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Papers by shiva shirazian

Bioscience Biotechnology Research Communications

Lichen Planus (LP) is an infl ammatory chronic mucocutaneous disease. Since the etiology of OLP i... more Lichen Planus (LP) is an infl ammatory chronic mucocutaneous disease. Since the etiology of OLP is unknown, efforts to understand the etiology and pathogenecity may lead to improve treatment modalities. Studies have shown the different levels of increase or decrease of various cytokines in saliva, serum or tissue culture of patients with OLP.As saliva originates from blood and its collection is an easy, non-invasive method, so it can be a diagnostic fl uid that has logistical advantages when compared with serum. The purpose of this study was to compare the salivary level of IL17 and IL22 in patients with and without OLP. Saliva of 52 patients with and without OLP was collected. The saliva level of IL17 and IL 22 was measured by using ELISA. Data were analyzed using independent T test, Mann-Whitney and Pearson Correlation test.The saliva concentration of IL 22 was significantly higher in control group than OLP but the difference was not signifi cant between reticular and atrophic-erosive type (P > 0.05).The difference between mean rank of IL17 for OLP and healthy cases and between reticular and erosive-atrophic form was not signifi cant (P > 0.05). There was no correlation between the level of IL17 and IL 22 (P > 0.05). Our fi ndings suggest that IL 22 may have an effect in the pathogenesis of OLP and its protective effect may be decreased in OLP patients.

Minerva Respiratory Medicine, 2018

Background and Aims: The objective of this study was the development of a checklist for assessmen... more Background and Aims: The objective of this study was the development of a checklist for assessment of students' clinical skills in the clinical oral medicine. The second aim was the assessment of stake holders' satisfaction of this checklist in comparison to the routine global rating method. Materials and Methods: The checklist was developed in an expert panel sessions and the validity and reliability of checklist were assessed by CVI and test-retest method, respectively. All students (n=66) were assessed in 2 groups, one with developed checklist and another with global rating. At the end of the session, the satisfaction's level of staff and students were analysized using Wilcoxon and Mann-Whitney test and the mean scores of students were analysized using Paired T test. Results: Content validity index (CV I) of checklist was 0.88. Reliability of checklist confirmed with high correlation coefficient (0.9). Staffs' satisfaction had no significant difference between the...

Journal of Islamic Dental Association of IRAN, 2018

Background and Aim: Temporomandibular disorders (TMDs) can be associated with pain in other areas... more Background and Aim: Temporomandibular disorders (TMDs) can be associated with pain in other areas such as the neck. Multiple causes have been suggested for TMDs; parafunctional habits such as bruxism and clenching are among the most commonly suggested etiologies. This study aimed to assess the efficacy of the amendment of oral parafunctional habits in the improvement of TMDs and neck pain. Materials and Methods: This before-and-after interventional study was conducted on 136 patients with TMDs, parafunctional habits, and neck pain. The patients were instructed on how to quit their parafunctional habits and were followed up for two months. The neck pain disability index (NPDI), anamnestic dysfunction index (Ai), and clinical dysfunction index (Di) of TMD were evaluated before and after the modification of parafunctional habits. Data were analyzed using paired Student's t-test, Wilcoxon, Mann-U-Whitney, Kruskal-Wallis, and Spearman tests. P<0.05 was considered significant. Results: Most TMD patients were women (74.5%). The patients' scores significantly decreased from 4 to 1 in the Ai, from 8 to 1 in the Di, and from 49 to 25 in the NPDI two months after the intervention (P<0.05). There were no significant differences in the NPDI, Ai, and Di scores following the amendment of oral parafunctional habits between males and females or among different age ranges. Age did not significantly correlate with the changes in the NPDI, Ai, and Di scores after the improvement of oral parafunctional habits. The NPDI significantly correlated with the Ai score. Conclusion: It seems that parafunctional habit modification improves TMDs and neck pain.

Iranian Endodontic Journal, 2006

INTRODUCTION: The aim of this study was to compare a clearing technique with conventional radiogr... more INTRODUCTION: The aim of this study was to compare a clearing technique with conventional radiography in studying certain features of the root canal system in single root premolars. A secondary aim was to assess inter examiner agreement for these features using radiographs. MATERIALS AND METHODS: Fifty-eight recently extracted single rooted premolars were included in this study. Two standard periapical radiographs were taken from buccolingual and 20° direction. The specimens were then decoronated, demineralized in 10% hydrochloric acid for 24 hours and then were cleared using methylsalicylate. The cleared teeth were examined using a magnifier (x10) and data relating to number of roots, canals, apical foramina and their positions were collected. The radiographs were examined by two independent trained endodontists using an X-ray viewer and the magnifying lens for same studied features using the clearing technique. RESULTS: The kappa values for the agreement between the clearing techn...

Metastatic lesions represent 1-8% of all malignant tumors of the mouth and jaws, which are regard... more Metastatic lesions represent 1-8% of all malignant tumors of the mouth and jaws, which are regarded as rare sites of metastases from different primary tumors. Metastases in mouth soft tissue are also rare, and within these it is on the gums where they more frequently occur. Primary tumors which metastasize to the mouth are most commonly: lung, breast, and kidney. Clear cell carcinoma is the most frequent cancer of the kidney (60-80% of cases). This tumor has a great propensity to metastasis. We report a case of a 45-year-old man with renal cell carcinoma in which the gingival symptoms (metastatic tumor) preceded the discovery of the primary lesions.

Iranian Journal of Radiation Research, 2015

Background: Different treatment and protecve approaches for radiaon- induced oral mucosis have be... more Background: Different treatment and protecve approaches for radiaon- induced oral mucosis have been pracced and have variees of success. Of which, radioprotecve agents, synthec or natural, have been of great interest for researchers. This study aims to evaluate the ef fect of curcuma longa topical gel as a herbal producon on mucosis induced by radiaon therapy of head and neck cancers. Materials and Methods: Thirty seven paents with head and neck cancer admi ed for radiaon therapy were selected. The paents were given curcuma longa or placebo topical gel for 8 weeks since the iniaon of the radiotherapy, and were evaluated weekly for the presence and the extent of oral mucosis. Results: No grade-3 mucosis was observed in paents who used curcuma longa topical gel, and the grade of the mucosis was significantly different between the two groups with be er effects found in case group compared to controls. No significant difference between the case and control groups was observed when compa...

Journal of Dental Medicine, 2017

رتكد نايروصنم شرآ ١ رتكد نايزاريش اويش ٢  رتكد يليلج دمحم ٣ رتكد روپ نطو يدهم ٤ رتكد يبارعا نموم... more رتكد نايروصنم شرآ ١ رتكد نايزاريش اويش ٢  رتكد يليلج دمحم ٣ رتكد روپ نطو يدهم ٤ رتكد يبارعا نموم روپ لايل ٥ ١ هورگ رايشناد شزومآ ي تروص و كف و ناهد ياهراميب ، يكشزپنادند هدكشناد ، يكشزپ مولع هاگشناد هب تامدخ و ينامرد ،يتشاد ت ،ناره نارهت ، ناريا وضع ؛ تاقيقحت زكرم يكشزپنادند هدكشناد ، يكشزپ مولع هاگشناد ينامرد ،يتشادهب تامدخ و ،نارهت ،نارهت ناريا ٢ هورگ رايداتسا يشزومآ كف و ناهد ياهراميب تروص و ، يكشزپنادند هدكشناد ، يكشزپ مولع هاگشناد ب تامدخ و ينامرد ،يتشاده هت نار ، ،نارهت ناريا ٣ هورگ رايشناد يشزومآ سناژروا بط ، يكشزپ هدكشناد ، يكشزپ مولع هاگشناد ينامرد ،يتشادهب تامدخ و نارهت ، رهت ،نا ناريا ٤ هورگ رايداتسا يشزومآ ،سكيتندودنا شزپنادند هدكشناد يك ، يملاسا دازآ هاگشناد نارهت ، ناريا ،نارهت ٥ كشزپنادند

Iranian Journal of Pharmaceutical Research, 2008

Oral Lichen Planus (OLP) is a chronic inflammatory disease of oral mucosa, with an immunological ... more Oral Lichen Planus (OLP) is a chronic inflammatory disease of oral mucosa, with an immunological origin. Atrophic/erosive OLP needs appropriate treatment, due to the pain and malignancy potential. Topical corticosteroids are the most effective drug therapy and mouthwashes are more effective topical dosage forms for this purpose. However, at present there are no corticosteroid mouthwashes available in Iran. In this study, the efficacy of a new mouthwash containing clobetasol, ketoconasole and amitriptyline was evaluated in comparison to the common treatment. In this double blind randomized clinical trial study, 50 patients who had inclusion criteria were grouped randomly, with no difference in demographic data. The experimental group was treated using 5ml of mouthwash four times a day for 5 min, while the control group was treated by dexamethasone tablet, nystatin drop and diphenhydramine syrup. Severity of the lesions and pain were followed as the chief complain and recorded in the ...

West Indian Medical Journal, 2016

Purpose: The purpose of this study was to compare salivary immunoglobulin A (IgA) and total prote... more Purpose: The purpose of this study was to compare salivary immunoglobulin A (IgA) and total protein (TP) in patients suffering from oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC), against healthy control. Methods: In a case-control study, 20 patients with OSCC, 30 patients suffering from OLP and 50 non-involved subjects were enrolled. The mean stimulated and unstimulated saliva IgA and TP levels were assayed by the Biuret method and immunoturbidometry respectively. Statistical analysis of the ANOVA was performed. Results: The mean concentration of stimulated and unstimulated saliva IgA and TP were significantly higher in both OLP and OSCC patients compared to control. Additionally TP, but not IgA, was higher in patients with OSCC compared with OLP patients d more salivary TP than OLP patients. Conclusion: Results suggest that salivary TP but not IgA is higher in OSCC patients than OLP patients.

iranian endodontic journal, 2008

External root resorption may be an uncontrolled phenomenon, and the most known interventions have... more External root resorption may be an uncontrolled phenomenon, and the most known interventions have no effect. Even progressive external root resorption may not be controlled by long term Ca(OH)2 therapy. Currently, there are no treatment options for vital tooth that suffer from root resorption. This invasive resorption can lead to extraction of the tooth. The use of new technologies such as low power laser may control this type of resorption. (Iranian Endodontic Journal 2008;3:93-4)

Iranian Endodontic Journal, 2008

In endodontics, treatment of an open apex tooth with necrotic pulp is a problem. It seems that wi... more In endodontics, treatment of an open apex tooth with necrotic pulp is a problem. It seems that with promotion of remnants of Hertwig’s epithelial sheath or rest of malassez accompany with a good irrigation of root canal we can expect root formation. (Iranian Endodontic Journal 2008;3:42-43)

Photochemistry and Photobiology, 2021

Potentially malignant disorders are one of the clinical challenges. Dysplasia in these lesions ca... more Potentially malignant disorders are one of the clinical challenges. Dysplasia in these lesions can be a predictor of more potential for malignant changes. Photo‐bio‐modulation in benign lesions has advantages, but there is doubt on its safety in potentially malignant lesions. This study aims to assess if low‐level laser can promote dysplastic changes while the method can play an important role in management of dysplastic lesions. Dysplasia was induced on anterior wall of the buccal pouch of 80 young Syrian male hamsters. Then, hamsters were divided to four groups to receive 4 and 12 sessions irradiation of 660 and 810 nanometers low‐level lasers. For histopathologic study of the tissue, we used light microscopes. Using SPSS, data were analyzed via Wilcoxon signed rank test and Mann–Whitney U‐test. In all of our four groups, the severity of dysplasia had no statistical difference in study sides comparing with their own controls. Wavelength and numbers of laser irradiation sessions ha...

Journal of Dental Medicine, 2020

رتكد نايزاريش اويش ١ رتكد ينانمج دازكين هنيكس ٢  رتكد نايرامعم ميرم ٣ رتكد يقاش امه ٤ ١ اتسا شاد... more رتكد نايزاريش اويش ١ رتكد ينانمج دازكين هنيكس ٢  رتكد نايرامعم ميرم ٣ رتكد يقاش امه ٤ ١ اتسا شادهب تامدخ و يكشزپ مولع هاگشناد ،يكشزپنادند هدكشناد ،تروص و كف و ناهد ياهراميب يشزومآ هورگ رايد ناريا ،نارهت ،نارهت ينامرد ،يت ٢ مرد ،يتشادهب تامدخ و يكشزپ مولع هاگشناد ،يكشزپنادند هدكشناد ،ينادند ياهزتورپ يشزومآ هورگ رايشناد نارهت ،نارهت ينا ٣ اد رايشن مرد ،يتشادهب تامدخ و يكشزپ مولع هاگشناد ،يكشزپنادند هدكشناد ،ينادند ياهزتورپ يشزومآ هورگ نارهت ،نارهت ينا ، ناريا ؛ تاقيقحت زكرم وضع يكشزپنادند ، ناريا ،نارهت ،نارهت ينامرد ،يتشادهب تامدخ و يكشزپ مولع هاگشناد ،يكشزپنادند مولع هدكشهوژپ ٤ كشزپنادند هدكشناد ، نارهت ،نارهت ينامرد ،يتشادهب تامدخ و يكشزپ مولع هاگشناد ،يكشزپنادند ناريا ،

Photochemistry and Photobiology, 2020

In the present study, the effects of 660 and 810 nm diode laser on the proliferation and invasion... more In the present study, the effects of 660 and 810 nm diode laser on the proliferation and invasion of cancer cells were investigated. Sixteen plates of oral cancer cells originated from tongue SCC were irradiated with diode laser at 660 nm (40 and 80 mW) and 810 nm (100 and 200 mW) with the energy density of 4 J cm−2. One plate received no irradiation (the control). Irradiation was performed at four times (0, 24, 72 and 168 h). Cell proliferation was measured by MTT assay. The Ki67 and vascular endothelial growth factor (VEGF) markers were examined by real‐time polymerase chain reaction (RT‐PCR). Cyclin D1, E‐cadherin, β‐catenin and matrix metalloproteinase‐9 (MMP‐9; flow cytometry) were also evaluated. Proliferation was lower in the irradiated groups. This result was significant for all groups at 24 h. The percentages of cyclin D1 and MMP‐9 were higher in 810 nm groups, β‐catenin and E‐cadherin were higher in 660 nm groups, VEGF marker was significantly lower in 810 nm/200 mW group, and Ki67 marker has no difference between the groups. According to the results of this study, laser irradiation at 0 and 24 h resulted in a significant inhibitory effect on cell proliferation especially in 660 nm/80 mW and 810 nm/200 mW. Further studies are needed in this respect.

Frontiers in Dentistry, 2020

Objectives: Oral candidiasis has increased in recent years because of the increasing number of hi... more Objectives: Oral candidiasis has increased in recent years because of the increasing number of high-risk populations. The prevalence of Candida species is different worldwide because of the difference between population characteristics, sampling protocols, and geographic regions. Therefore, determining the more prevalent Candida species in different geographic regions seems essential. This study aimed to determine the more prevalent Candida species in acute myeloid leukemia (AML) patients in comparison with healthy individuals in Iran in 2016. Materials and Methods: Fifty-one patients with AML and 62 healthy controls participated in this cross-sectional study. Samples were collected using a swab rubbed softly on the dorsal surface of the tongue and the oropharynx. The samples were cultured on CHROMagar Candida for 2 to 4 days. For differentiation between albicans and non-albicans species, positive samples were linearly inoculated on Corn Meal Agar with Tween-80. Candida species were...

Journal of Research in Dental and Maxillofacial Sciences, 2017

Background and aim: Gathering information about the patient's present illness by allocating adequ... more Background and aim: Gathering information about the patient's present illness by allocating adequate time to detect the main reason of referral is of utmost importance. This is mostly related to the manner of communication and interaction with the patient and active listening to his/her statements. Registering the information related to the illness and its history has an effective role in patient satisfaction, treatment outcomes, and dental expenses and even in lawsuits against practitioners. Therefore, the present study aimed to compare the average time allocated by general dentists and senior dental students of the dental school of Tehran University of Medical Sciences to obtain the history of the patient's present illness during 2012-2013. Materials and methods: In this cross-sectional study, 60 senior dental students of the dental school of Tehran University of Medical Sciences and 60 general dentists that had been graduated at least five years ago were selected. Each of them randomly selected three patients and recorded the patients' demographics such as age, gender, education level, and the chief complaint or the main reason of the patient's visit. The duration of the patient's statements regarding the present illness and its history was recorded in seconds in the designed questionnaire. Afterwards, the data were analyzed using T-test and Mann-U-Whitney, Kendall-tau and Chi-square tests. Results: The average interview time in the students and dentists groups was 24.41±9.17 seconds and 27.9±7.82 seconds, respectively, which were significantly different according to T-test (p=0.003). Generally, the longest allocated time equaled 49 seconds, while the shortest interview duration was 6 seconds. Conclusion: According to the results of the present study, it seems that dentists do not allocate the necessary and adequate time to gather information about the chief complaint and the history of the patient's reason of referral to guide them towards the correct diagnosis and suitable treatment method, and even the passage of time and the level of experience have no effect on this issue.

Journal of dentistry (Tehran, Iran), 2015

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. Its treatment is often sympto... more Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. Its treatment is often symptomatic and includes topical and systemic corticosteroids. Although corticosteroid therapy is usually successful, it has side effects and thus, an alternative treatment is favorable. The aim of this study was to compare the efficacy of topical curcumin and triamcinolone for treatment of oral lichen planus (OLP). In this study, 50 patients (36 women and 14 men) in the age range of 38 to 73 years with OLP were randomly divided into two groups. Each group received 0.1% triamcinolone or 5% curcumin oral paste three times a day for four weeks. Assessment of the appearance score and severity of pain was done at baseline and at the end of two and four weeks and recorded in the patients' questionnaires. The data were analyzed by SPSS 17 software, using the Mann-Whitney and Spearman's tests. With respect to pain reduction, nine patients (36%) in the curcumin group and eight patients (32%) i...