shradha shende - Profile on Academia.edu (original) (raw)

Papers by shradha shende

Strain variation in Azotabacter chroococum in relation to sensitivity to penicillin and mutual antagonism

Indian Journal of Agricultural Sciences, 1970

The Pharma Innovation Journal, 2019

In the current study a successful attempt was made to formulate bilayer floating tablets of clari... more In the current study a successful attempt was made to formulate bilayer floating tablets of clarithromycin and omeprazole by direct compression method containing loading dose, superdisintegrants in immediate release layer and maintenance dose, rate controlling polymers and gas generating agents in floating layer. The extended release was prepared by direct compression method using HPMC K15, HPMC K4, PVP K30, as sustained release polymer and sodium bicarbonate as gas generating agent to reduce floating lag time. Immediate release layer were prepared by direct compression using sodium starch glycolate, Croscarmellose sodium, crospovidone as super disintegrant. Gastro retentive floating drug delivery systems have been designed to increase its residence time in the stomach. The granules were evaluated for bulk density, tapped density, compressibility index, and hausner's ratio. The granules showed satisfactory flow properties. The optimized tablets were compressed to obtain bilayer tablets. The tablets were evaluated for various physicochemical parameters and dissolution study. Further, the bilayer tablets were subjected to accelerated stability study. The omeprazole tablet showing more than 99.45 % release in 15 min and clarithromycin tablet showing more than 99.76 % release at the end of 12 h of initial lag time were compressed one above the other to obtain bilayer tablet. The similar release pattern was observed with the bilayer tablets as that of individual tablets. The bilayer tablets were found to be stable at the end of 6 months storage period as per ICH guidelines. Both the layers of the bilayer formulation showed desired drug release at the end of time period.

Formulation, Development and Evaluation of Fast Dissolving Sublingual Wafers of an Antipsychotic Drug Using Film Former

Asian journal of pharmaceutical education and research, Oct 10, 2021

Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel

Asian Journal of Pharmacy and Technology, Nov 26, 2021

The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. T... more The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. The voriconazole microemulsified is prepared by Water Titration Method. In which voriconazole microemulsified incorporated with hydrogel, Blank gels of different polymers were prepared by distilled water. Finally, the carbopol gel was prepared by dispersing 0.5% carbopol w/v and 0.5% aloe vera powder in 100 ml of water with stirring on mechanical stir. Additionally, for preservation of formulations 0.8% methyl paraben was mixed. Oil phase was selected by dissolving the voriconazole pure in different oils, oleic acid, castor oil, coconut oil, olive oil, cooten seed mineral oil and soya oil. Oleic acid was selected on the basis of higher solubility of voriconazole in it. Combination of surfactant and co-surfactant was selected on clear visual observation. Span - 40: propylene glycol in ratio 1:1 and 2:1 selected for further preparation of microemulsion. From the study F-8, F-9, F-10, F-14 and F-15 were selected for further studies. Though F-16, F-17, F-18, F-19 and F-20 formulations are also stable, but rejected due to high concentration of surfactant can cause skin irritation, skin burning and/or other complications. Characterization of selected voriconazole microemulsion formulations were evaluated under various parameters like Droplet size, Zeta potential, Poly Dispersity Index (PDI) and (%) Drug content all results showed.

Formulation Development and Evaluation of Emulgel of Clindamycin Phosphate for Effective Treatment of Acne

Journal of Drug Delivery and Therapeutics, Jul 15, 2019

Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel

Asian Journal of Pharmacy and Technology, 2021

The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. T... more The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. The voriconazole microemulsified is prepared by Water Titration Method. In which voriconazole microemulsified incorporated with hydrogel, Blank gels of different polymers were prepared by distilled water. Finally, the carbopol gel was prepared by dispersing 0.5% carbopol w/v and 0.5% aloe vera powder in 100 ml of water with stirring on mechanical stir. Additionally, for preservation of formulations 0.8% methyl paraben was mixed. Oil phase was selected by dissolving the voriconazole pure in different oils, oleic acid, castor oil, coconut oil, olive oil, cooten seed mineral oil and soya oil. Oleic acid was selected on the basis of higher solubility of voriconazole in it. Combination of surfactant and co-surfactant was selected on clear visual observation. Span - 40: propylene glycol in ratio 1:1 and 2:1 selected for further preparation of microemulsion. From the study F-8, F-9, F-10, F-14 a...

The Pharma Innovation Journal, 2019

In the current study a successful attempt was made to formulate bilayer floating tablets of clari... more In the current study a successful attempt was made to formulate bilayer floating tablets of clarithromycin and omeprazole by direct compression method containing loading dose, superdisintegrants in immediate release layer and maintenance dose, rate controlling polymers and gas generating agents in floating layer. The extended release was prepared by direct compression method using HPMC K15, HPMC K4, PVP K30, as sustained release polymer and sodium bicarbonate as gas generating agent to reduce floating lag time. Immediate release layer were prepared by direct compression using sodium starch glycolate, Croscarmellose sodium, crospovidone as super disintegrant. Gastro retentive floating drug delivery systems have been designed to increase its residence time in the stomach. The granules were evaluated for bulk density, tapped density, compressibility index, and hausner’s ratio. The granules showed satisfactory flow properties. The optimized tablets were compressed to obtain bilayer tabl...

Fast dissolving oral film (FDOF) is used as a novel approach, as it dissolves rapidly in mouth an... more Fast dissolving oral film (FDOF) is used as a novel approach, as it dissolves rapidly in mouth and directly reaches to the systemic circulation. Oral film technology fulfills all the requirements of potential solid dosage form. The present study was aimed to formulate and evaluate fast dissolving oral films of Levosulpiride using Hydroxy Propyl Methyl Cellulose (HPMC), Sodium Starch Glycolate, Crospovidone, Croscarmellose Sodium, Mannitol and Citric Acid. The suitable plasticizer and its concentration were selected on the basis of flexibility, tensile strength and stickiness of the film. The films are prepared by solvent casting method and characterized by UV, FTIR studies. The films were evaluated for disintegration time, folding endurance, thickness, percentage of moisture content, drug content and in-vitro dissolution studies. The F8 formulation has given 99.85% drug release within 10 minutes.

Indian Journal of Pharmaceutical Sciences, 2012

Londhe and Umalkar: Fast Dissolving Film of Telmisartan Hypertension is a major cause of concern ... more Londhe and Umalkar: Fast Dissolving Film of Telmisartan Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it shows very less solubility in the pH range of 3-9. Various film forming agents and polyhydric alcohols were evaluated for optimizing composition of fast dissolving films. Fast dissolving films using hydroxypropyl methylcellulose, polyvinyl alcohol, glycerol, sorbitol, menthol and an alkalizer were formulated using solvent casting method. Optimized formulations were evaluated for their weight, thickness, folding endurance, appearance, tensile strength, disintegration time and dissolution profile.

Formulation Development and Evaluation of Sustained Release Tablets of Lornoxicam

World Journal of Pharmaceutical Research, 2017

Lornoxicam is a non-steroidal anti-inflammatory drug, Lornoxicam has short half-life (3-5 hr.), m... more Lornoxicam is a non-steroidal anti-inflammatory drug, Lornoxicam has short half-life (3-5 hr.), makes the development of sustained-release (SR) forms extremely advantageous, lornoxicam is weak acid having pKa 5.1, it has pH dependent solubility, characterized by poor solubility in low pH condition present in stomach, which consequently leads to a delayed onset of its analgesic action. Formulation of sustained release tablet is effective approach for nonsteroidal antiinflammatory drug (lornoxicam) for maximum pain relief with prolong drug concentration due to sustained release from tablet matrix. Different formulations (F1F8) were designed with HPMC (K4M and K100), MCC, PVP k30, magnesium stearate and talc. Pre and post compression parameters for all formulations were studied. Batch F8 selected as optimized batch on the basis of dissolution profile.

Journal of Drug Delivery and Therapeutics

A skin disease, like acne, is very common and normally happens to everyone at least once in their... more A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. One of the best options for successful drug delivery to the affected area of skin is the use of ethosomes which can be transported through the skin through channel-like structures. Tretinoin is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Drug loaded ethosomes had been prepared using phospholipid and ethanol, were optimized and characterized for entrapment efficiency, vesicular size, shape, In-vitro skin permeation, skin retention, drug‐membrane component interaction and stability...

Strain variation in Azotabacter chroococum in relation to sensitivity to penicillin and mutual antagonism

Indian Journal of Agricultural Sciences, 1970

The Pharma Innovation Journal, 2019

In the current study a successful attempt was made to formulate bilayer floating tablets of clari... more In the current study a successful attempt was made to formulate bilayer floating tablets of clarithromycin and omeprazole by direct compression method containing loading dose, superdisintegrants in immediate release layer and maintenance dose, rate controlling polymers and gas generating agents in floating layer. The extended release was prepared by direct compression method using HPMC K15, HPMC K4, PVP K30, as sustained release polymer and sodium bicarbonate as gas generating agent to reduce floating lag time. Immediate release layer were prepared by direct compression using sodium starch glycolate, Croscarmellose sodium, crospovidone as super disintegrant. Gastro retentive floating drug delivery systems have been designed to increase its residence time in the stomach. The granules were evaluated for bulk density, tapped density, compressibility index, and hausner's ratio. The granules showed satisfactory flow properties. The optimized tablets were compressed to obtain bilayer tablets. The tablets were evaluated for various physicochemical parameters and dissolution study. Further, the bilayer tablets were subjected to accelerated stability study. The omeprazole tablet showing more than 99.45 % release in 15 min and clarithromycin tablet showing more than 99.76 % release at the end of 12 h of initial lag time were compressed one above the other to obtain bilayer tablet. The similar release pattern was observed with the bilayer tablets as that of individual tablets. The bilayer tablets were found to be stable at the end of 6 months storage period as per ICH guidelines. Both the layers of the bilayer formulation showed desired drug release at the end of time period.

Formulation, Development and Evaluation of Fast Dissolving Sublingual Wafers of an Antipsychotic Drug Using Film Former

Asian journal of pharmaceutical education and research, Oct 10, 2021

Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel

Asian Journal of Pharmacy and Technology, Nov 26, 2021

The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. T... more The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. The voriconazole microemulsified is prepared by Water Titration Method. In which voriconazole microemulsified incorporated with hydrogel, Blank gels of different polymers were prepared by distilled water. Finally, the carbopol gel was prepared by dispersing 0.5% carbopol w/v and 0.5% aloe vera powder in 100 ml of water with stirring on mechanical stir. Additionally, for preservation of formulations 0.8% methyl paraben was mixed. Oil phase was selected by dissolving the voriconazole pure in different oils, oleic acid, castor oil, coconut oil, olive oil, cooten seed mineral oil and soya oil. Oleic acid was selected on the basis of higher solubility of voriconazole in it. Combination of surfactant and co-surfactant was selected on clear visual observation. Span - 40: propylene glycol in ratio 1:1 and 2:1 selected for further preparation of microemulsion. From the study F-8, F-9, F-10, F-14 and F-15 were selected for further studies. Though F-16, F-17, F-18, F-19 and F-20 formulations are also stable, but rejected due to high concentration of surfactant can cause skin irritation, skin burning and/or other complications. Characterization of selected voriconazole microemulsion formulations were evaluated under various parameters like Droplet size, Zeta potential, Poly Dispersity Index (PDI) and (%) Drug content all results showed.

Formulation Development and Evaluation of Emulgel of Clindamycin Phosphate for Effective Treatment of Acne

Journal of Drug Delivery and Therapeutics, Jul 15, 2019

Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel

Asian Journal of Pharmacy and Technology, 2021

The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. T... more The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. The voriconazole microemulsified is prepared by Water Titration Method. In which voriconazole microemulsified incorporated with hydrogel, Blank gels of different polymers were prepared by distilled water. Finally, the carbopol gel was prepared by dispersing 0.5% carbopol w/v and 0.5% aloe vera powder in 100 ml of water with stirring on mechanical stir. Additionally, for preservation of formulations 0.8% methyl paraben was mixed. Oil phase was selected by dissolving the voriconazole pure in different oils, oleic acid, castor oil, coconut oil, olive oil, cooten seed mineral oil and soya oil. Oleic acid was selected on the basis of higher solubility of voriconazole in it. Combination of surfactant and co-surfactant was selected on clear visual observation. Span - 40: propylene glycol in ratio 1:1 and 2:1 selected for further preparation of microemulsion. From the study F-8, F-9, F-10, F-14 a...

The Pharma Innovation Journal, 2019

In the current study a successful attempt was made to formulate bilayer floating tablets of clari... more In the current study a successful attempt was made to formulate bilayer floating tablets of clarithromycin and omeprazole by direct compression method containing loading dose, superdisintegrants in immediate release layer and maintenance dose, rate controlling polymers and gas generating agents in floating layer. The extended release was prepared by direct compression method using HPMC K15, HPMC K4, PVP K30, as sustained release polymer and sodium bicarbonate as gas generating agent to reduce floating lag time. Immediate release layer were prepared by direct compression using sodium starch glycolate, Croscarmellose sodium, crospovidone as super disintegrant. Gastro retentive floating drug delivery systems have been designed to increase its residence time in the stomach. The granules were evaluated for bulk density, tapped density, compressibility index, and hausner’s ratio. The granules showed satisfactory flow properties. The optimized tablets were compressed to obtain bilayer tabl...

Fast dissolving oral film (FDOF) is used as a novel approach, as it dissolves rapidly in mouth an... more Fast dissolving oral film (FDOF) is used as a novel approach, as it dissolves rapidly in mouth and directly reaches to the systemic circulation. Oral film technology fulfills all the requirements of potential solid dosage form. The present study was aimed to formulate and evaluate fast dissolving oral films of Levosulpiride using Hydroxy Propyl Methyl Cellulose (HPMC), Sodium Starch Glycolate, Crospovidone, Croscarmellose Sodium, Mannitol and Citric Acid. The suitable plasticizer and its concentration were selected on the basis of flexibility, tensile strength and stickiness of the film. The films are prepared by solvent casting method and characterized by UV, FTIR studies. The films were evaluated for disintegration time, folding endurance, thickness, percentage of moisture content, drug content and in-vitro dissolution studies. The F8 formulation has given 99.85% drug release within 10 minutes.

Indian Journal of Pharmaceutical Sciences, 2012

Londhe and Umalkar: Fast Dissolving Film of Telmisartan Hypertension is a major cause of concern ... more Londhe and Umalkar: Fast Dissolving Film of Telmisartan Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it shows very less solubility in the pH range of 3-9. Various film forming agents and polyhydric alcohols were evaluated for optimizing composition of fast dissolving films. Fast dissolving films using hydroxypropyl methylcellulose, polyvinyl alcohol, glycerol, sorbitol, menthol and an alkalizer were formulated using solvent casting method. Optimized formulations were evaluated for their weight, thickness, folding endurance, appearance, tensile strength, disintegration time and dissolution profile.

Formulation Development and Evaluation of Sustained Release Tablets of Lornoxicam

World Journal of Pharmaceutical Research, 2017

Lornoxicam is a non-steroidal anti-inflammatory drug, Lornoxicam has short half-life (3-5 hr.), m... more Lornoxicam is a non-steroidal anti-inflammatory drug, Lornoxicam has short half-life (3-5 hr.), makes the development of sustained-release (SR) forms extremely advantageous, lornoxicam is weak acid having pKa 5.1, it has pH dependent solubility, characterized by poor solubility in low pH condition present in stomach, which consequently leads to a delayed onset of its analgesic action. Formulation of sustained release tablet is effective approach for nonsteroidal antiinflammatory drug (lornoxicam) for maximum pain relief with prolong drug concentration due to sustained release from tablet matrix. Different formulations (F1F8) were designed with HPMC (K4M and K100), MCC, PVP k30, magnesium stearate and talc. Pre and post compression parameters for all formulations were studied. Batch F8 selected as optimized batch on the basis of dissolution profile.

Journal of Drug Delivery and Therapeutics

A skin disease, like acne, is very common and normally happens to everyone at least once in their... more A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. One of the best options for successful drug delivery to the affected area of skin is the use of ethosomes which can be transported through the skin through channel-like structures. Tretinoin is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Drug loaded ethosomes had been prepared using phospholipid and ethanol, were optimized and characterized for entrapment efficiency, vesicular size, shape, In-vitro skin permeation, skin retention, drug‐membrane component interaction and stability...