sandeep naik - Academia.edu (original) (raw)

Papers by sandeep naik

International Journal of Plant & Soil Science

Field experiment was carried out on silt clay loam soils at Regional Agricultural Research statio... more Field experiment was carried out on silt clay loam soils at Regional Agricultural Research station, Chintapalle, Visakhapatnam, Andhra Pradesh during 2018-2020 to study the yield of response of rainfed groundnut with different levels of Nano particulate zinc oxide application along with NPK Fertilizers. The experiment consisting of eight treatments, three replications with RDF design. Results of nano particulate zinc oxide on pod yield showed that (24.36 Q/ha) in the RDF+ nano scale zinc oxide level @ 200 ppm at 25 and 45 DAS was increased over to that of normal recommended dose of N,P,K fertilizers (100% RDF) which recorded pod yield of 17.14 Q/ha only. Application of ZnSO4 through soil along with RDF showed good results (17.24 Q/ha) than RDF + Foliar application of ZnSO4 @ 2g/lit at 25 and 45 DAS (20.66 Q/ha). Application of micronutrient (ZnO) had helped in further increase in grain yields at both levels of ZnO (150% and 200% ZnO at 25 and 45 DAS). Among different treatments, ...

International Journal of Orthopaedics Sciences

Background and Objective: There is an increased incidence of tibial eminence fractures in skeleta... more Background and Objective: There is an increased incidence of tibial eminence fractures in skeletally mature adults due to increased road traffic accidents and participation in sports activities (reference). The study has been undertaken to evaluate the functional outcome of acute tibial eminence fractures treated arthroscopically with a pull-through suture technique. Methods: This study included thirty-one patients with acute tibial eminence fractures treated arthroscopically between November 2019 and March 2021. All the fractures were fixed using a pullthrough suture technique and tied over the suture disc. Results: Among the thirty-one patients treated, the most common cause of injury was a road traffic accident, followed by sports injuries. Two patients were injured due to a kick by the bull. In sports injuries, Kabaddi was the most prevalent cause of anterior cruciate ligament damage. Males made up 29 (94%) cases, while females made up just 2 (6%). The majority of the patients were between the ages of 40 and 49 (45 per cent). 64.5 per cent of patients (n=20) had surgery within five days of their accident. In our study, the mean preoperative IKDC scores were 50.94, and the mean postoperative IKDC scores were 87.73, indicating a considerable improvement. The mean pre-operative Lysholm score was 60.1, and postoperative Lysholm scores were 91.5. One patient had five degrees of extensor lag, and one patient had a fixed flexion deformity at ten degrees due to poor compliance to rehabilitation. Patients showed significant improvement by the end of 3 months and were allowed to return to daily activities by the end of 3 months and sports by six months. The percentage of patients who ended up having good to excellent outcomes is 83.8 and the percentage of patients returning to pre-injury level is 70. Conclusion: Treating acute tibial eminence fractures with an arthroscopic pull-through suture technique gives good rigid fixation and improves the functional outcome.

International Journal of Orthopaedics Sciences

Background: We assessed the functional outcome of the patient following ACL reconstruction using ... more Background: We assessed the functional outcome of the patient following ACL reconstruction using quadrupled hamstring autograft. Methods: In this case series of 21 patients who had ACL insufficiency underwent arthroscopic assisted ACL reconstruction using quadrupled hamstring autograft from November 2019 to March 2021. The functional outcome of patients was assessed with Lyscholm Knee Scoring System and IKDC score. Results: The injury was predominant in males. A larger percentage of cases was operated less than 6 months from the date of injury. The mean graft diameter was 7.90 mm, with a positive correlation to the function of the knee. The preoperative mean Lysholm score of 59.19 improved to 94.95 after surgery. The mean preoperative IKDC score improved from 46.81 to 81.95. Excellent outcome was seen in a majority of patients. Two patients had an infection and one patient had reduced range of motion. The timing of surgery and rehabilitation influence the outcome largely Conclusion: ACL reconstruction surgery with quadrupled hamstring graft provides an excellent outcome in ACL injuries when the surgery is timed well, with sufficient graft thickness and good rehabilitation.

International Journal of Orthopaedics Sciences, 2021

Introduction: Unstable, Comminuted intertrochanteric fractures continue to pose a challenge to th... more Introduction: Unstable, Comminuted intertrochanteric fractures continue to pose a challenge to the orthopaedic surgeon because of severe osteoporosis and medical disorders that increase the risks associated with surgery and anaesthesia. To overcome problems like lateral wall impingement and prominence of the proximal end of the nail, the PFNA-II was introduced in 2008. The PFNA II design modifications include the flat lateral shape of the proximal portion and a decrease in the mediolateral bending angle from 6 0 to 5 0. The purpose of the study is to confirm that the PFNA II eliminates the problem of lateral wall impingement experienced with previous intramedullary nailing systems and provides stable fracture fixation with positive functional outcome. Materials and methods: This study was conducted on 52 patient of which 32 were available till follow up of 6 months. All patients we were diagnosed with unstable intertrochanteric fracture of femur and underwent closed reduction internal fixation with proximal femoral nail anti-rotation system II. Functional outcome was assessed with Modified Haris Hip Score and radiological outcome was assessed with TAD score and implant related complications. Results: Fracture union was appreciated on an average 4 months of postoperative period. 4 patient had superficial infection while 1 patient had deep infection. Only 1 patient had cut off of helical blade. According to modified Harris hip score, excellent to good outcome was noted in more than 80% of patient. Conclusion: From our study, we conclude that PFNA II can be a reliable and implant of choice for the management of unstable intertrochanteric fracture with high rates of union, restoring the anatomical alignment with less chances of implant failure and reduced chance of implant failure.

Indian Journal of Orthopaedics Surgery, 2021

Fungal septic arthritis is a rare medical and surgical problem in orthopaedics. It mainly occurs ... more Fungal septic arthritis is a rare medical and surgical problem in orthopaedics. It mainly occurs in immunocompromised state. However our patient was not immunodeficient. The knee is most common site involved. Sometimes polyarticular involvement is also seen. Our case had monoarticular left knee joint involvement. Debridement and Antifungal therapy are the main stay of the treatment. Few cases of fungal septic arthritis are reported in literature. Our Patient showed good result with our treatment. Keywords: Amphotericin B, Debridement of joint, Orthopaedic management and Poor prognosis.

Contact Lens and Anterior Eye, 2018

International Journal of Orthopaedics Sciences, 2019

Aims and Objectives: To study the functional outcome of unstable intertrochanteric fracture treat... more Aims and Objectives: To study the functional outcome of unstable intertrochanteric fracture treated with bipolar cemented prosthesis and complications associated with it. Also to facilitate early mobilization, early weight bearing with rapid rehabilitation in elderly patient with unstable intertrochanteric fractures Material and Methods: Prospective study of 31 cases presenting with unstable intertrochanteric fractures which satisfy inclusion and exclusion criteria admitted in shri B M Patil Medical College, Hospital, and Research center Vijayapura from year 2016-2018 who are treated with Cemented Bipolar Prosthesis. Results: In our study of 31 cases, there were 13 male and 18 female patients with mean age of 73.4 years. 84% of the cases admitted were due to trivial trauma, 16% due to RTA with left side being more common side affected. Mean duration of hospital stay was 11.03 days and mean time of full weight bearing was 3.97 days in our patients. One patient died on Postoperative day 5. 29% excellent, 32.3% good, 25% fair results obtained in our study according to Harris Hip Score. Conclusion: Our study concludes that Cemented Bipolar Hemiarthroplasty in elderly patient with unstable intertrochanteric fracture reduces complications of prolonged immobilization, prolonged rehabilitation which are associated with internal fixation. Also reduces need for secondary surgery which required in cases of malunited fractures, non-union and implant failure. The procedure offered rapid mobilization, rapid return to pre injury level and improved quality of life.

Abstracts of Papers of the American Chemical Society, 2011

Abstracts of Papers of the American Chemical Society, 2009

Journal of Radiology Case Reports, 2015

We present a case of neck pain in a middle-aged woman, initially attributed to a retropharyngeal ... more We present a case of neck pain in a middle-aged woman, initially attributed to a retropharyngeal infection and treated with urgent intubation. With the help of computed tomography, the diagnosis was later revised to acute prevertebral calcific tendinitis, a self-limiting condition caused by abnormal calcium hydroxyapatite deposition in the longus colli muscles. It is critical to differentiate between these two disease entities due to dramatic differences in management. A discussion of acute prevertebral calcific tendinitis and its imaging findings is provided below.

International Journal of Applied Management Sciences and Engineering, 2015

This paper discusses various issues involved with process improvement in pharmaceutical manufactu... more This paper discusses various issues involved with process improvement in pharmaceutical manufacturing firms which creates impediment in introducing change in manufacturing process and refers to the initiatives taken by PAT (Process Analytical Technology) Framework, which encourages pharma companies to introduce change in manufacturing processes for productivity improvement. Setup time contributes a substantial amount of reduction in machine availability in pharma companies. Through a case study of a pharma manufacturing firm the paper explains how SMED can be implemented resulting substantial saving of down time without increasing the work load of the operators. It shows how the activities involved in machine setup can be divided in two classes—internal and external—and how ECRS (Eliminate, Combine, Rearrange and simplify) principles can be applied to reduce the activity time.

Genetic divergence in the Indian mackerel Rastrelliger kanagurta (Cuv) from the west coast (Goa),... more Genetic divergence in the Indian mackerel Rastrelliger kanagurta (Cuv) from the west coast (Goa), east coast (Madras) and the Andaman Sea was estimated, using allozyme markers. Skeletal muscle and eye proteins were electrophoretically analysed for 5 enzymes and sarcoplasmic proteins. The sacroplasmic protein-2(PROT-2) locus of the west coast and east coast populations was highly polymorphic with 3 alleles (100, 125 and 150). Most of the individuals wre homozygous for PROT-2(-100)allele. The PROT-2 locus of the Andaman population was nearly monomorphic with the individuals being homozygous for PROT-2(-150)allele. Nei's mean genetic distances (D) ranged from 0.0003 to 0.0017 for the east coast samples and there was no geopgraphic strucuture in the distribution of genetic distances. Between the west coast/east coast and the Andaman samples the average D was0.059. This value lies on the higher range of values suggested for local races of a species.

Medical Imaging 2002: Visualization, Image-Guided Procedures, and Display, 2002

The gold standard for NASCET-type stenosis measurements is currently 2D digital subtraction angio... more The gold standard for NASCET-type stenosis measurements is currently 2D digital subtraction angiography (DSA). In this paper, we evaluate the efficacy of 3D cone-beam, Volumetric Subtraction Angiography (VSA) for assessing internal carotid artery stenosis, ...

Proceedings: Animal Sciences, 1990

The population structure of Rastrelliqer kanagurta (Cuvier 1817) from two localities off Goa (Ara... more The population structure of Rastrelliqer kanagurta (Cuvier 1817) from two localities off Goa (Arabian sea) was assessed from genetic and morphological characters. Seventeen loci were examined from 8 enzymes, sarcoplasmic proteins and hemoglobins. The allele frequencies were not significantly different between the two localities. Nei's genetic distance value was (}()()17. The proportion of polymorphic loci at the I% level was 47•1 and 52'9%. The level of genetic variation, estimated by average observed heterozygosity, was 5'8 and 6•6%. The sarcoplasmic protein-z locus was found to be highly polymorphic. Significant (P<(}()()I) departures from Hardy-Weinberg expectations were observed at this locus. About 67-B9% of the variation in meristic characters was found to be within the groups.

Clinical Psychopharmacology and Neuroscience, 2013

Hypoxic-ischemic brain injury encompasses a complex constellation of pathophysiological and cellu... more Hypoxic-ischemic brain injury encompasses a complex constellation of pathophysiological and cellular brain injury induced by hypoxia, ischemia, cytotoxicity, or combinations of these mechanisms and can result in poor outcomes including significant changes in personality and cognitive impairments in memory, cognition, and attention. We report a case of a male patient with normal premorbid functioning who developed prolonged delirium following hypoxic-ischemic brain insults subsequent to cardiac arrest. The case highlights the importance of adopting a multidisciplinary treatment approach involving the coordinated care of medical and nursing teams to optimise management of patients suffering from such a debilitating organic brain syndrome.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010

Langmuir, 2011

A series of poly(propylene oxide)-b-poly(L-lysine) (PPO-PK) block copolymers were synthesized usi... more A series of poly(propylene oxide)-b-poly(L-lysine) (PPO-PK) block copolymers were synthesized using Huisgen&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s 1,3-dipolar cycloaddition, and the solution self-assembly was studied using transmission electron microscopy, circular dichroism spectroscopy, and dynamic and static light scattering techniques. In contrast to previous studies of poly(lysine)-based block copolymers, PPO-PK exhibits a significant shift in the pH associated with the helix-coil transition of the poly(lysine) block, potentially a result of decreased hydrophobicity in the core PPO block. Given the proximity of the lower critical solution temperature of the PPO block, these materials exhibit both pH and temperature-responsive (i.e., &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;schizophrenic&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;) self-assembly, the latter of which was interpreted in terms of changes in the second osmotic virial coefficient. Finally, the vesicle morphology obtained from these polymers was studied for the propensity in drug encapsulation and passive release.

International Journal of Production Research, 2002

A disassembly plan is described by a disassembly bill of materials (DBOM), the sequence of proces... more A disassembly plan is described by a disassembly bill of materials (DBOM), the sequence of processing steps, the type of disassembly action, the part or fastener worked on each step, the tools used, and the resulting material and part outputs. The disassembly process planning problem (DP3) involves the generation of a feasible plan and its implementation at a disassembly facility. In this paper, we introduce and describe the DP3 model. This model includes a structured format for creating, documenting, and evaluating a disassembly process plan. The resulting plan is intended to be a readily implemented solution and hence can be adopted by any reclamation facility. A key utility of this model is that it provides a format for transmitting product knowledge from the original product manufacturer to the consumer and the end-of-life disassembler, via the disassembly bill of materials (DBOM). The DP3 is a descriptive model, in that it describes a plan that can be readily developed by a manufacturer and e ciently distributed to the disassembly community. It is left to the user though, to determine the sequence of disassembly steps. The model introduces a variety of standards for identifying unfastening actions, destructive actions, and the required tools. The DP3 model also provides an economic evaluation of di erent plans.

General Hospital Psychiatry, 2011

Hypoglycemia is a biochemical abnormality and often the rate-limiting step in the treatment of bo... more Hypoglycemia is a biochemical abnormality and often the rate-limiting step in the treatment of both type 1 and type 2 diabetes mellitus. Left uncorrected and prolonged, hypoglycemia can result in neuronal dysfunction and death, with deficits ranging from measurable cognitive impairments to aberrant behavior, seizures and coma. In this case report, hypoglycemia resulted in severe and persistent neurological (slurred speech and gait abnormalities), cognitive (inattention, disorientation and memory deficits) and behavioral manifestations (verbal hostility and irritability). It highlights the potentially severe neuropsychiatric sequelae following hypoglycemia and is timely for clinicians to be reminded that hypoglycemia prevention needs to be more of a focus of diabetes care in general.

Clinical Infectious Diseases, 2004

We describe, to our knowledge, the first reported case of Schistosoma mekongi infection with brai... more We describe, to our knowledge, the first reported case of Schistosoma mekongi infection with brain involvement. S. mekongi is a distinct species most closely related to Schistosoma japonicum that is endemic in a defined area of the Mekong River in Laos and Cambodia and characteristically associated with hepatosplenic disease. The patient had an excellent response to praziquantel therapy but required repeated courses of corticosteroid therapy to suppress recrudescent neurological symptoms. Case report. A 25-year-old Canadian-born man presented to his local hospital in November 2002 with a 3-week history of headache, nausea, right arm and leg paresthesias, and dysphasia. These symptoms started during a 2-month period in which the patient worked and traveled in Costa Rica and Panama. Previous travel included 2 months in northern Thailand and Laos in 2000. He experienced no illness during his Asian trip other than self-limited diarrhea. His past medical history was unremarkable. The only abnormal findings revealed by physical examination were papilledema and a mild, expressive aphasia. Findings of a complete blood cell count and differential count were normal, with an absolute eosinophil count of cells/L before 9

International Journal of Plant & Soil Science

Field experiment was carried out on silt clay loam soils at Regional Agricultural Research statio... more Field experiment was carried out on silt clay loam soils at Regional Agricultural Research station, Chintapalle, Visakhapatnam, Andhra Pradesh during 2018-2020 to study the yield of response of rainfed groundnut with different levels of Nano particulate zinc oxide application along with NPK Fertilizers. The experiment consisting of eight treatments, three replications with RDF design. Results of nano particulate zinc oxide on pod yield showed that (24.36 Q/ha) in the RDF+ nano scale zinc oxide level @ 200 ppm at 25 and 45 DAS was increased over to that of normal recommended dose of N,P,K fertilizers (100% RDF) which recorded pod yield of 17.14 Q/ha only. Application of ZnSO4 through soil along with RDF showed good results (17.24 Q/ha) than RDF + Foliar application of ZnSO4 @ 2g/lit at 25 and 45 DAS (20.66 Q/ha). Application of micronutrient (ZnO) had helped in further increase in grain yields at both levels of ZnO (150% and 200% ZnO at 25 and 45 DAS). Among different treatments, ...

International Journal of Orthopaedics Sciences

Background and Objective: There is an increased incidence of tibial eminence fractures in skeleta... more Background and Objective: There is an increased incidence of tibial eminence fractures in skeletally mature adults due to increased road traffic accidents and participation in sports activities (reference). The study has been undertaken to evaluate the functional outcome of acute tibial eminence fractures treated arthroscopically with a pull-through suture technique. Methods: This study included thirty-one patients with acute tibial eminence fractures treated arthroscopically between November 2019 and March 2021. All the fractures were fixed using a pullthrough suture technique and tied over the suture disc. Results: Among the thirty-one patients treated, the most common cause of injury was a road traffic accident, followed by sports injuries. Two patients were injured due to a kick by the bull. In sports injuries, Kabaddi was the most prevalent cause of anterior cruciate ligament damage. Males made up 29 (94%) cases, while females made up just 2 (6%). The majority of the patients were between the ages of 40 and 49 (45 per cent). 64.5 per cent of patients (n=20) had surgery within five days of their accident. In our study, the mean preoperative IKDC scores were 50.94, and the mean postoperative IKDC scores were 87.73, indicating a considerable improvement. The mean pre-operative Lysholm score was 60.1, and postoperative Lysholm scores were 91.5. One patient had five degrees of extensor lag, and one patient had a fixed flexion deformity at ten degrees due to poor compliance to rehabilitation. Patients showed significant improvement by the end of 3 months and were allowed to return to daily activities by the end of 3 months and sports by six months. The percentage of patients who ended up having good to excellent outcomes is 83.8 and the percentage of patients returning to pre-injury level is 70. Conclusion: Treating acute tibial eminence fractures with an arthroscopic pull-through suture technique gives good rigid fixation and improves the functional outcome.

International Journal of Orthopaedics Sciences

Background: We assessed the functional outcome of the patient following ACL reconstruction using ... more Background: We assessed the functional outcome of the patient following ACL reconstruction using quadrupled hamstring autograft. Methods: In this case series of 21 patients who had ACL insufficiency underwent arthroscopic assisted ACL reconstruction using quadrupled hamstring autograft from November 2019 to March 2021. The functional outcome of patients was assessed with Lyscholm Knee Scoring System and IKDC score. Results: The injury was predominant in males. A larger percentage of cases was operated less than 6 months from the date of injury. The mean graft diameter was 7.90 mm, with a positive correlation to the function of the knee. The preoperative mean Lysholm score of 59.19 improved to 94.95 after surgery. The mean preoperative IKDC score improved from 46.81 to 81.95. Excellent outcome was seen in a majority of patients. Two patients had an infection and one patient had reduced range of motion. The timing of surgery and rehabilitation influence the outcome largely Conclusion: ACL reconstruction surgery with quadrupled hamstring graft provides an excellent outcome in ACL injuries when the surgery is timed well, with sufficient graft thickness and good rehabilitation.

International Journal of Orthopaedics Sciences, 2021

Introduction: Unstable, Comminuted intertrochanteric fractures continue to pose a challenge to th... more Introduction: Unstable, Comminuted intertrochanteric fractures continue to pose a challenge to the orthopaedic surgeon because of severe osteoporosis and medical disorders that increase the risks associated with surgery and anaesthesia. To overcome problems like lateral wall impingement and prominence of the proximal end of the nail, the PFNA-II was introduced in 2008. The PFNA II design modifications include the flat lateral shape of the proximal portion and a decrease in the mediolateral bending angle from 6 0 to 5 0. The purpose of the study is to confirm that the PFNA II eliminates the problem of lateral wall impingement experienced with previous intramedullary nailing systems and provides stable fracture fixation with positive functional outcome. Materials and methods: This study was conducted on 52 patient of which 32 were available till follow up of 6 months. All patients we were diagnosed with unstable intertrochanteric fracture of femur and underwent closed reduction internal fixation with proximal femoral nail anti-rotation system II. Functional outcome was assessed with Modified Haris Hip Score and radiological outcome was assessed with TAD score and implant related complications. Results: Fracture union was appreciated on an average 4 months of postoperative period. 4 patient had superficial infection while 1 patient had deep infection. Only 1 patient had cut off of helical blade. According to modified Harris hip score, excellent to good outcome was noted in more than 80% of patient. Conclusion: From our study, we conclude that PFNA II can be a reliable and implant of choice for the management of unstable intertrochanteric fracture with high rates of union, restoring the anatomical alignment with less chances of implant failure and reduced chance of implant failure.

Indian Journal of Orthopaedics Surgery, 2021

Fungal septic arthritis is a rare medical and surgical problem in orthopaedics. It mainly occurs ... more Fungal septic arthritis is a rare medical and surgical problem in orthopaedics. It mainly occurs in immunocompromised state. However our patient was not immunodeficient. The knee is most common site involved. Sometimes polyarticular involvement is also seen. Our case had monoarticular left knee joint involvement. Debridement and Antifungal therapy are the main stay of the treatment. Few cases of fungal septic arthritis are reported in literature. Our Patient showed good result with our treatment. Keywords: Amphotericin B, Debridement of joint, Orthopaedic management and Poor prognosis.

Contact Lens and Anterior Eye, 2018

International Journal of Orthopaedics Sciences, 2019

Aims and Objectives: To study the functional outcome of unstable intertrochanteric fracture treat... more Aims and Objectives: To study the functional outcome of unstable intertrochanteric fracture treated with bipolar cemented prosthesis and complications associated with it. Also to facilitate early mobilization, early weight bearing with rapid rehabilitation in elderly patient with unstable intertrochanteric fractures Material and Methods: Prospective study of 31 cases presenting with unstable intertrochanteric fractures which satisfy inclusion and exclusion criteria admitted in shri B M Patil Medical College, Hospital, and Research center Vijayapura from year 2016-2018 who are treated with Cemented Bipolar Prosthesis. Results: In our study of 31 cases, there were 13 male and 18 female patients with mean age of 73.4 years. 84% of the cases admitted were due to trivial trauma, 16% due to RTA with left side being more common side affected. Mean duration of hospital stay was 11.03 days and mean time of full weight bearing was 3.97 days in our patients. One patient died on Postoperative day 5. 29% excellent, 32.3% good, 25% fair results obtained in our study according to Harris Hip Score. Conclusion: Our study concludes that Cemented Bipolar Hemiarthroplasty in elderly patient with unstable intertrochanteric fracture reduces complications of prolonged immobilization, prolonged rehabilitation which are associated with internal fixation. Also reduces need for secondary surgery which required in cases of malunited fractures, non-union and implant failure. The procedure offered rapid mobilization, rapid return to pre injury level and improved quality of life.

Abstracts of Papers of the American Chemical Society, 2011

Abstracts of Papers of the American Chemical Society, 2009

Journal of Radiology Case Reports, 2015

We present a case of neck pain in a middle-aged woman, initially attributed to a retropharyngeal ... more We present a case of neck pain in a middle-aged woman, initially attributed to a retropharyngeal infection and treated with urgent intubation. With the help of computed tomography, the diagnosis was later revised to acute prevertebral calcific tendinitis, a self-limiting condition caused by abnormal calcium hydroxyapatite deposition in the longus colli muscles. It is critical to differentiate between these two disease entities due to dramatic differences in management. A discussion of acute prevertebral calcific tendinitis and its imaging findings is provided below.

International Journal of Applied Management Sciences and Engineering, 2015

This paper discusses various issues involved with process improvement in pharmaceutical manufactu... more This paper discusses various issues involved with process improvement in pharmaceutical manufacturing firms which creates impediment in introducing change in manufacturing process and refers to the initiatives taken by PAT (Process Analytical Technology) Framework, which encourages pharma companies to introduce change in manufacturing processes for productivity improvement. Setup time contributes a substantial amount of reduction in machine availability in pharma companies. Through a case study of a pharma manufacturing firm the paper explains how SMED can be implemented resulting substantial saving of down time without increasing the work load of the operators. It shows how the activities involved in machine setup can be divided in two classes—internal and external—and how ECRS (Eliminate, Combine, Rearrange and simplify) principles can be applied to reduce the activity time.

Genetic divergence in the Indian mackerel Rastrelliger kanagurta (Cuv) from the west coast (Goa),... more Genetic divergence in the Indian mackerel Rastrelliger kanagurta (Cuv) from the west coast (Goa), east coast (Madras) and the Andaman Sea was estimated, using allozyme markers. Skeletal muscle and eye proteins were electrophoretically analysed for 5 enzymes and sarcoplasmic proteins. The sacroplasmic protein-2(PROT-2) locus of the west coast and east coast populations was highly polymorphic with 3 alleles (100, 125 and 150). Most of the individuals wre homozygous for PROT-2(-100)allele. The PROT-2 locus of the Andaman population was nearly monomorphic with the individuals being homozygous for PROT-2(-150)allele. Nei's mean genetic distances (D) ranged from 0.0003 to 0.0017 for the east coast samples and there was no geopgraphic strucuture in the distribution of genetic distances. Between the west coast/east coast and the Andaman samples the average D was0.059. This value lies on the higher range of values suggested for local races of a species.

Medical Imaging 2002: Visualization, Image-Guided Procedures, and Display, 2002

The gold standard for NASCET-type stenosis measurements is currently 2D digital subtraction angio... more The gold standard for NASCET-type stenosis measurements is currently 2D digital subtraction angiography (DSA). In this paper, we evaluate the efficacy of 3D cone-beam, Volumetric Subtraction Angiography (VSA) for assessing internal carotid artery stenosis, ...

Proceedings: Animal Sciences, 1990

The population structure of Rastrelliqer kanagurta (Cuvier 1817) from two localities off Goa (Ara... more The population structure of Rastrelliqer kanagurta (Cuvier 1817) from two localities off Goa (Arabian sea) was assessed from genetic and morphological characters. Seventeen loci were examined from 8 enzymes, sarcoplasmic proteins and hemoglobins. The allele frequencies were not significantly different between the two localities. Nei's genetic distance value was (}()()17. The proportion of polymorphic loci at the I% level was 47•1 and 52'9%. The level of genetic variation, estimated by average observed heterozygosity, was 5'8 and 6•6%. The sarcoplasmic protein-z locus was found to be highly polymorphic. Significant (P<(}()()I) departures from Hardy-Weinberg expectations were observed at this locus. About 67-B9% of the variation in meristic characters was found to be within the groups.

Clinical Psychopharmacology and Neuroscience, 2013

Hypoxic-ischemic brain injury encompasses a complex constellation of pathophysiological and cellu... more Hypoxic-ischemic brain injury encompasses a complex constellation of pathophysiological and cellular brain injury induced by hypoxia, ischemia, cytotoxicity, or combinations of these mechanisms and can result in poor outcomes including significant changes in personality and cognitive impairments in memory, cognition, and attention. We report a case of a male patient with normal premorbid functioning who developed prolonged delirium following hypoxic-ischemic brain insults subsequent to cardiac arrest. The case highlights the importance of adopting a multidisciplinary treatment approach involving the coordinated care of medical and nursing teams to optimise management of patients suffering from such a debilitating organic brain syndrome.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010

Langmuir, 2011

A series of poly(propylene oxide)-b-poly(L-lysine) (PPO-PK) block copolymers were synthesized usi... more A series of poly(propylene oxide)-b-poly(L-lysine) (PPO-PK) block copolymers were synthesized using Huisgen&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s 1,3-dipolar cycloaddition, and the solution self-assembly was studied using transmission electron microscopy, circular dichroism spectroscopy, and dynamic and static light scattering techniques. In contrast to previous studies of poly(lysine)-based block copolymers, PPO-PK exhibits a significant shift in the pH associated with the helix-coil transition of the poly(lysine) block, potentially a result of decreased hydrophobicity in the core PPO block. Given the proximity of the lower critical solution temperature of the PPO block, these materials exhibit both pH and temperature-responsive (i.e., &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;schizophrenic&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;) self-assembly, the latter of which was interpreted in terms of changes in the second osmotic virial coefficient. Finally, the vesicle morphology obtained from these polymers was studied for the propensity in drug encapsulation and passive release.

International Journal of Production Research, 2002

A disassembly plan is described by a disassembly bill of materials (DBOM), the sequence of proces... more A disassembly plan is described by a disassembly bill of materials (DBOM), the sequence of processing steps, the type of disassembly action, the part or fastener worked on each step, the tools used, and the resulting material and part outputs. The disassembly process planning problem (DP3) involves the generation of a feasible plan and its implementation at a disassembly facility. In this paper, we introduce and describe the DP3 model. This model includes a structured format for creating, documenting, and evaluating a disassembly process plan. The resulting plan is intended to be a readily implemented solution and hence can be adopted by any reclamation facility. A key utility of this model is that it provides a format for transmitting product knowledge from the original product manufacturer to the consumer and the end-of-life disassembler, via the disassembly bill of materials (DBOM). The DP3 is a descriptive model, in that it describes a plan that can be readily developed by a manufacturer and e ciently distributed to the disassembly community. It is left to the user though, to determine the sequence of disassembly steps. The model introduces a variety of standards for identifying unfastening actions, destructive actions, and the required tools. The DP3 model also provides an economic evaluation of di erent plans.

General Hospital Psychiatry, 2011

Hypoglycemia is a biochemical abnormality and often the rate-limiting step in the treatment of bo... more Hypoglycemia is a biochemical abnormality and often the rate-limiting step in the treatment of both type 1 and type 2 diabetes mellitus. Left uncorrected and prolonged, hypoglycemia can result in neuronal dysfunction and death, with deficits ranging from measurable cognitive impairments to aberrant behavior, seizures and coma. In this case report, hypoglycemia resulted in severe and persistent neurological (slurred speech and gait abnormalities), cognitive (inattention, disorientation and memory deficits) and behavioral manifestations (verbal hostility and irritability). It highlights the potentially severe neuropsychiatric sequelae following hypoglycemia and is timely for clinicians to be reminded that hypoglycemia prevention needs to be more of a focus of diabetes care in general.

Clinical Infectious Diseases, 2004

We describe, to our knowledge, the first reported case of Schistosoma mekongi infection with brai... more We describe, to our knowledge, the first reported case of Schistosoma mekongi infection with brain involvement. S. mekongi is a distinct species most closely related to Schistosoma japonicum that is endemic in a defined area of the Mekong River in Laos and Cambodia and characteristically associated with hepatosplenic disease. The patient had an excellent response to praziquantel therapy but required repeated courses of corticosteroid therapy to suppress recrudescent neurological symptoms. Case report. A 25-year-old Canadian-born man presented to his local hospital in November 2002 with a 3-week history of headache, nausea, right arm and leg paresthesias, and dysphasia. These symptoms started during a 2-month period in which the patient worked and traveled in Costa Rica and Panama. Previous travel included 2 months in northern Thailand and Laos in 2000. He experienced no illness during his Asian trip other than self-limited diarrhea. His past medical history was unremarkable. The only abnormal findings revealed by physical examination were papilledema and a mild, expressive aphasia. Findings of a complete blood cell count and differential count were normal, with an absolute eosinophil count of cells/L before 9