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Papers by s Bates

Research paper thumbnail of Long term effect of a medical emergency team on cardiac arrests in a teaching hospital

Critical care (London, England), 2005

It is unknown whether the reported short-term reduction in cardiac arrests associated with the in... more It is unknown whether the reported short-term reduction in cardiac arrests associated with the introduction of the medical emergency team (MET) system can be sustained. We conducted a prospective, controlled before-and-after examination of the effect of a MET system on the long-term incidence of cardiac arrests. We included consecutive patients admitted during three study periods: before the introduction of the MET; during the education phase preceding the implementation of the MET; and a period of four years from the implementation of the MET system. Cardiac arrests were identified from a log book of cardiac arrest calls and cross-referenced with case report forms and the intensive care unit admissions database. We measured the number of hospital admissions and MET reviews during each period, performed multivariate logistic regression analysis to identify predictors of mortality following cardiac arrest and studied the correlation between the rate of MET calls with the rate of card...

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Research paper thumbnail of Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228

Cancer research, 2001

The presence of coxsackie and adenovirus receptor (CAR) and alpha(v) integrin on cell surfaces is... more The presence of coxsackie and adenovirus receptor (CAR) and alpha(v) integrin on cell surfaces is required for efficient adenovirus infection. Treatment of cells with the histone deacetylase inhibitor FR901228 (depsipeptide) increased CAR and alpha(v) integrin RNA levels in six cancer cell lines. Sodium butyrate and trichostatin A, other histone deacetylase inhibitors, caused similar increases. Cells treated with FR901228 prior to infection had a 4-10-fold increase in transgene expression from a beta-galactosidase-expressing adenoviral vector. These studies suggest that FR901228 increases the efficiency of adenoviral transgene expression and may be useful in cancer gene therapy.

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Research paper thumbnail of An assessment of global and regional sea level in a suite of interannual CORE-II simulations: a synopsis

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Research paper thumbnail of Systemic Vulnerability vs Resilience in Small Island Territories: Keys for a Viable Adaptation of the Agricultural Sector

Advances in Animal Biosciences, 2010

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Research paper thumbnail of Enabling Architecture: How the GPII Supports Inclusive Software Development

Lecture Notes in Computer Science, 2014

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Research paper thumbnail of Cerebrovascular arteriopathy (arteriosclerosis) and ischemic childhood stroke

Stroke, 1982

The aim of this report is to describe the intracranial cerebrovascular abnormalities and clinical... more The aim of this report is to describe the intracranial cerebrovascular abnormalities and clinical status of 8 children who had familial lipoprotein disorders and evidence of thromboembolic cerebrovascular disease. Six of the 8 children had low levels of plasma high density lipoprotein cholesterol, two had high triglyceride levels, and all came from kindreds characterized by familial lipoprotein abnormalities and premature cardio- and/or cerebrovascular atherosclerosis. Vascular occlusion, irregularities of the arterial lumen, beading, tortuosity, and evidence of collateralization were consistently noted. We speculate that cerebrovascular arteriosclerosis in pediatric ischemic stroke victims who have familial lipoprotein abnormalities may be related to lipoprotein-mediated endothelial damage and thrombosis formation, or to the failure to restore endothelial cells' integrity following damage. The apparent association of lipoproteins and strokes in children and their families merit...

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Research paper thumbnail of The reporter’s privilege, then and now

Society, 2001

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Research paper thumbnail of Influence of Neutral-Beam Injection on Impurity Transport in the ISX-BTokamak

Physical Review Letters, 1981

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Research paper thumbnail of Beam test results of a Shashlik calorimeter in a high magnetic field

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1996

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Research paper thumbnail of Pion-induced damage in silicon detectors

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1996

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Research paper thumbnail of Journal of Experimental Social Psychology

Nature, 1965

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Research paper thumbnail of Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Nature, 2009

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Research paper thumbnail of Loss of Cell Wall Mannosylphosphate in Candida albicans Does Not Influence Macrophage Recognition

Journal of Biological Chemistry, 2004

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Research paper thumbnail of Mnt1p and Mnt2p of Candida albicans Are Partially Redundant α-1,2-Mannosyltransferases That Participate in O-Linked Mannosylation and Are Required for Adhesion and Virulence

Journal of Biological Chemistry, 2004

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Research paper thumbnail of Candida albicans Pmr1p, a Secretory Pathway P-type Ca2+/Mn2+-ATPase, Is Required for Glycosylation and Virulence

Journal of Biological Chemistry, 2005

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Research paper thumbnail of Candida albicans Iff11, a Secreted Protein Required for Cell Wall Structure and Virulence

Infection and Immunity, 2007

The Candida albicans cell wall is the immediate point of contact with the host and is implicated ... more The Candida albicans cell wall is the immediate point of contact with the host and is implicated in the host-fungal interaction and virulence. To date, a number of cell wall proteins have been identified and associated with virulence. Analysis of the C. albicans genome has identified the IFF gene family as encoding the largest family of cell wall-related proteins. This family is also conserved in a range of other Candida species. Iff11 differs from other family members in lacking a GPI anchor, and we have demonstrated it to be O glycosylated and secreted in C. albicans . A null mutant lacking IFF11 was hypersensitive to cell wall-damaging agents, suggesting a role in cell wall organization. In a murine model of systemic infection the null mutant was highly attenuated in virulence, and survival-standardized infections suggest it is required to establish an infection. This work provides the first evidence of the importance of this gene family in the host-fungal interaction and virulence.

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Research paper thumbnail of Modeling Abundance Effects in Distance Sampling

Ecology, 2004

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Research paper thumbnail of Mechanisms of p53-mediated apoptosis

Cellular and Molecular Life Sciences CMLS, 1999

The loss of p53-mediated apoptosis (programmed cell death) has been implicated as an important ev... more The loss of p53-mediated apoptosis (programmed cell death) has been implicated as an important event in tumour progression in a number of systems. p53 can induce or potentiate apoptosis through several mechanisms, both by regulating the expression of genes which can participate in the apoptotic response and through transcriptionally independent means. There appears to be cell type variability in both the response to p53 expression and in the requirement for p53 transcriptional transactivation for the induction of apoptosis. It seems clear, however, that the induction of p53 in untransformed cells is more likely to result in cell-cycle arrest, whereas the expression of p53 in their transformed counterparts is more likely to result in the induction of apoptosis, and this may, in part, reflect the deregulated expression of E2F-1 in tumour cells. The synergistic action of p53 and E2F-1 in the induction of apoptosis has raised the possibility that the reactivation of p53 in transformed cells can be an effective tumour therapy.

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Research paper thumbnail of A highly efficient and versatile carbon nanotube/ceramic composite filter

Carbon, 2013

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Research paper thumbnail of Attention should be paid to what women want

BMJ, 1996

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Research paper thumbnail of Long term effect of a medical emergency team on cardiac arrests in a teaching hospital

Critical care (London, England), 2005

It is unknown whether the reported short-term reduction in cardiac arrests associated with the in... more It is unknown whether the reported short-term reduction in cardiac arrests associated with the introduction of the medical emergency team (MET) system can be sustained. We conducted a prospective, controlled before-and-after examination of the effect of a MET system on the long-term incidence of cardiac arrests. We included consecutive patients admitted during three study periods: before the introduction of the MET; during the education phase preceding the implementation of the MET; and a period of four years from the implementation of the MET system. Cardiac arrests were identified from a log book of cardiac arrest calls and cross-referenced with case report forms and the intensive care unit admissions database. We measured the number of hospital admissions and MET reviews during each period, performed multivariate logistic regression analysis to identify predictors of mortality following cardiac arrest and studied the correlation between the rate of MET calls with the rate of card...

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Research paper thumbnail of Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228

Cancer research, 2001

The presence of coxsackie and adenovirus receptor (CAR) and alpha(v) integrin on cell surfaces is... more The presence of coxsackie and adenovirus receptor (CAR) and alpha(v) integrin on cell surfaces is required for efficient adenovirus infection. Treatment of cells with the histone deacetylase inhibitor FR901228 (depsipeptide) increased CAR and alpha(v) integrin RNA levels in six cancer cell lines. Sodium butyrate and trichostatin A, other histone deacetylase inhibitors, caused similar increases. Cells treated with FR901228 prior to infection had a 4-10-fold increase in transgene expression from a beta-galactosidase-expressing adenoviral vector. These studies suggest that FR901228 increases the efficiency of adenoviral transgene expression and may be useful in cancer gene therapy.

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Research paper thumbnail of An assessment of global and regional sea level in a suite of interannual CORE-II simulations: a synopsis

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Systemic Vulnerability vs Resilience in Small Island Territories: Keys for a Viable Adaptation of the Agricultural Sector

Advances in Animal Biosciences, 2010

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Research paper thumbnail of Enabling Architecture: How the GPII Supports Inclusive Software Development

Lecture Notes in Computer Science, 2014

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Research paper thumbnail of Cerebrovascular arteriopathy (arteriosclerosis) and ischemic childhood stroke

Stroke, 1982

The aim of this report is to describe the intracranial cerebrovascular abnormalities and clinical... more The aim of this report is to describe the intracranial cerebrovascular abnormalities and clinical status of 8 children who had familial lipoprotein disorders and evidence of thromboembolic cerebrovascular disease. Six of the 8 children had low levels of plasma high density lipoprotein cholesterol, two had high triglyceride levels, and all came from kindreds characterized by familial lipoprotein abnormalities and premature cardio- and/or cerebrovascular atherosclerosis. Vascular occlusion, irregularities of the arterial lumen, beading, tortuosity, and evidence of collateralization were consistently noted. We speculate that cerebrovascular arteriosclerosis in pediatric ischemic stroke victims who have familial lipoprotein abnormalities may be related to lipoprotein-mediated endothelial damage and thrombosis formation, or to the failure to restore endothelial cells' integrity following damage. The apparent association of lipoproteins and strokes in children and their families merit...

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Research paper thumbnail of The reporter’s privilege, then and now

Society, 2001

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Research paper thumbnail of Influence of Neutral-Beam Injection on Impurity Transport in the ISX-BTokamak

Physical Review Letters, 1981

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Research paper thumbnail of Beam test results of a Shashlik calorimeter in a high magnetic field

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1996

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Research paper thumbnail of Pion-induced damage in silicon detectors

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1996

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Research paper thumbnail of Journal of Experimental Social Psychology

Nature, 1965

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Research paper thumbnail of Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Nature, 2009

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Loss of Cell Wall Mannosylphosphate in Candida albicans Does Not Influence Macrophage Recognition

Journal of Biological Chemistry, 2004

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mnt1p and Mnt2p of Candida albicans Are Partially Redundant α-1,2-Mannosyltransferases That Participate in O-Linked Mannosylation and Are Required for Adhesion and Virulence

Journal of Biological Chemistry, 2004

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Candida albicans Pmr1p, a Secretory Pathway P-type Ca2+/Mn2+-ATPase, Is Required for Glycosylation and Virulence

Journal of Biological Chemistry, 2005

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Candida albicans Iff11, a Secreted Protein Required for Cell Wall Structure and Virulence

Infection and Immunity, 2007

The Candida albicans cell wall is the immediate point of contact with the host and is implicated ... more The Candida albicans cell wall is the immediate point of contact with the host and is implicated in the host-fungal interaction and virulence. To date, a number of cell wall proteins have been identified and associated with virulence. Analysis of the C. albicans genome has identified the IFF gene family as encoding the largest family of cell wall-related proteins. This family is also conserved in a range of other Candida species. Iff11 differs from other family members in lacking a GPI anchor, and we have demonstrated it to be O glycosylated and secreted in C. albicans . A null mutant lacking IFF11 was hypersensitive to cell wall-damaging agents, suggesting a role in cell wall organization. In a murine model of systemic infection the null mutant was highly attenuated in virulence, and survival-standardized infections suggest it is required to establish an infection. This work provides the first evidence of the importance of this gene family in the host-fungal interaction and virulence.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Modeling Abundance Effects in Distance Sampling

Ecology, 2004

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mechanisms of p53-mediated apoptosis

Cellular and Molecular Life Sciences CMLS, 1999

The loss of p53-mediated apoptosis (programmed cell death) has been implicated as an important ev... more The loss of p53-mediated apoptosis (programmed cell death) has been implicated as an important event in tumour progression in a number of systems. p53 can induce or potentiate apoptosis through several mechanisms, both by regulating the expression of genes which can participate in the apoptotic response and through transcriptionally independent means. There appears to be cell type variability in both the response to p53 expression and in the requirement for p53 transcriptional transactivation for the induction of apoptosis. It seems clear, however, that the induction of p53 in untransformed cells is more likely to result in cell-cycle arrest, whereas the expression of p53 in their transformed counterparts is more likely to result in the induction of apoptosis, and this may, in part, reflect the deregulated expression of E2F-1 in tumour cells. The synergistic action of p53 and E2F-1 in the induction of apoptosis has raised the possibility that the reactivation of p53 in transformed cells can be an effective tumour therapy.

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Research paper thumbnail of A highly efficient and versatile carbon nanotube/ceramic composite filter

Carbon, 2013

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Research paper thumbnail of Attention should be paid to what women want

BMJ, 1996

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