rezzan aydın - Academia.edu (original) (raw)

Papers by rezzan aydın

Case Reports in Psychiatry, 2015

Inhalant abuse is a problem that is getting more common all around the world. The increase in pre... more Inhalant abuse is a problem that is getting more common all around the world. The increase in prevalence of inhalant abuse escalates morbidity and mortality rates. About 22% of people using inhalant have died at their first attempt. Particularly propane, butane, or propane-butane mixture has highest mortality rates. Sudden sniffing death syndrome, cardiomyopathy, central nervous system toxicity, hematological abnormalities, kidney toxicity, and hepatocellular toxicities are the major complications of inhalant abuse. Herein we present a patient with inhalant use disorder. At the age of 19, after a stressful life event he had unsuccessfully tried to suicide by inhaling LPG (liquefied petroleum gas, a mixture of butane and propane gases). After he realized that he had hallucinations and felt better during the inhalation, he started to abuse it. He was addicted to LPG for 10 years at the time of admission. Besides being dangerous for the society security, this intense level of LPG inhal...

Pediatrics International, 2016

Childhood sexual abuse (CSA) can be a devastating life experience that produces higher incidences... more Childhood sexual abuse (CSA) can be a devastating life experience that produces higher incidences of mental disorders and suicide attempts. However, there are factors that may be found with a greater ratio in the vulnerable victims. We evaluated 181 Turkish children and adolescents with a history of CSA regarding their age, gender, suicide attempts, family relations and educational background. Abuse involving the insertion of an organ or foreign object into the individual&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s body was designated as a &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Qualified Sexual Abuse&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (QSA); other forms of sexual abuse were designated &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Basic Sexual Abuse&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (BSA). Suicide attempts were significantly higher in adolescent girls in the QSA subgroup; age, gender, family integrity, and school attendance did not associate with the risk of mental disorders in this group. Among BSA patients, family integrity statistically influenced suicide attempts. Suicide attempts were approximately 10 times higher (P = 0.005, 95%CI: 2.020-51.051, OR, 10.154) in the participants of children living in broken families. Family integrity and school attendance were also noted as weak protective factors against mental disorders in BSA patients. The incidence of mental disorders was 3.5 times higher in children who had not been attending school (P = 0.009, 95%CI: 1.379-9.211, OR, 3.564). We found that family integrity and school attendance weakly related with psychopathology (e.g., mental disorders or suicide attempts) for BSA survivors but not for QSA survivors. Female gender and puberty also increased the likelihood of a suicide attempt for QSA survivors. This article is protected by copyright. All rights reserved.

The Journal of Pediatric Research, 2014

Psikiyatrik hastalıkların oluşumunda biyopsikososyal model halen geçerliliğini korumaktadır. Diat... more Psikiyatrik hastalıkların oluşumunda biyopsikososyal model halen geçerliliğini korumaktadır. Diatez (yapısal yatkınlık) veya stres biyolojik, psikososyal, çevresel faktörlerle bir araya gelebilir. Bu üç faktörün kombinasyonu psikiyatrik bozukluklara yol açmaktadır (Şekil 1). Günümüzde depresif bozukluk etiyolojisinde pek çok etkenin birlikte rol oynadığı kabul edilmektedir. Etiyolojik faktörler biyolojik ve psikososyal faktörler olarak iki başlıkta incelenmektedir. Biyolojik faktörler arasında genetik, nörokimyasal, nöroanatomik ve nöroendokrin faktörler yer almakta iken; olumsuz yaşam olayları, bozuk ebeveyn-çocuk ilişkisi, sosyal destek eksikliği, sosyal beceri eksikliği ve kohort etkisi gibi faktörler ise psikososyal nedenler arasında bulunmaktadır (1). Tablo I'de pediatrik Majör depresif bozukluk (MDB) etyolojisinde yer alan faktörler gösterilmiştir. MDB yetişkinlik döneminde olduğu gibi çocuk ve ergenler için de önemli bir sağlık sorunudur. MDB görülme sıklığının çocuklarda yaklaşık %2 ve ergenlerde %4 ile %8 arasında olduğu tahmin edilmektedir (2). Çocuk ve ergenlerde görülme Özet ABS tRACt Günümüzde depresif bozukluk etiyolojisinde pek çok etkenin birlikte rol oynadığı kabul edilmektedir. Bu makalede pediatrik majör depresif bozukluğa neden olan etiyolojik faktörler, genetik alanda yapılan aile, ikiz ve evlat edinme çalışmaları, bağlantı çalışmaları, aday gen çalışmaları, genom çapında ilişki çalışmaları, genetik ve görüntülemenin bir arada kullanıldığı çalışmalar, farmakogenetik, gen-çevre etkileşimleri çalışmaları ve bu konularla ilgili güncel bilgilerin paylaşılması amaçlanmıştır. Bu amaç doğrultusunda "Major Depression Genetics", "Pediatric Depression Genetics", "Child and Adolescent Depression Genetics", "Mood Disorders Genetics", kelimeleri Pubmed arama motoruna yazılarak elde edilen makalelerden 2002-2012 yılları arasındaki yayınlar taranmış; konuyla ilgili bulunan ve güncel olma özelliği ön planda tutulan bilimsel yazılar gözden geçirilmiştir. Pediatrik majör depresif bozukluğa yol açan evrensel bir genetik risk faktörü veya bu duruma yol açan tek bir gen mevcut değildir. Majör depresif bozukluk küçük benzer etkileri olan çok sayıda genle ilişkilidir ve genetik faktörlerin çevresel faktörlerle etkileşimi ile komplike olmasıyla meydana gelir.

The Journal of Pediatric Research, 2014

Bipolar disorder (BPD) is chronic illness which courses with relapses of manic, hypomanic, mix an... more Bipolar disorder (BPD) is chronic illness which courses with relapses of manic, hypomanic, mix and depressive episodes. Despite BPD is described as a rarely seen disease in children and adolescents, in the present time increasing numbers of children which are having BPD diagnosis contributed to the description, classification and treatment of this disease. It becomes inevitable to evaluate genetic aspects of this disorder after detection of prevalence in children and adolescents, clinical properties of BPD and high frequency of this disorder in relatives of BPD children. It is being mentioned that early-onset BPD patients genetically resemble each other and genetic features take important role in those individuals. In this paper we tried to review articles which were published between years 1998 and 2012, particularly the actual samples. After studies about genes which are relevant to limbic system (such as SLC6A4, 5HTT, HTR2A, DRD2) resulted inconsistency; focusing on calcium channel system of neurons has become more important in recent years. Studies with pediatric age group are rare and it is a necessity to make new researches which aim to explain etiology of bipolar disorder. New molecular genetic researches may contribute to illumination of etiology of BPD.

Noro Psikiyatri Arsivi, 2015

Introduction: This study has two objectives. The first objective of this study was the determinat... more Introduction: This study has two objectives. The first objective of this study was the determination of some basic clinical and sociodemographical differences among the adolescents with substance abuse who apply to a treatment center with support from their family or by order of the probation office. The other objective of this study was the determination of the predictive factors in maintaining soberness among adolescents who successfully complete the probation treatment process. Methods: The target population of this study is young adults under 19 years of age who apply to a substance addiction center for adolescents as a result of encouragement from their family or ordered by the Probation Office between 2005 and 2013. These two groups were analyzed in terms of socio-demographical characteristics such as age, the age at which they tried the substance, the age at which they applied to the treatment center, sex, substances they used, education period, employment history, and street life experience. The Statistical Package for the Social Sciences (SPSS) 18.0 software was used for the statistical analysis. Results: It was detected that among the cases who applied to the treatment center with family support, their education period was longer than probation (PR) cases (p<0.0001), and the rates of previous treatment, their mother being alive, and having street life experiences were more frequent (p values: <0.0001; =0.010; =0.027; <0.0001, respectively) and employment history was higher among PR cases (p<0.0001). In terms of the substances used, ecstasy, alcohol, inhalants, and volatile substances are more common among those applying with family support (p=0.018; 0.001; <0.0001, respectively). However, use of cannabis was found to be more common among PR cases (p<0.0001). It was found that PR cases who successfully completed their treatment process had married parents (p=0.008) and had more years of education (p=0.004). It can be predicted that if the subject is well educated and does not use multiple substances or have an alcohol history, the treatment process for PR cases can be successfully completed. (R2=0.176; p<0.0001). Conclusion: The rates of completing the treatment among cases analyzed in this study were higher than those among cases from adults. In the studies conducted, the results of the treatment efficiency among PR cases were inconsistent. This inconsistency may result from, except for legal obligations, having different circumstances such as socioeconomic factors during the treatment period.