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Papers by rohit dutt
Journal of Applied Pharmaceutical Science
This study shows the development of probiotic (Lactobacillus helveticus Strain NS8) loaded gel fo... more This study shows the development of probiotic (Lactobacillus helveticus Strain NS8) loaded gel for the treatment of caffeine-induced anxiety. The formulation was developed by using Carbopol 980 by cold method and evaluated for clarity, pH, viscosity, spreadability, centrifugation, stability, and anti-anxiety efficacy in animal model. Caffeine was given to G1-G5 rats at a dosage of 25 mg/kg, i.p; while a probiotic formulation was given orally in G3 and G4 animal groups following caffeine. G5 group animals were applied with a probiotic topical gel to animals' foreheads. Eddy's hot plate, elevated plus maze test, and blood serum serotonin level were determined. F5 formulation showed excellent transparent, clear, and smooth characteristics with pH 5.3. The formulation showed desirable viscosity and spreadability for topical application. The animals (G5 group) treated with topical gel stayed longer on hot plate (5.95 and 7.35 seconds). Probiotic topical gel-treated animals (G5 group) also showed a significant increase in time spent in open arms when compared to anxiety control group. Animals treated with probiotic gel also showed significantly lower concentrations of serotonin levels. The stability studies conducted F5 showed no significant changes in clarity, pH, and consistency. The gel formulation showed a comparable reduction in anxiety to the diazepam-treated animals and can be potentially used for treatment of mild-moderate anxiety.
Current Drug Therapy
: Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical... more : Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical prospects have increased tremendously since the advent of biological agents as therapy options. NSAIDs such as indomethacin, celecoxib, and etoricoxib are used often in the treatment of RA but off-target effects decreased their use. DMARDs such as methotrexate and etanercept were also effective in the treatment of RA, but tolerance to methotrexate developed in many cases. Janus kinase inhibitors (JAKi) have also gained popularity as a treatment option for rheumatoid arthritis. Tofacitinib is the foremost JAK inhibitor that is used to treat RA as an individual agent or in combination with other DMARDs. The most frequently used route of administration for JAKi is oral. Since oral formulations of JAK inhibitors have a number of health hazards, such as systemic toxicity and patient noncompliance, topical formulations of JAK inhibitors have emerged as a preferable alternative for administering JAK inhibitors. Tofacitinib delivered topically, seems to have the potential to eliminate or reduce the occurrences of negative effects when compared to tofacitinib taken orally. Given the scarcity of knowledge on the techniques for topical distribution of JAKi, more effort will be required to develop a stable topical formulation of JAKi to address the limitations of oral route. The current review looks at JAK inhibitors and the ways that have been used to generate topical formulations of them.
BackgroundSARS-CoV-2 infection has severely ravaged health systems, economic and social progress ... more BackgroundSARS-CoV-2 infection has severely ravaged health systems, economic and social progress globally in 2020. Seroprevalence studies can provide relevant information on the target populations for vaccination. They are relevant not only in the community, but also for critical population subgroups such as nursing homes or health care facilities. They will assist in strategizing the vaccination policy especially since there is limited availability of the vaccine and vaccine hesitancyObjectiveTo evaluate the seroprevalence in Health Care Workers (HCW) at our hospital and to identify parameters which may affect it.MethodologyThe Baseline profiling and seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was assessed among 3258 healthcare workers (HCWs) of Medanta-The Medicity, Gurugram, Haryana, India, as a part of an ongoing cohort study.The fully automated LIAISON® SARS-CoV-2 S1/S2 IgG test using the chemiluminescence immunoassay (CLIA) for the quantitati...
Medical Oncology
Cancer therapy has undergone a drastic revolution in the past few decades with the introduction o... more Cancer therapy has undergone a drastic revolution in the past few decades with the introduction of several novel therapies, like immunotherapy (active and passive), stem cell-based therapies, and nanocarrier-based therapies. These therapies have addressed the issues of conventional cancer therapy (chemotherapy or radiotherapy), like specificity and off-target effects. Further, the introduction of such treatments has improved survival and converted a terminal disease into a more manageable condition. However, many clinical, ethical, and regulatory issues are raised with such novel additions. Several effective therapies are under research but could not come to market or are delayed due to regulatory concerns for marketing approval. The scope of this review encompasses the examination of these regulatory issues and discuss their possible solutions. A practical and flexible regulatory approach, harmonized globally, could help the patients suffering from a terminal illness to lead a quality life.
Recent Patents on Nanotechnology, 2022
Background: Controlled drug release and site-specific delivery of drugs make nanocapsules the mos... more Background: Controlled drug release and site-specific delivery of drugs make nanocapsules the most approbative drug delivery system for various kinds of drugs, bioactive, protein, and peptide compounds. Nanocapsules (NCs) are spherical shape microscopic shells consisting of a core (solid or liquid) in which the drug is positioned in a cavity enclosed by a distinctive polymeric membrane. Objectives: The main objective of the present study is to elaborate on various formulation techniques and methods of nanocapsules (NCs). The review also spotlights various biomedical applications as well as on the patents of NCs till date. Methods: The review was extracted from the searches performed using various search engines such as PubMed, Google Patents, Medline, and Google Scholars, etc. In order to emphasize the importance of NCs, some published patents of NCs have been also reported in the review. Results: NCs are tiny magical shells having incredible reproducibility. Various techniques can ...
Current Drug Research Reviews, 2022
: Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the signallin... more : Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the signalling network system of endocannabinoids, which is associated with various physiological processes like pain, inflammation, feeding cognition, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. The monoacylglycerol was also found to act as a regulator and the free fatty acid provider in the proliferation of cancer cells as well as numerous aggressive tumours such as colorectal cancer, neuroblastoma, and nasopharyngeal carcinoma. It also played an important role in increasing the concentration of specific lipids derived from free fatty acids like phosphatidic acid, lysophosphatidic acid, sphingosine-1-phosphate, and prostaglandin E2. These signalling lipids are associated with cell proliferation, survival, tumour cell migration, contribution to tumour development, maturation, and metastases. In this study, we present a review on structurally diverse MAGL inhibitors, their development, and their evaluation for different pharmacological activities.
Mini-Reviews in Medicinal Chemistry, 2021
Molecules, 2021
Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distribute... more Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including as a wound dressing, an antimicrobial, and mouthwash as well as in treatment of dysentery, diarrhea, skin diseases, etc. In this review, the core idea is to present the antifungal potential of the selected medicinal plant and its secondary metabolites against different fungal pathogens. Additionally, toxicological studies (safety profile) conducted on the amazing plant A. conyzoides L. are discussed for the possible clinical development of this medicinal herb. Articles available from 2000 to 2020 were reviewed in detail to exhibit recent appraisals of the antifungal properties of A. conyzoides. Efforts were aimed at delivering evidences for the medicinal application of A. conyzoides by using globally recognized scientific search engines and databases so that an effic...
International Journal of Scientific Research in Science and Technology, 2020
Moving on from the profile suggesting dietary intake levels for maintaining healthiness to counte... more Moving on from the profile suggesting dietary intake levels for maintaining healthiness to counteracting the effects of micro gravity, the nutritional sciences research is observing a compounding challenge given the space flights getting longer and complexity of the missions getting intensely greater. Nutritional research in space and ground based protocols has largely studied the intake of energy, protein, water, iron, calcium, sodium, potassium and vitamin D. Determining the dietary intake and corresponding role of dietary nutrients in counteracting the adverse physiological effects of micro gravity has paved a way for the formulation of optimal dietary needs of various macro and micro nutrients under the arena of scientific study. Concurrently, the space food menu has experienced an evolution from unappetizing, difficult to process and limited food options to a prolific and elaborate food system. The achievable food systems for the crew and their constructiveness in ensuring the ...
Mini-Reviews in Medicinal Chemistry, 2020
Dengue is a major health threat related to arbovirus and is endemic in more than 100 countries wi... more Dengue is a major health threat related to arbovirus and is endemic in more than 100 countries with an annual estimated above 390 million incidences of infection all around the world. During the period 1996-2015, a considerable increase in the number of dengue cases (more than 500%) was reported in India. Information about dengue disease burden, its prevalence, incidence and geographic distribution is critical in planning appropriate control measures against dengue fever. Till date, no specific treatment for dengue fever is available in any system of medicine, which can be accepted globally. Therefore, safe, cost-effective, and efficacious agents possessing anti-viral potential against dengue virus are needed to be searched in order to fight the dengue infection globally. The aim of the present review is to systematically revise the published research work available concerning the development and evaluation of some heterocyclic scaffolds in the management of dengue.
Current Applied Polymer Science, 2020
Background::Soluble films prepared using polymeric matrices have gained prominence in drug delive... more Background::Soluble films prepared using polymeric matrices have gained prominence in drug delivery because of its multifarious merits. They are emerging as a momentous technology for designing precision medicines using printing technology, wherein the drugs, proteins/peptides and hormones in printing ink solution can be printed on placebo films targeted for specific age group dosage administration. Advances made in 3D printing technology in biomanufacturing for sophisticated tailor-made scaffolds of bone and tissue have further given impetus to digitally-controlled depositing of materials to create freeform geometries in the field of dosage form development.Objective:The patent expiry of a significant number of existing chemical entities is an encouraging factor for the possible market potential of these films as a novel drug delivery system through the oral route, topical route and ocular route. Most prominent amongst them is the oral route simply because of its substantial advant...
Journal of Stress Physiology & …
Abstract: Background: Despite significant advances in understanding and management of neuropsychi... more Abstract: Background: Despite significant advances in understanding and management of neuropsychiatric disorders during past few decades, anxiety and depression, still remains the leading cause of deaths, primarily for want of effective and safe treatment of these ...
Current Topics in Medicinal Chemistry, 2013
Despite significant research in understanding of neoplastic diseases, the success rate for oncolo... more Despite significant research in understanding of neoplastic diseases, the success rate for oncology drugs is relatively very low. A major challenge before the scientific community is to design new chemical entities that will be highly selective for cancer cells so as to minimize side effects. Classification models (CMs) models play a prominent role in prediction of the biological properties of newly designed compounds before their synthesis and prevent non-optimal use of resources. Though correlation models far outnumber classification models for development of various therapeutic agents but the significance of classification models for development of anti-cancer agents can not be underestimated. Various techniques employed for development of classification models for anti-cancer activity have been briefly reviewed. Moreover, successful use of some of these classification techniques for the development of models for anti-proliferative activity has been illustrated using a data set comprising of 53 analogues of N-Benzoylated phenoxazines and phenothiazines. Resulting classification models with high degree of accuracy can play a vital role in providing lead structures for the development of novel anti-proliferative agents for cancer chemotherapy.
The therapeutic use of plants against critical human illnesses predates recorded history and repr... more The therapeutic use of plants against critical human illnesses predates recorded history and represents the most significant direct antecedent to modern medicine. With the advances of various in-silico technologies, the introduction of plant derived bioactive agents into the cancer armamentarium has changed the natural history of many types of human cancer. In spite of numerous advances in the field of cancer research, the world still continues to be in the grip of this dreadful disease and there is an urgent need to design well tolerated anti-cancer therapeutic agents. Numerous plants have the potential of anticancer activity but are still to be investigated. However, existing flora is so vast that it is humanly impossible to investigate each and every plant for anti-cancer activity. Increasing global warming, malnutrition and various environmental insults continue to increase the incidences of cancer. "Cancer is hostile to human body and hostile environment is cancerous to plants". Accordingly, those plants which are able to comfortably survive under multiple but diverse hostile environments may act as a vital source of anti-cancer agents. Moreover, these anticancer agents are likely to be safe by virtue of being of natural origin. Various plants reported/studied for anticancer activity till date have been briefly reviewed in the present article. An urgent need for screening plants surviving in diverse hostile environments for anticancer activity has been emphasized so as to accelerate development of effective but safe anticancer drugs.
International Journal of Pharmaceutics
Current Protein & Peptide Science
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Journal of Applied Pharmaceutical Science
Tretinoin (TRT), a natural all-trans retinoic acid occurring retinoid metabolite, belongs to the ... more Tretinoin (TRT), a natural all-trans retinoic acid occurring retinoid metabolite, belongs to the first generation of retinoids used to treat various skin ailments, like acne vulgaris and skin ageing and psoriasis. In this study, a combination of drugs using TRT and curcumin (CUR) nanoemulsion (NE) is fabricated, and is further added to a gel formulation to boost the efficacy and stability of the topical formulation. A high-energy sonication technique was used in the NE fabrication, and optimization was carried out using the Box-Behnken design. The TRT-CUR-NEs were found to have a mean particle size, zeta potential, and PDI of 77.6 ± 2.1 nm, −20.7 ± 4.4 mV, and 0.268 ± 0.029, respectively. The optimized formulation of TRT-CUR-NE has a % entrapment efficiency of 85.92% ± 2.6% and 88.31% ± 3.2% for TRT and CUR, respectively, and a % loading efficiency of 19.6% ± 1.2% and 18.7% ± 2.5%, respectively, for TRT and CUR, respectively. The in vitro release profile displayed % cumulative drug release of 28.64% ± 0.31%, 80.32% ± 0.42%, and 89.64% ± 0.97% after 24 hours for plain gel, TRT-CUR-NE, and TRT-CUR-nanoemulgel, respectively.
Journal of Applied Pharmaceutical Science
This study shows the development of probiotic (Lactobacillus helveticus Strain NS8) loaded gel fo... more This study shows the development of probiotic (Lactobacillus helveticus Strain NS8) loaded gel for the treatment of caffeine-induced anxiety. The formulation was developed by using Carbopol 980 by cold method and evaluated for clarity, pH, viscosity, spreadability, centrifugation, stability, and anti-anxiety efficacy in animal model. Caffeine was given to G1-G5 rats at a dosage of 25 mg/kg, i.p; while a probiotic formulation was given orally in G3 and G4 animal groups following caffeine. G5 group animals were applied with a probiotic topical gel to animals' foreheads. Eddy's hot plate, elevated plus maze test, and blood serum serotonin level were determined. F5 formulation showed excellent transparent, clear, and smooth characteristics with pH 5.3. The formulation showed desirable viscosity and spreadability for topical application. The animals (G5 group) treated with topical gel stayed longer on hot plate (5.95 and 7.35 seconds). Probiotic topical gel-treated animals (G5 group) also showed a significant increase in time spent in open arms when compared to anxiety control group. Animals treated with probiotic gel also showed significantly lower concentrations of serotonin levels. The stability studies conducted F5 showed no significant changes in clarity, pH, and consistency. The gel formulation showed a comparable reduction in anxiety to the diazepam-treated animals and can be potentially used for treatment of mild-moderate anxiety.
Current Drug Therapy
: Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical... more : Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical prospects have increased tremendously since the advent of biological agents as therapy options. NSAIDs such as indomethacin, celecoxib, and etoricoxib are used often in the treatment of RA but off-target effects decreased their use. DMARDs such as methotrexate and etanercept were also effective in the treatment of RA, but tolerance to methotrexate developed in many cases. Janus kinase inhibitors (JAKi) have also gained popularity as a treatment option for rheumatoid arthritis. Tofacitinib is the foremost JAK inhibitor that is used to treat RA as an individual agent or in combination with other DMARDs. The most frequently used route of administration for JAKi is oral. Since oral formulations of JAK inhibitors have a number of health hazards, such as systemic toxicity and patient noncompliance, topical formulations of JAK inhibitors have emerged as a preferable alternative for administering JAK inhibitors. Tofacitinib delivered topically, seems to have the potential to eliminate or reduce the occurrences of negative effects when compared to tofacitinib taken orally. Given the scarcity of knowledge on the techniques for topical distribution of JAKi, more effort will be required to develop a stable topical formulation of JAKi to address the limitations of oral route. The current review looks at JAK inhibitors and the ways that have been used to generate topical formulations of them.
BackgroundSARS-CoV-2 infection has severely ravaged health systems, economic and social progress ... more BackgroundSARS-CoV-2 infection has severely ravaged health systems, economic and social progress globally in 2020. Seroprevalence studies can provide relevant information on the target populations for vaccination. They are relevant not only in the community, but also for critical population subgroups such as nursing homes or health care facilities. They will assist in strategizing the vaccination policy especially since there is limited availability of the vaccine and vaccine hesitancyObjectiveTo evaluate the seroprevalence in Health Care Workers (HCW) at our hospital and to identify parameters which may affect it.MethodologyThe Baseline profiling and seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was assessed among 3258 healthcare workers (HCWs) of Medanta-The Medicity, Gurugram, Haryana, India, as a part of an ongoing cohort study.The fully automated LIAISON® SARS-CoV-2 S1/S2 IgG test using the chemiluminescence immunoassay (CLIA) for the quantitati...
Medical Oncology
Cancer therapy has undergone a drastic revolution in the past few decades with the introduction o... more Cancer therapy has undergone a drastic revolution in the past few decades with the introduction of several novel therapies, like immunotherapy (active and passive), stem cell-based therapies, and nanocarrier-based therapies. These therapies have addressed the issues of conventional cancer therapy (chemotherapy or radiotherapy), like specificity and off-target effects. Further, the introduction of such treatments has improved survival and converted a terminal disease into a more manageable condition. However, many clinical, ethical, and regulatory issues are raised with such novel additions. Several effective therapies are under research but could not come to market or are delayed due to regulatory concerns for marketing approval. The scope of this review encompasses the examination of these regulatory issues and discuss their possible solutions. A practical and flexible regulatory approach, harmonized globally, could help the patients suffering from a terminal illness to lead a quality life.
Recent Patents on Nanotechnology, 2022
Background: Controlled drug release and site-specific delivery of drugs make nanocapsules the mos... more Background: Controlled drug release and site-specific delivery of drugs make nanocapsules the most approbative drug delivery system for various kinds of drugs, bioactive, protein, and peptide compounds. Nanocapsules (NCs) are spherical shape microscopic shells consisting of a core (solid or liquid) in which the drug is positioned in a cavity enclosed by a distinctive polymeric membrane. Objectives: The main objective of the present study is to elaborate on various formulation techniques and methods of nanocapsules (NCs). The review also spotlights various biomedical applications as well as on the patents of NCs till date. Methods: The review was extracted from the searches performed using various search engines such as PubMed, Google Patents, Medline, and Google Scholars, etc. In order to emphasize the importance of NCs, some published patents of NCs have been also reported in the review. Results: NCs are tiny magical shells having incredible reproducibility. Various techniques can ...
Current Drug Research Reviews, 2022
: Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the signallin... more : Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the signalling network system of endocannabinoids, which is associated with various physiological processes like pain, inflammation, feeding cognition, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. The monoacylglycerol was also found to act as a regulator and the free fatty acid provider in the proliferation of cancer cells as well as numerous aggressive tumours such as colorectal cancer, neuroblastoma, and nasopharyngeal carcinoma. It also played an important role in increasing the concentration of specific lipids derived from free fatty acids like phosphatidic acid, lysophosphatidic acid, sphingosine-1-phosphate, and prostaglandin E2. These signalling lipids are associated with cell proliferation, survival, tumour cell migration, contribution to tumour development, maturation, and metastases. In this study, we present a review on structurally diverse MAGL inhibitors, their development, and their evaluation for different pharmacological activities.
Mini-Reviews in Medicinal Chemistry, 2021
Molecules, 2021
Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distribute... more Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including as a wound dressing, an antimicrobial, and mouthwash as well as in treatment of dysentery, diarrhea, skin diseases, etc. In this review, the core idea is to present the antifungal potential of the selected medicinal plant and its secondary metabolites against different fungal pathogens. Additionally, toxicological studies (safety profile) conducted on the amazing plant A. conyzoides L. are discussed for the possible clinical development of this medicinal herb. Articles available from 2000 to 2020 were reviewed in detail to exhibit recent appraisals of the antifungal properties of A. conyzoides. Efforts were aimed at delivering evidences for the medicinal application of A. conyzoides by using globally recognized scientific search engines and databases so that an effic...
International Journal of Scientific Research in Science and Technology, 2020
Moving on from the profile suggesting dietary intake levels for maintaining healthiness to counte... more Moving on from the profile suggesting dietary intake levels for maintaining healthiness to counteracting the effects of micro gravity, the nutritional sciences research is observing a compounding challenge given the space flights getting longer and complexity of the missions getting intensely greater. Nutritional research in space and ground based protocols has largely studied the intake of energy, protein, water, iron, calcium, sodium, potassium and vitamin D. Determining the dietary intake and corresponding role of dietary nutrients in counteracting the adverse physiological effects of micro gravity has paved a way for the formulation of optimal dietary needs of various macro and micro nutrients under the arena of scientific study. Concurrently, the space food menu has experienced an evolution from unappetizing, difficult to process and limited food options to a prolific and elaborate food system. The achievable food systems for the crew and their constructiveness in ensuring the ...
Mini-Reviews in Medicinal Chemistry, 2020
Dengue is a major health threat related to arbovirus and is endemic in more than 100 countries wi... more Dengue is a major health threat related to arbovirus and is endemic in more than 100 countries with an annual estimated above 390 million incidences of infection all around the world. During the period 1996-2015, a considerable increase in the number of dengue cases (more than 500%) was reported in India. Information about dengue disease burden, its prevalence, incidence and geographic distribution is critical in planning appropriate control measures against dengue fever. Till date, no specific treatment for dengue fever is available in any system of medicine, which can be accepted globally. Therefore, safe, cost-effective, and efficacious agents possessing anti-viral potential against dengue virus are needed to be searched in order to fight the dengue infection globally. The aim of the present review is to systematically revise the published research work available concerning the development and evaluation of some heterocyclic scaffolds in the management of dengue.
Current Applied Polymer Science, 2020
Background::Soluble films prepared using polymeric matrices have gained prominence in drug delive... more Background::Soluble films prepared using polymeric matrices have gained prominence in drug delivery because of its multifarious merits. They are emerging as a momentous technology for designing precision medicines using printing technology, wherein the drugs, proteins/peptides and hormones in printing ink solution can be printed on placebo films targeted for specific age group dosage administration. Advances made in 3D printing technology in biomanufacturing for sophisticated tailor-made scaffolds of bone and tissue have further given impetus to digitally-controlled depositing of materials to create freeform geometries in the field of dosage form development.Objective:The patent expiry of a significant number of existing chemical entities is an encouraging factor for the possible market potential of these films as a novel drug delivery system through the oral route, topical route and ocular route. Most prominent amongst them is the oral route simply because of its substantial advant...
Journal of Stress Physiology & …
Abstract: Background: Despite significant advances in understanding and management of neuropsychi... more Abstract: Background: Despite significant advances in understanding and management of neuropsychiatric disorders during past few decades, anxiety and depression, still remains the leading cause of deaths, primarily for want of effective and safe treatment of these ...
Current Topics in Medicinal Chemistry, 2013
Despite significant research in understanding of neoplastic diseases, the success rate for oncolo... more Despite significant research in understanding of neoplastic diseases, the success rate for oncology drugs is relatively very low. A major challenge before the scientific community is to design new chemical entities that will be highly selective for cancer cells so as to minimize side effects. Classification models (CMs) models play a prominent role in prediction of the biological properties of newly designed compounds before their synthesis and prevent non-optimal use of resources. Though correlation models far outnumber classification models for development of various therapeutic agents but the significance of classification models for development of anti-cancer agents can not be underestimated. Various techniques employed for development of classification models for anti-cancer activity have been briefly reviewed. Moreover, successful use of some of these classification techniques for the development of models for anti-proliferative activity has been illustrated using a data set comprising of 53 analogues of N-Benzoylated phenoxazines and phenothiazines. Resulting classification models with high degree of accuracy can play a vital role in providing lead structures for the development of novel anti-proliferative agents for cancer chemotherapy.
The therapeutic use of plants against critical human illnesses predates recorded history and repr... more The therapeutic use of plants against critical human illnesses predates recorded history and represents the most significant direct antecedent to modern medicine. With the advances of various in-silico technologies, the introduction of plant derived bioactive agents into the cancer armamentarium has changed the natural history of many types of human cancer. In spite of numerous advances in the field of cancer research, the world still continues to be in the grip of this dreadful disease and there is an urgent need to design well tolerated anti-cancer therapeutic agents. Numerous plants have the potential of anticancer activity but are still to be investigated. However, existing flora is so vast that it is humanly impossible to investigate each and every plant for anti-cancer activity. Increasing global warming, malnutrition and various environmental insults continue to increase the incidences of cancer. "Cancer is hostile to human body and hostile environment is cancerous to plants". Accordingly, those plants which are able to comfortably survive under multiple but diverse hostile environments may act as a vital source of anti-cancer agents. Moreover, these anticancer agents are likely to be safe by virtue of being of natural origin. Various plants reported/studied for anticancer activity till date have been briefly reviewed in the present article. An urgent need for screening plants surviving in diverse hostile environments for anticancer activity has been emphasized so as to accelerate development of effective but safe anticancer drugs.
International Journal of Pharmaceutics
Current Protein & Peptide Science
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Journal of Applied Pharmaceutical Science
Tretinoin (TRT), a natural all-trans retinoic acid occurring retinoid metabolite, belongs to the ... more Tretinoin (TRT), a natural all-trans retinoic acid occurring retinoid metabolite, belongs to the first generation of retinoids used to treat various skin ailments, like acne vulgaris and skin ageing and psoriasis. In this study, a combination of drugs using TRT and curcumin (CUR) nanoemulsion (NE) is fabricated, and is further added to a gel formulation to boost the efficacy and stability of the topical formulation. A high-energy sonication technique was used in the NE fabrication, and optimization was carried out using the Box-Behnken design. The TRT-CUR-NEs were found to have a mean particle size, zeta potential, and PDI of 77.6 ± 2.1 nm, −20.7 ± 4.4 mV, and 0.268 ± 0.029, respectively. The optimized formulation of TRT-CUR-NE has a % entrapment efficiency of 85.92% ± 2.6% and 88.31% ± 3.2% for TRT and CUR, respectively, and a % loading efficiency of 19.6% ± 1.2% and 18.7% ± 2.5%, respectively, for TRT and CUR, respectively. The in vitro release profile displayed % cumulative drug release of 28.64% ± 0.31%, 80.32% ± 0.42%, and 89.64% ± 0.97% after 24 hours for plain gel, TRT-CUR-NE, and TRT-CUR-nanoemulgel, respectively.