staffan meurling - Academia.edu (original) (raw)
Papers by staffan meurling
Acta chirurgica Scandinavica, 1981
There are limited data in the literature concerning the energy, fat and nitrogen balances in heal... more There are limited data in the literature concerning the energy, fat and nitrogen balances in healthy newborn infants of normal weight. For this reason, five healthy newborn infants were studied during the first week after birth. Balance studies on energy, fat, nitrogen, dry matter and water were performed. Oxygen consumption was determined by an open method. The weight decrease the first days was explained by a deficit of water and energy intake. Weight gain was seen when the water intake was 80-100 ml/kg/day and the energy intake 200-300 kJ/kg/day. A linear relation was found between the total evaporative water losses and ambient vapour pressure. The mean resting metabolic rate was 174 kJ/kg/day with the range 144-200 kJ/kg/day. With higher activity the metabolic rate increased 20-45%. Positive balances of nitrogen and fat were obtained when the intakes exceeded 150 and 275 mg/kg/day, respectively.
Läkartidningen, Jan 24, 1967
Acta chirurgica Scandinavica, 1981
A rat model relevant to paediatric praxis was designed in order to evaluate possible differences ... more A rat model relevant to paediatric praxis was designed in order to evaluate possible differences between total parenteral nutrition (TPN) with fat (Intralipid 20%), and isocaloric TPN without fat and also to compare continuous TPN (24 hours/day) versus intermittent TPN (12 hours/day). TPN with fat resulted in better growth and nitrogen utilization. Continuous TPN with fat resulted in statistically significant better nitrogen utilization. The results suggest that TPN in paediatric praxis should be continuous and include fat.
The European journal of surgery = Acta chirurgica, 1991
To find out if survival after peritonitis induced by caecal puncture and injection of endotoxin i... more To find out if survival after peritonitis induced by caecal puncture and injection of endotoxin is correlated with serum endotoxin concentrations in rats; whether this study could be carried out by studying the effects of vitamin A in rats with peritonitis; and if it was possible to differentiate between local and systemic effects of vitamin A on endotoxaemia in rats. Prospective randomised study. Sixty adult male Sprague-Dawley rats. Rats were kept on a diet containing no vitamin A for six days; 30 were given vitamin A 1,380 IU/kg/day intramuscularly and 30 were given peanut oil. Peritonitis was then induced in 16 rats by caecal puncture (treated n = 10, untreated n = 6) and the remainder received intraperitoneal injections of either 0.5 mg/kg endotoxin, or 2.0 mg/kg endotoxin. Plasma concentrations of vitamin A, vitamin E, and serum concentrations of endotoxin, estimation of erythrocyte volume fraction and leucocyte particle concentrations, and survival. Rats that were given 2 mg ...
Proceedings of the First International Workshop Neuherberg, Federal Republic of Germany, April 1980, 1980
Nordisk medicin, Aug 20, 1948
Journal of Equine Veterinary Science, 2014
Clinical Genetics, 2008
Two brothers, the only children of healthy, unrelated parents with normal karyotypes, had 47,XXY-... more Two brothers, the only children of healthy, unrelated parents with normal karyotypes, had 47,XXY-Klinefelter's syndrome and bilateral testicular teratomas. The oldest XXYboy had, in addition, congenital hydrocephalus caused by congenital stenosis of the aqueduct of Sylvius.
Acta chirurgica Scandinavica. Supplementum, 1983
Acta Paediatrica, 1976
A primary pancreatic tumour in a 6-year-old boy was removed by radical excision. From both light ... more A primary pancreatic tumour in a 6-year-old boy was removed by radical excision. From both light and electron microscopic observations the tumour was considered to be of exocrine origin, with some differentiation towards acinar cells. Although the tumour was highly differentiated, it was regarded as probably malignant because of tumour growth into the surrounding fibrous capsule. The case is discussed in relation to earlier rare reports of pancreatic tumours in infants and children.
Fettemulsionen in der parenteralen Ernährung, 1977
Einer der fuhrenden Kinderchirurgen der Welt hat kurzlich gesagt, das die parenterale Ernahrung d... more Einer der fuhrenden Kinderchirurgen der Welt hat kurzlich gesagt, das die parenterale Ernahrung die wichtigste Entwicklung in der Kinderchirurgie wahrend des letzten Jahrzehntes ist. Auch in anderen medizinischen Disziplinen scheint diese Entwicklung von groster Bedeutung zu sein. Der Amerikaner DUDRICK hat 1968 mit seiner Methode, den Calorienbedarf mit hochkonzentrierten Zuckerlosungen uber einen Katheter in der Vena cava zu decken, einen wertvollen Beitrag geleistet. Zu derselben Zeit hat man in der Chirurgie (HALLBERG et al. (7) ) damit begonnen, Fett, d.h. Intralipid intravenos zu applizieren, eine Technik, die die Kinderchirurgie revolutioniert hat (RICKHAM (13), B0RRESEN u. KNUTRUD (2)). Die amerikanische Technik schreibt Kohlenhydrate und Aminosauren vor, wobei die hohe Konzentration dieser Stoffe einen Katheter in der Vena cava notwendig macht. Unsere Technik beinhaltet auch intravenos zu verabreichendes Fett, und mit dieser Technik ist es in den meisten Fallen moglich, periphere Venen zu benutzen. Bei kleinen Kindern werden dabei die Schadelvenen mit einer Nadel punktiert. Die Risiken der amerikanischen Technik sind bekannt: Erstens besteht das Risiko einer osmotischen Diurese, wobei die Verluste im Urin bedeutend werden konnen.
African Journal of Paediatric Surgery, 2011
Journal of the Japanese Society of Pediatric Surgeons, 2000
Journal of the Japanese Society of Pediatric Surgeons, 2000
Children with SBS have a high morbidity and mortality rate despite improvements in both enteral a... more Children with SBS have a high morbidity and mortality rate despite improvements in both enteral and parenteral nutrition. Improved medical treatment must sometimes be combined with surgical procedures including intestinal lengthening and transplantation, thereby improving the status of these children.
Acta chirurgica Scandinavica, 1981
The possible advantages of including fat in a regimen of total parenteral nutrition (TPN) have lo... more The possible advantages of including fat in a regimen of total parenteral nutrition (TPN) have long been debated. In order to investigate the role of fat in liver function during different intravenous regimens, two groups of rats received a regimen including fat (Intralipid 20%) during 12 and 24 hours/day, respectively and two groups received a fat-free regimen, isocaloric and isonitrogenous, during the same intervals, all for a period of 10 days. A control group received for 10 days the fat-including regimen orally and libitum. The liver was investigated biochemically and morphologically. Fatty infiltration of the parenchymal liver cells, a low content of linoleic acid and a high content of palmitic and oleic acid among the liver lipids were found in the rats receiving the fat-free regimen. Fat pigments in the cells of the reticuloendothelial system of the livers and values of fatty acid among the liver lipids comparable to those found in orally-fed rats were seen in rat receiving ...
Pediatric Surgery International, 1992
For more than 15 years, we have practiced a policy of primary repair in cases of gastroschisis. R... more For more than 15 years, we have practiced a policy of primary repair in cases of gastroschisis. Regardless of the appearance of the intestine and the size of the abdominal cavity, a primary repair has always been considered the method of choice. Twenty-five cases treated consecutively at our departments from February 1984 to April 1990 were investigated. A majority of the infants were preterm and of low birth weight. A majority also had severe bowel abnormalities. In 1 case a delayed repair with a silo had to be performed. In 2 others a small fascial defect had to be temporarily covered with a silastic patch, but in the remaining 22 cases (88%) a primary repair could be carried out without significant morbidity. Two infants died, 1 from severe neonatal asphyxia and cerebral hemorrhage and 1 from liver failure associated with a short-bowel syndrome (the only silo case). It is our belief that primary closure is possible and should be considered in most newborns.
Acta chirurgica Scandinavica, 1981
The concentrations of 14 elements in red cells and serum in 23 healthy newborn infants were deter... more The concentrations of 14 elements in red cells and serum in 23 healthy newborn infants were determined with the aid of neutron activation analysis. Whole blood from seven mothers was also analysed. The mothers had no signs of trace element deficiency. In newborn infants the concentration of zinc in red cells was low and that of calcium was high, as compared with adults. The copper concentration in serum was low. In the newborn infants, higher ratios of intracellular to extracellular concentrations of sodium and potassium were found, as compared with adults. Iron and rubidium values in serum and red cells were similar to those found in adults. The ratio of intracellular to extracellular concentrations for chromium was two-the same value found in adults, although the levels were lower than reported in adults.
Acta chirurgica Scandinavica, 1981
There are limited data in the literature concerning the energy, fat and nitrogen balances in heal... more There are limited data in the literature concerning the energy, fat and nitrogen balances in healthy newborn infants of normal weight. For this reason, five healthy newborn infants were studied during the first week after birth. Balance studies on energy, fat, nitrogen, dry matter and water were performed. Oxygen consumption was determined by an open method. The weight decrease the first days was explained by a deficit of water and energy intake. Weight gain was seen when the water intake was 80-100 ml/kg/day and the energy intake 200-300 kJ/kg/day. A linear relation was found between the total evaporative water losses and ambient vapour pressure. The mean resting metabolic rate was 174 kJ/kg/day with the range 144-200 kJ/kg/day. With higher activity the metabolic rate increased 20-45%. Positive balances of nitrogen and fat were obtained when the intakes exceeded 150 and 275 mg/kg/day, respectively.
Läkartidningen, Jan 24, 1967
Acta chirurgica Scandinavica, 1981
A rat model relevant to paediatric praxis was designed in order to evaluate possible differences ... more A rat model relevant to paediatric praxis was designed in order to evaluate possible differences between total parenteral nutrition (TPN) with fat (Intralipid 20%), and isocaloric TPN without fat and also to compare continuous TPN (24 hours/day) versus intermittent TPN (12 hours/day). TPN with fat resulted in better growth and nitrogen utilization. Continuous TPN with fat resulted in statistically significant better nitrogen utilization. The results suggest that TPN in paediatric praxis should be continuous and include fat.
The European journal of surgery = Acta chirurgica, 1991
To find out if survival after peritonitis induced by caecal puncture and injection of endotoxin i... more To find out if survival after peritonitis induced by caecal puncture and injection of endotoxin is correlated with serum endotoxin concentrations in rats; whether this study could be carried out by studying the effects of vitamin A in rats with peritonitis; and if it was possible to differentiate between local and systemic effects of vitamin A on endotoxaemia in rats. Prospective randomised study. Sixty adult male Sprague-Dawley rats. Rats were kept on a diet containing no vitamin A for six days; 30 were given vitamin A 1,380 IU/kg/day intramuscularly and 30 were given peanut oil. Peritonitis was then induced in 16 rats by caecal puncture (treated n = 10, untreated n = 6) and the remainder received intraperitoneal injections of either 0.5 mg/kg endotoxin, or 2.0 mg/kg endotoxin. Plasma concentrations of vitamin A, vitamin E, and serum concentrations of endotoxin, estimation of erythrocyte volume fraction and leucocyte particle concentrations, and survival. Rats that were given 2 mg ...
Proceedings of the First International Workshop Neuherberg, Federal Republic of Germany, April 1980, 1980
Nordisk medicin, Aug 20, 1948
Journal of Equine Veterinary Science, 2014
Clinical Genetics, 2008
Two brothers, the only children of healthy, unrelated parents with normal karyotypes, had 47,XXY-... more Two brothers, the only children of healthy, unrelated parents with normal karyotypes, had 47,XXY-Klinefelter's syndrome and bilateral testicular teratomas. The oldest XXYboy had, in addition, congenital hydrocephalus caused by congenital stenosis of the aqueduct of Sylvius.
Acta chirurgica Scandinavica. Supplementum, 1983
Acta Paediatrica, 1976
A primary pancreatic tumour in a 6-year-old boy was removed by radical excision. From both light ... more A primary pancreatic tumour in a 6-year-old boy was removed by radical excision. From both light and electron microscopic observations the tumour was considered to be of exocrine origin, with some differentiation towards acinar cells. Although the tumour was highly differentiated, it was regarded as probably malignant because of tumour growth into the surrounding fibrous capsule. The case is discussed in relation to earlier rare reports of pancreatic tumours in infants and children.
Fettemulsionen in der parenteralen Ernährung, 1977
Einer der fuhrenden Kinderchirurgen der Welt hat kurzlich gesagt, das die parenterale Ernahrung d... more Einer der fuhrenden Kinderchirurgen der Welt hat kurzlich gesagt, das die parenterale Ernahrung die wichtigste Entwicklung in der Kinderchirurgie wahrend des letzten Jahrzehntes ist. Auch in anderen medizinischen Disziplinen scheint diese Entwicklung von groster Bedeutung zu sein. Der Amerikaner DUDRICK hat 1968 mit seiner Methode, den Calorienbedarf mit hochkonzentrierten Zuckerlosungen uber einen Katheter in der Vena cava zu decken, einen wertvollen Beitrag geleistet. Zu derselben Zeit hat man in der Chirurgie (HALLBERG et al. (7) ) damit begonnen, Fett, d.h. Intralipid intravenos zu applizieren, eine Technik, die die Kinderchirurgie revolutioniert hat (RICKHAM (13), B0RRESEN u. KNUTRUD (2)). Die amerikanische Technik schreibt Kohlenhydrate und Aminosauren vor, wobei die hohe Konzentration dieser Stoffe einen Katheter in der Vena cava notwendig macht. Unsere Technik beinhaltet auch intravenos zu verabreichendes Fett, und mit dieser Technik ist es in den meisten Fallen moglich, periphere Venen zu benutzen. Bei kleinen Kindern werden dabei die Schadelvenen mit einer Nadel punktiert. Die Risiken der amerikanischen Technik sind bekannt: Erstens besteht das Risiko einer osmotischen Diurese, wobei die Verluste im Urin bedeutend werden konnen.
African Journal of Paediatric Surgery, 2011
Journal of the Japanese Society of Pediatric Surgeons, 2000
Journal of the Japanese Society of Pediatric Surgeons, 2000
Children with SBS have a high morbidity and mortality rate despite improvements in both enteral a... more Children with SBS have a high morbidity and mortality rate despite improvements in both enteral and parenteral nutrition. Improved medical treatment must sometimes be combined with surgical procedures including intestinal lengthening and transplantation, thereby improving the status of these children.
Acta chirurgica Scandinavica, 1981
The possible advantages of including fat in a regimen of total parenteral nutrition (TPN) have lo... more The possible advantages of including fat in a regimen of total parenteral nutrition (TPN) have long been debated. In order to investigate the role of fat in liver function during different intravenous regimens, two groups of rats received a regimen including fat (Intralipid 20%) during 12 and 24 hours/day, respectively and two groups received a fat-free regimen, isocaloric and isonitrogenous, during the same intervals, all for a period of 10 days. A control group received for 10 days the fat-including regimen orally and libitum. The liver was investigated biochemically and morphologically. Fatty infiltration of the parenchymal liver cells, a low content of linoleic acid and a high content of palmitic and oleic acid among the liver lipids were found in the rats receiving the fat-free regimen. Fat pigments in the cells of the reticuloendothelial system of the livers and values of fatty acid among the liver lipids comparable to those found in orally-fed rats were seen in rat receiving ...
Pediatric Surgery International, 1992
For more than 15 years, we have practiced a policy of primary repair in cases of gastroschisis. R... more For more than 15 years, we have practiced a policy of primary repair in cases of gastroschisis. Regardless of the appearance of the intestine and the size of the abdominal cavity, a primary repair has always been considered the method of choice. Twenty-five cases treated consecutively at our departments from February 1984 to April 1990 were investigated. A majority of the infants were preterm and of low birth weight. A majority also had severe bowel abnormalities. In 1 case a delayed repair with a silo had to be performed. In 2 others a small fascial defect had to be temporarily covered with a silastic patch, but in the remaining 22 cases (88%) a primary repair could be carried out without significant morbidity. Two infants died, 1 from severe neonatal asphyxia and cerebral hemorrhage and 1 from liver failure associated with a short-bowel syndrome (the only silo case). It is our belief that primary closure is possible and should be considered in most newborns.
Acta chirurgica Scandinavica, 1981
The concentrations of 14 elements in red cells and serum in 23 healthy newborn infants were deter... more The concentrations of 14 elements in red cells and serum in 23 healthy newborn infants were determined with the aid of neutron activation analysis. Whole blood from seven mothers was also analysed. The mothers had no signs of trace element deficiency. In newborn infants the concentration of zinc in red cells was low and that of calcium was high, as compared with adults. The copper concentration in serum was low. In the newborn infants, higher ratios of intracellular to extracellular concentrations of sodium and potassium were found, as compared with adults. Iron and rubidium values in serum and red cells were similar to those found in adults. The ratio of intracellular to extracellular concentrations for chromium was two-the same value found in adults, although the levels were lower than reported in adults.