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Research paper thumbnail of Pengaruh pemberian ekstrak etanol buah kurma Ajwa (Phenix dactylifera) terhadap proliferasi sel endometrium kambing secara In Vitro

ABSTRAK Kegagalan implantasi embrio pada uterus dapat menyebabkan terjadinya keguguran atau abort... more ABSTRAK Kegagalan implantasi embrio pada uterus dapat menyebabkan terjadinya keguguran atau abortus. Salah satu faktor kuatnya uterus sebagai tempat implantasi adalah ketersediaan hormon yang cukup. Endometrium merupakan lapisan jaringan pada uterus yang sangat responsif terhadap perubahan hormon. Suksesnya implantasi bergantung pada kuatnya sel epitel dan sel stroma endometrium. Kemampuan proliferasi sel endometrium akibat pengaruh hormon dipelajari secara in vitro dengan mengetahui nilai viabilitas (%) dan nilai PDT (jam) sel endometrium yang dikultur. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh ekstrak etanol buah kurma Ajwa (Phoenix dactylifera) terhadap proliferasi sel endometrium kambing secara in vitro. Penelitian ini merupakan penelitian eksperimental menggunakan 5 konsentrasi perlakuan yaitu pemberian ekstrak etanol buah kurma Ajwa (Phoenix dactylifera) pada medium DMEM 10% dengan konsentrasi 0 µM, 10µM, 20µM, 30µM, dan 40µM dan 1 perlakuan kontrol 10µM geni...

Research paper thumbnail of The In Silico Analysis and Identification of Possible Inhibitor of H5N1 Virus: Compounds Analysis and Identification of Possible Neuraminidase Inhibitors

Bioinformatics and Biomedical Research Journal, Sep 3, 2018

Fingerroot (Boesenbergia pandurata (Roxb.) belongs to the family Zingiberaceae (Ginger). B. pandu... more Fingerroot (Boesenbergia pandurata (Roxb.) belongs to the family Zingiberaceae (Ginger). B. pandurata has pharmacological benefits such as neuroprotective, chemoprotective, anti-inflammatory, anti-angiogenic, antioxidant, an inhibitor of protease enzyme NS2B/NS3 dengue virus, Japanese encephalitis virus and swine flu virus (H1N1). This study aims to determine the most effective compounds from B. pandurata as neuraminidase inhibitors of H5N1 virus. The amino acid sequence for neuraminidase of avian influenza A virus subtype H5N1 of A/China/GD02/2006 (ABX57872.1) was retrieved from protein sequence database at NCBI. Then, modeled by Swiss Model. Analyse of molecular docking was performed using PyRx and the interactions between neuraminidase inhibitors of H5N1 and B. pandurata active compound was analyzed by PyMol software and LigPlot+ software. From the 30 active compounds which have been docked, 4-hydroxypanduratin A, rubranine, boesenbergin B, boesenbergin A, 5,7-dimethoxyflavone, and tectochrysin had an equal or smaller free binding energy than control compound. 4-hydroxypanduratin A proved to be the most potent active compound as a neuraminidase inhibitor (NA 1) because it has the most negative binding energy and the same amino acid binding residue with the control compound. Therefore, 4-hydroxypanduratin A is predicted to be used as inhibitors of neuraminidase in the H5N1 virus.

Research paper thumbnail of The In Silico Analysis and Identification of Possible Inhibitor of H5N1 Virus

Fingerroot (Boesenbergia pandurata (Roxb.)) belongs to the family Zingiberaceae (Ginger). B. pand... more Fingerroot (Boesenbergia pandurata (Roxb.)) belongs to the family Zingiberaceae (Ginger). B. pandurata has pharmacological benefits such as neuroprotective, chemoprotective, anti-inflammatory, anti-angiogenic, antioxidant, an inhibitor of protease enzyme NS2B/NS3 dengue virus, Japanese encephalitis virus and swine flu virus (H1N1). This study aims to determine the most effective compounds from B. pandurata as neuraminidase inhibitors of H5N1 virus. The amino acid sequence for neuraminidase of avian influenza A virus subtype H5N1 of A/China/GD02/2006 was retrieved from protein sequence database at NCBI. Then, modeled by Swiss Model. Analyse of molecular docking was performed using PyRx and the interactions between neuraminidase inhibitors of H5N1 and B. pandurata active compound was analyzed by PyMol software and LigPlot+ software. From the 30 active compounds which have been docked, 4-hydroxypanduratin A, rubranine, boesenbergin B, boesenbergin A, 5,7-dimethoxyflavone, and tectochry...

Research paper thumbnail of The Invasive Plants Species along the Hiking Track of Mount Panderman Nature Tourism, Batu, East Java

Journal of Indonesian Tourism and Development Studies, 2018

Indonesia has the highest biodiversity that places ecotourism as a sustainable development sector... more Indonesia has the highest biodiversity that places ecotourism as a sustainable development sector. The negative impact of ecotourism is the vulnerability to invasive plant species growth. They invade the habitat of the native plants and potentially alter the biodiversity balance. This invasive plant introduction is predicted caused by tourist and hiker visits. Therefore, the inventory of invasive plant species is urgently needed. The field survey was conducted on March 11-12, 2017 to inventory invasive plant species along the Panderman Mountain hiking track that common travelers explored and then identified. Species of Pinus Caribaea , Chromolaena odorata , Lantana camara , Leucaena leucocephala , Pennisetum purpureum are categorized invasive plants. Four species of plants otherwise potentially invasive include Calliandra calothrysus , Ageratum conyzoides , Bidens pilosa , and Acacia deccurens . The widespread access to protected environmental destinations leads to the spread of hig...

Research paper thumbnail of Pengaruh pemberian ekstrak etanol buah kurma Ajwa (Phenix dactylifera) terhadap proliferasi sel endometrium kambing secara In Vitro

ABSTRAK Kegagalan implantasi embrio pada uterus dapat menyebabkan terjadinya keguguran atau abort... more ABSTRAK Kegagalan implantasi embrio pada uterus dapat menyebabkan terjadinya keguguran atau abortus. Salah satu faktor kuatnya uterus sebagai tempat implantasi adalah ketersediaan hormon yang cukup. Endometrium merupakan lapisan jaringan pada uterus yang sangat responsif terhadap perubahan hormon. Suksesnya implantasi bergantung pada kuatnya sel epitel dan sel stroma endometrium. Kemampuan proliferasi sel endometrium akibat pengaruh hormon dipelajari secara in vitro dengan mengetahui nilai viabilitas (%) dan nilai PDT (jam) sel endometrium yang dikultur. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh ekstrak etanol buah kurma Ajwa (Phoenix dactylifera) terhadap proliferasi sel endometrium kambing secara in vitro. Penelitian ini merupakan penelitian eksperimental menggunakan 5 konsentrasi perlakuan yaitu pemberian ekstrak etanol buah kurma Ajwa (Phoenix dactylifera) pada medium DMEM 10% dengan konsentrasi 0 µM, 10µM, 20µM, 30µM, dan 40µM dan 1 perlakuan kontrol 10µM geni...

Research paper thumbnail of The In Silico Analysis and Identification of Possible Inhibitor of H5N1 Virus: Compounds Analysis and Identification of Possible Neuraminidase Inhibitors

Bioinformatics and Biomedical Research Journal, Sep 3, 2018

Fingerroot (Boesenbergia pandurata (Roxb.) belongs to the family Zingiberaceae (Ginger). B. pandu... more Fingerroot (Boesenbergia pandurata (Roxb.) belongs to the family Zingiberaceae (Ginger). B. pandurata has pharmacological benefits such as neuroprotective, chemoprotective, anti-inflammatory, anti-angiogenic, antioxidant, an inhibitor of protease enzyme NS2B/NS3 dengue virus, Japanese encephalitis virus and swine flu virus (H1N1). This study aims to determine the most effective compounds from B. pandurata as neuraminidase inhibitors of H5N1 virus. The amino acid sequence for neuraminidase of avian influenza A virus subtype H5N1 of A/China/GD02/2006 (ABX57872.1) was retrieved from protein sequence database at NCBI. Then, modeled by Swiss Model. Analyse of molecular docking was performed using PyRx and the interactions between neuraminidase inhibitors of H5N1 and B. pandurata active compound was analyzed by PyMol software and LigPlot+ software. From the 30 active compounds which have been docked, 4-hydroxypanduratin A, rubranine, boesenbergin B, boesenbergin A, 5,7-dimethoxyflavone, and tectochrysin had an equal or smaller free binding energy than control compound. 4-hydroxypanduratin A proved to be the most potent active compound as a neuraminidase inhibitor (NA 1) because it has the most negative binding energy and the same amino acid binding residue with the control compound. Therefore, 4-hydroxypanduratin A is predicted to be used as inhibitors of neuraminidase in the H5N1 virus.

Research paper thumbnail of The In Silico Analysis and Identification of Possible Inhibitor of H5N1 Virus

Fingerroot (Boesenbergia pandurata (Roxb.)) belongs to the family Zingiberaceae (Ginger). B. pand... more Fingerroot (Boesenbergia pandurata (Roxb.)) belongs to the family Zingiberaceae (Ginger). B. pandurata has pharmacological benefits such as neuroprotective, chemoprotective, anti-inflammatory, anti-angiogenic, antioxidant, an inhibitor of protease enzyme NS2B/NS3 dengue virus, Japanese encephalitis virus and swine flu virus (H1N1). This study aims to determine the most effective compounds from B. pandurata as neuraminidase inhibitors of H5N1 virus. The amino acid sequence for neuraminidase of avian influenza A virus subtype H5N1 of A/China/GD02/2006 was retrieved from protein sequence database at NCBI. Then, modeled by Swiss Model. Analyse of molecular docking was performed using PyRx and the interactions between neuraminidase inhibitors of H5N1 and B. pandurata active compound was analyzed by PyMol software and LigPlot+ software. From the 30 active compounds which have been docked, 4-hydroxypanduratin A, rubranine, boesenbergin B, boesenbergin A, 5,7-dimethoxyflavone, and tectochry...

Research paper thumbnail of The Invasive Plants Species along the Hiking Track of Mount Panderman Nature Tourism, Batu, East Java

Journal of Indonesian Tourism and Development Studies, 2018

Indonesia has the highest biodiversity that places ecotourism as a sustainable development sector... more Indonesia has the highest biodiversity that places ecotourism as a sustainable development sector. The negative impact of ecotourism is the vulnerability to invasive plant species growth. They invade the habitat of the native plants and potentially alter the biodiversity balance. This invasive plant introduction is predicted caused by tourist and hiker visits. Therefore, the inventory of invasive plant species is urgently needed. The field survey was conducted on March 11-12, 2017 to inventory invasive plant species along the Panderman Mountain hiking track that common travelers explored and then identified. Species of Pinus Caribaea , Chromolaena odorata , Lantana camara , Leucaena leucocephala , Pennisetum purpureum are categorized invasive plants. Four species of plants otherwise potentially invasive include Calliandra calothrysus , Ageratum conyzoides , Bidens pilosa , and Acacia deccurens . The widespread access to protected environmental destinations leads to the spread of hig...