saleem umar - Academia.edu (original) (raw)
Papers by saleem umar
The American journal of surgical pathology, 2018
The incidence of renal cell carcinoma (RCC) is known to be higher in patients with end-stage rena... more The incidence of renal cell carcinoma (RCC) is known to be higher in patients with end-stage renal disease, including those with acquired cystic kidney disease due to dialysis. Acquired cystic disease (ACD)-associated RCC was recently incorporated into the 2016 WHO Classification of Tumors of the Urinary System and Male Genital Tract as a distinct entity and is reportedly the most common RCC arising in end-stage renal disease. In this study, we sought to further describe clinicopathologic findings in a large series of ACD-RCC, emphasizing histologic features, immunophenotype, clinical outcome, and patterns of disease spread. We collected 40 previously unpublished cases of ACD-RCC with mean clinical follow-up of 27 months (median, 19 mo; range, 1 to 126 mo). Mean tumor size was 2.7 cm (median, 2.4 cm), and 32 tumors (80%) were confined to the kidney (pT stage less than pT3a). International Society of Urological Pathology grade was 3 in 37 cases (92.5%), grade 2 in 1 case (2.5%), and ...
Consultant, 2009
Dr Renner is a third-year dermatology resident at Michigan State University/Pontiac Osteopathic H... more Dr Renner is a third-year dermatology resident at Michigan State University/Pontiac Osteopathic Hospital. Dr Brodell is professor of internal medicine, clinical professor of dermatopathology, and master teacher at Northeastern Ohio Universities Colleges of ...
The Journal of Urology, Aug 1, 2008
Journal of drugs in dermatology : JDD
Hailey-Hailey disease, or familial benign chronic pemphigus, is a chronic disease without a known... more Hailey-Hailey disease, or familial benign chronic pemphigus, is a chronic disease without a known cure. Current therapeutic strategies attempt to suppress Hailey-Hailey outbreaks and allow the patient to live comfortably with this condition. We have found that applying topical tacrolimus 0.1% ointment (Protopic) twice a day to affected areas is an excellent way to control Hailey-Hailey disease. In addition to effectively controlling Hailey-Hailey outbreaks, tacrolimus is a relatively safe and noninvasive mode of treatment, without significant side effects. We recommend intermittent therapy with clobetasol propionate 0.05% foam (Olux Foam) for patients who break through suppressive therapy with tacrolimus a few times per year. In patients with frequent outbreaks of Hailey-Hailey disease despite suppressive therapy with tacrolimus, we recommend alternating the tacrolimus with clobetasol propionate 0.05% foam every 6 weeks.
Journal of Radiology Case Reports, 2013
Silicone lymphadenopathy is a recognized complication of silicone gel implant rupture; the ipsila... more Silicone lymphadenopathy is a recognized complication of silicone gel implant rupture; the ipsilateral axillary lymph nodes are most commonly involved. We report imaging findings on a range of different imaging modalities and biopsy results in a case of biopsy-proven silicone lymphadenitis involving contralateral intramammary and axillary lymph nodes in a patient with an intact standard dual-lumen breast implant in the opposite reconstructed breast. This case demonstrates that in a patient with disrupted lymph drainage due to prior mastectomy and axillary node dissection for breast cancer treatment, silicone particles can migrate in a retrograde fashion via the ipsilateral internal mammary lymph nodes and reach not only the contralateral axilla but also the outer quadrants of the contralateral breast, even in the presence of an intact breast implant. Radiology Case. 2013 Nov; 7(11):24-31 Breast Imaging: Contralateral Intramammary Silicone Lymphadenitis in a Patient with an Intact Standard Dual-Lumen Breast Implant in the Opposite Reconstructed Breast
Urologia Internationalis, 2012
Primary neuroendocrine carcinomas of the genitourinary tract are rare and aggressive tumors carry... more Primary neuroendocrine carcinomas of the genitourinary tract are rare and aggressive tumors carrying a bad prognosis. With squamous cell and transitional cell carcinoma being the most commonly reported urethral malignancies, primary small cell carcinoma (SCC) of the urethra is extremely rare. To date, only 5 cases have been reported in the literature. We present the first case of primary SCC occurring in the bulbar urethra in an 89-year-old male. We discuss the clinical, histological and immunohistochemical features of SCC of the urethra. Furthermore, we summarize the available literature and discuss the possible treatment options for this rare yet aggressive neoplasm.
Modern Pathology, 2014
The International Consultations on Urological Diseases are international consensus meetings, supp... more The International Consultations on Urological Diseases are international consensus meetings, supported by the World Health Organization and the Union Internationale Contre le Cancer, which have occurred since 1981. Each consultation has the goal of convening experts to review data and provide evidence-based recommendations to improve practice. In 2012, the selected subject was bladder cancer, a disease which remains a major public health problem with little improvement in many years. The proceedings of the 2nd International Consultation on Bladder Cancer, which included a…
Journal of the American Society of Cytopathology, 2013
The Journal of Urology, 2008
The Journal of Urology, 2012
The Journal of Urology, 2012
The Journal of Urology, 2009
International Journal of Infectious Diseases, 2011
Poster Presentations, Poster Session Travel Medicine and Tropical Diseases S113 and horse were 5.... more Poster Presentations, Poster Session Travel Medicine and Tropical Diseases S113 and horse were 5.3%, 6.9%, 6.3% and 9.1% respectively. For PCR test, the potential infection rates of goats, ox and horse were 38.9%, 37.5% and 36.4% respectively. There were significant divergence of A. phogocytophium isolates in this study and Homology analysis showed that they were broadly distributed in other regions of China and other countries around China. Conclusion: Infection of A. phogocytophium in domestic animals and human exited in Yili areas of Xinjiang Province. Differential diagnoses of unknown febrile patients should be emphasized in clinics and further investigation of ecological characterization of Anaplasmoses including its vectors and hosts should be practiced.
International Journal of Infectious Diseases, 2011
European Urology, 2013
a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w... more a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e u r o p e a n u r o l o g y . c o m Abstract Context: Pathology standards for the diagnosis of bladder cancer (BCa) have recently evolved to better reflect patient diagnosis and clinical outcomes. Objective: To update pathology reporting standards for BCa. Evidence acquisition: We searched the international medical literature and reviewed all articles that addressed BCa gross dissection, pathologic diagnosis, staging, and reporting * Corresponding author.
Diagnostic Cytopathology, 2012
The vaginal apex is the most common site of recurrence in patients with endometrial cancer. Altho... more The vaginal apex is the most common site of recurrence in patients with endometrial cancer. Although studies demonstrate that <1% of asymptomatic vaginal recurrences are detected by routine vaginal cytology alone, many practitioners still include it as part of the routine surveillance in these patients after hysterectomy. To further evaluate the effectiveness of vaginal cytology as a surveillance tool, we assessed the subsequent findings in patients reported to have benign and atypical glandular cells on vaginal cytology after hysterectomy performed for endometrial cancer.
Diabetes, 1991
Mono- and diaminoguanidine inhibited ambient glucose-induced glycosylated end product formation o... more Mono- and diaminoguanidine inhibited ambient glucose-induced glycosylated end product formation of albumin and collagen 125I-labeled albumin covalent binding in vitro. Diaminoguanidine was a stronger inhibitor than monoaminoguanidine. These compounds also inhibited rat eye lens aldose reductase activity in vitro noncompetitively with respect to NADPH with Ki = 30.6 mM for monoaminoguanidine and Ki = 12.5 mM for diaminoguanidine. When administered daily for 98 days at a dose of 25 mg/kg body wt i.p., both compounds lowered eye lens sorbitol and aldose reductase activity in normoglycemic and alloxan-induced diabetic rats. Again, diaminoguanidine was a better inhibitor. Daily long-term administration of mono- and diaminoguanidine (25 mg/kg body wt i.p.) inhibited and prevented experimental diabetes-induced lens opacity in rats, respectively. It appears that diaminoguanidine has a better therapeutic potential in controlling diabetic complications.
Biochemical Pharmacology, 1991
The American journal of surgical pathology, 2018
The incidence of renal cell carcinoma (RCC) is known to be higher in patients with end-stage rena... more The incidence of renal cell carcinoma (RCC) is known to be higher in patients with end-stage renal disease, including those with acquired cystic kidney disease due to dialysis. Acquired cystic disease (ACD)-associated RCC was recently incorporated into the 2016 WHO Classification of Tumors of the Urinary System and Male Genital Tract as a distinct entity and is reportedly the most common RCC arising in end-stage renal disease. In this study, we sought to further describe clinicopathologic findings in a large series of ACD-RCC, emphasizing histologic features, immunophenotype, clinical outcome, and patterns of disease spread. We collected 40 previously unpublished cases of ACD-RCC with mean clinical follow-up of 27 months (median, 19 mo; range, 1 to 126 mo). Mean tumor size was 2.7 cm (median, 2.4 cm), and 32 tumors (80%) were confined to the kidney (pT stage less than pT3a). International Society of Urological Pathology grade was 3 in 37 cases (92.5%), grade 2 in 1 case (2.5%), and ...
Consultant, 2009
Dr Renner is a third-year dermatology resident at Michigan State University/Pontiac Osteopathic H... more Dr Renner is a third-year dermatology resident at Michigan State University/Pontiac Osteopathic Hospital. Dr Brodell is professor of internal medicine, clinical professor of dermatopathology, and master teacher at Northeastern Ohio Universities Colleges of ...
The Journal of Urology, Aug 1, 2008
Journal of drugs in dermatology : JDD
Hailey-Hailey disease, or familial benign chronic pemphigus, is a chronic disease without a known... more Hailey-Hailey disease, or familial benign chronic pemphigus, is a chronic disease without a known cure. Current therapeutic strategies attempt to suppress Hailey-Hailey outbreaks and allow the patient to live comfortably with this condition. We have found that applying topical tacrolimus 0.1% ointment (Protopic) twice a day to affected areas is an excellent way to control Hailey-Hailey disease. In addition to effectively controlling Hailey-Hailey outbreaks, tacrolimus is a relatively safe and noninvasive mode of treatment, without significant side effects. We recommend intermittent therapy with clobetasol propionate 0.05% foam (Olux Foam) for patients who break through suppressive therapy with tacrolimus a few times per year. In patients with frequent outbreaks of Hailey-Hailey disease despite suppressive therapy with tacrolimus, we recommend alternating the tacrolimus with clobetasol propionate 0.05% foam every 6 weeks.
Journal of Radiology Case Reports, 2013
Silicone lymphadenopathy is a recognized complication of silicone gel implant rupture; the ipsila... more Silicone lymphadenopathy is a recognized complication of silicone gel implant rupture; the ipsilateral axillary lymph nodes are most commonly involved. We report imaging findings on a range of different imaging modalities and biopsy results in a case of biopsy-proven silicone lymphadenitis involving contralateral intramammary and axillary lymph nodes in a patient with an intact standard dual-lumen breast implant in the opposite reconstructed breast. This case demonstrates that in a patient with disrupted lymph drainage due to prior mastectomy and axillary node dissection for breast cancer treatment, silicone particles can migrate in a retrograde fashion via the ipsilateral internal mammary lymph nodes and reach not only the contralateral axilla but also the outer quadrants of the contralateral breast, even in the presence of an intact breast implant. Radiology Case. 2013 Nov; 7(11):24-31 Breast Imaging: Contralateral Intramammary Silicone Lymphadenitis in a Patient with an Intact Standard Dual-Lumen Breast Implant in the Opposite Reconstructed Breast
Urologia Internationalis, 2012
Primary neuroendocrine carcinomas of the genitourinary tract are rare and aggressive tumors carry... more Primary neuroendocrine carcinomas of the genitourinary tract are rare and aggressive tumors carrying a bad prognosis. With squamous cell and transitional cell carcinoma being the most commonly reported urethral malignancies, primary small cell carcinoma (SCC) of the urethra is extremely rare. To date, only 5 cases have been reported in the literature. We present the first case of primary SCC occurring in the bulbar urethra in an 89-year-old male. We discuss the clinical, histological and immunohistochemical features of SCC of the urethra. Furthermore, we summarize the available literature and discuss the possible treatment options for this rare yet aggressive neoplasm.
Modern Pathology, 2014
The International Consultations on Urological Diseases are international consensus meetings, supp... more The International Consultations on Urological Diseases are international consensus meetings, supported by the World Health Organization and the Union Internationale Contre le Cancer, which have occurred since 1981. Each consultation has the goal of convening experts to review data and provide evidence-based recommendations to improve practice. In 2012, the selected subject was bladder cancer, a disease which remains a major public health problem with little improvement in many years. The proceedings of the 2nd International Consultation on Bladder Cancer, which included a…
Journal of the American Society of Cytopathology, 2013
The Journal of Urology, 2008
The Journal of Urology, 2012
The Journal of Urology, 2012
The Journal of Urology, 2009
International Journal of Infectious Diseases, 2011
Poster Presentations, Poster Session Travel Medicine and Tropical Diseases S113 and horse were 5.... more Poster Presentations, Poster Session Travel Medicine and Tropical Diseases S113 and horse were 5.3%, 6.9%, 6.3% and 9.1% respectively. For PCR test, the potential infection rates of goats, ox and horse were 38.9%, 37.5% and 36.4% respectively. There were significant divergence of A. phogocytophium isolates in this study and Homology analysis showed that they were broadly distributed in other regions of China and other countries around China. Conclusion: Infection of A. phogocytophium in domestic animals and human exited in Yili areas of Xinjiang Province. Differential diagnoses of unknown febrile patients should be emphasized in clinics and further investigation of ecological characterization of Anaplasmoses including its vectors and hosts should be practiced.
International Journal of Infectious Diseases, 2011
European Urology, 2013
a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w... more a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e u r o p e a n u r o l o g y . c o m Abstract Context: Pathology standards for the diagnosis of bladder cancer (BCa) have recently evolved to better reflect patient diagnosis and clinical outcomes. Objective: To update pathology reporting standards for BCa. Evidence acquisition: We searched the international medical literature and reviewed all articles that addressed BCa gross dissection, pathologic diagnosis, staging, and reporting * Corresponding author.
Diagnostic Cytopathology, 2012
The vaginal apex is the most common site of recurrence in patients with endometrial cancer. Altho... more The vaginal apex is the most common site of recurrence in patients with endometrial cancer. Although studies demonstrate that <1% of asymptomatic vaginal recurrences are detected by routine vaginal cytology alone, many practitioners still include it as part of the routine surveillance in these patients after hysterectomy. To further evaluate the effectiveness of vaginal cytology as a surveillance tool, we assessed the subsequent findings in patients reported to have benign and atypical glandular cells on vaginal cytology after hysterectomy performed for endometrial cancer.
Diabetes, 1991
Mono- and diaminoguanidine inhibited ambient glucose-induced glycosylated end product formation o... more Mono- and diaminoguanidine inhibited ambient glucose-induced glycosylated end product formation of albumin and collagen 125I-labeled albumin covalent binding in vitro. Diaminoguanidine was a stronger inhibitor than monoaminoguanidine. These compounds also inhibited rat eye lens aldose reductase activity in vitro noncompetitively with respect to NADPH with Ki = 30.6 mM for monoaminoguanidine and Ki = 12.5 mM for diaminoguanidine. When administered daily for 98 days at a dose of 25 mg/kg body wt i.p., both compounds lowered eye lens sorbitol and aldose reductase activity in normoglycemic and alloxan-induced diabetic rats. Again, diaminoguanidine was a better inhibitor. Daily long-term administration of mono- and diaminoguanidine (25 mg/kg body wt i.p.) inhibited and prevented experimental diabetes-induced lens opacity in rats, respectively. It appears that diaminoguanidine has a better therapeutic potential in controlling diabetic complications.
Biochemical Pharmacology, 1991