smriti rathore - Academia.edu (original) (raw)

Papers by smriti rathore

Objective: To test whether point of care measurement is as safe, as lab measurement of patient as... more Objective: To test whether point of care measurement is as safe, as lab measurement of patient as assessed by therapeutic international normalized ratio(INR) control. Methods:It is a hospital based prospective comparative study, including 80 patients, dividing into group 1, in which INR was measured with the help of point of care device at OPD and in group 2, in which INR was measured by standard lab and accordingly dose adjustments were done monthly and were followed up for 6 months. Results: The incidence of major bleed was 5% in group 2 and no major bleeding events in group 1. The incidence of thromboembolic events was equal in both groups which was 5% in each group. The incidence of major events was 5% and 10% patient year respectively in group 1 and 2. The incidence of minor bleeding events was 20% and 10% respectively in group 1 and 2.Overall incidence of adverse event was 25% and 20% respectively in group 1 and 2. Percentage of time in therapeutic range which can be considere...

Indian Journal of Pathology and Oncology, 2020

Introduction: India is the diabetic capital of the world. Vitamin B12 deficiency has been recogni... more Introduction: India is the diabetic capital of the world. Vitamin B12 deficiency has been recognized since many years ago as an important side effect in diabetic patients who take metformin for more than 5-10 years.This research aimed to determine the prevalence of anemia in type 2 diabetes mellitus (T2DM) and its association with vitamin B12 deficiency due to use of Metformin. Materials and Methods: Total 200 type 2 diabetes mellitus (T2DM) males and females were included in the study.Blood collection for Fasting blood glucose and Hba1c levels were measured from all participants in tubes without anticoagulant. Hemoglobin, mean corpuscular volume (MCV) were measured by automated cell counters. Measurement of vitamin B12 level was done only in those patients who presented with Macrocytic anemia. Results: Among 200 patients, 113 patients were on vegetarian. The prevalence of anemia in this study population was 65(32.5%). 11(16.9%) were diagnosed as Normocytic Normochromic anemia, 22 (...

Diabetes is a complex metabolic syndrome. Countries with highest absolute number of diabetes are ... more Diabetes is a complex metabolic syndrome. Countries with highest absolute number of diabetes are India (19million), China (16million) and United States (14million). The prevalence of diabetic microvascular complications is higher in patients with poor glycemic control, longer duration of diabetes mellitus (DM), associated hypertension and obesity. Platelets may be involved in micro/macro vascular complication as a causative agent with respect to altered platelet morphology and function. Platelet volume, a marker of platelet function and activation is measured as Mean Platelet Volume (MPV) by haematology analyzers. We have made an attempt to assess the platelet activity by determining MPV in 100 diabetic patients in comparison with 100 non-diabetic controls. A cross sectional study was carried out in 100 known type 2 diabetic patients and 100 non diabetic healthy subjects. Patients with anemias and who are on antiplatelet therapy were excluded.Blood samples were collected for Complet...

International Journal of Medical Research and Review, 2017

Background: Head and Neck squamous cell carcinoma (HNSCC) is the seventh most common cancer in th... more Background: Head and Neck squamous cell carcinoma (HNSCC) is the seventh most common cancer in the world with poor overall survival rate which is unchang ed during the last two decades. Aim: Aim of ou r study is to measure the level o f Epidermal Growth Factor Receptor (EGFR) exp ression in HNSCC by immunohistochemistry (IHC) and to correlate EGFR with clinicopathological variables. Settings and Design: Cross sectional study from 1 st October 2012 to 31st of March 2014 was performed. Materials and Methods: After taking d etailed history and a thorough examination, biopsy/ specimen o f HNSCC region were evaluated to con firm the diagnosis o f HNSCC. Paraffin blocks o f such tumors were process ed for EGFR staining. Staining intensity was evaluated by using scale from 1 to 4. Statistical Analysis: Chi-square test was used as appropriate fo r data analysis. Results: In the present study 38/50 (78%) patients were diagnosed as well differentiated, 12/50(24%) were diagnosed as moderately di fferentiated. For EGFR staining, 24/50 (48%) scored as +2, 16/50(32%) as +3, 8/50(16%) as +1 and 2/50(4%) scored as 0. 23/38(60.5%) well differentiat ed SCC cases pres ented as +2, 5/38(13.2%) as +3, 8/38(21.1%) as +1 and 2/38(5.3%) as 0. 11/12(91.6%) moderately differentiated SCC cas es were sco red as +3, 1/12(8.3%) as +2. p v alue 0.001, which is highly signifi cant. However, correlation o f EGFR scoring with patients age, sex, addiction history, site of the tumor was insignificant. Conclusion: EGFR was highly expressed in HNSCC. The result of our study showed that, high EGFR scoring was associated with high grad e o f the tumor. There was no signi ficant rel ationship between EGFR scoring and clinicopathological variables.

Objective: To test whether point of care measurement is as safe, as lab measurement of patient as... more Objective: To test whether point of care measurement is as safe, as lab measurement of patient as assessed by therapeutic international normalized ratio(INR) control. Methods:It is a hospital based prospective comparative study, including 80 patients, dividing into group 1, in which INR was measured with the help of point of care device at OPD and in group 2, in which INR was measured by standard lab and accordingly dose adjustments were done monthly and were followed up for 6 months. Results: The incidence of major bleed was 5% in group 2 and no major bleeding events in group 1. The incidence of thromboembolic events was equal in both groups which was 5% in each group. The incidence of major events was 5% and 10% patient year respectively in group 1 and 2. The incidence of minor bleeding events was 20% and 10% respectively in group 1 and 2.Overall incidence of adverse event was 25% and 20% respectively in group 1 and 2. Percentage of time in therapeutic range which can be considere...

Indian Journal of Pathology and Oncology, 2020

Introduction: India is the diabetic capital of the world. Vitamin B12 deficiency has been recogni... more Introduction: India is the diabetic capital of the world. Vitamin B12 deficiency has been recognized since many years ago as an important side effect in diabetic patients who take metformin for more than 5-10 years.This research aimed to determine the prevalence of anemia in type 2 diabetes mellitus (T2DM) and its association with vitamin B12 deficiency due to use of Metformin. Materials and Methods: Total 200 type 2 diabetes mellitus (T2DM) males and females were included in the study.Blood collection for Fasting blood glucose and Hba1c levels were measured from all participants in tubes without anticoagulant. Hemoglobin, mean corpuscular volume (MCV) were measured by automated cell counters. Measurement of vitamin B12 level was done only in those patients who presented with Macrocytic anemia. Results: Among 200 patients, 113 patients were on vegetarian. The prevalence of anemia in this study population was 65(32.5%). 11(16.9%) were diagnosed as Normocytic Normochromic anemia, 22 (...

Diabetes is a complex metabolic syndrome. Countries with highest absolute number of diabetes are ... more Diabetes is a complex metabolic syndrome. Countries with highest absolute number of diabetes are India (19million), China (16million) and United States (14million). The prevalence of diabetic microvascular complications is higher in patients with poor glycemic control, longer duration of diabetes mellitus (DM), associated hypertension and obesity. Platelets may be involved in micro/macro vascular complication as a causative agent with respect to altered platelet morphology and function. Platelet volume, a marker of platelet function and activation is measured as Mean Platelet Volume (MPV) by haematology analyzers. We have made an attempt to assess the platelet activity by determining MPV in 100 diabetic patients in comparison with 100 non-diabetic controls. A cross sectional study was carried out in 100 known type 2 diabetic patients and 100 non diabetic healthy subjects. Patients with anemias and who are on antiplatelet therapy were excluded.Blood samples were collected for Complet...

International Journal of Medical Research and Review, 2017

Background: Head and Neck squamous cell carcinoma (HNSCC) is the seventh most common cancer in th... more Background: Head and Neck squamous cell carcinoma (HNSCC) is the seventh most common cancer in the world with poor overall survival rate which is unchang ed during the last two decades. Aim: Aim of ou r study is to measure the level o f Epidermal Growth Factor Receptor (EGFR) exp ression in HNSCC by immunohistochemistry (IHC) and to correlate EGFR with clinicopathological variables. Settings and Design: Cross sectional study from 1 st October 2012 to 31st of March 2014 was performed. Materials and Methods: After taking d etailed history and a thorough examination, biopsy/ specimen o f HNSCC region were evaluated to con firm the diagnosis o f HNSCC. Paraffin blocks o f such tumors were process ed for EGFR staining. Staining intensity was evaluated by using scale from 1 to 4. Statistical Analysis: Chi-square test was used as appropriate fo r data analysis. Results: In the present study 38/50 (78%) patients were diagnosed as well differentiated, 12/50(24%) were diagnosed as moderately di fferentiated. For EGFR staining, 24/50 (48%) scored as +2, 16/50(32%) as +3, 8/50(16%) as +1 and 2/50(4%) scored as 0. 23/38(60.5%) well differentiat ed SCC cases pres ented as +2, 5/38(13.2%) as +3, 8/38(21.1%) as +1 and 2/38(5.3%) as 0. 11/12(91.6%) moderately differentiated SCC cas es were sco red as +3, 1/12(8.3%) as +2. p v alue 0.001, which is highly signifi cant. However, correlation o f EGFR scoring with patients age, sex, addiction history, site of the tumor was insignificant. Conclusion: EGFR was highly expressed in HNSCC. The result of our study showed that, high EGFR scoring was associated with high grad e o f the tumor. There was no signi ficant rel ationship between EGFR scoring and clinicopathological variables.