Dr.Sohel solanki - Academia.edu (original) (raw)
Papers by Dr.Sohel solanki
International Journal of Pharmaceutical Sciences and Research, 2024
The chick was chosen as a model because it is more readily available than rats or mice and its o... more The chick was chosen as a model because it is more readily
available than rats or mice and its organogenesis is analogous to that of
humans. Rolapitant is a highly potent, powerful antagonist of the neurokinin-
1 receptor, featuring a high degree of infiltration to the brain. The study
aimed to assess the morphological and histopathological analysis of the brain
(cerebral cortex) of growing chick embryos in response to the rolapitant's
effect. Three hundred fertilised white leghorn chicken eggs were utilised,
separated into five control groups (C1 to C5) and five experimental groups
(E1 to E5), each with thirty eggs. On the fifth day of incubation, eggs from
five experimental groups were exposed to different concentrations of
rolapitant at 0.00039 mg, 0.0005 mg, 0.00075 mg, 0.001 mg, and 0.00125
mg respectively, whilst five control groups received the same concentration
of normal saline. Chick brains were obtained and weighed. The cerebral
cortex (brain) was sectioned and stained to examine the histopathological
abnormalities. A significant growth retardation and decreased weight of the
brain of experimental groups were noted. The number of chick embryos with
abnormal “Histopathological findings such as” neuronophagia and perineural
vacuolation in the cerebral cortex was also significant in experimental groups
E4 and E5 (p-value < 0.05). Mild to moderate degenerative changes in the
cerebral cortex of experimental groups E3, E4 and E5 and some
haemorrhagic spots in experimental groups E4 and E5 were also noted.
When taken in large doses, the rolapitant demonstrated its toxic effects on
the brain of chick embryos.
The chick was chosen as a model because it is more readily available than rats or mice and its or... more The chick was chosen as a model because it is more readily available than rats or mice and its organogenesis is analogous to that of humans. Rolapitant is a highly potent, powerful antagonist of the neurokinin-1 receptor, featuring a high degree of infiltration to the brain. The study aimed to assess the morphological and histopathological analysis of the brain (cerebral cortex) of growing chick embryos in response to the rolapitant's effect. Three hundred fertilised white leghorn chicken eggs were utilised, separated into five control groups (C1 to C5) and five experimental groups (E1 to E5), each with thirty eggs. On the fifth day of incubation, eggs from five experimental groups were exposed to different concentrations of rolapitant at 0.00039 mg, 0.0005 mg, 0.00075 mg, 0.001 mg, and 0.00125 mg respectively, whilst five control groups received the same concentration of normal saline. Chick brains were obtained and weighed. The cerebral cortex (brain) was sectioned and stained to examine the histopathological abnormalities. A significant growth retardation and decreased weight of the brain of experimental groups were noted. The number of chick embryos with abnormal "Histopathological findings such as" neuronophagia and perineural vacuolation in the cerebral cortex was also significant in experimental groups E4 and E5 (p-value < 0.05). Mild to moderate degenerative changes in the cerebral cortex of experimental groups E3, E4 and E5 and some haemorrhagic spots in experimental groups E4 and E5 were also noted. When taken in large doses, the rolapitant demonstrated its toxic effects on the brain of chick embryos.
Cureus
Introduction Although coronavirus disease 2019 (COVID-19) first appeared in 2019, the symptoms ar... more Introduction Although coronavirus disease 2019 (COVID-19) first appeared in 2019, the symptoms are similar to common viral illnesses, and if undiagnosed or there is a delay in treatment, it may prove fatal because of the virus's propensity to attack the respiratory and cardiovascular system. The antigenic conversion status of reverse transcription-polymerase chain reaction (RT-PCR) was an important criterion for discharge among the COVID-19 patients of the two hospitals in the study. Aim The aim of the study was to assess the time taken to antigenic conversion from positive to negative in RT-PCR test for COVID-19 done on patients admitted to the two hospitals where the study took place. Materials and methods A prospective cross-sectional study with repeated sampling for antigenic conversion by RT-PCR was done on 117 patients of different age groups admitted to Bangur Hospital and Agarsen Bhavan in Pali, Rajasthan, India, from April 27 to June 30, 2020. Pharyngeal and nasal swabs were analyzed by real-time RT-PCR for COVID-19 infection. The patients' first positive sample was taken as "zero sample". If the repeat sample taken on the fifth day was positive, sampling was repeated after 48 hours on consecutive days 7, 9, 11, 13, and 15 of admission till the RT-PCR test returned negative. Results Among the 117 patients, 92 (78.63%) were treated as mild, 10 (8.54%) were moderately severe, and 15 (12.82%) were very severe requiring ICU care. The median rate of conversion of RT-PCR test (positive to negative) from the day of admission was quite variable as five patients converted to negative by RT-PCR test on day seven of admission, one on day eight of admission, 26 on day nine, 30 on day 10, five on day 11, 13 on day 12, 10 on day 13, 11 on day 14, five on day 15, six on day 16, three on day 17, and one on day 18 of admission. Conclusion The study proved that follow-up of patients, prompt and comprehensive treatment, and repeated sampling ensures fast recovery with implications on time to discharge of such patients in a pandemic. The study justified and heralds the message that the inherent immunity of an individual corresponds to the time taken to conversion from positive to negative in the RT-PCR test.
International Journal of Research in Medical Sciences, 2020
Background: Human body is studied by dissection method on unclaimed or donated human cadavers. An... more Background: Human body is studied by dissection method on unclaimed or donated human cadavers. Anatomy is of paramount importance taught for the first year M.B.B.S students all over Indian Medical Colleges since decades.Methods: Medical Institution was started in month of September 2019 with 100 intakes on merit basis. Aim was to teach the human anatomy to 1st MBBS students by dissecting the cadavers for which an Awareness programme was conducted by department of anatomy regarding to Body donation. Study was done going through and studying the donated forms with full consent in duly signed consent forms. Their age, physical conditions and mental status were taken into considerations as the yard sticks.Results: Since college has started in September 2019, there was poor response and awareness about body donation. So far fifteen live donors including 12 males and 3 females have filled their forms in perfect normal status and with NO compulsion from anybody. Five dead bodies (Cadavers)...
Background: Flexor digitorum breves is an intrinsic muscle of the sole of the foot that lies supe... more Background: Flexor digitorum breves is an intrinsic muscle of the sole of the foot that lies superior to the central part of planter apponurosis and inferior to the tendons of flexor digitorum longus. This flat spindle shaped muscle arise from the medial process of tuber calcanei, proximal part of planter apponurosis, inter muscular septa and adjacent fascial layers. The muscle fiber conver anteriorly forming four tendons one each for the four lateral toes at the bases of proximal phalenges each tendon splits into two slips around the tendon of flexor digitorum longus, reunites into a chiasma, devides again to insert into margins of intermediate phalenges of lateral four toes. Methods: This study was carried out by routine dissection classes for undergraduate medical students classes from July 2010 to January 2014 in the department of anatomy, Teerthanker Mahaveer medical college Moradabad; department of anatomy, Rama medical college Kanpur; Department of Anatomy, Hamdard Institute ...
Background: The Carrying Angle of the elbow is defined as the angle between the long axis of the ... more Background: The Carrying Angle of the elbow is defined as the angle between the long axis of the extended forearm as it lies lateral to the long axis of the arm. It may change with skeletal growth. Clinically carrying angle increases with age up to 15 years, after which there was a slight decrease in the angles. Aims: To measure obliquity of fore arm on arm (carrying angle). This is done in both the aspects; the radiological aspects as well as the living objects Materials and Methods: The present study consists of 250 living objects and 40 radiographs. All these objects are been carefully taken with normal elbow and any deformity, neuropathy, any fractured condition of the elbow is been excluded from study Conclusion: The carrying angle is significantly greater in females than in males, so it can be considered as a secondary sex character. The recorded measurements might be helpful in management of disorders of the elbow and its reconstruction after fractures. Moreover, the proposed...
Background: In the investigation of fever, Malaria and Typhoid are major health problems in tropi... more Background: In the investigation of fever, Malaria and Typhoid are major health problems in tropical and subtropical countries. Both cause significant morbidity, mortality and economic loss. The aim of study is to evaluate the prevalence of Malaria and Typhoid. Methods: Five hundred three samples were collected from patients suspected for malaria and typhoid fever. Peripheral blood smears (thick and thin) were used for microscopic examination and also malaria card test used for malaria parasite. For Typhoid, Widal agglutination test and Typhi dot IgG/IgM conducted for the identification of antibodies. Result: The study indicated that out of 503 patients, in which 158 male (69%) followed by 71 female (31%) were found positive. The prevalence rate of infection was 45.52%. Conclusion: The prevalence rate of malaria and typhoid fever was high. Salmonella typhi appears to be the most prevalent species infecting people. In other studies prevalence rate were quite low. Most of the studies ...
Large amount of electronic data is generated in Cloud computing every day. Efficient maintenance ... more Large amount of electronic data is generated in Cloud computing every day. Efficient maintenance of this data requires proper services. Hence a method to collect data securely, by protecting and developing backups is mentioned. The Objective is to provide Auto Response Server, better solutions for data backup and restoring using Cloud. Data can be collected and sent to a centralized repository in a platform independent format without any network consideration. This data can then be used according to the requirement. The purpose of this particular Remote Backup Server is to collect information from any remote location even if network connectivity is not available at that point of time and provide proper services as well as to recover data in case of loss.
njmr.in
The fourth ventricle enlarges in various conditions like hydrocephalus, dementias, mutism etc. So... more The fourth ventricle enlarges in various conditions like hydrocephalus, dementias, mutism etc. So, it is necessary to know the normal range of dimensions of forth ventricle. Present study was conducted at anatomy Dept. P.D.U. medical college, Rajkot, Gujarat during October 2009 to October 2010. The casts of ventricular system of 20 formalinized cadaveric human brains were prepared after injecting epoxyresin+hardener (BOND TITE) mixture. From the cast, measurements of height (from upper end of impression of superior medullary valum to obex) and breadth (at the level of lateral recesses) of 4 th ventricle were taken by vernier caliper. The data was analyzed statistically and was compared with the data obtained from radiological methods. In present study, the mean height of fourth ventricle 2.29 cm (range 1.9-2.7cm, S.D. 0.30) and mean breadth 2.38 cm (range 1.75-3 cm, S.D. 0.44). Present data differs significantly from data of radiological studies, which could be due to different methodologies, whereas the radiological methods are indirect and two dimensional; the present study with cast gives direct and three dimensional results without distorting the dimensions of fourth ventricle.
International Journal of Medical Research and Health Sciences, 2021
Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on... more Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on chick embryo development in 200 white leghorn chicken eggs used that met the inclusion-exclusion criteria. Material and method: The present study utilized 200 eggs, randomly assigned to experimental groups A and B and control groups a and b. Eggs incubated in the presence of Rolapitant had their Rolapitant dose increased on the fifth day of incubation from 0.18 mg to 0.36 mg. In contrast to the control groups, all of the subjects in the treatment groups received the same amount of normal saline. Eggs were broken on the twentieth day of incubation, and embryos were extracted on the same day. Results: The weight and CRL of the chick embryos were measured, and gross anatomical malformations were observed-the percentile lethality of Rolapitant increase with dose with the odds ratio of 1.175 and 1.313. While analyzing the abnormal weight and abnormal CR length due to the effects of Rolapitant, a significant difference was observed. In each case, an increased t-value concerning an increase in dose shows the lethality of Rolapitant. Conclusion: The present study observed an increased mortality rate and a decrease in weight and crown-rump length following a double dose of Rolapitant. The author remanded additional research with a larger sample size to improve the current observation's reliability and generalizability.
Annals of International Medical and Dental Research, 2016
Background: Flexor digitorum breves is an intrinsic muscle of the sole of the foot that lies supe... more Background: Flexor digitorum breves is an intrinsic muscle of the sole of the foot that lies superior to the central part of planter apponurosis and inferior to the tendons of flexor digitorum longus. This flat spindle shaped muscle arise from the medial process of tuber calcanei, proximal part of planter apponurosis, inter muscular septa and adjacent fascial layers. The muscle fiber conver anteriorly forming four tendons one each for the four lateral toes at the bases of proximal phalenges each tendon splits into two slips around the tendon of flexor digitorum longus, reunites into a chiasma, devides again to insert into margins of intermediate phalenges of lateral four toes. Methods: This study was carried out by routine dissection classes for undergraduate medical students classes from July 2010 to January 2014 in the department of anatomy, Teerthanker Mahaveer medical college Moradabad; department of anatomy, Rama medical college Kanpur; Department of Anatomy, Hamdard Institute of Medical Science & Research, Jamia Hamdard New Delhi. Total no. of 80 cadavers (48 male and 32 female) all the cadavers were been preserved in 10% of formalin and age ranged between 45 to 67 years. Results: Summarising the result indicates out of 80 cadavers 25% were having none anatomical variation, 46% of cadavers had bilateral absence of tendon for fifth toe of flexor digitorum breves while 18% of cadavers having variation on the left foot and rare 9% of cadavers were represented having variation on the right foot while the left foot was anatomically normal. Conclusion: Variation of flexor digitorum breves may occur as phylogenetical changes due to minimal use of little toe in evolved bipedal posture.
International Journal of Research in Medical Sciences, 2020
Background: Human body is studied by dissection method on unclaimed or donated human cadavers. An... more Background: Human body is studied by dissection method on unclaimed or donated human cadavers. Anatomy is of paramount importance taught for the first year M.B.B.S students all over Indian Medical Colleges since decades. Methods: Medical Institution was started in month of September 2019 with 100 intakes on merit basis. Aim was to teach the human anatomy to 1 st MBBS students by dissecting the cadavers for which an Awareness programme was conducted by department of anatomy regarding to Body donation. Study was done going through and studying the donated forms with full consent in duly signed consent forms. Their age, physical conditions and mental status were taken into considerations as the yard sticks. Results: Since college has started in September 2019, there was poor response and awareness about body donation. So far fifteen live donors including 12 males and 3 females have filled their forms in perfect normal status and with NO compulsion from anybody. Five dead bodies (Cadavers) received in the Department of Anatomy of Government Medical College, Barmer for the propose of dissection to teach the 1 st year MBBS students. Awareness of donation of the body is in progress. Conclusions: In the present study, authors concluded that only few people gave response in favour of awareness programme of body donation showing the lack of awareness towards the body donation. So, the study has shown the requirement of more awareness programmes about body donation among the population. It will help to clarifying any myths or/and superstition so that the general public should aware and show interest towards the body donation.
International Journal of Medical Research & Health Sciences,, 2021
Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on... more Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on chick embryo development in 200 white leghorn chicken eggs used that met the inclusion-exclusion criteria. Material and method: The present study utilized 200 eggs, randomly assigned to experimental groups A and B and control groups a and b. Eggs incubated in the presence of Rolapitant had their Rolapitant dose increased on the fifth day of incubation from 0.18 mg to 0.36 mg. In contrast to the control groups, all of the subjects in the treatment groups received the same amount of normal saline. Eggs were broken on the twentieth day of incubation, and embryos were extracted on the same day. Results: The weight and CRL of the chick embryos were measured, and gross anatomical malformations were observed-the percentile lethality of Rolapitant increase with dose with the odds ratio of 1.175 and 1.313. While analyzing the abnormal weight and abnormal CR length due to the effects of Rolapitant, a significant difference was observed. In each case, an increased t-value concerning an increase in dose shows the lethality of Rolapitant. Conclusion: The present study observed an increased mortality rate and a decrease in weight and crown-rump length following a double dose of Rolapitant. The author remanded additional research with a larger sample size to improve the current observation's reliability and generalizability.
Pubmed, 2022
Introduction Although coronavirus disease 2019 (COVID-19) first appeared in 2019, the symptoms ar... more Introduction Although coronavirus disease 2019 (COVID-19) first appeared in 2019, the symptoms are similar to common viral illnesses, and if undiagnosed or there is a delay in treatment, it may prove fatal because of the virus's propensity to attack the respiratory and cardiovascular system. The antigenic conversion status of reverse transcription-polymerase chain reaction (RT-PCR) was an important criterion for discharge among the COVID-19 patients of the two hospitals in the study. Aim The aim of the study was to assess the time taken to antigenic conversion from positive to negative in RT-PCR test for COVID-19 done on patients admitted to the two hospitals where the study took place. Materials and methods A prospective cross-sectional study with repeated sampling for antigenic conversion by RT-PCR was done on 117 patients of different age groups admitted to Bangur Hospital and Agarsen Bhavan in Pali, Rajasthan, India, from April 27 to June 30, 2020. Pharyngeal and nasal swabs were analyzed by real-time RT-PCR for COVID-19 infection. The patients' first positive sample was taken as "zero sample". If the repeat sample taken on the fifth day was positive, sampling was repeated after 48 hours on consecutive days 7, 9, 11, 13, and 15 of admission till the RT-PCR test returned negative. Results Among the 117 patients, 92 (78.63%) were treated as mild, 10 (8.54%) were moderately severe, and 15 (12.82%) were very severe requiring ICU care. The median rate of conversion of RT-PCR test (positive to negative) from the day of admission was quite variable as five patients converted to negative by RT-PCR test on day seven of admission, one on day eight of admission, 26 on day nine, 30 on day 10, five on day 11, 13 on day 12, 10 on day 13, 11 on day 14, five on day 15, six on day 16, three on day 17, and one on day 18 of admission. Conclusion The study proved that follow-up of patients, prompt and comprehensive treatment, and repeated sampling ensures fast recovery with implications on time to discharge of such patients in a pandemic. The study justified and heralds the message that the inherent immunity of an individual corresponds to the time taken to conversion from positive to negative in the RT-PCR test.
At all doses, the mean weight and crown-rump (CR) length of chick embryos were signi icantly grea... more At all doses, the mean weight and crown-rump (CR) length of chick embryos were signi icantly greater in the control group than in the experimental group. The experimental group died at a higher rate than the control group. Additionally, it was found that the mortality due to the rolapitant dosages increases with dose. All groups except group A showed skeletal anomalies such as poor ossi ication, bent, and displacement, and morphological abnormalities such as yolk sac retraction, hematoma, and scanty feathers were found in experimental groups C, D, and E. This was shown to be more prevalent in the experimental groups and was exacerbated by subsequent rolapitant dosages. Conclusion Rolapitant is toxic when taken in large doses and for an extended period. As a result, rolapitant should be taken only when a valid diagnosis has been established and only at the recommended dose, not at a larger dose or for an extended period of time.
International Journal of Pharmaceutical Sciences and Research, 2024
The chick was chosen as a model because it is more readily available than rats or mice and its o... more The chick was chosen as a model because it is more readily
available than rats or mice and its organogenesis is analogous to that of
humans. Rolapitant is a highly potent, powerful antagonist of the neurokinin-
1 receptor, featuring a high degree of infiltration to the brain. The study
aimed to assess the morphological and histopathological analysis of the brain
(cerebral cortex) of growing chick embryos in response to the rolapitant's
effect. Three hundred fertilised white leghorn chicken eggs were utilised,
separated into five control groups (C1 to C5) and five experimental groups
(E1 to E5), each with thirty eggs. On the fifth day of incubation, eggs from
five experimental groups were exposed to different concentrations of
rolapitant at 0.00039 mg, 0.0005 mg, 0.00075 mg, 0.001 mg, and 0.00125
mg respectively, whilst five control groups received the same concentration
of normal saline. Chick brains were obtained and weighed. The cerebral
cortex (brain) was sectioned and stained to examine the histopathological
abnormalities. A significant growth retardation and decreased weight of the
brain of experimental groups were noted. The number of chick embryos with
abnormal “Histopathological findings such as” neuronophagia and perineural
vacuolation in the cerebral cortex was also significant in experimental groups
E4 and E5 (p-value < 0.05). Mild to moderate degenerative changes in the
cerebral cortex of experimental groups E3, E4 and E5 and some
haemorrhagic spots in experimental groups E4 and E5 were also noted.
When taken in large doses, the rolapitant demonstrated its toxic effects on
the brain of chick embryos.
The chick was chosen as a model because it is more readily available than rats or mice and its or... more The chick was chosen as a model because it is more readily available than rats or mice and its organogenesis is analogous to that of humans. Rolapitant is a highly potent, powerful antagonist of the neurokinin-1 receptor, featuring a high degree of infiltration to the brain. The study aimed to assess the morphological and histopathological analysis of the brain (cerebral cortex) of growing chick embryos in response to the rolapitant's effect. Three hundred fertilised white leghorn chicken eggs were utilised, separated into five control groups (C1 to C5) and five experimental groups (E1 to E5), each with thirty eggs. On the fifth day of incubation, eggs from five experimental groups were exposed to different concentrations of rolapitant at 0.00039 mg, 0.0005 mg, 0.00075 mg, 0.001 mg, and 0.00125 mg respectively, whilst five control groups received the same concentration of normal saline. Chick brains were obtained and weighed. The cerebral cortex (brain) was sectioned and stained to examine the histopathological abnormalities. A significant growth retardation and decreased weight of the brain of experimental groups were noted. The number of chick embryos with abnormal "Histopathological findings such as" neuronophagia and perineural vacuolation in the cerebral cortex was also significant in experimental groups E4 and E5 (p-value < 0.05). Mild to moderate degenerative changes in the cerebral cortex of experimental groups E3, E4 and E5 and some haemorrhagic spots in experimental groups E4 and E5 were also noted. When taken in large doses, the rolapitant demonstrated its toxic effects on the brain of chick embryos.
Cureus
Introduction Although coronavirus disease 2019 (COVID-19) first appeared in 2019, the symptoms ar... more Introduction Although coronavirus disease 2019 (COVID-19) first appeared in 2019, the symptoms are similar to common viral illnesses, and if undiagnosed or there is a delay in treatment, it may prove fatal because of the virus's propensity to attack the respiratory and cardiovascular system. The antigenic conversion status of reverse transcription-polymerase chain reaction (RT-PCR) was an important criterion for discharge among the COVID-19 patients of the two hospitals in the study. Aim The aim of the study was to assess the time taken to antigenic conversion from positive to negative in RT-PCR test for COVID-19 done on patients admitted to the two hospitals where the study took place. Materials and methods A prospective cross-sectional study with repeated sampling for antigenic conversion by RT-PCR was done on 117 patients of different age groups admitted to Bangur Hospital and Agarsen Bhavan in Pali, Rajasthan, India, from April 27 to June 30, 2020. Pharyngeal and nasal swabs were analyzed by real-time RT-PCR for COVID-19 infection. The patients' first positive sample was taken as "zero sample". If the repeat sample taken on the fifth day was positive, sampling was repeated after 48 hours on consecutive days 7, 9, 11, 13, and 15 of admission till the RT-PCR test returned negative. Results Among the 117 patients, 92 (78.63%) were treated as mild, 10 (8.54%) were moderately severe, and 15 (12.82%) were very severe requiring ICU care. The median rate of conversion of RT-PCR test (positive to negative) from the day of admission was quite variable as five patients converted to negative by RT-PCR test on day seven of admission, one on day eight of admission, 26 on day nine, 30 on day 10, five on day 11, 13 on day 12, 10 on day 13, 11 on day 14, five on day 15, six on day 16, three on day 17, and one on day 18 of admission. Conclusion The study proved that follow-up of patients, prompt and comprehensive treatment, and repeated sampling ensures fast recovery with implications on time to discharge of such patients in a pandemic. The study justified and heralds the message that the inherent immunity of an individual corresponds to the time taken to conversion from positive to negative in the RT-PCR test.
International Journal of Research in Medical Sciences, 2020
Background: Human body is studied by dissection method on unclaimed or donated human cadavers. An... more Background: Human body is studied by dissection method on unclaimed or donated human cadavers. Anatomy is of paramount importance taught for the first year M.B.B.S students all over Indian Medical Colleges since decades.Methods: Medical Institution was started in month of September 2019 with 100 intakes on merit basis. Aim was to teach the human anatomy to 1st MBBS students by dissecting the cadavers for which an Awareness programme was conducted by department of anatomy regarding to Body donation. Study was done going through and studying the donated forms with full consent in duly signed consent forms. Their age, physical conditions and mental status were taken into considerations as the yard sticks.Results: Since college has started in September 2019, there was poor response and awareness about body donation. So far fifteen live donors including 12 males and 3 females have filled their forms in perfect normal status and with NO compulsion from anybody. Five dead bodies (Cadavers)...
Background: Flexor digitorum breves is an intrinsic muscle of the sole of the foot that lies supe... more Background: Flexor digitorum breves is an intrinsic muscle of the sole of the foot that lies superior to the central part of planter apponurosis and inferior to the tendons of flexor digitorum longus. This flat spindle shaped muscle arise from the medial process of tuber calcanei, proximal part of planter apponurosis, inter muscular septa and adjacent fascial layers. The muscle fiber conver anteriorly forming four tendons one each for the four lateral toes at the bases of proximal phalenges each tendon splits into two slips around the tendon of flexor digitorum longus, reunites into a chiasma, devides again to insert into margins of intermediate phalenges of lateral four toes. Methods: This study was carried out by routine dissection classes for undergraduate medical students classes from July 2010 to January 2014 in the department of anatomy, Teerthanker Mahaveer medical college Moradabad; department of anatomy, Rama medical college Kanpur; Department of Anatomy, Hamdard Institute ...
Background: The Carrying Angle of the elbow is defined as the angle between the long axis of the ... more Background: The Carrying Angle of the elbow is defined as the angle between the long axis of the extended forearm as it lies lateral to the long axis of the arm. It may change with skeletal growth. Clinically carrying angle increases with age up to 15 years, after which there was a slight decrease in the angles. Aims: To measure obliquity of fore arm on arm (carrying angle). This is done in both the aspects; the radiological aspects as well as the living objects Materials and Methods: The present study consists of 250 living objects and 40 radiographs. All these objects are been carefully taken with normal elbow and any deformity, neuropathy, any fractured condition of the elbow is been excluded from study Conclusion: The carrying angle is significantly greater in females than in males, so it can be considered as a secondary sex character. The recorded measurements might be helpful in management of disorders of the elbow and its reconstruction after fractures. Moreover, the proposed...
Background: In the investigation of fever, Malaria and Typhoid are major health problems in tropi... more Background: In the investigation of fever, Malaria and Typhoid are major health problems in tropical and subtropical countries. Both cause significant morbidity, mortality and economic loss. The aim of study is to evaluate the prevalence of Malaria and Typhoid. Methods: Five hundred three samples were collected from patients suspected for malaria and typhoid fever. Peripheral blood smears (thick and thin) were used for microscopic examination and also malaria card test used for malaria parasite. For Typhoid, Widal agglutination test and Typhi dot IgG/IgM conducted for the identification of antibodies. Result: The study indicated that out of 503 patients, in which 158 male (69%) followed by 71 female (31%) were found positive. The prevalence rate of infection was 45.52%. Conclusion: The prevalence rate of malaria and typhoid fever was high. Salmonella typhi appears to be the most prevalent species infecting people. In other studies prevalence rate were quite low. Most of the studies ...
Large amount of electronic data is generated in Cloud computing every day. Efficient maintenance ... more Large amount of electronic data is generated in Cloud computing every day. Efficient maintenance of this data requires proper services. Hence a method to collect data securely, by protecting and developing backups is mentioned. The Objective is to provide Auto Response Server, better solutions for data backup and restoring using Cloud. Data can be collected and sent to a centralized repository in a platform independent format without any network consideration. This data can then be used according to the requirement. The purpose of this particular Remote Backup Server is to collect information from any remote location even if network connectivity is not available at that point of time and provide proper services as well as to recover data in case of loss.
njmr.in
The fourth ventricle enlarges in various conditions like hydrocephalus, dementias, mutism etc. So... more The fourth ventricle enlarges in various conditions like hydrocephalus, dementias, mutism etc. So, it is necessary to know the normal range of dimensions of forth ventricle. Present study was conducted at anatomy Dept. P.D.U. medical college, Rajkot, Gujarat during October 2009 to October 2010. The casts of ventricular system of 20 formalinized cadaveric human brains were prepared after injecting epoxyresin+hardener (BOND TITE) mixture. From the cast, measurements of height (from upper end of impression of superior medullary valum to obex) and breadth (at the level of lateral recesses) of 4 th ventricle were taken by vernier caliper. The data was analyzed statistically and was compared with the data obtained from radiological methods. In present study, the mean height of fourth ventricle 2.29 cm (range 1.9-2.7cm, S.D. 0.30) and mean breadth 2.38 cm (range 1.75-3 cm, S.D. 0.44). Present data differs significantly from data of radiological studies, which could be due to different methodologies, whereas the radiological methods are indirect and two dimensional; the present study with cast gives direct and three dimensional results without distorting the dimensions of fourth ventricle.
International Journal of Medical Research and Health Sciences, 2021
Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on... more Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on chick embryo development in 200 white leghorn chicken eggs used that met the inclusion-exclusion criteria. Material and method: The present study utilized 200 eggs, randomly assigned to experimental groups A and B and control groups a and b. Eggs incubated in the presence of Rolapitant had their Rolapitant dose increased on the fifth day of incubation from 0.18 mg to 0.36 mg. In contrast to the control groups, all of the subjects in the treatment groups received the same amount of normal saline. Eggs were broken on the twentieth day of incubation, and embryos were extracted on the same day. Results: The weight and CRL of the chick embryos were measured, and gross anatomical malformations were observed-the percentile lethality of Rolapitant increase with dose with the odds ratio of 1.175 and 1.313. While analyzing the abnormal weight and abnormal CR length due to the effects of Rolapitant, a significant difference was observed. In each case, an increased t-value concerning an increase in dose shows the lethality of Rolapitant. Conclusion: The present study observed an increased mortality rate and a decrease in weight and crown-rump length following a double dose of Rolapitant. The author remanded additional research with a larger sample size to improve the current observation's reliability and generalizability.
Annals of International Medical and Dental Research, 2016
Background: Flexor digitorum breves is an intrinsic muscle of the sole of the foot that lies supe... more Background: Flexor digitorum breves is an intrinsic muscle of the sole of the foot that lies superior to the central part of planter apponurosis and inferior to the tendons of flexor digitorum longus. This flat spindle shaped muscle arise from the medial process of tuber calcanei, proximal part of planter apponurosis, inter muscular septa and adjacent fascial layers. The muscle fiber conver anteriorly forming four tendons one each for the four lateral toes at the bases of proximal phalenges each tendon splits into two slips around the tendon of flexor digitorum longus, reunites into a chiasma, devides again to insert into margins of intermediate phalenges of lateral four toes. Methods: This study was carried out by routine dissection classes for undergraduate medical students classes from July 2010 to January 2014 in the department of anatomy, Teerthanker Mahaveer medical college Moradabad; department of anatomy, Rama medical college Kanpur; Department of Anatomy, Hamdard Institute of Medical Science & Research, Jamia Hamdard New Delhi. Total no. of 80 cadavers (48 male and 32 female) all the cadavers were been preserved in 10% of formalin and age ranged between 45 to 67 years. Results: Summarising the result indicates out of 80 cadavers 25% were having none anatomical variation, 46% of cadavers had bilateral absence of tendon for fifth toe of flexor digitorum breves while 18% of cadavers having variation on the left foot and rare 9% of cadavers were represented having variation on the right foot while the left foot was anatomically normal. Conclusion: Variation of flexor digitorum breves may occur as phylogenetical changes due to minimal use of little toe in evolved bipedal posture.
International Journal of Research in Medical Sciences, 2020
Background: Human body is studied by dissection method on unclaimed or donated human cadavers. An... more Background: Human body is studied by dissection method on unclaimed or donated human cadavers. Anatomy is of paramount importance taught for the first year M.B.B.S students all over Indian Medical Colleges since decades. Methods: Medical Institution was started in month of September 2019 with 100 intakes on merit basis. Aim was to teach the human anatomy to 1 st MBBS students by dissecting the cadavers for which an Awareness programme was conducted by department of anatomy regarding to Body donation. Study was done going through and studying the donated forms with full consent in duly signed consent forms. Their age, physical conditions and mental status were taken into considerations as the yard sticks. Results: Since college has started in September 2019, there was poor response and awareness about body donation. So far fifteen live donors including 12 males and 3 females have filled their forms in perfect normal status and with NO compulsion from anybody. Five dead bodies (Cadavers) received in the Department of Anatomy of Government Medical College, Barmer for the propose of dissection to teach the 1 st year MBBS students. Awareness of donation of the body is in progress. Conclusions: In the present study, authors concluded that only few people gave response in favour of awareness programme of body donation showing the lack of awareness towards the body donation. So, the study has shown the requirement of more awareness programmes about body donation among the population. It will help to clarifying any myths or/and superstition so that the general public should aware and show interest towards the body donation.
International Journal of Medical Research & Health Sciences,, 2021
Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on... more Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on chick embryo development in 200 white leghorn chicken eggs used that met the inclusion-exclusion criteria. Material and method: The present study utilized 200 eggs, randomly assigned to experimental groups A and B and control groups a and b. Eggs incubated in the presence of Rolapitant had their Rolapitant dose increased on the fifth day of incubation from 0.18 mg to 0.36 mg. In contrast to the control groups, all of the subjects in the treatment groups received the same amount of normal saline. Eggs were broken on the twentieth day of incubation, and embryos were extracted on the same day. Results: The weight and CRL of the chick embryos were measured, and gross anatomical malformations were observed-the percentile lethality of Rolapitant increase with dose with the odds ratio of 1.175 and 1.313. While analyzing the abnormal weight and abnormal CR length due to the effects of Rolapitant, a significant difference was observed. In each case, an increased t-value concerning an increase in dose shows the lethality of Rolapitant. Conclusion: The present study observed an increased mortality rate and a decrease in weight and crown-rump length following a double dose of Rolapitant. The author remanded additional research with a larger sample size to improve the current observation's reliability and generalizability.
Pubmed, 2022
Introduction Although coronavirus disease 2019 (COVID-19) first appeared in 2019, the symptoms ar... more Introduction Although coronavirus disease 2019 (COVID-19) first appeared in 2019, the symptoms are similar to common viral illnesses, and if undiagnosed or there is a delay in treatment, it may prove fatal because of the virus's propensity to attack the respiratory and cardiovascular system. The antigenic conversion status of reverse transcription-polymerase chain reaction (RT-PCR) was an important criterion for discharge among the COVID-19 patients of the two hospitals in the study. Aim The aim of the study was to assess the time taken to antigenic conversion from positive to negative in RT-PCR test for COVID-19 done on patients admitted to the two hospitals where the study took place. Materials and methods A prospective cross-sectional study with repeated sampling for antigenic conversion by RT-PCR was done on 117 patients of different age groups admitted to Bangur Hospital and Agarsen Bhavan in Pali, Rajasthan, India, from April 27 to June 30, 2020. Pharyngeal and nasal swabs were analyzed by real-time RT-PCR for COVID-19 infection. The patients' first positive sample was taken as "zero sample". If the repeat sample taken on the fifth day was positive, sampling was repeated after 48 hours on consecutive days 7, 9, 11, 13, and 15 of admission till the RT-PCR test returned negative. Results Among the 117 patients, 92 (78.63%) were treated as mild, 10 (8.54%) were moderately severe, and 15 (12.82%) were very severe requiring ICU care. The median rate of conversion of RT-PCR test (positive to negative) from the day of admission was quite variable as five patients converted to negative by RT-PCR test on day seven of admission, one on day eight of admission, 26 on day nine, 30 on day 10, five on day 11, 13 on day 12, 10 on day 13, 11 on day 14, five on day 15, six on day 16, three on day 17, and one on day 18 of admission. Conclusion The study proved that follow-up of patients, prompt and comprehensive treatment, and repeated sampling ensures fast recovery with implications on time to discharge of such patients in a pandemic. The study justified and heralds the message that the inherent immunity of an individual corresponds to the time taken to conversion from positive to negative in the RT-PCR test.
At all doses, the mean weight and crown-rump (CR) length of chick embryos were signi icantly grea... more At all doses, the mean weight and crown-rump (CR) length of chick embryos were signi icantly greater in the control group than in the experimental group. The experimental group died at a higher rate than the control group. Additionally, it was found that the mortality due to the rolapitant dosages increases with dose. All groups except group A showed skeletal anomalies such as poor ossi ication, bent, and displacement, and morphological abnormalities such as yolk sac retraction, hematoma, and scanty feathers were found in experimental groups C, D, and E. This was shown to be more prevalent in the experimental groups and was exacerbated by subsequent rolapitant dosages. Conclusion Rolapitant is toxic when taken in large doses and for an extended period. As a result, rolapitant should be taken only when a valid diagnosis has been established and only at the recommended dose, not at a larger dose or for an extended period of time.