sherin shazly - Academia.edu (original) (raw)

Papers by sherin shazly

Journal of obstetrics and gynaecology of India, 2018

To compare between the sequential and concurrent use of vaginal misoprostol plus Foley catheter f... more To compare between the sequential and concurrent use of vaginal misoprostol plus Foley catheter for labor induction. This single-center, non-blinded randomized study was conducted at the department of Obstetrics and Gynecology, Faculty of medicine, Zagazig University. A total of 160 women with full term singleton pregnancy, cephalic presentation and bishop score ≤ 6 were randomized for labor induction with either concurrent or sequential use of vaginal misoprostol plus Foley catheter (80 cases in each group). The primary outcome measured was induction-to-delivery interval and secondary outcomes mesaured were vaginal delivery within 24 h, number of doses needed to induce labor, need of oxytocin for augmentation of labor, cesarean section rate, maternal or neonatal complications. The mean induction-to-delivery interval was 22.33 ± 13.28 h versus 18.45 ± 14.34 h ( = 0.041) in sequential and concurrent group, respectively. The percentage of women who completed vaginal delivery within 24...

The Journal of Maternal-Fetal & Neonatal Medicine, 2017

Does implementing a regime of Dexamethasone before planned cesarean section at term reduce admiss... more Does implementing a regime of Dexamethasone before planned cesarean section at term reduce admission with respiratory morbidity to neonatal intensive care unit? A randomized controlled trial

The Egyptian Journal of Hospital Medicine

Background: Expectant parents are extremely interested in learning the gender of the fetus during... more Background: Expectant parents are extremely interested in learning the gender of the fetus during the early stages of pregnancy. Yet, clinicians are also interested in identifying the gender of fetuses at increased risk of inheriting genderdependent genetic diseases. In the presence of hereditary illnesses associated with gender, it becomes a necessity rather than an interest. Objective: The aim of the current study is to evaluate the reliability of early-trimester fetal sex diagnosis of pregnancy, as well as the relationship between anogenital distance (AGD) in the first trimester and fetal sex determination. Patients and methods: A prospective cohort study was conducted at the Department Obstetrics and Gynecology of Zagazig University Hospitals, from August 2021 to December 2022. The study included 245 pregnant women, aged between 18 and 35 years. Participants were singleton pregnancy with gestational age from 11 to 13 weeks (+6 days). The enrolled pregnant women in our study were divided into 3 groups; Group 1 included fetuses that aged 11 weeks (+6 days), Group 2 included fetuses that aged 12 weeks (+6 days), and Group 3 included fetuses that aged 13 weeks (+6 days). Result: Our research indicated no statistically significant difference between AGD in groups 2 and 3 (P=0.758), although there was a statistically significant difference between Group 1 and both Groups 2 and 3 (P<0.001), thus, both groups 2 and 3 were combined into one group. It was established that the optimal cutoff value for the merged group was 4.9mm, AUC 0.961 (P<0.000). The sensitivity was 93.41%, specificity was 86.49%, positive predictive value 89.47%, negative predictive value 91.43%, and likelihood ratio 6.91. Conclusion: This research backs the use of fetal AGD measurement as a new ultrasonographic technique signal for determining a baby's gender early on. This procedure appears to be accurate, especially after 12 weeks of pregnancy. It is recommended measuring AGD during the first trimester of early pregnancy for accurate gender prediction.

Egyptian Journal of Medical Microbiology

The immune response of the mother against her embryo is supposed to be responsible for about 50 %... more The immune response of the mother against her embryo is supposed to be responsible for about 50 % of recurrent spontaneous abortion (RSA) case. Objectives: To assess the prevalence of HLA-G 14bp insertion/deletion (ins/del) polymorphism in females with RSA and normal pregnant females and compare the plasma levels of soluble HLA-G (sHLA-G) in the studying groups. Also, we intended to explore the association between HLA-G 14 bp polymorphism and sHLA-G plasma levels. Methodology: This case-control study involved 50 females with RSA and 50 control pregnant females. The genotype for HLA-G 14 bp (ins/del) polymorphism was performed by PCR and their sHLA-G plasma levels were measured. Results: The HLA-G del/del genotype and ins/ins genotype frequencies were significantly different in RSA group as compared to controls (P=0.002). Additionally, the incidence of the 14-bp ins allele was significantly raised in RSA group than in control (67 vs. 41%, respectively; P=0.0004). Consequently, the higher frequency of 14-bp ins allele in RSA group as compared to controls indicate that this allele is associated with an increased risk of RSA (OR 2.9, 95% CI: 1.6-5.2, P=0.0003). Conclusion: The plasma level of sHLA-G is a promising marker in the management of RSA and could be an early indicator of the fate of In Vitro Fertilization (IVF). The polymorphism in the HLA-G gene, specifically, in the 3′UTR region of exon 8 affects the plasma level of sHLA-G and subsequent pregnancy outcome.

International Journal of Breast Cancer

Background. Triple negative breast cancer (TNBC) is a biologically separate entity of breast canc... more Background. Triple negative breast cancer (TNBC) is a biologically separate entity of breast cancer that cannot get benefits from targeted or endocrine therapy. Objective. To assess the expression of MALAT1 and BACH1, as well as monocyte-myeloid-derived suppressor cell (Mo-MDSC) levels and circulating tumor cell (CTC) count in TNBC to correlate these markers with the clinic-pathological criteria of TNCB patients and to evaluate their roles as predictive markers for selection of the patients that can be operated by oncoplastic conserving breast surgery. Methods. Eighty-eight TNBC were managed by modified doughnut breast oncoplastic surgery in early stages and by modified radical mastectomy for patients with late stages unsuitable for breast-conserving. All were examined for MALAT1 and BACH1 expression by immunohistochemistry and RT-PCR as well as Mo-MDSC levels and CTCs. Results. MALAT1 and BACH1 expressions are correlated with the larger size, lymph node, distance metastasis, and TN...

The Journal of Obstetrics and Gynecology of India

Pregnant PCOS patients were found to suffer from many adverse outcomes of pregnancy. Prediction o... more Pregnant PCOS patients were found to suffer from many adverse outcomes of pregnancy. Prediction of the fate of pregnancy and labor in PCOS patients was highly needed. There were recently discovered roles of serum AMH in those patients who were seeking for pregnancy and who were conceiving with assisted reproductive techniques. To analyze the predictive roles of measuring serum levels of AMH in patients with PCOS who became pregnant spontaneously or used assisted reproductive techniques regarding abortion and preterm delivery. A total of 100 females with PCOS were included in the study and they underwent assisted reproductive techniques were included in the study and underwent measurement of AMH levels regularly. We found that a total of 70 patients had a term delivery, and 30 patients had a preterm delivery. We found no statistically significant differences between both groups regarding their age or body mass index (BMI). We showed that serum AMH levels were higher in the group of PCOS patients who had preterm delivery than in the group of patients with term delivery (p < .0.001). High serum AMH levels were found to be associated with higher risks of occurrence of preterm labor in patients with PCOS who underwent assisted reproductive techniques. Our results gave a clue to clinicians for better management of the pregnancy process in these patients.

Fertility Science and Research, 2021

Objectives: To assess the effect of booster dose of human chorionic gonadotropin (HCG) on the unr... more Objectives: To assess the effect of booster dose of human chorionic gonadotropin (HCG) on the unruptured follicles in non-in vitro fertilization/intracytoplasmic sperm injection cycles. Setting and design: This randomized controlled multicenter study was conducted at Tanta and Zagazig University hospitals in the period from August 1, 2018 to January 1, 2021. Patients and methods: Enrolled patients (n = 160) who had unruptured mature Graafian follicle 48 hours after intramuscular (IM) 10,000 IU HCG dose. Patients were allocated randomly into intervention group and control group. In the intervention group, another booster dose (10,000 IU of HCG) was given IM, whereas in the control group, 1 mL normal saline was given IM. Study outcomes: Ovulation and pregnancy rates. Results: The number of cases who had follicular rupture was similar to those in the control group. The incidence of luteinized unruptured follicle (LUF) was nearly similar in both groups. No significant differences were noticed regarding pregnancy rates in both groups. Conclusion: Booster dose of HCG for unruptured follicles has no benefit in ovulation triggering nor in the prevention of LUF syndrome. There was no significant difference in pregnancy rates in both groups.

The Egyptian Journal of Medical Microbiology, 2017

Background: Miscarriage is the most common adverse outcome of pregnancy. Bacterial vaginosis (BV)... more Background: Miscarriage is the most common adverse outcome of pregnancy. Bacterial vaginosis (BV) is known as alteration of vaginal milieu. C. trachomatis is intracellular, sexually transmitted bacteria. Objectives: we aimed to investigating the role of BV and C. trachomatis in 1 st trimester miscarriage. Methodology: This study included 95 pregnant women with gestational age < 14 weeks. For each subject we investigate BV by Amsel's criteria and Nugent scoring. Anti chlamydial IgG antibodies were detected using qualitative ELISA. C. trachomatis DNA of cryptic plasmid were detected in urine sample by polymerase chain reaction. Results: BV was not risk factor for 1 st trimester miscarriage, however it was significantly associated with smoking ( P = 0.001), vaginal douching ( P = 0.001), intrauterine device ( P = 0.001) and history of preterm labor ( P = 0.002). C. trachomatis infection was significantly associated with 1 st trimester miscarriage (P = 0.001), hormonal contracept...

Objective: The purpose of this study is to compare between Atosiban acetate and magnesium sulphat... more Objective: The purpose of this study is to compare between Atosiban acetate and magnesium sulphate and calcium channel blocker as short-term tocolytic agents for managing preterm labor. Study desine: Randomized comparative single-blinded trial. Methods: In this study, one hundred forty pregnant women were recruited. They were admitted with threatened preterm labor on attending the Obstetrics and Gynecology Emergency Department of Zagazig University Hospital (N=140). They divided into three groups, atosiban group 20 cases, nifedipine group 60 cases, magnesium sulfate group 60 cases, each group receive initial dose then maintenance dose till cessation of uterine contractions. We estimate pregnancy prolongation on 48 hours and 7 days and also the maternal and fetal side effects reported in each group. Results: The result of the current study showed no significant difference between the three groups as regard pregnancy prolongation but there is statistically significant difference betwe...

Zagazig University Medical Journal, 2021

Benha Medical Journal, 2020

Territoire, industrie et « bien système » : Le cas de l'émergence d'une industrie du Véhicule Éle... more Territoire, industrie et « bien système » : Le cas de l'émergence d'une industrie du Véhicule Électrique en Californie When territory tackles with "system-good": The case of the emergence of an Electric Vehicle industry in California

Zagazig University Medical Journal, 2020

Background: Preterm birth (PTB) refers to the birth of a baby that occurs before 37 completed wee... more Background: Preterm birth (PTB) refers to the birth of a baby that occurs before 37 completed weeks of gestation. The aim of this work was to identify the risk factors leading to preterm labor and evaluation the outcome of both neonate and mother. Methods: Observational prospective study was carried out to identify risk factors of preterm birth, at Obstetrics and Gynecology Department, Zagazig University Hospitals during the period from November 2017 to November 2018. The study 126 incident (45.5% of pregnant females with preterm pregnancy had preeclampsia compared to 20.5% of females with full term pregnancy) preterm labor cases (any labor between 28 and 37 completed weeks of gestation). Data were collected using a predesigned interviewing and record review. Ultrasonographic examination by abdominal ultrasound was done for all patients to confirm viability of fetus and to assess the accurate gestational age. Results: The most predominant causes of preterm labor were premature rupture of membranes and preterm contractions in 31%, followed by Vaginal bleeding due to placental abnormalities 21.4%then preeclampsia in 17.5% and neonatal outcome was relatively good as 73.0% of studied pregnant females had good neonatal outcome, 20.6% of them their babes need to be incubated with poor outcome and the newborn died in 6.3% of them. Conclusions: There was significant difference between maternal outcome in relation to age, gravidity and mode of delivery among the studied pregnant females where complicated maternal outcome was associated more with younger females or older than 35 years old and CS with hysterectomy.

The Egyptian Journal of Radiology and Nuclear Medicine, 2010

Objective: To assess the role of different imaging modalities including ultrasonography, hysteros... more Objective: To assess the role of different imaging modalities including ultrasonography, hysterosalpingogram, and magnetic resonance imaging in detection of variable Mu¨llerian anomalies. Preoperative proper diagnosis data about Mu¨llerian anomalies necessary for clear indications of how and when to operate. Patients and methods: A retrospective MRI study of 34 patients was done in the period from February 2008 to February 2010, their age ranging from 3 months to 38 years (mean 24 years), with uterovaginal anomalies. Ultrasonography was performed for all cases; HSG was performed in 16 cases before MRI imaging. Results: MRI is the most reliable method for evaluating uterovaginal anomalies, particularly in pediatrics and virgins. MRI is an accurate examination for identification and categorization of MDAs and should be carried out prior to any surgery, in this study MRI allowed correct diagnosis of 34 uterine anomalies (accuracy 100%) whereas US was correct in 30 out of 34 cases (accuracy 88%). HSG had a limited role as cannot be preformed for virgins, and cannot identify non-communicating horns in unicornuate cases. Conclusion: MRI is the examination of choice in uterovaginal anomalies. Endovaginal ultrasound cannot be preformed for children or females who have never had sexual intercourse. TAUS have not proved completely reliable in Mu¨llerian duct anomalies.

Open Journal of Obstetrics and Gynecology, 2014

Background: Unexplained infertility represents about 15%-20% of infertile couples. Usually, these... more Background: Unexplained infertility represents about 15%-20% of infertile couples. Usually, these cases need assistance. Clomiphene citrate is the most used drug for this problem but sometimes pregnancy failed to achieve it, so other options for assistance are gonadotrophin or letrezole. The objective of our study was to compare the pregnancy rate for letrezole and gonadotropin in unexplained infertile women's who failed to conceive with clomiphene citrate. Methods: This prospective quasi-randomized trial was carried out in cytogenetic unite at obstetrics and gynecology department, Zagazig University Hospital. 140 infertile females were included, induction of ovulation by letrozole for half of them and by gonadotrophin for the other half. Results: There was statistically highly significant decrease in duration of stimulation, E2 levels and endometrial thickness at day of HCG in letrezole group, no significant difference between two groups as regard number of follicles and pregnancy rate per cycle, while the cumulative pregnancy rate and the cost of stimulation are significantly higher in gonadotrophin group. Conclusion: In patient with unexplained infertility who failed to conceive with clomiphene citrate, gonadotrophins have a higher pregnancy rate than letrezole. However, pregnancy rate was high enough with lower cost with letrezole to be acceptable and justified its use in this group of patients.