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Papers by shafatuj jahan

Research paper thumbnail of Association between Inflammatory Markers and the Outcome of Critically Ill COVID-19 Patients

Scholars journal of applied medical sciences, Oct 4, 2022

Original Research Article Background: Coronavirus disease (COVID-19) is an infectious disease cau... more Original Research Article Background: Coronavirus disease (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). It had emerged from Wuhan, China and has rapidly spread around the world. In critically ill patients, the mortality rates are significantly high. This study analyzed the various inflammatory markers and their association with patient mortality, thus helping to identify critically ill patients with a high possibility of worsening prognosis. Materials and Methods: In this multicenter, prospective study, 85 patients were included and were followed until either of two outcomes was achieved: patients were successfully discharged or patients expired at the ICU. Correlation between the patient outcome and inflammatory markers were analyzed. Cutoff values for patients with worse prognosis were speculated through ROC curve. Results: Significantly, mortality was associated with CRP (P<0.001), d-dimer (P<0.001)., LDH (P=0.001), IL-6(P<0.001), serum ferritin(P=0.001), procalcitonin (P<0.001)along with neutropenia (P<0.001) and lymphocytosis (P<0.001). Conclusion: With the following inflammatory markers such as CRP, d-dimer, LDH, IL-6, procalcitonin and serum ferritin, patients who have a worse prognosis can be identified among the critically ill patients at the ICU. Hence, close monitoring and early management of such patients can help improve their prognosis.

Research paper thumbnail of Relation of Vaccination with Severity, Oxygen Requirement and Outcome of COVID-19 Infection in Chattogram, Bangladesh

Archives of Clinical and Biomedical Research, 2021

Introduction: Peoples all around the world are waiting for vaccination against COVID-19 infection... more Introduction: Peoples all around the world are waiting for vaccination against COVID-19 infection. In Bangladesh, Astra-Zeneca (AZ) vaccine was provided, but patients had infections of SARS-COV-2 even after vaccination. We focused on observing the severity, oxygen requirement and outcome of the COVID-19 infected patients who took the first dose or completed the immunization regimen. Methods: This is an observational study done among 174 COVID-19 patients from three COVID-19 dedicated hospitals of Chattogram, Bangladesh, who took AZ vaccines 1st dose or completed the schedule. All patients were Real-Time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) positive for COVID-19. Patients were enrolled after receiving written informed consent. Suspected cases or unwilling patients were excluded from the study. Ethical approval was granted by the CMOSH-ERB. SPSS-20 was used to analyze the information gathered. Results: Among 174 vaccinated patients, 55 (31.61%) completed the vaccination schedule, and 119 (68.39%) took their 1st dose of the COVID-19 vaccine. Gender distributions revealed 67 (38.5%) female and 107 (61.5%) male got the vaccine, and 55 patients completed the full two doses, and 119 patients took the 1st dose. Most of the patients were 40 years and above. In the completed vaccination group, 33 (60.0%) out of 55 in and in the first dose vaccinated group, 75 (63.0%) out of 119 had a mild COVID-19, and severe and critical cases were found very minimum. Among the patients who have completed the vaccination, 32 (58.2%) needed no oxygen, and who was given the first dose, 78 (65%) needed no oxygen. No death occurred who completed the vaccine, and 3 (2.5%) patients died who took 1st dose of the vaccine. Conclusion: Vaccine provided in Bangladesh to the people so far seems safe and effective. Severe and critical COVID-19 is low, and the need for oxygen to admitted patients is less, and the death rate is minimal.

Research paper thumbnail of Association between Inflammatory Markers and the Outcome of Critically Ill COVID-19 Patients

Scholars journal of applied medical sciences, Oct 4, 2022

Original Research Article Background: Coronavirus disease (COVID-19) is an infectious disease cau... more Original Research Article Background: Coronavirus disease (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). It had emerged from Wuhan, China and has rapidly spread around the world. In critically ill patients, the mortality rates are significantly high. This study analyzed the various inflammatory markers and their association with patient mortality, thus helping to identify critically ill patients with a high possibility of worsening prognosis. Materials and Methods: In this multicenter, prospective study, 85 patients were included and were followed until either of two outcomes was achieved: patients were successfully discharged or patients expired at the ICU. Correlation between the patient outcome and inflammatory markers were analyzed. Cutoff values for patients with worse prognosis were speculated through ROC curve. Results: Significantly, mortality was associated with CRP (P<0.001), d-dimer (P<0.001)., LDH (P=0.001), IL-6(P<0.001), serum ferritin(P=0.001), procalcitonin (P<0.001)along with neutropenia (P<0.001) and lymphocytosis (P<0.001). Conclusion: With the following inflammatory markers such as CRP, d-dimer, LDH, IL-6, procalcitonin and serum ferritin, patients who have a worse prognosis can be identified among the critically ill patients at the ICU. Hence, close monitoring and early management of such patients can help improve their prognosis.

Research paper thumbnail of Relation of Vaccination with Severity, Oxygen Requirement and Outcome of COVID-19 Infection in Chattogram, Bangladesh

Archives of Clinical and Biomedical Research, 2021

Introduction: Peoples all around the world are waiting for vaccination against COVID-19 infection... more Introduction: Peoples all around the world are waiting for vaccination against COVID-19 infection. In Bangladesh, Astra-Zeneca (AZ) vaccine was provided, but patients had infections of SARS-COV-2 even after vaccination. We focused on observing the severity, oxygen requirement and outcome of the COVID-19 infected patients who took the first dose or completed the immunization regimen. Methods: This is an observational study done among 174 COVID-19 patients from three COVID-19 dedicated hospitals of Chattogram, Bangladesh, who took AZ vaccines 1st dose or completed the schedule. All patients were Real-Time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) positive for COVID-19. Patients were enrolled after receiving written informed consent. Suspected cases or unwilling patients were excluded from the study. Ethical approval was granted by the CMOSH-ERB. SPSS-20 was used to analyze the information gathered. Results: Among 174 vaccinated patients, 55 (31.61%) completed the vaccination schedule, and 119 (68.39%) took their 1st dose of the COVID-19 vaccine. Gender distributions revealed 67 (38.5%) female and 107 (61.5%) male got the vaccine, and 55 patients completed the full two doses, and 119 patients took the 1st dose. Most of the patients were 40 years and above. In the completed vaccination group, 33 (60.0%) out of 55 in and in the first dose vaccinated group, 75 (63.0%) out of 119 had a mild COVID-19, and severe and critical cases were found very minimum. Among the patients who have completed the vaccination, 32 (58.2%) needed no oxygen, and who was given the first dose, 78 (65%) needed no oxygen. No death occurred who completed the vaccine, and 3 (2.5%) patients died who took 1st dose of the vaccine. Conclusion: Vaccine provided in Bangladesh to the people so far seems safe and effective. Severe and critical COVID-19 is low, and the need for oxygen to admitted patients is less, and the death rate is minimal.