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Frontiers in Immunology, 2021
N6-methyladenosine (m6A) RNA modification is a reversible mechanism that regulates eukaryotic gen... more N6-methyladenosine (m6A) RNA modification is a reversible mechanism that regulates eukaryotic gene expression. Growing evidence has demonstrated an association between m6A modification and tumorigenesis and response to immunotherapy. However, the overall influence of m6A regulators on the tumor microenvironment and their effect on the response to immunotherapy in lung adenocarcinoma remains to be explored. Here, we comprehensively analyzed the m6A modification patterns of 936 lung adenocarcinoma samples based on 24 m6A regulators. First, we described the features of genetic variation in these m6A regulators. Many m6A regulators were aberrantly expressed in tumors and negatively correlated with most tumor-infiltrating immune cell types. Furthermore, we identified three m6A modification patterns using a consensus clustering method. m6A cluster B was preferentially associated with a favorable prognosis and enriched in metabolism-associated pathways. In contrast, m6A cluster A was assoc...
Sustainability, Dec 8, 2021
The reuse of treated wastewater is attractive as a communal source of excess water source in wate... more The reuse of treated wastewater is attractive as a communal source of excess water source in water-scarce counties and nations. The expansion of the urban population and the increase in the coverage of water supply networks and sewage networks will raise the amount of municipal sewage. This can turn into a new-fangled water resource. In the current research, the new campus city was selected as the first case study to design a wastewater reuse and recycling system. Accordingly, one of the most important innovations in the proposed research is the unique applied dimensions, in addition to its first-time performance, and the application of the Geo-land method in wastewater recycling as the theoretical dimension of the design. Clustering the decentralized reuse of wastewater for urban areas showed that significant parts of residential areas are located in the first high priority group. Urban planners can consider the results in establishing a comprehensive plan to prioritize the decentralized use of wastewater in the urban area.
Frontiers in Immunology, 2021
N6-methyladenosine (m6A) RNA modification is a reversible mechanism that regulates eukaryotic gen... more N6-methyladenosine (m6A) RNA modification is a reversible mechanism that regulates eukaryotic gene expression. Growing evidence has demonstrated an association between m6A modification and tumorigenesis and response to immunotherapy. However, the overall influence of m6A regulators on the tumor microenvironment and their effect on the response to immunotherapy in lung adenocarcinoma remains to be explored. Here, we comprehensively analyzed the m6A modification patterns of 936 lung adenocarcinoma samples based on 24 m6A regulators. First, we described the features of genetic variation in these m6A regulators. Many m6A regulators were aberrantly expressed in tumors and negatively correlated with most tumor-infiltrating immune cell types. Furthermore, we identified three m6A modification patterns using a consensus clustering method. m6A cluster B was preferentially associated with a favorable prognosis and enriched in metabolism-associated pathways. In contrast, m6A cluster A was assoc...
Sustainability, Dec 8, 2021
The reuse of treated wastewater is attractive as a communal source of excess water source in wate... more The reuse of treated wastewater is attractive as a communal source of excess water source in water-scarce counties and nations. The expansion of the urban population and the increase in the coverage of water supply networks and sewage networks will raise the amount of municipal sewage. This can turn into a new-fangled water resource. In the current research, the new campus city was selected as the first case study to design a wastewater reuse and recycling system. Accordingly, one of the most important innovations in the proposed research is the unique applied dimensions, in addition to its first-time performance, and the application of the Geo-land method in wastewater recycling as the theoretical dimension of the design. Clustering the decentralized reuse of wastewater for urban areas showed that significant parts of residential areas are located in the first high priority group. Urban planners can consider the results in establishing a comprehensive plan to prioritize the decentralized use of wastewater in the urban area.