shivakumar swamy - Academia.edu (original) (raw)
Papers by shivakumar swamy
International Journal of Radiation Oncology*Biology*Physics, 2020
We sought to determine whether specific taxa in the communities of the C57BL/6J mouse intestinal ... more We sought to determine whether specific taxa in the communities of the C57BL/6J mouse intestinal microbiome were associated with survival after the LD 50/30 dose of total body irradiation (TBI), and if administration of a second-generation probiotic producing anti-inflammatory Interleukin-22 (IL-22) mitigated Gastrointestinal Syndrome inducing doses of total body irradiation (TBI). Materials/Methods: Female C57BL/6J mice were irradiated to LD 50/30 9.25 Gy TBI, or 19.75 Gy whole abdominal irradiation, and evaluated for primary endpoint of survival and secondary endpoint of expression of inflammatory proteins and bone marrow CFU-GEMMs per 10 4 cells. Daily collected fecal samples were analyzed for 16sRNA associated with 15 major taxa in the intestinal microbiome. Second-generation probiotic Lactobacillus reuteri or Escherichia-coli producing IL-22 (LR-IL-22 or E. coli-IL-22, respectively) was administered to subgroups by gavage at 24 hours after irradiation. The results were compared to subcutaneous administration of IL-22 (n Z 12). Results: Thirty-day TBI survivors of 9.25 Gy had at day 14 a predictive increased relative abundance of Lactobacillus, Roseburia, and Akkermansia, compared to other taxa, as did radiation mitigator treated (G-CSF or JP4-039) mice. Administration of LR-IL-22 at 24 hours after irradiation increased survival (p Z 0.0144), as did E. coli-IL-22. GFP-IL-22 fusion protein producing probiotics showed uptake in intestinal villi at 2 h after gavage and clearance by day 5. At 24 hrs. after 9.25 Gy TBI, mice with 4 antibiotic-cleared intestinal microbiomes (5 weeks administration in drinking water of vancomycin, neomycin trisulfate, metronidazole, and ampicillin) had increased survival when treated with E. coli-IL-22, (p < 0.0001). On day 5 after 9.25 Gy TBI, the intestine and bone marrow were isolated. Luminex assay showed significantly decreased inflammatory proteins in mice gavaged with LR-IL-22, and bone marrow had significantly increased CFU-GEMMs per 10 4 cells compared to 9.25 Gy only (15.1 AE 1.1 and 9.1 AE 1.5, respectively, p Z 0.0351). Whole abdomen irradiation to 19.75 Gy followed by gavage at 24 hrs. of LR-IL-22, or E. coli-IL-22 significantly increased survival (p Z 0.0138, 0.0473). Conclusion: These data indicate that the relative abundance of specific taxa in the intestinal microbiome correlates with survival after total body irradiation. Furthermore, gavage of LR-IL-22 improves survival after GI Syndrome inducing doses of irradiation. Elucidation of the molecular mechanism of interaction of pro-survival microbiome communities with intestinal stem cells and regenerating crypts should identify new targets for intestinal radiation protection and mitigation.
International Journal of Radiation Oncology*Biology*Physics, 2019
Indian Journal of Medical and Paediatric Oncology, Jul 1, 2019
Drug-induced pancreatitis is reported as one of the less common causes of acute pancreatitis. Man... more Drug-induced pancreatitis is reported as one of the less common causes of acute pancreatitis. Many drugs such as sulfonamides, estrogens, tetracyclines, valproic acid, antiretroviral drugs, some chemotherapy drugs such as azathioprine, and 6 MP are known to cause acute pancreatitis. We report a case of acute pancreatitis following administration of chemotherapy for non-small cell lung cancer (NSCLC). The patient was diagnosed to have NSCLC (histologically proven adenocarcinoma). After thorough evaluation including radiological investigations consisting of a positron-emission tomography computed tomography scan, he was staged as a Stage III B NSCLC. As per protocol, he was started on combination chemotherapy with pemetrexed and carboplatin. After 2 weeks of chemotherapy, he developed acute pancreatitis which was managed conservatively. He was administered different drug combination during the next cycle involving gemcitabine and carboplatin. However, he developed recurrent acute pancreatitis which was managed conservatively. He was then referred to the radiotherapy department as it was deemed that he is at risk of recurrent episodes of pancreatitis if further cycles of chemotherapy are continued.
Journal of Clinical Oncology, 2020
e15522 Background: Taxanes are an integral part of chemotherapy for a broad range of tumor types.... more e15522 Background: Taxanes are an integral part of chemotherapy for a broad range of tumor types. The usual toxicities associated with Taxane use are peripheral neuropathy, myelosuppression and musculoskeletal adverse effects. Very few studies have reported taxane induced pulmonary toxicity objectively. In our study we explored Taxane induced pulmonary toxicity based on discrete CT findings. Methods: 40 non-smokers diagnosed with Her-2 negative breast cancer who received Taxane monotherapy from 2017 to 2018 were retrospectively analyzed for pre and post therapy CT changes. Following CT findings were considered significant as pulmonary toxicity; (a) Nonspecific area with ground-glass attenuation, (b) multifocal areas of airspace consolidation, (c) patchy distribution of ground-glass attenuation accompanied by interlobular septal thickening and (d) extensive bilateral ground-glass attenuation or airspace consolidations with traction bronchiectasis. The CT findings were assessed indepe...
World Neurosurgery, 2022
BACKGROUND: Mucormycosis infection of the maxillofacial region and brain has been associated with... more BACKGROUND: Mucormycosis infection of the maxillofacial region and brain has been associated with coronavirus disease 2019 (COVID-19) infection. Mucormycosis was relatively a rare infection before COVID-19, and imaging findings are not very well described.-CONCLUSIONS: We describe the imaging findings in the largest cohort of patients with rhino-orbito-cerebral mucormycosis in the context of the current COVID-19 pandemic. A simplified staging system described here is helpful for standardized reporting and carries prognostic information.
Poster: "ECR 2018 / C-2345 / A peek into leukemic brain - Pictorial review" by: "S... more Poster: "ECR 2018 / C-2345 / A peek into leukemic brain - Pictorial review" by: "S. S. Shivalingappa1, I. Desai2, M. ASHOK KUMAR2, S. Sampangi2, A. Kesari2, D. Basavalingu2; 1Bangalore, Karnataka/IN, 2Bangalore/IN"
Poster: "ECR 2018 / C-1461 / Orthopaedic oncology :simplied by Interventional radiology"... more Poster: "ECR 2018 / C-1461 / Orthopaedic oncology :simplied by Interventional radiology" by: "V. Bhargavi1, I. Subbanna2, S. S. Shivalingappa3; 1Bangalore, Ka/IN, 2BANGALORE/IN, 3BANGALORE, KARNATAKA/IN"
Poster: "ECR 2019 / C-0228 / Chemotherapy induced adverse effects in oncology set up-What an... more Poster: "ECR 2019 / C-0228 / Chemotherapy induced adverse effects in oncology set up-What an onco-radiologist should know?" by: "N. K. Jain1, S. S. Shivalingappa2, I. Desai1, S. Sampangi2, M. Kumar3, A. Kesari1, Y. kumaraswamy1; 1BANGALORE/IN, 2Bangalore, Karnataka/IN, 3BIKANER/IN"
Poster: "ECR 2013 / C-1799 / C11-choline PET CT for evaluation of prostate cancer and its re... more Poster: "ECR 2013 / C-1799 / C11-choline PET CT for evaluation of prostate cancer and its recurrence." by: "S. S. Shivalingappa; Bangalore, KARNATAKA/IN"
Indian Journal of Medical Sciences, 2020
Objectives: Radiological lung changes in COVID-19 infections present a noteworthy avenue to devel... more Objectives: Radiological lung changes in COVID-19 infections present a noteworthy avenue to develop chest X-ray (CXR) -based testing models to support existing rapid detection techniques. The purpose of this study is to evaluate the accuracy of artificial intelligence (AI) -based screening model employing deep convolutional neural network for lung involvement. Material and Methods: An AI-based screening model was developed with state-of-the-art neural networks using Indian data sets from COVID-19 positive patients by authors of CAIR, DRDO, in collaboration with the other authors. Our dataset was comprised of 1324 COVID-19, 1108 Normal, and 1344 Pneumonia CXR images. Transfer learning was carried out on Indian dataset using popular deep neural networks, which includes DenseNet, ResNet50, and ResNet18 network architectures to classify CXRs into three categories. The model was retrospectively used to test CXRs from reverse transcriptase-polymerase chain reaction (RT-PCR) proven COVID-1...
International Journal of Radiation Oncology*Biology*Physics, 2019
Conclusion: An investigation was performed to estimate the geometric distortion in clinical MR se... more Conclusion: An investigation was performed to estimate the geometric distortion in clinical MR sequences for an MR-Linac system. The magnitude of measured geometric distortion varied depending on the clinical MR sequence used for image acquisition. Any MR-Linac radiation treatment related decision-making should take this source of uncertainty into consideration.
International Journal of Radiation Oncology*Biology*Physics, 2019
International Journal of Radiation Oncology*Biology*Physics, 2019
to evaluate the impact of RT on cognitive function over time as assessed using brief (approximate... more to evaluate the impact of RT on cognitive function over time as assessed using brief (approximately 30 minute) Cogstate battery. Materials/Methods: Patients receiving cranial RT for primary CNS tumors with expected median survival > 5 years are eligible for enrollment on this prospective observational trial. Cogstate tests utilized in this study are: Detection (DET) measuring processing speed, Identification (IDN) measuring attention, One-card learning (OCL) measuring visual learning, and International shopping list (ISL) measuring verbal learning. Cogstate battery is administered prior to start of RT (baseline), end of RT, and at 3, 6, 12, and 24 months. This preliminary report is an analysis comparing assessments from baseline to 6 months after RT. Reliable change index (RCI) was computed to account for natural variability of test-taking. A decrease in RCI score ! 0.5 from baseline was considered significant change in the targeted cognitive domain. Fisher's exact tests were performed to investigate the association between the clinical or treatment characteristics and changes in specific cognitive function domains. Results: Between 2017 and 2018, 35 patients (23 female, 12 male) completed baseline assessments. Of patients eligible for assessments, 33 (95%), 20 (57%), and 18 (51%) completed end of RT, 3, and 6 month assessments, respectively. Median age at diagnosis was 37 (range 21-73). Patients with tumor resection had worse baseline DET scores compared to patients with biopsy only. Tumor resection was associated with significant decline in processing speed (DET, pZ0.012) at the end of RT. DET scores for surgical patients returned to baseline at 3 and 6 months. Patients without tumor resection had continued improvement of DET scores from baseline to 6 months after RT. Attention (IDN) appears to decline from baseline to 6 months. Right sided tumor and higher RT dose (!54Gy) were associated with significant decline in verbal learning (ISL, p Z0.026 and pZ0.027, respectively) at the end of RT which recovered to above baseline at 3 and 6 months. Visual learning (OCL) declined at the end of RT with peak decline at 3 months, followed by recovery at 6 months. Conclusion: Changes in processing speed and verbal learning are detectable as early as end of RT in subgroups of patients receiving cranial RT. The 4-test Cogstate battery appears to detect early changes in cognitive function in domains consistent with previously published work suggesting further evaluation with larger patient population and longer follow-up is warranted.
![Research paper thumbnail of Concomitant Venous Thromboembolism [VTE] with Cancer and its Effect on Survival in Indian Patients](https://attachments.academia-assets.com/108015325/thumbnails/1.jpg)
](Biomedical Journal of Scientific & Technical Research, 2018
Cancer patients concurrently diagnosed with deep venous thrombosis have a poorer survival. In sum... more Cancer patients concurrently diagnosed with deep venous thrombosis have a poorer survival. In summary, Concurrent deep venous thrombosis confers a worse prognosis upon cancer patients. Stage at diagnosis, treatment effects, Medical comorbidities could explain differences by cancer site and time frame between deep venous thrombosis diagnosis and cancer outcome and overall survival.
Indian Journal of Radiology and Imaging, 2011
Internal gold fiducials are necessary for tracking the translational and rotational movements of ... more Internal gold fiducials are necessary for tracking the translational and rotational movements of target lesions during stereotactic radiosurgery. The fiducials are generally placed under image guidance in and around the lesions by interventional radiologists. Specific challenges are encountered during the procedure. This article discusses the basic principles and techniques as well as the specific complications.
Indian Journal of Medical and Paediatric Oncology
Cancer is one of the leading causes of morbidity and mortality. Imaging studies are central to th... more Cancer is one of the leading causes of morbidity and mortality. Imaging studies are central to the initial staging and follow-up management of cancers. In the past, oncologists have largely relied on anatomical imaging for staging, restaging, and therapy monitoring. The introduction of positron emission tomography-computed tomography (PET-CT) and its availability has transformed the practice of cancer imaging. PET-CT is an imaging technique that provides complementary information to imaging by CT or magnetic resonance imaging alone as it incorporates functional imaging to the anatomic information. It actually embeds tumor biology on the anatomical image. There are significant contributions of the CT component in adding value to the strength of PET-CT. PET-CT is useful for initial staging of cancers. It is particularly useful in detection of distant metastases, in assessing response to therapy and in detection of recurrence. Its utility in restaging and follow-up of cancers is now we...
Case Reports in Oncology, 2020
Ogilvie syndrome or intestinal pseudo-obstruction is a clinical syndrome characterized by autonom... more Ogilvie syndrome or intestinal pseudo-obstruction is a clinical syndrome characterized by autonomic imbalance affecting peristalsis of colon leading to obstructive signs and symptoms. The etiologies commonly implicated are drugs affecting the cholinergic system, narcotics, electrolyte imbalance, severe sepsis, cancer, major surgery, and renal and cardiac failure. Ogilvie syndrome secondary to chemotherapy is a very rare phenomenon with very few reports in the literature. Cisplatin-induced neuropathy has been reported to occur when the cumulative dose exceeds 360 mg/m2. It manifests predominantly as peripheral sensory neuropathy with autonomic neuropathy occurring very rarely in a subset of patients. All the reported cases to date who presented with autonomic dysfunction secondary to cisplatin also had peripheral sensory neuropathy. Herein, we report a case of metastatic nonseminomatous germ cell tumor treated with cisplatin based regimen, who presented with severe intestinal pseudo-...
Indian Journal of Medical and Paediatric Oncology, 2020
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric age group. They ar... more Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric age group. They are classified based on the histopathological characteristics. The prognosis of RMS depends on the site of occurrence and the histopathology. Although paratesticular site is considered as one of the favorable sites, pleomorphic histology, even at this favorable site, confers a poor prognosis. Treatment includes surgery chemotherapy and radiation in metastatic cases. Here, we describe a case of an adolescent boy with pleomorphic paratesticular RMS treated successfully with chemotherapy.
International Journal of Radiation Oncology*Biology*Physics, 2020
We sought to determine whether specific taxa in the communities of the C57BL/6J mouse intestinal ... more We sought to determine whether specific taxa in the communities of the C57BL/6J mouse intestinal microbiome were associated with survival after the LD 50/30 dose of total body irradiation (TBI), and if administration of a second-generation probiotic producing anti-inflammatory Interleukin-22 (IL-22) mitigated Gastrointestinal Syndrome inducing doses of total body irradiation (TBI). Materials/Methods: Female C57BL/6J mice were irradiated to LD 50/30 9.25 Gy TBI, or 19.75 Gy whole abdominal irradiation, and evaluated for primary endpoint of survival and secondary endpoint of expression of inflammatory proteins and bone marrow CFU-GEMMs per 10 4 cells. Daily collected fecal samples were analyzed for 16sRNA associated with 15 major taxa in the intestinal microbiome. Second-generation probiotic Lactobacillus reuteri or Escherichia-coli producing IL-22 (LR-IL-22 or E. coli-IL-22, respectively) was administered to subgroups by gavage at 24 hours after irradiation. The results were compared to subcutaneous administration of IL-22 (n Z 12). Results: Thirty-day TBI survivors of 9.25 Gy had at day 14 a predictive increased relative abundance of Lactobacillus, Roseburia, and Akkermansia, compared to other taxa, as did radiation mitigator treated (G-CSF or JP4-039) mice. Administration of LR-IL-22 at 24 hours after irradiation increased survival (p Z 0.0144), as did E. coli-IL-22. GFP-IL-22 fusion protein producing probiotics showed uptake in intestinal villi at 2 h after gavage and clearance by day 5. At 24 hrs. after 9.25 Gy TBI, mice with 4 antibiotic-cleared intestinal microbiomes (5 weeks administration in drinking water of vancomycin, neomycin trisulfate, metronidazole, and ampicillin) had increased survival when treated with E. coli-IL-22, (p < 0.0001). On day 5 after 9.25 Gy TBI, the intestine and bone marrow were isolated. Luminex assay showed significantly decreased inflammatory proteins in mice gavaged with LR-IL-22, and bone marrow had significantly increased CFU-GEMMs per 10 4 cells compared to 9.25 Gy only (15.1 AE 1.1 and 9.1 AE 1.5, respectively, p Z 0.0351). Whole abdomen irradiation to 19.75 Gy followed by gavage at 24 hrs. of LR-IL-22, or E. coli-IL-22 significantly increased survival (p Z 0.0138, 0.0473). Conclusion: These data indicate that the relative abundance of specific taxa in the intestinal microbiome correlates with survival after total body irradiation. Furthermore, gavage of LR-IL-22 improves survival after GI Syndrome inducing doses of irradiation. Elucidation of the molecular mechanism of interaction of pro-survival microbiome communities with intestinal stem cells and regenerating crypts should identify new targets for intestinal radiation protection and mitigation.
International Journal of Radiation Oncology*Biology*Physics, 2019
Indian Journal of Medical and Paediatric Oncology, Jul 1, 2019
Drug-induced pancreatitis is reported as one of the less common causes of acute pancreatitis. Man... more Drug-induced pancreatitis is reported as one of the less common causes of acute pancreatitis. Many drugs such as sulfonamides, estrogens, tetracyclines, valproic acid, antiretroviral drugs, some chemotherapy drugs such as azathioprine, and 6 MP are known to cause acute pancreatitis. We report a case of acute pancreatitis following administration of chemotherapy for non-small cell lung cancer (NSCLC). The patient was diagnosed to have NSCLC (histologically proven adenocarcinoma). After thorough evaluation including radiological investigations consisting of a positron-emission tomography computed tomography scan, he was staged as a Stage III B NSCLC. As per protocol, he was started on combination chemotherapy with pemetrexed and carboplatin. After 2 weeks of chemotherapy, he developed acute pancreatitis which was managed conservatively. He was administered different drug combination during the next cycle involving gemcitabine and carboplatin. However, he developed recurrent acute pancreatitis which was managed conservatively. He was then referred to the radiotherapy department as it was deemed that he is at risk of recurrent episodes of pancreatitis if further cycles of chemotherapy are continued.
Journal of Clinical Oncology, 2020
e15522 Background: Taxanes are an integral part of chemotherapy for a broad range of tumor types.... more e15522 Background: Taxanes are an integral part of chemotherapy for a broad range of tumor types. The usual toxicities associated with Taxane use are peripheral neuropathy, myelosuppression and musculoskeletal adverse effects. Very few studies have reported taxane induced pulmonary toxicity objectively. In our study we explored Taxane induced pulmonary toxicity based on discrete CT findings. Methods: 40 non-smokers diagnosed with Her-2 negative breast cancer who received Taxane monotherapy from 2017 to 2018 were retrospectively analyzed for pre and post therapy CT changes. Following CT findings were considered significant as pulmonary toxicity; (a) Nonspecific area with ground-glass attenuation, (b) multifocal areas of airspace consolidation, (c) patchy distribution of ground-glass attenuation accompanied by interlobular septal thickening and (d) extensive bilateral ground-glass attenuation or airspace consolidations with traction bronchiectasis. The CT findings were assessed indepe...
World Neurosurgery, 2022
BACKGROUND: Mucormycosis infection of the maxillofacial region and brain has been associated with... more BACKGROUND: Mucormycosis infection of the maxillofacial region and brain has been associated with coronavirus disease 2019 (COVID-19) infection. Mucormycosis was relatively a rare infection before COVID-19, and imaging findings are not very well described.-CONCLUSIONS: We describe the imaging findings in the largest cohort of patients with rhino-orbito-cerebral mucormycosis in the context of the current COVID-19 pandemic. A simplified staging system described here is helpful for standardized reporting and carries prognostic information.
Poster: "ECR 2018 / C-2345 / A peek into leukemic brain - Pictorial review" by: "S... more Poster: "ECR 2018 / C-2345 / A peek into leukemic brain - Pictorial review" by: "S. S. Shivalingappa1, I. Desai2, M. ASHOK KUMAR2, S. Sampangi2, A. Kesari2, D. Basavalingu2; 1Bangalore, Karnataka/IN, 2Bangalore/IN"
Poster: "ECR 2018 / C-1461 / Orthopaedic oncology :simplied by Interventional radiology"... more Poster: "ECR 2018 / C-1461 / Orthopaedic oncology :simplied by Interventional radiology" by: "V. Bhargavi1, I. Subbanna2, S. S. Shivalingappa3; 1Bangalore, Ka/IN, 2BANGALORE/IN, 3BANGALORE, KARNATAKA/IN"
Poster: "ECR 2019 / C-0228 / Chemotherapy induced adverse effects in oncology set up-What an... more Poster: "ECR 2019 / C-0228 / Chemotherapy induced adverse effects in oncology set up-What an onco-radiologist should know?" by: "N. K. Jain1, S. S. Shivalingappa2, I. Desai1, S. Sampangi2, M. Kumar3, A. Kesari1, Y. kumaraswamy1; 1BANGALORE/IN, 2Bangalore, Karnataka/IN, 3BIKANER/IN"
Poster: "ECR 2013 / C-1799 / C11-choline PET CT for evaluation of prostate cancer and its re... more Poster: "ECR 2013 / C-1799 / C11-choline PET CT for evaluation of prostate cancer and its recurrence." by: "S. S. Shivalingappa; Bangalore, KARNATAKA/IN"
Indian Journal of Medical Sciences, 2020
Objectives: Radiological lung changes in COVID-19 infections present a noteworthy avenue to devel... more Objectives: Radiological lung changes in COVID-19 infections present a noteworthy avenue to develop chest X-ray (CXR) -based testing models to support existing rapid detection techniques. The purpose of this study is to evaluate the accuracy of artificial intelligence (AI) -based screening model employing deep convolutional neural network for lung involvement. Material and Methods: An AI-based screening model was developed with state-of-the-art neural networks using Indian data sets from COVID-19 positive patients by authors of CAIR, DRDO, in collaboration with the other authors. Our dataset was comprised of 1324 COVID-19, 1108 Normal, and 1344 Pneumonia CXR images. Transfer learning was carried out on Indian dataset using popular deep neural networks, which includes DenseNet, ResNet50, and ResNet18 network architectures to classify CXRs into three categories. The model was retrospectively used to test CXRs from reverse transcriptase-polymerase chain reaction (RT-PCR) proven COVID-1...
International Journal of Radiation Oncology*Biology*Physics, 2019
Conclusion: An investigation was performed to estimate the geometric distortion in clinical MR se... more Conclusion: An investigation was performed to estimate the geometric distortion in clinical MR sequences for an MR-Linac system. The magnitude of measured geometric distortion varied depending on the clinical MR sequence used for image acquisition. Any MR-Linac radiation treatment related decision-making should take this source of uncertainty into consideration.
International Journal of Radiation Oncology*Biology*Physics, 2019
International Journal of Radiation Oncology*Biology*Physics, 2019
to evaluate the impact of RT on cognitive function over time as assessed using brief (approximate... more to evaluate the impact of RT on cognitive function over time as assessed using brief (approximately 30 minute) Cogstate battery. Materials/Methods: Patients receiving cranial RT for primary CNS tumors with expected median survival > 5 years are eligible for enrollment on this prospective observational trial. Cogstate tests utilized in this study are: Detection (DET) measuring processing speed, Identification (IDN) measuring attention, One-card learning (OCL) measuring visual learning, and International shopping list (ISL) measuring verbal learning. Cogstate battery is administered prior to start of RT (baseline), end of RT, and at 3, 6, 12, and 24 months. This preliminary report is an analysis comparing assessments from baseline to 6 months after RT. Reliable change index (RCI) was computed to account for natural variability of test-taking. A decrease in RCI score ! 0.5 from baseline was considered significant change in the targeted cognitive domain. Fisher's exact tests were performed to investigate the association between the clinical or treatment characteristics and changes in specific cognitive function domains. Results: Between 2017 and 2018, 35 patients (23 female, 12 male) completed baseline assessments. Of patients eligible for assessments, 33 (95%), 20 (57%), and 18 (51%) completed end of RT, 3, and 6 month assessments, respectively. Median age at diagnosis was 37 (range 21-73). Patients with tumor resection had worse baseline DET scores compared to patients with biopsy only. Tumor resection was associated with significant decline in processing speed (DET, pZ0.012) at the end of RT. DET scores for surgical patients returned to baseline at 3 and 6 months. Patients without tumor resection had continued improvement of DET scores from baseline to 6 months after RT. Attention (IDN) appears to decline from baseline to 6 months. Right sided tumor and higher RT dose (!54Gy) were associated with significant decline in verbal learning (ISL, p Z0.026 and pZ0.027, respectively) at the end of RT which recovered to above baseline at 3 and 6 months. Visual learning (OCL) declined at the end of RT with peak decline at 3 months, followed by recovery at 6 months. Conclusion: Changes in processing speed and verbal learning are detectable as early as end of RT in subgroups of patients receiving cranial RT. The 4-test Cogstate battery appears to detect early changes in cognitive function in domains consistent with previously published work suggesting further evaluation with larger patient population and longer follow-up is warranted.
Biomedical Journal of Scientific & Technical Research, 2018
Cancer patients concurrently diagnosed with deep venous thrombosis have a poorer survival. In sum... more Cancer patients concurrently diagnosed with deep venous thrombosis have a poorer survival. In summary, Concurrent deep venous thrombosis confers a worse prognosis upon cancer patients. Stage at diagnosis, treatment effects, Medical comorbidities could explain differences by cancer site and time frame between deep venous thrombosis diagnosis and cancer outcome and overall survival.
Indian Journal of Radiology and Imaging, 2011
Internal gold fiducials are necessary for tracking the translational and rotational movements of ... more Internal gold fiducials are necessary for tracking the translational and rotational movements of target lesions during stereotactic radiosurgery. The fiducials are generally placed under image guidance in and around the lesions by interventional radiologists. Specific challenges are encountered during the procedure. This article discusses the basic principles and techniques as well as the specific complications.
Indian Journal of Medical and Paediatric Oncology
Cancer is one of the leading causes of morbidity and mortality. Imaging studies are central to th... more Cancer is one of the leading causes of morbidity and mortality. Imaging studies are central to the initial staging and follow-up management of cancers. In the past, oncologists have largely relied on anatomical imaging for staging, restaging, and therapy monitoring. The introduction of positron emission tomography-computed tomography (PET-CT) and its availability has transformed the practice of cancer imaging. PET-CT is an imaging technique that provides complementary information to imaging by CT or magnetic resonance imaging alone as it incorporates functional imaging to the anatomic information. It actually embeds tumor biology on the anatomical image. There are significant contributions of the CT component in adding value to the strength of PET-CT. PET-CT is useful for initial staging of cancers. It is particularly useful in detection of distant metastases, in assessing response to therapy and in detection of recurrence. Its utility in restaging and follow-up of cancers is now we...
Case Reports in Oncology, 2020
Ogilvie syndrome or intestinal pseudo-obstruction is a clinical syndrome characterized by autonom... more Ogilvie syndrome or intestinal pseudo-obstruction is a clinical syndrome characterized by autonomic imbalance affecting peristalsis of colon leading to obstructive signs and symptoms. The etiologies commonly implicated are drugs affecting the cholinergic system, narcotics, electrolyte imbalance, severe sepsis, cancer, major surgery, and renal and cardiac failure. Ogilvie syndrome secondary to chemotherapy is a very rare phenomenon with very few reports in the literature. Cisplatin-induced neuropathy has been reported to occur when the cumulative dose exceeds 360 mg/m2. It manifests predominantly as peripheral sensory neuropathy with autonomic neuropathy occurring very rarely in a subset of patients. All the reported cases to date who presented with autonomic dysfunction secondary to cisplatin also had peripheral sensory neuropathy. Herein, we report a case of metastatic nonseminomatous germ cell tumor treated with cisplatin based regimen, who presented with severe intestinal pseudo-...
Indian Journal of Medical and Paediatric Oncology, 2020
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric age group. They ar... more Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric age group. They are classified based on the histopathological characteristics. The prognosis of RMS depends on the site of occurrence and the histopathology. Although paratesticular site is considered as one of the favorable sites, pleomorphic histology, even at this favorable site, confers a poor prognosis. Treatment includes surgery chemotherapy and radiation in metastatic cases. Here, we describe a case of an adolescent boy with pleomorphic paratesticular RMS treated successfully with chemotherapy.