süleyman pişkin - Academia.edu (original) (raw)
Papers by süleyman pişkin
Turkiye Klinikleri Dermatology - Special Topics, 2018
DergiPark (Istanbul University), Mar 1, 1988
DergiPark (Istanbul University), 1994
Bozok tıp dergisi, Sep 1, 2011
Turkiye Klinikleri Dermatology - Special Topics, 2013
PubMed, Aug 1, 2007
Acne is a disease of the pilosebaceous unit with involving abnormalities in sebum production, mic... more Acne is a disease of the pilosebaceous unit with involving abnormalities in sebum production, microbial flora changes, abnormal keratinization, and inflammation. There are several therapeutic options like topical and systemic retinoids, antibiotics, and systemic hormonal drugs. The topical retinoids a play very important role in the treatment of acne vulgaris. However, their use is limited due to skin irritation. A new generation product, adapalene is a good choice in the treatment of acne vulgaris with less side effects and high efficacy confirmed by numerous clinical studies.
Medicine Science | International Medical Journal, 2018
Dermoscopy has frequently been used for hair and scalp disorders. Dermoscopic examinations of pso... more Dermoscopy has frequently been used for hair and scalp disorders. Dermoscopic examinations of psoriasis and seborrheic dermatitis lesions yielded different morphologies. This study aimed to investigate the usefulness of dermoscopy in the clinical differentiation of psoriasis and seborrheic dermatitis on the scalp and additionally to evaluate its capacity in determining disease severity. The study included 46 psoriasis and 50 seborrheic dermatitis patients who were clinically diagnosed and had scalp lesions. Dermoscopic images taken from lesional scalp were then reviewed for microvascular patterns. In addition, we assessed the severity of scalp disease and looked for a correlation with these patterns. The frequency of twisted loops, glomerular vessels, red dots/globules, and polymorphous beaded lines/circles were statistically higher in the psoriasis group, whereas the frequencies of simple loops and arborizing vessels were statistically higher in the seborrheic dermatitis group (p<0.001). There was no significant difference in the frequency of featureless areas between two groups (p=0.579). There was no correlation with disease severity and dermoscopic findings. In conclusion, dermoscopy is a valuable and easy-to-use tool for differentiating psoriasis and seborrheic dermatitis on the scalp even if it doesn't have enough strength to determine disease severity. In addition, there is some diversity and ambiguity concerning terminology, which can be resolved with future studies and the establishment of conventional terms.
Journal of Dermatology, Dec 1, 2004
Treatment of warts can involve medical and surgical methods. Infrared coagulation is a surgical m... more Treatment of warts can involve medical and surgical methods. Infrared coagulation is a surgical method very rarely used in the treatment of warts. We planned an open‐labeled prospective study to research the effect of infrared coagulation in the treatment of common warts, comparing it with electrocoagulation, and discussing its applicability as an alternative therapy regimen. Eighteen patients with common warts were included in this study. There were 49 warts of various sizes (1 mm to 1 cm) in these 18 patients. Twenty‐seven warts were treated with infrared coagulation, and 22 warts were treated with electrocoagulation. Sixteen patients were treated with both infrared coagulation and electrocoagulation; two patients were treated with only infrared coagulation. The patients were followed‐up for six months after treatment. Changes in sizes of warts, healing times, and cure rates were compared by Mann‐Whitney U test. The mean healing time was 35.5 ± 5.7 days with infrared coagulation and 32.9 ± 4.0 days with electrocoagulation. There was not any significant difference between healing times (p>0.05). Bacterial infection was seen on seven (31.8%) warts treated with electrocoagulation, but no side effects were seen with infrared coagulation. There was a significant difference between side effect rates in two groups (p<0.01). Nine (33.3%) of the warts treated with infrared coagulation and seven (31.8%) of the warts treated with electrocoagulation recurred in the six‐month follow‐up period. The overall cure rates at the end of the follow‐up period were 66.7% and 68.2% respectively. There was not any significant difference between the cure rates in the two groups (P>0.05). We conclude that infrared coagulation is a safe and cheap method and should be kept in mind as an alternative modality for the treatment of common warts.
Yonsei Medical Journal, 2003
Turkderm, Jul 3, 2023
Background and Design: Oxidative stress is known to play a role in the etiopathogenesis of psoria... more Background and Design: Oxidative stress is known to play a role in the etiopathogenesis of psoriasis. Recent data suggest that osteopontin (OPN) can also play a role in the pathogenesis of psoriasis. In the current study, OPN levels and oxidative stress were evaluated in patients with psoriasis. Materials and Methods: The study included 61 patients with psoriasis and 62 healthy controls. The OPN levels, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were measured using serum. The disease severity was evaluated using the psoriasis area and severity index (PASI). Results: No statistically significant differences in OPN, TAS, and OSI values were identified between the psoriasis and control groups. A negative correlation was found with the TAS. There was no statistically significant correlation between the PASI score and OPN, TAS, TOS, and OSI values. Conclusion: We did not find a statistically significant correlation between OPN levels and oxidative stress in patients with psoriasis. We believe that larger and more detailed studies are needed to highlight the role of OPN and oxidative stress in the etiopathogenesis of psoriasis.
Tumori Journal, Mar 1, 2006
Skin metastasis from nasopharyngeal carcinoma is a rare clinical finding. The most common form of... more Skin metastasis from nasopharyngeal carcinoma is a rare clinical finding. The most common form of appearance is a few solitary skin nodules. However, massive and extensive nodular dissemination or diffuse dermal lymphatic infiltration is extremely rare. We here present a case of a 40-year-old man with widespread nodular skin metastases from undifferentiated nasopharyngeal carcinoma.
Clinical Rheumatology, Aug 17, 2006
Sjogren's syndrome (SS) is an autoimmune disease that is characterized by exocrine gland involvem... more Sjogren's syndrome (SS) is an autoimmune disease that is characterized by exocrine gland involvement. It is reported that the skin is affected in nearly half of SS patients. Cutaneous manifestations consist of xerosis, angular cheilitis, eyelid dermatitis, pruritus, cutaneous vasculitis (frequently manifesting as palpable purpura), and erythema annulare. Most of them are nonspecific and less severe than the oral, ocular, or musculoskeletal symptoms. We present two patients with primary SS who have many cutaneous manifestations including erythema annulare and pernio-like lesions and review the literature about this topic.
Journal of The European Academy of Dermatology and Venereology, Mar 1, 2005
Background and aims Androgen hormones play an important role in the pathogenesis of acne. Despite... more Background and aims Androgen hormones play an important role in the pathogenesis of acne. Despite the demonstrated effects, spironolactone, an androgen receptor blocker, is not commonly used to treat acne. We planned an open-labelled, prospective study to evaluate the effects and side-effects of spironolactone therapy in women with acne. Materials and methods Thirty-five consecutive patients with acne were treated with spironolactone 100 mg/day, 16 days each month for 3 months. The patients were divided according to the clinical severity of the lesions as having mild, moderate and severe acne. Serum total testosterone and dehydroepiandrosterone sulfate (DHEAS) levels were measured before and after treatment. Lesion numbers and hormone levels before and after treatment were compared with one-sampled t-test. Results The mean age of the patients was 21.4 ± 3.5 years. Two patients discontinued the study due to sideeffects. Five patients were lost in the follow-up. Clinically significant improvement was noted in 24 patients (85.71%). No response was seen in four patients. All of the nonresponding patients had received previous unsuccessful therapies. Mean number of lesions and mean DHEAS levels of the 24 patients with clinical improvement decreased significantly after treatment (P < 0.01 and P < 0.05, respectively). There was no change in the mean total testosterone levels before and after treatment (P > 0.05). Conclusion Spironolactone is a safe and effective medication for women with acne vulgaris. Although its side-effects seem to be high, they are in the majority of cases not a reason to stop treatment.
DergiPark (Istanbul University), Mar 1, 1988
Turkiye Klinikleri Dermatology - Special Topics, 2016
Turkiye Klinikleri Dermatology - Special Topics, 2012
Türkiye klinikleri tıp bilimleri dergisi, 2010
ig men te pur pu rik der ma toz lar (PPD), sa rı ya da pas ren gin den kah ve ren gi nede ği şenr... more ig men te pur pu rik der ma toz lar (PPD), sa rı ya da pas ren gin den kah ve ren gi nede ği şenrenk ler depal peedi le me yenpur pu ra,pe teşiveba zente len ji ek ta ziileka rak te ri zebirgruphas ta lık tır. 1 Hasta lı ğınpur pu raan nu la riste len ji ek to i des(Ma jocc hihas ta lı ğı),prog re sif pig men tepur pu rikder ma toz(Scham bergpur pu ra sı), pig men tepur pu rik li ke no idder ma tit(Go u ge rot-Blumhas ta lı ğı),Do u casveKa pe te na kis 'in eg za ma to idpur pu ra sı,gra nü lo ma tözpig men tepur pu ra,dis se mi nepur puri ji nözan ji o der ma tit(ka şın tı lıpur pu ra)veli kenau re usgi bialttip le ri mev cut tur. 1,2 Li kenau re us,Mar tinta ra fın danilkola rak1958'de"li ken pur pu ri ku s"ola rakta nım lan mışda hason radaCal nansa rı-kah ve ren gi pur pu riklez yon la rıta nım la makiçin"li kenau re u s"te ri mi nikul lan mıştır. 1
Revista española de cardiología, 2009
Introduction and objectives. In this study we analyzed the susceptibility to atherosclerosis of p... more Introduction and objectives. In this study we analyzed the susceptibility to atherosclerosis of patients with psoriasis and psoriatic arthritis (PsA) by determining the femoral-carotid pulse wave velocity (PWV), which is a measure of the viscoelastic properties of blood vessels. Methods. The study included 25 patients with psoriasis (age 18-63 years, 13 male), of whom 9 had arthritis, as well as 39 sex-and age-matched healthy control subjects (age 24-70 years, 25 male). The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, body mass index (BMI), and waist-to-hip ratio (WHR) of all participants were recorded and, in patients, skin lesions were assessed using the psoriasis area and severity index (PASI). Arterial distensibility was determined by automatic carotid-femoral PWV measurement using the Complior Colson device. Results. Mean PWV, SBP and DBP were significantly higher in psoriatic patients than in control subjects (P=.036, P<.001, and P=.005, respectively). In PsA patients, the mean WHR, SBP, DBP and PWV were all significantly higher than in control subjects (P=.001, P=.031, P=.001, and P=.014, respectively). Conclusions. The carotid-femoral PWV is increased in patients with psoriasis and PsA.
Journal of Dermatology, Mar 1, 2005
Benzoyl peroxide and adapalene are among the most effective topical agents used in the treatment ... more Benzoyl peroxide and adapalene are among the most effective topical agents used in the treatment of acne. We planned an open-labeled, prospective study to compare the effects and side effects of these two drugs alone and in combination in the treatment of acne vulgaris. One hundred and five consecutive patients (30 men and 75 women) with acne vulgaris were included in this study. The patients were randomly divided into three groups with 35 patients in each. The groups were randomly assigned to 0.1% adapalene gel, 5% benzoyl peroxide lotion, or combination of 0.1% adapalene gel +5% benzoyl peroxide treatment. Acne lesions were classified as noninflammatory (open and closed comedones) and inflammatory (papule, pustule, nodule, cyst), and the lesions on the face were counted before the therapy, during the control visits, and after the treatment. Erythema, dryness, burning, and other side effects were recorded during the treatment. The mean age of the patients was 18.44 ± 3.75 years. Eight patients were excluded because of noncompliance with the treatment regimen or the follow-up schedule, and four patients were excluded due to allergic contact dermatitis. The study revealed that all three therapy protocols were effective in treating noninflammatory and inflammatory lesions in acne vulgaris (p<0.05) and that there was no significant difference between the groups in efficacy or side effects (p>0.05). Adapalene and benzoyl peroxide are effective and well tolerated agents for acne vulgaris; combination therapy has no superiority over adapalene or benzoyl peroxide alone.
DergiPark (Istanbul University), 1994
Turkiye Klinikleri Dermatology - Special Topics, 2018
DergiPark (Istanbul University), Mar 1, 1988
DergiPark (Istanbul University), 1994
Bozok tıp dergisi, Sep 1, 2011
Turkiye Klinikleri Dermatology - Special Topics, 2013
PubMed, Aug 1, 2007
Acne is a disease of the pilosebaceous unit with involving abnormalities in sebum production, mic... more Acne is a disease of the pilosebaceous unit with involving abnormalities in sebum production, microbial flora changes, abnormal keratinization, and inflammation. There are several therapeutic options like topical and systemic retinoids, antibiotics, and systemic hormonal drugs. The topical retinoids a play very important role in the treatment of acne vulgaris. However, their use is limited due to skin irritation. A new generation product, adapalene is a good choice in the treatment of acne vulgaris with less side effects and high efficacy confirmed by numerous clinical studies.
Medicine Science | International Medical Journal, 2018
Dermoscopy has frequently been used for hair and scalp disorders. Dermoscopic examinations of pso... more Dermoscopy has frequently been used for hair and scalp disorders. Dermoscopic examinations of psoriasis and seborrheic dermatitis lesions yielded different morphologies. This study aimed to investigate the usefulness of dermoscopy in the clinical differentiation of psoriasis and seborrheic dermatitis on the scalp and additionally to evaluate its capacity in determining disease severity. The study included 46 psoriasis and 50 seborrheic dermatitis patients who were clinically diagnosed and had scalp lesions. Dermoscopic images taken from lesional scalp were then reviewed for microvascular patterns. In addition, we assessed the severity of scalp disease and looked for a correlation with these patterns. The frequency of twisted loops, glomerular vessels, red dots/globules, and polymorphous beaded lines/circles were statistically higher in the psoriasis group, whereas the frequencies of simple loops and arborizing vessels were statistically higher in the seborrheic dermatitis group (p<0.001). There was no significant difference in the frequency of featureless areas between two groups (p=0.579). There was no correlation with disease severity and dermoscopic findings. In conclusion, dermoscopy is a valuable and easy-to-use tool for differentiating psoriasis and seborrheic dermatitis on the scalp even if it doesn't have enough strength to determine disease severity. In addition, there is some diversity and ambiguity concerning terminology, which can be resolved with future studies and the establishment of conventional terms.
Journal of Dermatology, Dec 1, 2004
Treatment of warts can involve medical and surgical methods. Infrared coagulation is a surgical m... more Treatment of warts can involve medical and surgical methods. Infrared coagulation is a surgical method very rarely used in the treatment of warts. We planned an open‐labeled prospective study to research the effect of infrared coagulation in the treatment of common warts, comparing it with electrocoagulation, and discussing its applicability as an alternative therapy regimen. Eighteen patients with common warts were included in this study. There were 49 warts of various sizes (1 mm to 1 cm) in these 18 patients. Twenty‐seven warts were treated with infrared coagulation, and 22 warts were treated with electrocoagulation. Sixteen patients were treated with both infrared coagulation and electrocoagulation; two patients were treated with only infrared coagulation. The patients were followed‐up for six months after treatment. Changes in sizes of warts, healing times, and cure rates were compared by Mann‐Whitney U test. The mean healing time was 35.5 ± 5.7 days with infrared coagulation and 32.9 ± 4.0 days with electrocoagulation. There was not any significant difference between healing times (p>0.05). Bacterial infection was seen on seven (31.8%) warts treated with electrocoagulation, but no side effects were seen with infrared coagulation. There was a significant difference between side effect rates in two groups (p<0.01). Nine (33.3%) of the warts treated with infrared coagulation and seven (31.8%) of the warts treated with electrocoagulation recurred in the six‐month follow‐up period. The overall cure rates at the end of the follow‐up period were 66.7% and 68.2% respectively. There was not any significant difference between the cure rates in the two groups (P>0.05). We conclude that infrared coagulation is a safe and cheap method and should be kept in mind as an alternative modality for the treatment of common warts.
Yonsei Medical Journal, 2003
Turkderm, Jul 3, 2023
Background and Design: Oxidative stress is known to play a role in the etiopathogenesis of psoria... more Background and Design: Oxidative stress is known to play a role in the etiopathogenesis of psoriasis. Recent data suggest that osteopontin (OPN) can also play a role in the pathogenesis of psoriasis. In the current study, OPN levels and oxidative stress were evaluated in patients with psoriasis. Materials and Methods: The study included 61 patients with psoriasis and 62 healthy controls. The OPN levels, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were measured using serum. The disease severity was evaluated using the psoriasis area and severity index (PASI). Results: No statistically significant differences in OPN, TAS, and OSI values were identified between the psoriasis and control groups. A negative correlation was found with the TAS. There was no statistically significant correlation between the PASI score and OPN, TAS, TOS, and OSI values. Conclusion: We did not find a statistically significant correlation between OPN levels and oxidative stress in patients with psoriasis. We believe that larger and more detailed studies are needed to highlight the role of OPN and oxidative stress in the etiopathogenesis of psoriasis.
Tumori Journal, Mar 1, 2006
Skin metastasis from nasopharyngeal carcinoma is a rare clinical finding. The most common form of... more Skin metastasis from nasopharyngeal carcinoma is a rare clinical finding. The most common form of appearance is a few solitary skin nodules. However, massive and extensive nodular dissemination or diffuse dermal lymphatic infiltration is extremely rare. We here present a case of a 40-year-old man with widespread nodular skin metastases from undifferentiated nasopharyngeal carcinoma.
Clinical Rheumatology, Aug 17, 2006
Sjogren's syndrome (SS) is an autoimmune disease that is characterized by exocrine gland involvem... more Sjogren's syndrome (SS) is an autoimmune disease that is characterized by exocrine gland involvement. It is reported that the skin is affected in nearly half of SS patients. Cutaneous manifestations consist of xerosis, angular cheilitis, eyelid dermatitis, pruritus, cutaneous vasculitis (frequently manifesting as palpable purpura), and erythema annulare. Most of them are nonspecific and less severe than the oral, ocular, or musculoskeletal symptoms. We present two patients with primary SS who have many cutaneous manifestations including erythema annulare and pernio-like lesions and review the literature about this topic.
Journal of The European Academy of Dermatology and Venereology, Mar 1, 2005
Background and aims Androgen hormones play an important role in the pathogenesis of acne. Despite... more Background and aims Androgen hormones play an important role in the pathogenesis of acne. Despite the demonstrated effects, spironolactone, an androgen receptor blocker, is not commonly used to treat acne. We planned an open-labelled, prospective study to evaluate the effects and side-effects of spironolactone therapy in women with acne. Materials and methods Thirty-five consecutive patients with acne were treated with spironolactone 100 mg/day, 16 days each month for 3 months. The patients were divided according to the clinical severity of the lesions as having mild, moderate and severe acne. Serum total testosterone and dehydroepiandrosterone sulfate (DHEAS) levels were measured before and after treatment. Lesion numbers and hormone levels before and after treatment were compared with one-sampled t-test. Results The mean age of the patients was 21.4 ± 3.5 years. Two patients discontinued the study due to sideeffects. Five patients were lost in the follow-up. Clinically significant improvement was noted in 24 patients (85.71%). No response was seen in four patients. All of the nonresponding patients had received previous unsuccessful therapies. Mean number of lesions and mean DHEAS levels of the 24 patients with clinical improvement decreased significantly after treatment (P < 0.01 and P < 0.05, respectively). There was no change in the mean total testosterone levels before and after treatment (P > 0.05). Conclusion Spironolactone is a safe and effective medication for women with acne vulgaris. Although its side-effects seem to be high, they are in the majority of cases not a reason to stop treatment.
DergiPark (Istanbul University), Mar 1, 1988
Turkiye Klinikleri Dermatology - Special Topics, 2016
Turkiye Klinikleri Dermatology - Special Topics, 2012
Türkiye klinikleri tıp bilimleri dergisi, 2010
ig men te pur pu rik der ma toz lar (PPD), sa rı ya da pas ren gin den kah ve ren gi nede ği şenr... more ig men te pur pu rik der ma toz lar (PPD), sa rı ya da pas ren gin den kah ve ren gi nede ği şenrenk ler depal peedi le me yenpur pu ra,pe teşiveba zente len ji ek ta ziileka rak te ri zebirgruphas ta lık tır. 1 Hasta lı ğınpur pu raan nu la riste len ji ek to i des(Ma jocc hihas ta lı ğı),prog re sif pig men tepur pu rikder ma toz(Scham bergpur pu ra sı), pig men tepur pu rik li ke no idder ma tit(Go u ge rot-Blumhas ta lı ğı),Do u casveKa pe te na kis 'in eg za ma to idpur pu ra sı,gra nü lo ma tözpig men tepur pu ra,dis se mi nepur puri ji nözan ji o der ma tit(ka şın tı lıpur pu ra)veli kenau re usgi bialttip le ri mev cut tur. 1,2 Li kenau re us,Mar tinta ra fın danilkola rak1958'de"li ken pur pu ri ku s"ola rakta nım lan mışda hason radaCal nansa rı-kah ve ren gi pur pu riklez yon la rıta nım la makiçin"li kenau re u s"te ri mi nikul lan mıştır. 1
Revista española de cardiología, 2009
Introduction and objectives. In this study we analyzed the susceptibility to atherosclerosis of p... more Introduction and objectives. In this study we analyzed the susceptibility to atherosclerosis of patients with psoriasis and psoriatic arthritis (PsA) by determining the femoral-carotid pulse wave velocity (PWV), which is a measure of the viscoelastic properties of blood vessels. Methods. The study included 25 patients with psoriasis (age 18-63 years, 13 male), of whom 9 had arthritis, as well as 39 sex-and age-matched healthy control subjects (age 24-70 years, 25 male). The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, body mass index (BMI), and waist-to-hip ratio (WHR) of all participants were recorded and, in patients, skin lesions were assessed using the psoriasis area and severity index (PASI). Arterial distensibility was determined by automatic carotid-femoral PWV measurement using the Complior Colson device. Results. Mean PWV, SBP and DBP were significantly higher in psoriatic patients than in control subjects (P=.036, P<.001, and P=.005, respectively). In PsA patients, the mean WHR, SBP, DBP and PWV were all significantly higher than in control subjects (P=.001, P=.031, P=.001, and P=.014, respectively). Conclusions. The carotid-femoral PWV is increased in patients with psoriasis and PsA.
Journal of Dermatology, Mar 1, 2005
Benzoyl peroxide and adapalene are among the most effective topical agents used in the treatment ... more Benzoyl peroxide and adapalene are among the most effective topical agents used in the treatment of acne. We planned an open-labeled, prospective study to compare the effects and side effects of these two drugs alone and in combination in the treatment of acne vulgaris. One hundred and five consecutive patients (30 men and 75 women) with acne vulgaris were included in this study. The patients were randomly divided into three groups with 35 patients in each. The groups were randomly assigned to 0.1% adapalene gel, 5% benzoyl peroxide lotion, or combination of 0.1% adapalene gel +5% benzoyl peroxide treatment. Acne lesions were classified as noninflammatory (open and closed comedones) and inflammatory (papule, pustule, nodule, cyst), and the lesions on the face were counted before the therapy, during the control visits, and after the treatment. Erythema, dryness, burning, and other side effects were recorded during the treatment. The mean age of the patients was 18.44 ± 3.75 years. Eight patients were excluded because of noncompliance with the treatment regimen or the follow-up schedule, and four patients were excluded due to allergic contact dermatitis. The study revealed that all three therapy protocols were effective in treating noninflammatory and inflammatory lesions in acne vulgaris (p<0.05) and that there was no significant difference between the groups in efficacy or side effects (p>0.05). Adapalene and benzoyl peroxide are effective and well tolerated agents for acne vulgaris; combination therapy has no superiority over adapalene or benzoyl peroxide alone.
DergiPark (Istanbul University), 1994