sneha sebastian - Academia.edu (original) (raw)

Papers by sneha sebastian

Research paper thumbnail of (2019-2020) The Quality of Life of Primary Caregivers of Children and Adolescents with Psychiatric Disorders, Enrolled in Child and Adolescent Psychiatry Unit in a Tertiary Care Hospital Setting in South India: A Cross Sectional study

Research paper thumbnail of Current Practice of Intravenous to Oral Conversion of Antibiotics at a Tertiary Care Hospital: A Prospective Study

Introduction: The patients admitted in general ward of a hospital with severe infections who adeq... more Introduction: The patients admitted in general ward of a hospital with severe infections who adequately absorb oral medication and initially require IV therapy can be safely switched to oral therapy within 2-3 days. There are number of advantages like fewer complications and decreased length of hospital stay (LOHS). Aim: To evaluate the practice of switching from IV to oral antibiotics, identification of IV complications in non-converted patients, case related barriers to an early switch and thereby influence in LOHS. Materials and Methods: A prospective observational study was conducted over a period of 3 months from March-May 2019. NUH guidelines were used to evaluate the early switch based on clinical stability. Clinical based end points such as complications, barriers for conversion, duration of antibiotics and LOHS were assessed. Results: The study reveals that among antibiotic courses, 51% and 49% were converted and non-converted respectively. Sequential conversion therapy was...

Research paper thumbnail of The Risk of Cardiovascular Disease Among Immigrants in Canada

Cureus, 2022

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. The globa... more Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. The global surge in migration to high-income countries, especially Canada, highlights the importance of studies evaluating the risk factors and the disparities in the rate of incidence of CVD among immigrants. Canada is home to a diverse group of immigrants, each presenting with a risk profile that is unique to their ethnicity and country of birth. A variety of cardiac risk factors, such as dietary habits, physical activity, smoking, cultural traditions as well as preponderance to certain diseases like type II diabetes mellitus, hypertension, and high lipid levels act in concert and impact CVD risk and overall incidence. This narrative review focuses on CVD risks and how it is related to the immigration status among various ethnic groups in Canada.

Research paper thumbnail of Role of Clinical Pharmacist in Medication Management of Inotropes and Vasopressors in Intensive Care Unit

Indian Journal of Pharmacy Practice, Jun 18, 2020

Background: Medication management of inotropes and vasopressors are essential in critically ill p... more Background: Medication management of inotropes and vasopressors are essential in critically ill patients, as it is considered as important life-saving medications. The present study was carried out to understand the effect of these drugs on unstable patient and identifying drug-related problems like significant interactions, adverse effects, incompatibility and its factors. Methods: A prospective observational study was carried out in the medical, surgical Intensive Care Unit for a period of 6 months. All the interventions and drug related problems were categorized based on the Pharmaceutical Care Network Europe. Results: Out of 150 study population male patients were more and the majority of patients were from the age group of 60-80 years (56.66%). Most of the admissions were due to septic shock (50%). Noradrenaline (64%) were mostly prescribed. This study illustrates that there is an increased effect of drugs on hemodynamic instability based on mean arterial pressure and heart rate. By comparing before and after administration there was a significant (P<0.0001) increased effect in unstable patients. Among 108 significant drug interactions, dobutamine (50.92%) shows high in frequency. Tachycardia (18.66%) is the most common adverse drug reactions. Among 11 incompatible combinations, Dobutamine+pantoprazole (30.18%) shows the highest and the factors affecting the incompatibility of drugs such as diluents used, rate and duration of infusion, pH of drug solution. Out of 126 recommendations given by clinical pharmacist, 70 problems were solved. Conclusion: Interventions made by a clinical pharmacist improves medication safety in critically ill patients by the safe and effective use of inotropes and vasopressors.

Research paper thumbnail of (2019-2020) The Quality of Life of Primary Caregivers of Children and Adolescents with Psychiatric Disorders, Enrolled in Child and Adolescent Psychiatry Unit in a Tertiary Care Hospital Setting in South India: A Cross Sectional study

Research paper thumbnail of Current Practice of Intravenous to Oral Conversion of Antibiotics at a Tertiary Care Hospital: A Prospective Study

Introduction: The patients admitted in general ward of a hospital with severe infections who adeq... more Introduction: The patients admitted in general ward of a hospital with severe infections who adequately absorb oral medication and initially require IV therapy can be safely switched to oral therapy within 2-3 days. There are number of advantages like fewer complications and decreased length of hospital stay (LOHS). Aim: To evaluate the practice of switching from IV to oral antibiotics, identification of IV complications in non-converted patients, case related barriers to an early switch and thereby influence in LOHS. Materials and Methods: A prospective observational study was conducted over a period of 3 months from March-May 2019. NUH guidelines were used to evaluate the early switch based on clinical stability. Clinical based end points such as complications, barriers for conversion, duration of antibiotics and LOHS were assessed. Results: The study reveals that among antibiotic courses, 51% and 49% were converted and non-converted respectively. Sequential conversion therapy was...

Research paper thumbnail of The Risk of Cardiovascular Disease Among Immigrants in Canada

Cureus, 2022

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. The globa... more Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. The global surge in migration to high-income countries, especially Canada, highlights the importance of studies evaluating the risk factors and the disparities in the rate of incidence of CVD among immigrants. Canada is home to a diverse group of immigrants, each presenting with a risk profile that is unique to their ethnicity and country of birth. A variety of cardiac risk factors, such as dietary habits, physical activity, smoking, cultural traditions as well as preponderance to certain diseases like type II diabetes mellitus, hypertension, and high lipid levels act in concert and impact CVD risk and overall incidence. This narrative review focuses on CVD risks and how it is related to the immigration status among various ethnic groups in Canada.

Research paper thumbnail of Role of Clinical Pharmacist in Medication Management of Inotropes and Vasopressors in Intensive Care Unit

Indian Journal of Pharmacy Practice, Jun 18, 2020

Background: Medication management of inotropes and vasopressors are essential in critically ill p... more Background: Medication management of inotropes and vasopressors are essential in critically ill patients, as it is considered as important life-saving medications. The present study was carried out to understand the effect of these drugs on unstable patient and identifying drug-related problems like significant interactions, adverse effects, incompatibility and its factors. Methods: A prospective observational study was carried out in the medical, surgical Intensive Care Unit for a period of 6 months. All the interventions and drug related problems were categorized based on the Pharmaceutical Care Network Europe. Results: Out of 150 study population male patients were more and the majority of patients were from the age group of 60-80 years (56.66%). Most of the admissions were due to septic shock (50%). Noradrenaline (64%) were mostly prescribed. This study illustrates that there is an increased effect of drugs on hemodynamic instability based on mean arterial pressure and heart rate. By comparing before and after administration there was a significant (P<0.0001) increased effect in unstable patients. Among 108 significant drug interactions, dobutamine (50.92%) shows high in frequency. Tachycardia (18.66%) is the most common adverse drug reactions. Among 11 incompatible combinations, Dobutamine+pantoprazole (30.18%) shows the highest and the factors affecting the incompatibility of drugs such as diluents used, rate and duration of infusion, pH of drug solution. Out of 126 recommendations given by clinical pharmacist, 70 problems were solved. Conclusion: Interventions made by a clinical pharmacist improves medication safety in critically ill patients by the safe and effective use of inotropes and vasopressors.