shalini salwan - Academia.edu (original) (raw)

Papers by shalini salwan

Ca2+ channel antagonists find their uses as anti-arrhythmic agents and in the treatment of hypert... more Ca2+ channel antagonists find their uses as anti-arrhythmic agents and in the treatment of hypertension and CHF.Besides a wide variety of uses in angina,migraine,raynaud's disease,clinical trials are underway to evaluate their role to slow the progression of renal failure.In view of the above, efforts are on to develop new compounds having Ca2+ channel blocking activity. To compare the smooth muscle relaxant activity of dihydropyrimidine derivatives 5-acyl-6-methyl-4-phenyl-2-S-ethyl-1,4-dihydropyrimidine(BK VI) and 5-acyl-6-methyl-4(2,3 methylenedioxy) Phenyl 2-S-benzyl-1,4-dihydropyrimidine (BK VII) on isolated rat uterus. Effect of the test compounds BK-VI, BK-VII and nifedipine on the smooth muscles of isolated rat uterus was observed. Observations were made with increasing bath concentrations of each compound. Six preparations were used for each dose of BK-VI, BK-VII and nifedipine. Mean effect of increasing doses of BK-VI,BK-VII and nifedipine on the height of Ca2+ depend...

Ca2+ channel antagonists find their uses as anti-arrhythmic agents and in the treatment of hypert... more Ca2+ channel antagonists find their uses as anti-arrhythmic agents and in the treatment of hypertension and CHF.Besides a wide variety of uses in angina,migraine,raynaud’s disease,clinical trials are underway to evaluate their role to slow the progression of renal failure.In view of the above, efforts are on to develop new compounds having Ca2+ channel blocking activity. To compare the smooth muscle relaxant activity of dihydropyrimidine derivatives 5-acyl-6-methyl-4-phenyl-2-S-ethyl-1,4-dihydropyrimidine(BK VI) and 5-acyl-6-methyl-4(2,3 methylenedioxy) Phenyl 2-S-benzyl-1,4-dihydropyrimidine (BK VII) on isolated rat uterus. Effect of the test compounds BK-VI, BK-VII and nifedipine on the smooth muscles of isolated rat uterus was observed. Observations were made with increasing bath concentrations of each compound. Six preparations were used for each dose of BK-VI, BK-VII and nifedipine. Mean effect of increasing doses of BKVI,BK-VII and nifedipine on the height of Ca2+ dependent, K...

Research and reviews: journal of medical and health sciences, 2014

Lornoxicam is comparatively a newer NSAID. This study was done to compare the efficacy and tolera... more Lornoxicam is comparatively a newer NSAID. This study was done to compare the efficacy and tolerability of lornoxicam and diclofenac in the treatment of patients suffering from osteoarthritis over 32 weeks. A randomized, open, parallel-group trial of patients with OA of knee enrolled 223 patients. Out of 223 patients enrolled 216 patients participated in the study. The available patients were randomly divided into two groups. One group of 108 patients received lornoxicam 4-8 mg BID. for 32 weeks, another group of 108 patients received diclofenac 50-100 mg TID. for 32 weeks. Assessments were made at baseline, 4 weeks, 8 weeks and then every 10 weeks. They comprised pain score, adverse reactions and withdrawals. The VAS score was reduced in lornoxicam group by 22.51% and 19.16% in diclofenac group. These values were significant from baseline values in both the groups and reduction in lornoxicam group was significant in comparison to diclofenac group. During the next 22 weeks pain inte...

Objective: To investigate the myocardial depressant activity of a dihydropyrimidine derivative 5-... more Objective: To investigate the myocardial depressant activity of a dihydropyrimidine derivative 5-acyl-6methyl-4-phenyl-2-S-ethyl-1,4-dihydropyrimidine (BK-VI) and 5-acyl-6-methyl-4(2,3 methylenedioxy) Phenyl 2-S-benzyl-1,4-dihydropyrimidine (BK VII)and comparing with nifedipine on Isolated perfused rabbit heart. Material and Methods: Effects of the test compoundS BK-VI and BK-VII on the amplitude,heart rate and coronary flow on isolated perfused rabbit heart was noted and compared with nifedipine.Observations were made with increasing concentrations of BK-VI, BK-VII and Nifedipine with dimethylsulfoxide(DMSO) as the solvent.Six preparations were used for each dose of BK-VI,BK-VII and nifedipine.Heart rate ,amplitude and coronary flow were noted down every minute for five minutes after injection of each drug and control. Results: On comparing the effects of BK-VI,BK-VII and nifedipine, it was found that all the compounds under investigation had a negative inotropic and negative chron...

International Journal of Advanced Research, 2018

Aim: Pharmacotherapy might be improved if MBBS students receive an integrated educational program... more Aim: Pharmacotherapy might be improved if MBBS students receive an integrated educational programme in pharmacology and pharmacotherapeutics. This study investigated whether there are differences in the pharmacology and pharmacotherapy knowledge between medical students and interns after their undergraduate training. Differences could serve as a starting point from which integrated educational programmes can be developed for better MBBS education. Methods: In a cross-sectional design, the knowledge of medical students and interns were assessed, using a standardized test with four domains (Emergency conditions, cardiovascular pharmacology, analgesics and Chemotherapy). Results: One hundred medical students and one hundred interns were included in the cross-sectional questionnaire based study. The response rate was 91.36% for MBBS and 98.16% for Interns. Interns had better knowledge of Cardivascular pharmacology than medical students (mean score of Interns 4.53± 1.3; MBBS 2.35± 1.2).In addition, data related to drugs used in emergency and chemotherapy showed much better knowledge of the interns (mean score of Interns 2.24± 0.7; & MBBS 1.97± 0.7) and (mean score of Interns 4.12± 1.05 & MBBS 3.5± 1.23) respectively. However, the two groups had almost similar knowledge of analgesic use and dosage (mean score of Interns 2.53± 0.78 & MBBS 2.41± 0.93). Conclusions: Interns have better knowledge of basic pharmacology and of the application of knowledge of pharmacology than medical students. Differences in knowledge and skills therefore might well stem from their undergraduate education. Knowledge of these differences could be harnessed to develop an integrated teaching programme for medical students.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016

International Journal of Medical and Clinical Research, 2012

Objective-To investigate the myocardial depressant activity of a newly synthesised dihydropyrimid... more Objective-To investigate the myocardial depressant activity of a newly synthesised dihydropyrimidine derivative 5-acyl-6-methyl-4-phenyl-2-S-ethyl-1,4-dihydropyrimidine (BK-vi) and comparing with nifedipine on Isolated perfused rabbit heart. Material and Methods-Effects of the test compound BK-vi on the amplitude,heart rate and coronary flow on isolated perfused rabbit heart was compared with nifedipine.Observations were made with increasing concentrations of BK-vi and Nifedipine with dimethylsulfoxide (DMSO) as the solvent.Six preparations were used for each dose of BK-vi and nifedipine.Heart rate ,amplitude and coronary flow were noted down every minute for five minutes after injection of each drug and control. Results-On comparing the effects of BK-vi and nifedipine, it was found that both had a negative inotropic and negative chronotropic effect. Compound BK-vi did not produce significant effect on heart rate at all the four doses. In comparison, nifedipine produced a significant to highly significant decrease in heart rate.Significant decrease in amplitude with BK-vi was seen at dose of 7.29 X 10-4M and 14.5 X 10-4M by 42% and 56.98% respectively and in coronary flow by 39.95% at dose of 14.5 X 10-4M .Nifedipine significantly decreased heart rate and amplitude at all doses with cardiac arrest at 4.6 X 10-5M.A significant increase in coronary flow was seen with nifedipine by 9.4% and 13% at doses of 0.5 X 10-5M and 1.15 X 10-5M respectively though this property was lost at higher doses.On comparison, BK-vi produced significant myocardial depression at much higher dose than nifedipine. Conclusion-BK-vi has calcium channel blocking activity like nifedipine and produced less potent myocardial depression in comparison with nifedipine.

Journal of Pharmacovigilance and Drug Research, 2021

Introduction: Health care professionals dealing with pediatric patients face a lot of challenges ... more Introduction: Health care professionals dealing with pediatric patients face a lot of challenges and pass through hurdles during their daily practice of medicines owing to the scarcity of suitable drugs and other facilities. A fundamental part of the antibiotic prescription is inappropriate due to errors in the selection of appropriate antibiotics, dose, duration, route of administration, and frequency for treatment. Medication use evaluation and audits are an integral part of evaluating whether the drugs are being utilized appropriately considering the social, economic, and medical points. Objectives: The main objective of this study was to do an antibiotic audit to analyze the prescribing pattern in the in-patient department of pediatrics of the hospital. Methods: A prospective observational study was conducted in the inpatient pediatrics department of Punjab Institute of Medical Science and Hospital, Jalandhar. The study was conducted on a total of 150 hospitalized children and i...

Background: Recurrent syncope is a distressing symptom in which the cause may remain undetermined... more Background: Recurrent syncope is a distressing symptom in which the cause may remain undetermined. A definitive diagnosis may help the patients to lead a normal life and avoid the unnecessary risk to their lives. Objective: To evaluate the effectiveness and safety of Head up Tilt Test (HUTT) in patients with undiagnosed syncope and to detect and follow up any complications arising out of the procedure. Material and methods: The head up tilt table test was performed in department of cardiology. 72 patients with a history of syncope or presyncope underwent upright tilt table testing to exclude vasovagal syncope, with baseline tilt and if negative followed by progressively increasing doses of isoprenaline infusion. 70° tilt was used and continuous heart rate and non-invasive BP recordings were made every 2 minutes or earlier when symptomatic. Results: The mean age of the patients was 48±16 years. None of the patients had carotid sinus hypersensitivity. Forty-five patients (62.5%) were ...

International Journal of Basic & Clinical Pharmacology

Background: Drug utilization studies promote rational use of drugs and help to decrease the adver... more Background: Drug utilization studies promote rational use of drugs and help to decrease the adverse drug reactions. Such studies are powerful tools to evaluate the role of drugs in the society. The present study is aimed to analyse and evaluate the trends and patterns of prescribing drugs among chronic obstructive pulmonary disease (COPD) patients.Methods: A prospective observational study was conducted in 112 patients of COPD admitted in the general and pulmonary medicine departments over a period of 1-year in SGT Medical College, Hospital and Research Institute, SGT University, Gurugram. Patients, who satisfied the inclusion criteria, were enrolled in the study after taking informed consent. Data was collected by using the specially designed data entry form and put in tabulated form. The results were expressed as percentages. The following information was collected for each patient: social demographics, smoking history, prescribed COPD treatments. Health related quality of life in...

Journal of Drug Delivery and Therapeutics, 2015

Journal of Drug Delivery and Therapeutics, 2012

Journal of Research in Medical Education & Ethics, 2012

Ca2+ channel antagonists find their uses as anti-arrhythmic agents and in the treatment of hypert... more Ca2+ channel antagonists find their uses as anti-arrhythmic agents and in the treatment of hypertension and CHF.Besides a wide variety of uses in angina,migraine,raynaud’s disease,clinical trials are underway to evaluate their role to slow the progression of renal failure.In view of the above, efforts are on to develop new compounds having Ca2+ channel blocking activity. To compare the smooth muscle relaxant activity of dihydropyrimidine derivatives 5-acyl-6-methyl-4-phenyl-2-S-ethyl-1,4-dihydropyrimidine(BK VI) and 5-acyl-6-methyl-4(2,3 methylenedioxy) Phenyl 2-S-benzyl-1,4-dihydropyrimidine (BK VII) on isolated rat uterus. Effect of the test compounds BK-VI, BK-VII and nifedipine on the smooth muscles of isolated rat uterus was observed. Observations were made with increasing bath concentrations of each compound. Six preparations were used for each dose of BK-VI, BK-VII and nifedipine. Mean effect of increasing doses of BKVI,BK-VII and nifedipine on the height of Ca2+ dependent, K...