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Papers by sanchita kundu

Journal of International Medical Research, 2008

Amelanotic malignant melanoma in the oral region is extremely rare and has not previously been re... more Amelanotic malignant melanoma in the oral region is extremely rare and has not previously been reported in the parotid gland. This present case report describes an amelanotic malignant melanoma in the parotid gland, with no other primary lesion detectable. The medical history, pathology and immunohistochemical analysis of the case are described and the relevant literature is reviewed in order to help in the recognition of this uncommon tumour. Amelanotic malignant melanoma is a melanoma subtype with little or no pigmentation and, because of this lack of pigmentation and its wide-ranging clinical appearance, it often defies clinical diagnosis. A high level of vigilance is, therefore, necessary in diagnosing such a tumour in the parotid gland. Where it is suspected, positive expression of S-100 protein and human melanoma black 45 (HMB45) using immunohistochemical analysis can be considered reliable methods of confirming diagnosis.

International journal of pharma and bio sciences, 2015

Calcifying cystic odontogenic tumor (CCOT) is a rare odontogenic lesion comprising about 2% of al... more Calcifying cystic odontogenic tumor (CCOT) is a rare odontogenic lesion comprising about 2% of all odontogenic pathological changes in the jaw. Clinically presents as painless swelling of jaw, while histopathology demonstrates characteristic "Ghost" epithelial cells with a propensity to calcify. Due to its varied clinical presentation, including cystic and neoplastic forms and recurrence rates posses a great challenge to decide its course of treatment. Here, we report, a classic case of CCOT, showing an aggressive clinical course and different histopathologic presentations along with a brief review of literature.

Indian Journal of Dental Sciences, 2020

Nucleostemin (NS) is a guanine nucleotide binding protein like 3 (GNLP 3) found in the nucleolus ... more Nucleostemin (NS) is a guanine nucleotide binding protein like 3 (GNLP 3) found in the nucleolus in neuroepithelial stem cells, embryonic stem cells and in cancer stem cells. It is observed to be an initiator for uncontrolled cellular proliferation that is responsible for cancer progression by interaction with p53, mouse double minute 2 (MDM2) and cell-cycle.

International Journal of Applied and Basic Medical Research

Granular cell tumor (GCT) is a rare benign tumor chiefly affecting the orofacial region, especial... more Granular cell tumor (GCT) is a rare benign tumor chiefly affecting the orofacial region, especially tongue. The origin of this neoplasia, after remaining a controversy for years, was finally identified to be from Schwann cell or neuroendocrine cell. They usually present as asymptomatic, firm, sessile, submucosal, solitary, or multiple nodule/papule like lesions. Histopathologically, the presence of sheets, cords or nests of large cells having abundant, eosinophilic granular cytoplasm, and pseudoepitheliomatous hyperplasia are the characteristic features of this neoplasm. Immunohistochemical stains such as S100, Cluster of differentiation 68, neuron-specific enolase, and laminin also aid in the proper diagnosis of granular cells. We hereby present a case of GCT in a 50-year-old male, which had a unique exophytic appearance, probably being only the second to be reported till date.

SRM Journal of Research in Dental Sciences, 2014

Oral submucous fibrosis (OSF) is a chronic condition of the oral mucosa, first described among fi... more Oral submucous fibrosis (OSF) is a chronic condition of the oral mucosa, first described among five East African women of Indian origin under the term atrophia idiopathica (tropica) mucosae oris. It is characterized by a generalized submucous fibrosis. The pathogenesis of the disease is not well-established, but epidemiological evidences strongly indicate the association of betel quid habit. It is logical to hypothesize that the increased collagen production or reduced collagen degradation is the possible mechanism in the development of the disease. The malignant potentiality and also the origin of cancers in different intraoral locations in OSF patients is attributable to the generalized epithelial atrophy. Here, a clinical case of OSF in a 36-year-old male patient is being discussed, encompassing the pathogenesis and malignant potentiality of the disease.

Contemporary Clinical Dentistry, 2011

Chondrosarcoma is a rare primary malignant neoplasm of the head, neck, oral and maxillofacial reg... more Chondrosarcoma is a rare primary malignant neoplasm of the head, neck, oral and maxillofacial regions. The clinicopathological and radiographic findings are usually characteristic; however, not decisive. The neoplasm is usually treated by wide surgical resection because it is traditionally radioresistant. However, radiotherapy is generally advised for high-grade lesions, and chemotherapy has a palliative role. The treatment and management are primarily guided by the histological grades of the neoplasm. Prognosis of jaw lesions is poor as compared to the lesions affecting the long bones of the body, and the cause of death is usually by direct extension in the base of the skull or due to distant metastasis to lungs and other bones. A clinical case of chondrosarcoma, involving the right half of mandible of a 36 year old male patient is discussed herewith, encompassing the entire gamut of clinicopathological, radiological and treatment modalities rendered.

Diffuse large B cell Lymphomas are defined as neoplasms of large transformed B cells, i.e with nu... more Diffuse large B cell Lymphomas are defined as neoplasms of large transformed B cells, i.e with nuclear diameter more than twice that of a normal lymphocyte. This accounts for 30-40% of all adult Non Hodgekins Lymphomas. Intraoral lymphomas are relatively rare and often difficult to diagnose clinically. In this case report, we describe a case of Diffuse Large B cell Lymphoma affecting the palate of a 35 years old male, along with its clinical, radiological, histopathological and immunohistochemical features.

Journal of Cancer Research and Therapeutics, 2022

Contemporary Clinical Dentistry

Journal of clinical and diagnostic research : JCDR, 2017

Myofibroma is a benign uncommon fibroblastic tumour originating from the soft tissue, bone and ma... more Myofibroma is a benign uncommon fibroblastic tumour originating from the soft tissue, bone and may affect both children and adults. Radiographically myofibroma presents as unilocular radiolucency. Histologically, typical biphasic cellular arrangement is noted. Immunohistochemical markers are useful for definitive diagnosis of this uncommon neoplasm. Here, a case of six-year-old male child with a localized swelling in the left body of mandible is presented. The clinical, radiological, histological and immunohistochemical findings were corroborative of Infantile Myofibroma.

Journal of Oral and Maxillofacial Pathology, 2017

Chondrosarcoma (CS) is an uncommon, slow enlarging malignant neoplasm that originates from primit... more Chondrosarcoma (CS) is an uncommon, slow enlarging malignant neoplasm that originates from primitive cartilage forming mesenchyme, and produces a pure hyaline cartilage that results in abnormal bone and/or cartilage growth. [1] It is the second most common primary bone cancer after osteosarcoma. [2] The involvement of the craniofacial region is very rare and accounts for <10% of all CSs. [2] Different types of CS have been described as follows: [3] • Conventional CS-which accounts for nearly 90% of all CSs • Dedifferentiated CS • Clear cell CS • Mesenchymal chondrosarcoma (MC) • Juxtacortical CS • Secondary CS. MCs are relatively rare malignancies of bone and soft tissue with cartilaginous differentiation. [4] Fewer than 2% of all CSs are MCs. The maxilla and mandible are the most common sites of involvement, followed by the vertebrae, the ribs, the pelvis and the humerus. [3] It was first described by Lightenstein and Bernstein in 1959 as a biphasic tumor, comprising spindle cells interspersed with areas of chondroid differentiation. [5] Usually, MCs of the head and neck region arise from the maxilla, with relatively few arising from the mandible. [6] Females are more frequently affected than males. It is commonly seen in younger age group compared with conventional CS. [7] The majority of MCs are asymptomatic, although some patients present with rapidly invasive asymptomatic swellings, resulting in loosening of the teeth and expansion of the cortical plates. [8] Radiographically, it is difficult to differentiate between MC from other cartilaginous neoplasms or Mesenchymal chondrosarcoma (MC) is a rare variety of chondrosarcoma (CS), which is both clinically unique and histologically distinct compared with conventional CS. Maxillofacial MCs are aggressive, have a tendency for recurrence and significant distant metastasis to lung and bone, and are associated with overall poor prognosis. Histopathologically, it is a biphasic tumor comprising of islands of hyaline cartilage with undifferentiated small round cells. Here, we present an interesting case of MC involving the left half of maxilla along with a brief review of the relevant literature.

$Research paper thumbnail of Surgical management of chronic hyperplastic candidiasis refractory to systemic antifungal treatment$

Journal of laboratory physicians

Chronic hyperplastic candidiasis (CHC), earlier known as candidal leukoplakia, is a variant of or... more Chronic hyperplastic candidiasis (CHC), earlier known as candidal leukoplakia, is a variant of oral candidiasis that classically presents as a white patch on the commissures of the oral mucosa and it is mostly caused by Candida albicans. Clinically, the lesions are usually asymptomatic and regress after appropriate antifungal therapy and correction of the underlying cause. If the lesions are untreated, a small portion may develop dysplasia and later progress into carcinoma. The purpose of this article is to report a case of CHC in a 57-year-old male patient with a significant smoking habit, who presented with a thick, nonscrapable, brownish-white coating on the dorsum of the tongue for 9 years. This case is of particular importance and concern because of the high risk for malignant transformation in CHC. The role of biopsy and histopathology is also stressed through this case report in arriving at a definitive diagnosis and treatment planning. Further, this case is interesting becau...

Contemporary clinical dentistry

Clear cell odontogenic carcinoma is a rare, aggressive neoplasm of the jaw with only 74 reported ... more Clear cell odontogenic carcinoma is a rare, aggressive neoplasm of the jaw with only 74 reported cases. It occurs predominantly in the mandibular anterior region during fifth to seventh decades of life. Clinically it manifests as intra-bony swelling with a variable degree of pain. Microscopically, it reveals nests of cells with clear cytoplasm in connective tissue stroma arranged in different patterns. It is often misdiagnosed due to the rarity of lesion and confusing histopathology. Immunohistochemical staining plays an intricate role to uncertain the native of the clear cell to reach a confirmative diagnosis. The article aims to highlight the clinicopathologic features of clear cell odontogenic carcinoma in a middle-aged man with special emphasis on its differential diagnosis.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015

Actinomycosis is a rare chronic infectious disease caused primarily by Actinomyces israelli. Alth... more Actinomycosis is a rare chronic infectious disease caused primarily by Actinomyces israelli. Although they are normal inhabitants of the oral cavity, infection occurs when there is a breach in the mucosa allowing them access to the subcutaneous tissues. Poor oral hygiene, dental caries, recent dental extraction, oromaxillofacial trauma have been implicated as risk factors for actinomycosis. Cervicofacial actinomycosis is the most common form of this rare disease. Here, we are presenting a rare case of actinomycosis involving the parotid gland and coronoid process of mandible in a young child where diagnosis was made based on histopathological findings since the classical clinical manifestations of actinomycosis, were absent in the case.