savio dsouza - Academia.edu (original) (raw)
Papers by savio dsouza
The Journal of the Association of Physicians of India, 2015
D contracture is a slowly progressive f ibroproliferative disease of the palmar fascia in the han... more D contracture is a slowly progressive f ibroproliferative disease of the palmar fascia in the hand.1 The etiology and pathogenesis of Dupuytren disease are not well u n d e r s t o o d . A b n o r m a l c o l l a g e n deposition results in nodule and cord formation that causes the affected fingers to contract. Genetic associations of disease revealed reduced expression levels of three matrix metallopeptidases (MMP1,MMP3, MMP16), follistatin, and STAT1, and significantly increased expression levels of fibroblast growth factors (FGF9, FGF11) , a number of col lagen genes and other ECM genes in DD patient samples.2 Besides genetic predisposition, the other most common associations are cirrhosis of liver, diabetes and seizure disorders. Literature suggests that the frequency of Dupuytren’s disease is ten times greater in diabetes than in the general population, with an incidence of 5%.3 Although bilaterality of Dupuytren’s disease has been reported in 53% of the cases, in diabetics the...
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2018
Takayasu arteritis, also known as "pulseless disease" is an inflammatory disease characterized by... more Takayasu arteritis, also known as "pulseless disease" is an inflammatory disease characterized by large caliber artery inflammation. Although tuberculosis and syphilis are known to be associated with Takayasu arteritis, it is rarely found in association with Systemic Lupus Erythematosus (SLE). We report a case of 28-year-old Indian female with SLE, on low dose corticosteroids, she presented with hypertension and developed sudden onset of abdominal pain. She was found to have features suggestive of large vessel vasculitis. The patient was treated with one month of high dose corticosteroids and discharged. She was reviewed, once inflammation subsided and underwent procedure of placement of a self-expandable stent. She had improvement of blood pressure immediate post procedure and reduction of abdominal pain and claudication pain after two weeks of follow up. Although, SLE is known to involve small and medium-sized arteries, large vessel involvement and features of Takayasu arteritis are extremely rare, clinically.
Journal of clinical and diagnostic research : JCDR, 2017
Snake bites are common all around the world with a great prevalence in South Asia and the Indian ... more Snake bites are common all around the world with a great prevalence in South Asia and the Indian subcontinent. Although they are associated with common complications such as local swelling, bleeding at site of bite, coagulopathy, etc., few rare cardiac complications such as myocardial infarctions and arrhythmias have also been described in literature. The following is a case report of a patient who had a snake bite with a Russell's viper which resulted in atrial fibrillation, which resolved on treatment with anti snake venom.
Journal of clinical and diagnostic research : JCDR, 2017
Typhoid fever is a very common illness in developing countries. Patients most often present with ... more Typhoid fever is a very common illness in developing countries. Patients most often present with a history of fever, vomiting, anorexia, abdominal pain, etc. Rarely there is hepatic involvement due to the disease process. This is a case report of a 26-year-old male who had presented with fever, jaundice and ascites. The widal titres were found to be within normal limits (1:80) however the patient was found to have Salmonella typhi on ascitic fluid culture. The patient was treated with the appropriate antibiotics and was later discharged.
Journal of clinical and diagnostic research : JCDR, 2017
Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for par... more Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of death is either acute lung injury or multi-organ failure. To evaluate the role of early haemoperfusion as a therapy in paraquat poisoned patients. This study was a retrospective analysis of patients admitted to a Tertiary Medical College Hospital between January 2012 and December 2015 with history of paraquat consumption, comparing outcomes in those who received only gastric lavage and symptomatic treatment with those who received haemoperfusion as a therapy. The role of early haemoperfusion (≤ 6 hours) vs late haemoperfusion (> 6 hours) in paraquat poisoned patients was also compared. The data of these patients was extracted and analysed with respect to age, sex, mode of treatment, the outcome in patients who received early and late haemoperfusion. A total of 101 patients were studied out of which 62 died. Deaths were mo...
Journal of clinical and diagnostic research : JCDR, 2016
Pulmonary tuberculosis is a common infection associated with immunocompromised state. It usually ... more Pulmonary tuberculosis is a common infection associated with immunocompromised state. It usually presents with fibrosis or fibrocavitary lesions in the lung. We report a case of bilateral tuberculous pneumonia of acute presentation in a young lady who was being treated for systemic lupus erythematosus.
The Journal of the Association of Physicians of India, 2015
The Journal of the Association of Physicians of India, 2015
D contracture is a slowly progressive f ibroproliferative disease of the palmar fascia in the han... more D contracture is a slowly progressive f ibroproliferative disease of the palmar fascia in the hand.1 The etiology and pathogenesis of Dupuytren disease are not well u n d e r s t o o d . A b n o r m a l c o l l a g e n deposition results in nodule and cord formation that causes the affected fingers to contract. Genetic associations of disease revealed reduced expression levels of three matrix metallopeptidases (MMP1,MMP3, MMP16), follistatin, and STAT1, and significantly increased expression levels of fibroblast growth factors (FGF9, FGF11) , a number of col lagen genes and other ECM genes in DD patient samples.2 Besides genetic predisposition, the other most common associations are cirrhosis of liver, diabetes and seizure disorders. Literature suggests that the frequency of Dupuytren’s disease is ten times greater in diabetes than in the general population, with an incidence of 5%.3 Although bilaterality of Dupuytren’s disease has been reported in 53% of the cases, in diabetics the...
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2018
Takayasu arteritis, also known as "pulseless disease" is an inflammatory disease characterized by... more Takayasu arteritis, also known as "pulseless disease" is an inflammatory disease characterized by large caliber artery inflammation. Although tuberculosis and syphilis are known to be associated with Takayasu arteritis, it is rarely found in association with Systemic Lupus Erythematosus (SLE). We report a case of 28-year-old Indian female with SLE, on low dose corticosteroids, she presented with hypertension and developed sudden onset of abdominal pain. She was found to have features suggestive of large vessel vasculitis. The patient was treated with one month of high dose corticosteroids and discharged. She was reviewed, once inflammation subsided and underwent procedure of placement of a self-expandable stent. She had improvement of blood pressure immediate post procedure and reduction of abdominal pain and claudication pain after two weeks of follow up. Although, SLE is known to involve small and medium-sized arteries, large vessel involvement and features of Takayasu arteritis are extremely rare, clinically.
Journal of clinical and diagnostic research : JCDR, 2017
Snake bites are common all around the world with a great prevalence in South Asia and the Indian ... more Snake bites are common all around the world with a great prevalence in South Asia and the Indian subcontinent. Although they are associated with common complications such as local swelling, bleeding at site of bite, coagulopathy, etc., few rare cardiac complications such as myocardial infarctions and arrhythmias have also been described in literature. The following is a case report of a patient who had a snake bite with a Russell's viper which resulted in atrial fibrillation, which resolved on treatment with anti snake venom.
Journal of clinical and diagnostic research : JCDR, 2017
Typhoid fever is a very common illness in developing countries. Patients most often present with ... more Typhoid fever is a very common illness in developing countries. Patients most often present with a history of fever, vomiting, anorexia, abdominal pain, etc. Rarely there is hepatic involvement due to the disease process. This is a case report of a 26-year-old male who had presented with fever, jaundice and ascites. The widal titres were found to be within normal limits (1:80) however the patient was found to have Salmonella typhi on ascitic fluid culture. The patient was treated with the appropriate antibiotics and was later discharged.
Journal of clinical and diagnostic research : JCDR, 2017
Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for par... more Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of death is either acute lung injury or multi-organ failure. To evaluate the role of early haemoperfusion as a therapy in paraquat poisoned patients. This study was a retrospective analysis of patients admitted to a Tertiary Medical College Hospital between January 2012 and December 2015 with history of paraquat consumption, comparing outcomes in those who received only gastric lavage and symptomatic treatment with those who received haemoperfusion as a therapy. The role of early haemoperfusion (≤ 6 hours) vs late haemoperfusion (> 6 hours) in paraquat poisoned patients was also compared. The data of these patients was extracted and analysed with respect to age, sex, mode of treatment, the outcome in patients who received early and late haemoperfusion. A total of 101 patients were studied out of which 62 died. Deaths were mo...
Journal of clinical and diagnostic research : JCDR, 2016
Pulmonary tuberculosis is a common infection associated with immunocompromised state. It usually ... more Pulmonary tuberculosis is a common infection associated with immunocompromised state. It usually presents with fibrosis or fibrocavitary lesions in the lung. We report a case of bilateral tuberculous pneumonia of acute presentation in a young lady who was being treated for systemic lupus erythematosus.
The Journal of the Association of Physicians of India, 2015