saurabh patel - Academia.edu (original) (raw)
Papers by saurabh patel
![Research paper thumbnail of COMPUTATIONAL STUDIES, EFFICIENT SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLO[3,4- d]PYRIMIDINES AS POTENT INHIBITORS OF CHRONIC MYELOID LEUKEMIA, LUNG CARCINOMA AND BREAST CARCINOMA](https://attachments.academia-assets.com/86166315/thumbnails/1.jpg)
](Rasayan Journal of chemistry, 2020
Ophthalmology, 2005
To compare the efficacy and efficiency of retrobulbar versus sub-Tenon's capsule injection of loc... more To compare the efficacy and efficiency of retrobulbar versus sub-Tenon's capsule injection of local anesthetic in vitreoretinal surgery. Design: Prospective, randomized, double-masked clinical trial. Participants and Intervention: Sixty-four eyes from 61 patients undergoing vitreoretinal surgery were randomized to receive either retrobulbar or sub-Tenon's capsule injection of 5 ml of a 50:50 mixture of 4% lidocaine and 0.75% bupivacaine. Main Outcome Measures: The primary outcome measured was intraoperative eye pain, which was rated by patients in both groups using an 11-point (0-10) numerical visual analogue scale immediately after surgery and again the next morning. The surgeons indicated whether they perceived patient discomfort during 4 different stages of the operation: opening of the conjunctiva, vitrectomy (if performed), placement of scleral buckle (if performed), and closing of the conjunctiva. The preincision time, need for supplemental local anesthesia, and use of IV sedation for additional pain control were compared between the two groups. Results: Thirty-four eyes were randomized to retrobulbar injections, and 30 eyes were randomized to sub-Tenon's capsule injections. There was no significant difference in patient-reported intraoperative pain scores between the retrobulbar and sub-Tenon's capsule groups when assessed immediately after surgery (median, 2.0 vs. 2.0; P ϭ 0.52) or the next day (median, 2.0 vs. 1.0; P ϭ 0.26). The surgeons reported no difference between the two groups in terms of the percentages of patients with pain during opening of the conjunctiva (20.6% vs. 3.3%; P ϭ 0.058), vitrectomy (31% vs. 32%; P ϭ 1.00), placement of scleral buckle (33.3% vs. 40%; P ϭ 1.00), and closing of the conjunctiva (26.5% vs. 26.7%; P ϭ 1.00). There was a suggestion that preincision time was longer in the sub-Tenon's capsule group. Approximately equal percentages of patients in each group required supplemental local anesthesia (38% vs. 37%; P ϭ 0.90) or IV medication (85% vs. 70%; P ϭ 0.14) for pain control. Conclusions: Sub-Tenon's capsule injection of local anesthetic seems as effective as retrobulbar injection at controlling intraoperative pain in vitreoretinal surgery.
![Research paper thumbnail of Synthesis of Functionalized H -[1]Benzopyrano[2,3- b ]pyridines by the Friedländer Approach: Antimycobacterial and Antimicrobial Profile](https://attachments.academia-assets.com/86166344/thumbnails/1.jpg)
](Helvetica Chimica Acta, 2013
A series of functionalized H-[1]benzopyrano[2,3-b]pyridine derivatives were synthesized by the Fr... more A series of functionalized H-[1]benzopyrano[2,3-b]pyridine derivatives were synthesized by the Friedländer reaction of 2-amino-4-oxo-4H-chromene-3-carbonitriles 1 with malononitrile, ethyl cyanoacetate, or acetophenone (Scheme). The synthesized compounds 2-4 were screened for their in vitro activity against antitubercular, antibacterial, and antifungal species (Fig., Table). Among the synthesized compounds, 3c and 4f were the most active with 99% inhibition against Mycobacterium tuberculosis H 37 Rv, while compounds 2f, 3f, and 4d exhibited 69%, 63%, and 61% inhibition, respectively. The 4-amino-7,9-dibromo-1,5-dihydro-2,5-dioxo-2H-chromeno[2,3-b]pyridine-3-carbonitrile (3b) showed the most potent antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. Several chromeno[2,3-b]pyridine derivatives showed equal or more potency against Staphylococcus aureus and Candida albicans.
Bioorganic & Medicinal Chemistry Letters, 2010
The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid i... more The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H-(substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes (gram +ve), Escherichia coli, Pseudomonas aeruginosa (gram Àve) and antifungal activity against Aspergillus niger and anticancer activity (HL-60, Hep-2 & HEK293T) by MTT assay. Chloro substituted compounds showed antimicrobial and anticancer activity with IC 50 values in the low micromolar range.
European Journal of Medicinal Chemistry, 2010
The clinical significance of pyran and pyrimidine condensed systems and the raise in problem of m... more The clinical significance of pyran and pyrimidine condensed systems and the raise in problem of multidrug resistant bacterial pathogens has directed us to synthesize pyranopyrimidine derivatives via the reactions of the versatile, 2-amino-4-(4-methoxyphenyl)-4H-substituted chromene-3-carbonitrile with the appropriate reagents. The newly synthesized compounds were characterized by IR, (1)H NMR, (13)C NMR, Mass spectra and Elemental analysis. The compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H(37)Rv [ATCC-27294] and antibacterial activity against Staphylococcus aureus [ATCC-25923] and Streptococcus pyogenes [MTCC-443] as gram-positive, Escherichia coli [ATCC-25922] and Pseudomonas aeruginosa [MTCC-441] as gram-negative bacterial strains and antifungal activity against Aspergillus niger [MTCC-282]. Several derivatives exhibited pronounced antitubercular and antimicrobial activities.
Rasayan Journal of chemistry, 2020
Ophthalmology, 2005
To compare the efficacy and efficiency of retrobulbar versus sub-Tenon's capsule injection of loc... more To compare the efficacy and efficiency of retrobulbar versus sub-Tenon's capsule injection of local anesthetic in vitreoretinal surgery. Design: Prospective, randomized, double-masked clinical trial. Participants and Intervention: Sixty-four eyes from 61 patients undergoing vitreoretinal surgery were randomized to receive either retrobulbar or sub-Tenon's capsule injection of 5 ml of a 50:50 mixture of 4% lidocaine and 0.75% bupivacaine. Main Outcome Measures: The primary outcome measured was intraoperative eye pain, which was rated by patients in both groups using an 11-point (0-10) numerical visual analogue scale immediately after surgery and again the next morning. The surgeons indicated whether they perceived patient discomfort during 4 different stages of the operation: opening of the conjunctiva, vitrectomy (if performed), placement of scleral buckle (if performed), and closing of the conjunctiva. The preincision time, need for supplemental local anesthesia, and use of IV sedation for additional pain control were compared between the two groups. Results: Thirty-four eyes were randomized to retrobulbar injections, and 30 eyes were randomized to sub-Tenon's capsule injections. There was no significant difference in patient-reported intraoperative pain scores between the retrobulbar and sub-Tenon's capsule groups when assessed immediately after surgery (median, 2.0 vs. 2.0; P ϭ 0.52) or the next day (median, 2.0 vs. 1.0; P ϭ 0.26). The surgeons reported no difference between the two groups in terms of the percentages of patients with pain during opening of the conjunctiva (20.6% vs. 3.3%; P ϭ 0.058), vitrectomy (31% vs. 32%; P ϭ 1.00), placement of scleral buckle (33.3% vs. 40%; P ϭ 1.00), and closing of the conjunctiva (26.5% vs. 26.7%; P ϭ 1.00). There was a suggestion that preincision time was longer in the sub-Tenon's capsule group. Approximately equal percentages of patients in each group required supplemental local anesthesia (38% vs. 37%; P ϭ 0.90) or IV medication (85% vs. 70%; P ϭ 0.14) for pain control. Conclusions: Sub-Tenon's capsule injection of local anesthetic seems as effective as retrobulbar injection at controlling intraoperative pain in vitreoretinal surgery.
Helvetica Chimica Acta, 2013
A series of functionalized H-[1]benzopyrano[2,3-b]pyridine derivatives were synthesized by the Fr... more A series of functionalized H-[1]benzopyrano[2,3-b]pyridine derivatives were synthesized by the Friedländer reaction of 2-amino-4-oxo-4H-chromene-3-carbonitriles 1 with malononitrile, ethyl cyanoacetate, or acetophenone (Scheme). The synthesized compounds 2-4 were screened for their in vitro activity against antitubercular, antibacterial, and antifungal species (Fig., Table). Among the synthesized compounds, 3c and 4f were the most active with 99% inhibition against Mycobacterium tuberculosis H 37 Rv, while compounds 2f, 3f, and 4d exhibited 69%, 63%, and 61% inhibition, respectively. The 4-amino-7,9-dibromo-1,5-dihydro-2,5-dioxo-2H-chromeno[2,3-b]pyridine-3-carbonitrile (3b) showed the most potent antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. Several chromeno[2,3-b]pyridine derivatives showed equal or more potency against Staphylococcus aureus and Candida albicans.
Bioorganic & Medicinal Chemistry Letters, 2010
The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid i... more The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H-(substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes (gram +ve), Escherichia coli, Pseudomonas aeruginosa (gram Àve) and antifungal activity against Aspergillus niger and anticancer activity (HL-60, Hep-2 & HEK293T) by MTT assay. Chloro substituted compounds showed antimicrobial and anticancer activity with IC 50 values in the low micromolar range.
European Journal of Medicinal Chemistry, 2010
The clinical significance of pyran and pyrimidine condensed systems and the raise in problem of m... more The clinical significance of pyran and pyrimidine condensed systems and the raise in problem of multidrug resistant bacterial pathogens has directed us to synthesize pyranopyrimidine derivatives via the reactions of the versatile, 2-amino-4-(4-methoxyphenyl)-4H-substituted chromene-3-carbonitrile with the appropriate reagents. The newly synthesized compounds were characterized by IR, (1)H NMR, (13)C NMR, Mass spectra and Elemental analysis. The compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H(37)Rv [ATCC-27294] and antibacterial activity against Staphylococcus aureus [ATCC-25923] and Streptococcus pyogenes [MTCC-443] as gram-positive, Escherichia coli [ATCC-25922] and Pseudomonas aeruginosa [MTCC-441] as gram-negative bacterial strains and antifungal activity against Aspergillus niger [MTCC-282]. Several derivatives exhibited pronounced antitubercular and antimicrobial activities.