July 2013 and June 2014 in Department of General Medicine at Rajiv Gandhi Institute of Medical sciences (RIMS) an 800 bedded hospital, Kadapa. A total of 462 patients were studied in one year, out of 462, male patients were 203 (43.93%) and female patients were 259 (56.06%), age group of 60-69 years were more (43.72%) and above 80 years were least (15.35%), most of the patients were identified as illiterate (85.06%). 5-10 years disease duration consists higher population (48.21%) and least (6.4%) was observed in 20 years and above of disease duration. Major risk factors were identified as sedentary life style, alcohol consumption, diet (excess salt intake), cigarette smoking and minor risk factor as hereditary. Target organ damage like stroke, myocardial infarction, heart failure, chronic kidney disease and periphera...

INTRODUCTION: Polycystic ovarian syndrome (PCOS) was originally described in 1935 by American gyn... more INTRODUCTION: Polycystic ovarian syndrome (PCOS) was originally described in 1935 by American gynaecologistsIrving F. Stein& Michael L. Leventhal from whom the original name of SteinLeventhal Syndrome is taken, as a syndrome manifested by amenorrhoea, hirsutism and obesity associated with enlarged polycystic ovaries. PCOS is one of the most common syndromes in the modern world in women during their reproductive age. It is now recognized as a common, heterogeneous, heritable disorder affecting women throughout their lifetime. PCOS is characterized by hyperandrogenism, ovulatory dysfunction& polycystic ovaries. However, there is considerable interindividual variation in presentation. Although not required for diagnosis, the presence of insulin resistance and hyper insulinaemia is common and places those affected at increased risk of diabetes and cardiovascular disease. PCOS is a condition in which a woman has an imbalance of sex hormones. This may lead to menstrual cycle changes, cyst...

Indo American Journal of Pharmaceutical Research, 2015