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Papers by sutapa biswas majee

International Journal of Pharmaceutical Sciences Review and Research, 2022

Transdermal drug delivery is the administration of therapeutic agents through intact skin for sys... more Transdermal drug delivery is the administration of therapeutic agents through intact skin for systemic effect. Polymers are the backbone of the matrix-type transdermal patches. Based on the nature of origin, these polymers can be Natural, Semi-synthetic, and Synthetic polymers. Several experimental results have revealed the fact that in the case of the fabrication of matrix-type patches, the use of a polymeric blend becomes more effective than the use of a single polymer to control the rate of drug release from the patch. In this context, the selection of an appropriate combination of polymers becomes very crucial to modulate the rate and extent of release of drugs from matrix-type patches. It is essential to have sound knowledge of the inherent properties of different polymers for the selection of an appropriate combination of polymers to achieve the controlled drug release from the matrix-type patches. This article assembles comprehensive up-to-date information on various categori...

Nano-enabled Agrochemicals in Agriculture, 2022

Asian Journal of Pharmaceutical and Clinical Research, 2022

Pulmonary dosage forms constitute an important route of drug delivery for systemic absorption of ... more Pulmonary dosage forms constitute an important route of drug delivery for systemic absorption of drugs in management of respiratory diseases as well as diseases such as diabetes, migraine, osteoporosis, and cancer. Performance of different pulmonary dosage forms is greatly influenced by aerodynamic particle size distribution of inhalable particles, spray pattern, fraction of dose actually deposited on pulmonary epithelium, dissolution of active pharmaceutical ingredient and ultimately absorption across pulmonary barriers. In vitro dissolution study should be designed to predict in vivo performance precisely, providing key information on bioavailability and establishing in vitro-in vivo correlation. To obtain meaningful data from dissolution study, focus should be on composition of dissolution medium, dissolution conditions and dissolution test apparatus. For pulmonary dosage forms, selection of physiologically relevant dissolution medium, mimicking lung fluid (LF) is a challenging t...

Background: Oleogel is a thermo-reversible, viscoelastic, semisolid self-assembled preparation in... more Background: Oleogel is a thermo-reversible, viscoelastic, semisolid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40 / Tween 80based soybean oleogels for topical application and to establish a relationship between viscosity, flexibility, thermal stability and drug release of the oleogels by modeling of gelation and release kinetics. Method: Span 40(gelator)/Tween 80(surfactant)-based soybean oleogel formulations were prepared and subjected to organoleptic evaluation, FTIR spectroscopy, thermal analysis, viscosity study, kinetic modeling of gelation and drug release. Results: Tween 80 reduced critical gelator concentration (CGC) of Span 40-based oleogels and also enhanced their thermal stability and viscosity. Gelation time was lowered with the increase in ...

Journal of Applied Pharmaceutical Science, 2016

Polysaccharides of natural, synthetic or semi-synthetic origin have been used from time immemoria... more Polysaccharides of natural, synthetic or semi-synthetic origin have been used from time immemorial in the development of drug delivery systems designed to achieve tailored and site-specific drug release. Starch-based polysaccharides derived from plants have been extensively studied in this regard. Natural polymeric excipients are preferred over their synthetic counterparts owing to their low cost, availability, biocompatibility, biodegradability and non-toxicity. The present review attempts to provide a new direction and a comprehensive insight on the physical properties, rheological behavior, toxicity profile, pharmaceutical applications, swelling behavior and drug diffusion kinetics from dosage forms based on non-starch polysaccharides of plant origin such as, psyllium, pectin, arabinoxylan, xyloglucan, guar gum galactomannan and konjac glucomannan. It has been observed from the current review that non-starch polysaccharides are safe for human consumption and can be successfully employed to deliver drugs specifically to stomach and colon in a sustained fashion. They have thus widened the scope of natural polymeric excipients and demand better industrial utilization on a commercial scale to minimize cost of production and to satisfy therapeutic needs in safe and effective manner.

Long-term infection by Human Immunodeficiency Virus produces a multitude of clinical symptoms res... more Long-term infection by Human Immunodeficiency Virus produces a multitude of clinical symptoms resulting in total suppression of the immune system dominated by depletion in CD4 T cell count and reduction in density of Human Immunodeficiency Virus specific Cytotoxic T-Lymphocyte immune responses. Since the dynamics between viral infection and replication parameters and the host immunity system changes from short-term to long-term chronic infection, mathematical modeling of long-term dynamics necessitates incorporation of negative feedback control mechanism. By applying optimal control theory approach to the administration of combination therapy of reverse transcriptase inhibitor and interleukin 2 in the same model, the most cost-effective strategy has been established where maximum recovery of CD4 T cell population is attained. KeywordsHuman Immunodeficiency Virus; Host Immune System; Negative Feedback Control; Optimal Control

African journal of pharmacy and pharmacology

In vitro dissolution testing should discriminate between the impact of excipients on release prof... more In vitro dissolution testing should discriminate between the impact of excipients on release profile of Biopharmaceutics Classification System class 2 drugs. Among the four batches of carvedilol solid dispersion tablets, SDT-2-L containing 30% w/w mannitol and 2.5% w/w L-hydroxypropyl cellulose LH- 11 exhibited least mean dissolution time in gastric buffer (pH = 1.2) and phosphate buffer (pH = 6.8). However, inter-batch differences in release parameters from phosphate buffer were usually higher and also statistically significant at p < 0.05. Drug release from an individual formulation exhibited different kinetics in two media. Therefore, improper selection of dissolution medium may fail to discriminate between product performances.

Journal of Medicinal Plants Research, 2018

Plant pectin constitutes an important class of naturally occurring polysaccharides and are widely... more Plant pectin constitutes an important class of naturally occurring polysaccharides and are widely distributed in various fruits and vegetables consumed on a regular basis. These biomolecules are reported to exhibit a vast array of biological activities including effects on digestive system, chemopreventive effect in colon cancer, regulation of blood cholesterol level and immune-potentiating effects. However, variation in spectrum of activity and efficacy occurs due to different sources of pectin and also different methods of extraction. Pectin modification by pH treatment, change in temperature or enzymatic modification methods can ensure derivatives with variable but defined degrees of esterification, customized physicochemical properties and improved pharmacological and therapeutic profile, mainly in cancer prevention and management. Pharmaceutical utility of plant pectin is attributed to the unique rheological behavior and gelling properties in aqueous medium and have been successfully employed in development of colon specific sustained release drug delivery systems and edible pectin films with stabilizing effect on entrapped labile molecules. The goal of the review article is to focus on the therapeutic and pharmaceutical benefits of native and modified pectin. Although, several milestones towards understanding the process of pectin modification have been established, most of the data generated till date are obtained from in vitro studies or on commercial varieties of modified pectin. Complete characterization of structure-activity relationships of modified pectin, wellplanned in vivo investigations and optimization of pectin-based scaffolds for controlled and targeted drug delivery in oncotherapy are yet to be ascertained for enhancing the marketing potential of these renewable plant-derived biopolymers.

For the preparation of buccal controlled release patches hydrophilic, swellable, porous polymeric... more For the preparation of buccal controlled release patches hydrophilic, swellable, porous polymeric material alone or in optimum combination and optimum mucoadhesive strength is essential. The use of naturally occurring biocompatible polymers has been the area of interest of recent research activity for designing controlled release dosage forms. Diclofenac causes gastro-intestinal irritation and ulceration upon oral administration. Hence an approach has been adopted to prepare buccal mucoadhesive patches of Diclofenac potassium to overcome the above mentioned problem and avoidance of hepatic “first-pass” effect. Buccal patches of Diclofenac potassium were prepared with Carbopol 974P, HPMCK4M, Ethyl cellulose and Gum karaya. HPMCK4M and Ethyl cellulose were used to prepare all the patches whereas Carbopol 934P and Gum karaya were incorporated in the patches as 1:0 (F1), 1:1 (FGK1) and 0:1 (FGK2). The patches were evaluated for their mucoadhesive strength, folding endurance, surface pH,...

Superdisintegrant absorbs water by wicking or capillary action undergoes swelling, induces hydrod... more Superdisintegrant absorbs water by wicking or capillary action undergoes swelling, induces hydrodynamic pressure in the tablet core causing rupture and disintegration to finer particles of higher specific surface area available for interaction with dissolution medium. Disintegrant efficiency and its performance in dissolution improvement is markedly influenced by the hydrophilicity of the filler excipient. In the present experimental work, soluble diluent, lactose(L) and hygroscopic, insoluble diluent, di-calcium phosphate dihydrate(D), were combined with superdisintegrant, Ac-di-sol to produce tablets of Danazol solid dispersion(DZ-SDT) and evaluated for determination of their water absorption percentage, disintegration time and release kinetics. High hydrophilicity and fibrous nature of Ac-di-sol resulted in water absorption percentages of 60% and 52% into the tablet structure for the batches DZ-SDT(L)-2 and DZ-SDT(D)-2 respectively. Use of di-calcium phosphate dihydrate as filler...

To get successful buccal controlled release dosage form hydrophilic, swellable polymeric material... more To get successful buccal controlled release dosage form hydrophilic, swellable polymeric material alone or in optimum combination is essential. This dosage form should get stuck to the oral cavity and release the drug at a controlled rate under the conditions prevailing in the mouth. Here a natural gum (Gum karaya) has been selected to prepare buccal tablets of Amoxicillin trihydrate. The tablets were prepared by wet granulation method. After granulation the pre-compression evaluation tests were performed. The granules showed good flow ability and compressibility. Physicochemical tests of the tablets revealed satisfactory results. Buccoadhesive strength of the tablets was found to be in the range of 28-39 gm, which is good enough to hold the tablets in the buccal cavity. Percent Swelling of the tablets was 10-107.87 % in phosphate buffer pH-6.8. The release data were fitted in kinetic models of zero order, first order and Higuchi. The tablets with 10- 15 % of gum karaya showed zero ...

International Journal of Current Pharmaceutical Research, 2021

Objective: Oral disintegrating films consisting of hydrophilic polymer are designed to be quickly... more Objective: Oral disintegrating films consisting of hydrophilic polymer are designed to be quickly hydrated by saliva, adhere to the mucosa and disintegrate rapidly to release the drug. The aim of the present study was to prepare stable, flexible swellable rapid release oral films with hydroxypropyl methylcellulose E15 LV (HPMC) and polyvinyl alcohol (PVA) in different ratios. Guar gum was incorporated as the mucoadhesive agent. In order to achieve rapid disintegration of the film cross carmellose sodium (superdisintegrant) and surfactant like Tween 80 were added. The model drug used in the study was diclofenac sodium. Methods: Films were developed using HPMC E15 LV and PVA by solvent casting method and characterized for thickness, swelling index, disintegration time, folding endurance, drug content, and in vitro drug release pattern and kinetics. Results: The prepared swellable rapid release oral films were quite flexible and transparent with a smooth texture. The swelling index stu...

With the advent of biopharmaceuticals into the market, lyophilisation or freeze-drying forms an e... more With the advent of biopharmaceuticals into the market, lyophilisation or freeze-drying forms an essential step in their manufacturing technique. Stability and sterility are achieved more easily with the process than with other conventional techniques. Design, development, control, optimisation and scale-up of the process requires consideration of several aspects such as theoretical knowledge of the stages of freeze-drying cycle, determination of end-point of primary drying stage, evaluation and analysis of the process and the product, techniques for optimization in practice and their relevance to the variables in question. Application of the process in commercial scale throws up challenges in terms of design of dryer, batch size, duration of process. Description of factors responsible for problems related to scale-up should be investigated in details and should be appropriately controlled to reduce the production cost to a minimum without compromising with the process efficiency or ...

Asian Journal of Pharmaceutical and Clinical Research, 2021

Meningitis, a serious communicable inflammatory disease continues to be a worldwide threat especi... more Meningitis, a serious communicable inflammatory disease continues to be a worldwide threat especially in sub-Saharan Africa affecting millions of people with high death rates every year. Strains from six serogroups of the principal causative organism Neisseria meningitidis are found to be responsible for the majority of infections. Incidences of antibiotic resistance and efforts to provide mass protection have necessitated the development of meningococcal vaccines since the latter half of the 20th century. Aiming to ostracize meningitis by 2030, the World Health Organization focuses on vaccination as an important strategy to reach the goal. Due to limited efficacy and stability issues of earlier polysaccharide and protein conjugate vaccines respectively, outer membrane vesicle (OMV) vaccines were developed. Gene manipulations have also led to the development of more efficacious tailor-made OMV vaccines due to over-expression of antigenic outer membrane proteins along with lesser pyr...

Asian Journal of Applied Sciences, 2015

Mathematical modeling involves construction of a set of equations or description of a stochastic ... more Mathematical modeling involves construction of a set of equations or description of a stochastic process closely mimicking a real phenomenon of practical significance and biological or physiological relevance. This paper reviews some specific pathological conditions of the skin and permeation of drugs across the skin during topical administration and transdermal route of delivery in the light of mathematical modeling. It aims at providing an insight into different variables governing any pathological situation of the skin involving a complex architecture of chemical mediators. The factors controlling skin permeability of a drug molecule have also been studied. The final outcome of the paper is to equip non-mathematicians with simple mathematical tools to conduct real experiments in a more satisfactory manner and explain the physiological phenomena in a robust fashion.

Drug release mechanism from matrix dosage form is governed by polymer swelling, polymer erosion, ... more Drug release mechanism from matrix dosage form is governed by polymer swelling, polymer erosion, drug dissolution/diffusion, drug distribution inside the matrix and drug/polymer ratio. Thus for the preparation of controlled release dosage form , hydrophilic , swellable, porous polymeric material alone or in optimum combination is essential. Here a plant derived polymer like Gum karaya (GK) and HPMCK4M have been selected to prepare buccal tablets to study the buccoadhesive strength and the release kinetics of Carvedilol phosphate. Three different ratios of HPMCK4M and Gum karaya have been considered to prepare buccoadhesive tablets. Their physicochemical tests revealed satisfactory results. Buccoadhesive strength was found to be in the range of 32-36 gm, which is good enough to hold the buccal tablets inside the buccal cavity. Percent Swelling of the buccoadhesive tablets were in the range of 47.11-53.09. Swelling is maximum in the tablet where GK and HPMCK4M ratio is 1:1. Drug disso...

Hydrophilic swellable polymers are widely used to control the release of drugs from matrix formul... more Hydrophilic swellable polymers are widely used to control the release of drugs from matrix formulations. The natural polymers are biodegradable and nontoxic, which hydrate and swell on contact with aqueous media. The present investigation is aimed to formulate the controlled release matrix granules of Amoxicillin trihydrate with different concentration of a plant derived gum, gum karaya, using no other varying parameter. Prepared granules were evaluated for different micrometrics properties like bulk density, tapped density, Hausner’s ratio, Carr’s index. The drug content and swelling behaviour were also investigated along with drug release kinetics. Percent swelling of the granules was 10-107.87 % in phosphate buffer pH-6.8. The drug release data from the granules were fitted in kinetic models of zero order, first order and Higuchi. The granules with 10-15% of gum karaya reveal the dominance of the highly swollen layer which controls the drug release from the granules. The findings...

Journal of Applied Pharmaceutical Science, 2017

Over the last few decades, numerous bacterial exopolysaccharides have been extensively studied fo... more Over the last few decades, numerous bacterial exopolysaccharides have been extensively studied for their composition, structure, biosynthesis and functional properties, owing to their unique properties over traditional plant-derived gums and synthetic polysaccharides. They have been employed in food processing industries as rheology modifiers, gelling agents, in oil drilling and cement industries. But their full-fledged commercialization is yet to be achieved and their scope and possibilities in pharmaceutical field and optimized drug delivery are yet to be explored. The present review outlines, critically evaluates and summarizes the research outcomes on structure, solubility, solution behavior, rheological characterization, gelation mechanism and potential industrial and pharmaceutical applications of curdlan, polysaccharide 13140, Fucopol, levan, sphingans, succinoglycan and several other bacterial exopolysaccharides in their native form and also their derivatives. It also aims to identify and propose potential drug delivery systems where gelling and non gel-forming exopolysaccharides can be utilized successfully for development of stable, acceptable and effective dosage form.