shafeek sanbar - Academia.edu (original) (raw)

Papers by shafeek sanbar

American Heart Journal, 1969

The Journal of Law, Medicine & Ethics, 1978

... Is Mental Health Advocacy Under Attack? ... that the legal concept of dangerousness which is ... more ... Is Mental Health Advocacy Under Attack? ... that the legal concept of dangerousness which is now required for involuntary commitments, unreasonably restricts the physician-psychiatrist in ... While mental health advocates favor the need for a showing of an overt act to support the ...

The Journal of the Oklahoma State Medical Association, 1975

The Journal of the Oklahoma State Medical Association, 1976

Journal of Legal Medicine, 1983

1. J Leg Med. 1983 Mar;4(1):87-108. Developing standards of care for the diagnosis and treatment ... more 1. J Leg Med. 1983 Mar;4(1):87-108. Developing standards of care for the diagnosis and treatment of coronary artery disease. Sanbar SS, Thompson CS. PMID: 6602197 [PubMed - indexed for MEDLINE]. Publication Types: Research Support, Non-US Gov't. MeSH Terms: ...

Metabolism, 1966

Abstract The effect of intravenous administration of L-leucine on glucose turnover was investigat... more Abstract The effect of intravenous administration of L-leucine on glucose turnover was investigated in 8 healthy, anesthetized dogs, each serving as its own control, by 2 isotope dilution technics: the method of successive measured injection of tracer glucose-U-C 14 (3 dogs) and the procedure of priming injection-continuous infusion of tracer (5 dogs). Results obtained with both technics were complementary. In dogs, infusion of 0.5 Gm. L-leucine/Kg. body weight over a period of 30 minutes evoked a consistent and significant reduction in plasma glucose concentration, with mean ± 1 S.E. maximal decrease of 19 ± 1.7 mg. per cent. The intermixing glucose mass was also significantly decreased by an average of 64 mg./Kg. body weight while the apparent distribution space of glucose unaltered. Both rates of glucose appearance, Ra (primarily hepatic production) and disappearance, Rd (tissue utilization) were decreased during infusion of L-leucine with mean maximal diminution of 55 per cent in Ra at t=5 minutes and 45 per cent in Rd at t=20 minutes after starting L-leucine; both rates returned to control values after stopping the infusion of L-leucine. The changes in both rates of glucose appearance and disappearance occurred within minutes after starting L-leucine infusion, but the effect on Ra was proportionately greater than the Rd effect, thereby accounting for the decrements in plasma glucose concentration and intermixing glucose mass. These alterations in glucose turnover in dogs are discussed in light of recent findings by others that L-leucine stimulates increased release of insulin.

Circulation, 1968

Intravenous infusion of 500 ml of 6% polyvinylpyrrolidone (PVP, average molecular weight 40,000) ... more Intravenous infusion of 500 ml of 6% polyvinylpyrrolidone (PVP, average molecular weight 40,000) in isotonic saline solution daily for 2 days induced prompt and significant reductions in serum cholesterol and triglyceride concentrations in eight hyperlipidemic patients. Mean maximal decrements in serum cholesterol and triglyceride were 29% and 28% below control values, respectively, occurring 5 days after infusion of PVP. Mean values for hematocrit and total serum protein concentration were slightly decreased following PVP infusion, but there were no changes in percentage composition of serum proteins, blood sugar, serum sodium and potassium, body weight, and blood pressure. The hypolipidemic effect of PVP persisted beyond the period of plasma volume expansion, as demonstrated by measurement of the plasma volume isotopically and by long-term follow-up in five of the patients.

Canadian Journal of Physiology and Pharmacology, 1967

Studies were carried out in anesthetized dogs to elucidate the mechanism of action of octanoate o... more Studies were carried out in anesthetized dogs to elucidate the mechanism of action of octanoate on glucose metabolism.Octanoate infusion in intact healthy dogs significantly decreased plasma glucose concentration, and in four out of seven dogs it raised plasma insulin concentration in peripheral blood. In contrast, intravenous administration of octanoate in four totally pancreatectomized dogs produced only small changes in plasma glucose concentration. These data suggest that the hypoglycemic action of octanoate may be mediated by increased secretion of insulin.The mean k value ([Formula: see text] of plasma glucose concentration) of intravenous glucose tolerance tests was significantly higher (2.38/minute) in healthy dogs that received an infusion of octanoate than in dogs that did not (1.2/minute). Octanoate also produced in healthy dogs greater increases in plasma insulin concentrations of peripheral blood during the tolerance tests. Furthermore, when delivered during a continuou...

Biochimica et Biophysica Acta, 1963

The American Journal of Cardiology, 1970

Lebanese Medical Journal, 1961

Journal of Laboratory and Clinical Medicine, 1964

Thrombosis et diathesis haemorrhagica, Oct 31, 1970

SummaryIn 30 non-anesthetized rabbits, platelet adhesiveness of arterial blood was determined bef... more SummaryIn 30 non-anesthetized rabbits, platelet adhesiveness of arterial blood was determined before and 2, 6, and 24 h after 10 min intravenous infusions of either 20 ml isotonic saline solution (5 control rabbits), or 2.4 g each of dextran 40,000 (4 rabbits), dextran 70,000 (4 rabbits), polyvinylpyrrolidone (P. V. P.) 40,000 (8 rabbits), hydroxyethyl starch (H. E. S.) 60,000 (4 rabbits), or H. E. S. 450,000 (5 rabbits) in saline solution.Platelet adhesiveness did not change significantly after infusions of saline, dextran 40,000, or H. E. S. 450,000. In contrast, dextran 70,000 and H. E. S. 60,000 promptly produced about one-third decrease in platelet adhesiveness which returned toward control levels 24 h after the infusions. Finally, P.V.P. also promptly diminished percent platelet adhesiveness by about one-third of control values and this effect persisted 24 h after infusion. Changes in platelet adhesiveness did not correlate with alterations in hematocrit or platelet count.On a weight basis, P. V. P. elicits the most persistent decrease in platelet adhesiveness.

The Journal of the Oklahoma State Medical Association, 1977

The Journal of the Oklahoma State Medical Association, 1975

American Heart Journal, 1969

The Journal of Law, Medicine & Ethics, 1978

... Is Mental Health Advocacy Under Attack? ... that the legal concept of dangerousness which is ... more ... Is Mental Health Advocacy Under Attack? ... that the legal concept of dangerousness which is now required for involuntary commitments, unreasonably restricts the physician-psychiatrist in ... While mental health advocates favor the need for a showing of an overt act to support the ...

The Journal of the Oklahoma State Medical Association, 1975

The Journal of the Oklahoma State Medical Association, 1976

Journal of Legal Medicine, 1983

1. J Leg Med. 1983 Mar;4(1):87-108. Developing standards of care for the diagnosis and treatment ... more 1. J Leg Med. 1983 Mar;4(1):87-108. Developing standards of care for the diagnosis and treatment of coronary artery disease. Sanbar SS, Thompson CS. PMID: 6602197 [PubMed - indexed for MEDLINE]. Publication Types: Research Support, Non-US Gov't. MeSH Terms: ...

Metabolism, 1966

Abstract The effect of intravenous administration of L-leucine on glucose turnover was investigat... more Abstract The effect of intravenous administration of L-leucine on glucose turnover was investigated in 8 healthy, anesthetized dogs, each serving as its own control, by 2 isotope dilution technics: the method of successive measured injection of tracer glucose-U-C 14 (3 dogs) and the procedure of priming injection-continuous infusion of tracer (5 dogs). Results obtained with both technics were complementary. In dogs, infusion of 0.5 Gm. L-leucine/Kg. body weight over a period of 30 minutes evoked a consistent and significant reduction in plasma glucose concentration, with mean ± 1 S.E. maximal decrease of 19 ± 1.7 mg. per cent. The intermixing glucose mass was also significantly decreased by an average of 64 mg./Kg. body weight while the apparent distribution space of glucose unaltered. Both rates of glucose appearance, Ra (primarily hepatic production) and disappearance, Rd (tissue utilization) were decreased during infusion of L-leucine with mean maximal diminution of 55 per cent in Ra at t=5 minutes and 45 per cent in Rd at t=20 minutes after starting L-leucine; both rates returned to control values after stopping the infusion of L-leucine. The changes in both rates of glucose appearance and disappearance occurred within minutes after starting L-leucine infusion, but the effect on Ra was proportionately greater than the Rd effect, thereby accounting for the decrements in plasma glucose concentration and intermixing glucose mass. These alterations in glucose turnover in dogs are discussed in light of recent findings by others that L-leucine stimulates increased release of insulin.

Circulation, 1968

Intravenous infusion of 500 ml of 6% polyvinylpyrrolidone (PVP, average molecular weight 40,000) ... more Intravenous infusion of 500 ml of 6% polyvinylpyrrolidone (PVP, average molecular weight 40,000) in isotonic saline solution daily for 2 days induced prompt and significant reductions in serum cholesterol and triglyceride concentrations in eight hyperlipidemic patients. Mean maximal decrements in serum cholesterol and triglyceride were 29% and 28% below control values, respectively, occurring 5 days after infusion of PVP. Mean values for hematocrit and total serum protein concentration were slightly decreased following PVP infusion, but there were no changes in percentage composition of serum proteins, blood sugar, serum sodium and potassium, body weight, and blood pressure. The hypolipidemic effect of PVP persisted beyond the period of plasma volume expansion, as demonstrated by measurement of the plasma volume isotopically and by long-term follow-up in five of the patients.

Canadian Journal of Physiology and Pharmacology, 1967

Studies were carried out in anesthetized dogs to elucidate the mechanism of action of octanoate o... more Studies were carried out in anesthetized dogs to elucidate the mechanism of action of octanoate on glucose metabolism.Octanoate infusion in intact healthy dogs significantly decreased plasma glucose concentration, and in four out of seven dogs it raised plasma insulin concentration in peripheral blood. In contrast, intravenous administration of octanoate in four totally pancreatectomized dogs produced only small changes in plasma glucose concentration. These data suggest that the hypoglycemic action of octanoate may be mediated by increased secretion of insulin.The mean k value ([Formula: see text] of plasma glucose concentration) of intravenous glucose tolerance tests was significantly higher (2.38/minute) in healthy dogs that received an infusion of octanoate than in dogs that did not (1.2/minute). Octanoate also produced in healthy dogs greater increases in plasma insulin concentrations of peripheral blood during the tolerance tests. Furthermore, when delivered during a continuou...

Biochimica et Biophysica Acta, 1963

The American Journal of Cardiology, 1970

Lebanese Medical Journal, 1961

Journal of Laboratory and Clinical Medicine, 1964

Thrombosis et diathesis haemorrhagica, Oct 31, 1970

SummaryIn 30 non-anesthetized rabbits, platelet adhesiveness of arterial blood was determined bef... more SummaryIn 30 non-anesthetized rabbits, platelet adhesiveness of arterial blood was determined before and 2, 6, and 24 h after 10 min intravenous infusions of either 20 ml isotonic saline solution (5 control rabbits), or 2.4 g each of dextran 40,000 (4 rabbits), dextran 70,000 (4 rabbits), polyvinylpyrrolidone (P. V. P.) 40,000 (8 rabbits), hydroxyethyl starch (H. E. S.) 60,000 (4 rabbits), or H. E. S. 450,000 (5 rabbits) in saline solution.Platelet adhesiveness did not change significantly after infusions of saline, dextran 40,000, or H. E. S. 450,000. In contrast, dextran 70,000 and H. E. S. 60,000 promptly produced about one-third decrease in platelet adhesiveness which returned toward control levels 24 h after the infusions. Finally, P.V.P. also promptly diminished percent platelet adhesiveness by about one-third of control values and this effect persisted 24 h after infusion. Changes in platelet adhesiveness did not correlate with alterations in hematocrit or platelet count.On a weight basis, P. V. P. elicits the most persistent decrease in platelet adhesiveness.

The Journal of the Oklahoma State Medical Association, 1977

The Journal of the Oklahoma State Medical Association, 1975