shradha shende - Academia.edu (original) (raw)

Papers by shradha shende

Research paper thumbnail of Formulation development and evaluation of fast dissolving film of telmisartan

Indian Journal of Pharmaceutical Sciences, 2012

Londhe and Umalkar: Fast Dissolving Film of Telmisartan Hypertension is a major cause of concern ... more Londhe and Umalkar: Fast Dissolving Film of Telmisartan Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it shows very less solubility in the pH range of 3-9. Various film forming agents and polyhydric alcohols were evaluated for optimizing composition of fast dissolving films. Fast dissolving films using hydroxypropyl methylcellulose, polyvinyl alcohol, glycerol, sorbitol, menthol and an alkalizer were formulated using solvent casting method. Optimized formulations were evaluated for their weight, thickness, folding endurance, appearance, tensile strength, disintegration time and dissolution profile.

Research paper thumbnail of Formulation Development and Evaluation of Sustained Release Tablets of Lornoxicam

World Journal of Pharmaceutical Research, 2017

Lornoxicam is a non-steroidal anti-inflammatory drug, Lornoxicam has short half-life (3-5 hr.), m... more Lornoxicam is a non-steroidal anti-inflammatory drug, Lornoxicam has short half-life (3-5 hr.), makes the development of sustained-release (SR) forms extremely advantageous, lornoxicam is weak acid having pKa 5.1, it has pH dependent solubility, characterized by poor solubility in low pH condition present in stomach, which consequently leads to a delayed onset of its analgesic action. Formulation of sustained release tablet is effective approach for nonsteroidal antiinflammatory drug (lornoxicam) for maximum pain relief with prolong drug concentration due to sustained release from tablet matrix. Different formulations (F1F8) were designed with HPMC (K4M and K100), MCC, PVP k30, magnesium stearate and talc. Pre and post compression parameters for all formulations were studied. Batch F8 selected as optimized batch on the basis of dissolution profile.

Research paper thumbnail of Formulation and Evaluation of Gel Containing Ethosomes Entrapped with Tretinoin

Journal of Drug Delivery and Therapeutics

A skin disease, like acne, is very common and normally happens to everyone at least once in their... more A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. One of the best options for successful drug delivery to the affected area of skin is the use of ethosomes which can be transported through the skin through channel-like structures. Tretinoin is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Drug loaded ethosomes had been prepared using phospholipid and ethanol, were optimized and characterized for entrapment efficiency, vesicular size, shape, In-vitro skin permeation, skin retention, drug‐membrane component interaction and stability...

Research paper thumbnail of Formulation development and evaluation of fast dissolving film of telmisartan

Indian Journal of Pharmaceutical Sciences, 2012

Londhe and Umalkar: Fast Dissolving Film of Telmisartan Hypertension is a major cause of concern ... more Londhe and Umalkar: Fast Dissolving Film of Telmisartan Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it shows very less solubility in the pH range of 3-9. Various film forming agents and polyhydric alcohols were evaluated for optimizing composition of fast dissolving films. Fast dissolving films using hydroxypropyl methylcellulose, polyvinyl alcohol, glycerol, sorbitol, menthol and an alkalizer were formulated using solvent casting method. Optimized formulations were evaluated for their weight, thickness, folding endurance, appearance, tensile strength, disintegration time and dissolution profile.

Research paper thumbnail of Formulation Development and Evaluation of Sustained Release Tablets of Lornoxicam

World Journal of Pharmaceutical Research, 2017

Lornoxicam is a non-steroidal anti-inflammatory drug, Lornoxicam has short half-life (3-5 hr.), m... more Lornoxicam is a non-steroidal anti-inflammatory drug, Lornoxicam has short half-life (3-5 hr.), makes the development of sustained-release (SR) forms extremely advantageous, lornoxicam is weak acid having pKa 5.1, it has pH dependent solubility, characterized by poor solubility in low pH condition present in stomach, which consequently leads to a delayed onset of its analgesic action. Formulation of sustained release tablet is effective approach for nonsteroidal antiinflammatory drug (lornoxicam) for maximum pain relief with prolong drug concentration due to sustained release from tablet matrix. Different formulations (F1F8) were designed with HPMC (K4M and K100), MCC, PVP k30, magnesium stearate and talc. Pre and post compression parameters for all formulations were studied. Batch F8 selected as optimized batch on the basis of dissolution profile.

Research paper thumbnail of Formulation and Evaluation of Gel Containing Ethosomes Entrapped with Tretinoin

Journal of Drug Delivery and Therapeutics

A skin disease, like acne, is very common and normally happens to everyone at least once in their... more A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. One of the best options for successful drug delivery to the affected area of skin is the use of ethosomes which can be transported through the skin through channel-like structures. Tretinoin is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Drug loaded ethosomes had been prepared using phospholipid and ethanol, were optimized and characterized for entrapment efficiency, vesicular size, shape, In-vitro skin permeation, skin retention, drug‐membrane component interaction and stability...