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Research paper thumbnail of International Clinical Experience for Midwifery Students

Journal of Midwifery & Women's Health, 2011

The purpose of this survey was to obtain information that would elucidate what types and amounts ... more The purpose of this survey was to obtain information that would elucidate what types and amounts of international clinical experiences are available to midwifery students in accredited midwifery programs. Furthermore, the survey assessed the need for and interest in an online pre-trip preparation course and the possibility of future collaborative efforts between midwifery programs. Methods: A formal electronic descriptive survey was sent to eligible directors of midwifery education (DOME) from 38 accredited institutions in the United States. Results: Twenty-nine of 38 (76%) responded to the survey, and 9 of 29 programs (31%) offer international clinical experiences. Sixteen (80%) of the 20 programs not currently offering international experiences indicated interest in offering these experiences. Of the 9 programs that have international experiences, only 1 reported offering a formal pre-trip course. Discussion: The results of this survey suggest that there is interest in collaborative efforts for developing a formal pre-trip preparation course and sharing international experiences that would promote sustainable programs of international experiences for student midwives.

Research paper thumbnail of Promoting Strategy Change: Mere Exposure to Alternative Strategies Helps, but Feedback Can Hurt

Journal of Cognition and Development

ABSTRACT This study investigated effects of feedback and exposure to alternative strategies on st... more ABSTRACT This study investigated effects of feedback and exposure to alternative strategies on strategy change in children (N = 106, age range = 7;3–10;0) learning about mathematical equivalence. Children’s strategies were evaluated before and after a brief instructional intervention. During the intervention, children either were exposed to a set of 4 alternative strategies (2 correct, 2 incorrect) without information about the validity of the strategies or completed a control task. In addition, some children received feedback about existing strategies, and others did not. Exposure to alternative strategies led to more strategy change and better performance on a problem-solving task. The effect of feedback on strategy change depended on children’s confidence in their existing strategies and on their pretest knowledge.

Research paper thumbnail of Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity

Dalton Transactions, 2012

Picoplatin is a sterically hindered mononuclear platinum drug undergoing clinical trials. The 2-m... more Picoplatin is a sterically hindered mononuclear platinum drug undergoing clinical trials. The 2-methylpyridine ring provides steric hindrance to the drug, preventing attack from biological nucleophiles. BBR3464 is a trinuclear platinum drug which was recently in Phase II clinical trials, and is highly cytotoxic both in vitro and in vivo; it derives this activity through the flexible adducts it forms with DNA. In this work we sought to combine the properties of both drugs to synthesise a family of sterically hindered, dinuclear platinum complexes as potential anticancer agents. The bis-pyridyl-based ligands were synthesised through a peptide coupling reaction using diaminoalkanes of differing lengths (n = 2, 4 or 8) and 4-carboxypyridine or 2-methyl-4-carboxypyridine. The resultant dinuclear platinum complexes were synthesised by reacting two equivalents of transplatin or mono-aquated transplatin to each ligand, followed by purification by precipitation with acetone. The unprotected complexes react faster with 5′-guanosine monophosphate (drug to nucleotide ratio 1 : 2; t 1/2 = 2 h), glutathione (1 : 10, t 1/2 = 55 min) and human serum albumin (HSA) (1 : 1, t 1/2 = 24 h) compared to their hindered, protected equivalents (5′-guanosine monophosphate, t 1/2 = 3.5 h; glutathione = 1.7 h; HSA, t 1/2 = 110 h). The complexes were tested for in vitro cytotoxicity in the A2780 and A2780/cp70 ovarian cancer cell line. The unprotected platinum complexes were more cytotoxic than their protected derivatives, but none of the complexes were able to overcome resistance. The results provide important proof-of-concept for the development of a larger family of sterically hindered multinuclear-based platinum complexes.

Research paper thumbnail of International competition and the labor market prospects of union and nonunion workers

Journal of Labor Research, 2001

Research paper thumbnail of International Clinical Experience for Midwifery Students

Journal of Midwifery & Women's Health, 2011

The purpose of this survey was to obtain information that would elucidate what types and amounts ... more The purpose of this survey was to obtain information that would elucidate what types and amounts of international clinical experiences are available to midwifery students in accredited midwifery programs. Furthermore, the survey assessed the need for and interest in an online pre-trip preparation course and the possibility of future collaborative efforts between midwifery programs. Methods: A formal electronic descriptive survey was sent to eligible directors of midwifery education (DOME) from 38 accredited institutions in the United States. Results: Twenty-nine of 38 (76%) responded to the survey, and 9 of 29 programs (31%) offer international clinical experiences. Sixteen (80%) of the 20 programs not currently offering international experiences indicated interest in offering these experiences. Of the 9 programs that have international experiences, only 1 reported offering a formal pre-trip course. Discussion: The results of this survey suggest that there is interest in collaborative efforts for developing a formal pre-trip preparation course and sharing international experiences that would promote sustainable programs of international experiences for student midwives.

Research paper thumbnail of Promoting Strategy Change: Mere Exposure to Alternative Strategies Helps, but Feedback Can Hurt

Journal of Cognition and Development

ABSTRACT This study investigated effects of feedback and exposure to alternative strategies on st... more ABSTRACT This study investigated effects of feedback and exposure to alternative strategies on strategy change in children (N = 106, age range = 7;3–10;0) learning about mathematical equivalence. Children’s strategies were evaluated before and after a brief instructional intervention. During the intervention, children either were exposed to a set of 4 alternative strategies (2 correct, 2 incorrect) without information about the validity of the strategies or completed a control task. In addition, some children received feedback about existing strategies, and others did not. Exposure to alternative strategies led to more strategy change and better performance on a problem-solving task. The effect of feedback on strategy change depended on children’s confidence in their existing strategies and on their pretest knowledge.

Research paper thumbnail of Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity

Dalton Transactions, 2012

Picoplatin is a sterically hindered mononuclear platinum drug undergoing clinical trials. The 2-m... more Picoplatin is a sterically hindered mononuclear platinum drug undergoing clinical trials. The 2-methylpyridine ring provides steric hindrance to the drug, preventing attack from biological nucleophiles. BBR3464 is a trinuclear platinum drug which was recently in Phase II clinical trials, and is highly cytotoxic both in vitro and in vivo; it derives this activity through the flexible adducts it forms with DNA. In this work we sought to combine the properties of both drugs to synthesise a family of sterically hindered, dinuclear platinum complexes as potential anticancer agents. The bis-pyridyl-based ligands were synthesised through a peptide coupling reaction using diaminoalkanes of differing lengths (n = 2, 4 or 8) and 4-carboxypyridine or 2-methyl-4-carboxypyridine. The resultant dinuclear platinum complexes were synthesised by reacting two equivalents of transplatin or mono-aquated transplatin to each ligand, followed by purification by precipitation with acetone. The unprotected complexes react faster with 5′-guanosine monophosphate (drug to nucleotide ratio 1 : 2; t 1/2 = 2 h), glutathione (1 : 10, t 1/2 = 55 min) and human serum albumin (HSA) (1 : 1, t 1/2 = 24 h) compared to their hindered, protected equivalents (5′-guanosine monophosphate, t 1/2 = 3.5 h; glutathione = 1.7 h; HSA, t 1/2 = 110 h). The complexes were tested for in vitro cytotoxicity in the A2780 and A2780/cp70 ovarian cancer cell line. The unprotected platinum complexes were more cytotoxic than their protected derivatives, but none of the complexes were able to overcome resistance. The results provide important proof-of-concept for the development of a larger family of sterically hindered multinuclear-based platinum complexes.

Research paper thumbnail of International competition and the labor market prospects of union and nonunion workers

Journal of Labor Research, 2001

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