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Papers by sylvester ugariogu

Research paper thumbnail of Dereplication Study and Pharmacological Potentials of Phytochemical Constituents of Nigerian Propolis from Umudike

Palestinian medical and pharmaceutical journal/Palestinian medical & pharmaceutical journal, Jun 1, 2024

Research paper thumbnail of INSILICO DETERMINATION OF ANTI CANCER ACTIVITY OF PHYTOCHEMICAL FROM CLOVE (Syzygium aromaticum L) SEED

Bulletin of the Chemical Society of Nigeria, Aug 26, 2023

Syzygium aromaticum seed from the family of Myrtaceae is a highly priced natural spice used in pr... more Syzygium aromaticum seed from the family of Myrtaceae is a highly priced natural spice used in preparation of food which have been acclaimed and reported by previous researchers to have anticancer activities potentials. Due to the rising burden of cancer worldwide its severity and fatality coupled with side effects of synthetic drugs calls for an alternative treatment solution. Hence the current research studied the phytocompounds from the seed by extracting and screening the compounds using solvent maceration method and gas chromatography coupled to mass selective detector respectively to extract, identify and quantify the component phytochemicals present in the seed. Site directed multi-ligand docking of the identified compounds was performance on progesterone receptor protein responsible for breast cancer development using the compounds from GCMS results and compared with four standard breast cancer drugs by molecular docking method. The result showed that the alpha cubebene (-7 kcal/mol), Velerena-4, 7-(II) diene (-7.1 kcal/mol), caryophyllene (-7.4 kcal/mol), caryophyllene oxide (-7.4 kcal/mol), dibutyl phthalate have binding affinity close to the standard breast cancer drugs Abemaciclib (-8.3), Anastrozole (-7.2 kcal/mol) and Paclitaxel (-8.8 kcal/mol) and they have better binding affinity than the drug Cyclophasphamide (-5.6 kcal/mol). The result also revealed that some compounds from the GC-MS were found to have a binding affinity closer tothat of thecocrystallized ligand (-10.7 kcal/mol). Other compounds from clove seed showed favourable docking scores in comparison with the drugs as many of the compounds have docking scores of more than (-6 kcal/mol) suggesting that the compounds have anti breast cancer activities since their amino acids showed hydrogen bonding corresponding to that on the binding site

Research paper thumbnail of Natural Product Chemistry and Computer Aided Drug Design an Approach to Drug Discovery: A Review Article

International Journal of Pharmacognosy & Chinese Medicine

Natural products have been an inherent part of sustaining acculturation because of their medicina... more Natural products have been an inherent part of sustaining acculturation because of their medicinal properties. Past discoveries of bioactive natural products have relied on serendipity and accidental experience, and these compounds serve as inspiration for the generation of analogs with desired physicochemical properties. Bioactive natural products with therapeutic potential are abundantly available in nature and some of them are beyond exploration by conventional methods. However there has been a great breakthrough in the study of computer aided drug design (CADD) as many unfruitful lab researches have been averted and money, time and energies saved through CADD. Computer-aided drug design is a stimulating, arousing and manifold discipline where various aspects of applied and basic research integrate and induce each other. The empirical basis of CADD involves quantum mechanics and molecular modeling studies like structure based drug design; ligand-based drug design; database search...

Research paper thumbnail of The Potentials of Medicinal Plants in the Treatment of Covid-19 Patients: A Review

International Journal of Pharmacognosy & Chinese Medicine

COVID-19 pandemic (corona virus disease 2019 is a life threatening SARS-Cov-19 severe acute respi... more COVID-19 pandemic (corona virus disease 2019 is a life threatening SARS-Cov-19 severe acute respiratory syndrome virus 2) situation that was declared a public health emergency by WHO in early 2020. Today’s primary emphasis is on the treatment of COVID-19 yet the specific mode of action of antiviral agents being employed must be identified. At present, the human on risk are being vaccinated but there is no clear anti-COVID 19 medicine. This study focuses on herbal approaches as a potential alternative therapy for COVID-19, based on medicinal plants. Some herbs are well-known in different traditional medicines for prevention, cure and recovery of the diseases like COVID-19. Mostly the plant’s herbal extract inhibits viral replication; however several studies have shown that conventional herbal extracts may interact with important viral proteins associated with the virulence. The update on traditional medicines suggested for the prevention of COVID-19 has been analyzed here.

Research paper thumbnail of Antibacterial Activity and Identification of Metabolites from the Semi-Purified Fraction of Chrysophyllum albidum Leaf (African Star Apple)

Traditional medicine which rely on plant resources to treat various diseases and ailment remains ... more Traditional medicine which rely on plant resources to treat various diseases and ailment remains an important (in some case, the only) form of treatment in many developing countries and its use is increasing worldwide. 1 According to the world Health Organization (WHO), 75% of world population still rely on plant based traditional medicines for their primary healthcare of which 85% is based on the use of plant extracts. 2 Similarly, it is estimated that 39% of 520 new approved drugs (between 1983 and 1994), 5080% of antibacterial and anticancer drugs were derived from natural product. 3 The increased interest in the use of natural products is for a number of reasons, the perception that such products are safe, ecofriendly, low cost, readily available and of little or no side effects. The use of natural products has led in many drug discoveries as they provided chemical building blocks used in their synthesis or used as new drugs in their unmodified state. 4

Research paper thumbnail of Dereplication Study and Pharmacological Potentials of Phytochemical Constituents of Nigerian Propolis from Umudike

Palestinian medical and pharmaceutical journal/Palestinian medical & pharmaceutical journal, Jun 1, 2024

Research paper thumbnail of INSILICO DETERMINATION OF ANTI CANCER ACTIVITY OF PHYTOCHEMICAL FROM CLOVE (Syzygium aromaticum L) SEED

Bulletin of the Chemical Society of Nigeria, Aug 26, 2023

Syzygium aromaticum seed from the family of Myrtaceae is a highly priced natural spice used in pr... more Syzygium aromaticum seed from the family of Myrtaceae is a highly priced natural spice used in preparation of food which have been acclaimed and reported by previous researchers to have anticancer activities potentials. Due to the rising burden of cancer worldwide its severity and fatality coupled with side effects of synthetic drugs calls for an alternative treatment solution. Hence the current research studied the phytocompounds from the seed by extracting and screening the compounds using solvent maceration method and gas chromatography coupled to mass selective detector respectively to extract, identify and quantify the component phytochemicals present in the seed. Site directed multi-ligand docking of the identified compounds was performance on progesterone receptor protein responsible for breast cancer development using the compounds from GCMS results and compared with four standard breast cancer drugs by molecular docking method. The result showed that the alpha cubebene (-7 kcal/mol), Velerena-4, 7-(II) diene (-7.1 kcal/mol), caryophyllene (-7.4 kcal/mol), caryophyllene oxide (-7.4 kcal/mol), dibutyl phthalate have binding affinity close to the standard breast cancer drugs Abemaciclib (-8.3), Anastrozole (-7.2 kcal/mol) and Paclitaxel (-8.8 kcal/mol) and they have better binding affinity than the drug Cyclophasphamide (-5.6 kcal/mol). The result also revealed that some compounds from the GC-MS were found to have a binding affinity closer tothat of thecocrystallized ligand (-10.7 kcal/mol). Other compounds from clove seed showed favourable docking scores in comparison with the drugs as many of the compounds have docking scores of more than (-6 kcal/mol) suggesting that the compounds have anti breast cancer activities since their amino acids showed hydrogen bonding corresponding to that on the binding site

Research paper thumbnail of Natural Product Chemistry and Computer Aided Drug Design an Approach to Drug Discovery: A Review Article

International Journal of Pharmacognosy & Chinese Medicine

Natural products have been an inherent part of sustaining acculturation because of their medicina... more Natural products have been an inherent part of sustaining acculturation because of their medicinal properties. Past discoveries of bioactive natural products have relied on serendipity and accidental experience, and these compounds serve as inspiration for the generation of analogs with desired physicochemical properties. Bioactive natural products with therapeutic potential are abundantly available in nature and some of them are beyond exploration by conventional methods. However there has been a great breakthrough in the study of computer aided drug design (CADD) as many unfruitful lab researches have been averted and money, time and energies saved through CADD. Computer-aided drug design is a stimulating, arousing and manifold discipline where various aspects of applied and basic research integrate and induce each other. The empirical basis of CADD involves quantum mechanics and molecular modeling studies like structure based drug design; ligand-based drug design; database search...

Research paper thumbnail of The Potentials of Medicinal Plants in the Treatment of Covid-19 Patients: A Review

International Journal of Pharmacognosy & Chinese Medicine

COVID-19 pandemic (corona virus disease 2019 is a life threatening SARS-Cov-19 severe acute respi... more COVID-19 pandemic (corona virus disease 2019 is a life threatening SARS-Cov-19 severe acute respiratory syndrome virus 2) situation that was declared a public health emergency by WHO in early 2020. Today’s primary emphasis is on the treatment of COVID-19 yet the specific mode of action of antiviral agents being employed must be identified. At present, the human on risk are being vaccinated but there is no clear anti-COVID 19 medicine. This study focuses on herbal approaches as a potential alternative therapy for COVID-19, based on medicinal plants. Some herbs are well-known in different traditional medicines for prevention, cure and recovery of the diseases like COVID-19. Mostly the plant’s herbal extract inhibits viral replication; however several studies have shown that conventional herbal extracts may interact with important viral proteins associated with the virulence. The update on traditional medicines suggested for the prevention of COVID-19 has been analyzed here.

Research paper thumbnail of Antibacterial Activity and Identification of Metabolites from the Semi-Purified Fraction of Chrysophyllum albidum Leaf (African Star Apple)

Traditional medicine which rely on plant resources to treat various diseases and ailment remains ... more Traditional medicine which rely on plant resources to treat various diseases and ailment remains an important (in some case, the only) form of treatment in many developing countries and its use is increasing worldwide. 1 According to the world Health Organization (WHO), 75% of world population still rely on plant based traditional medicines for their primary healthcare of which 85% is based on the use of plant extracts. 2 Similarly, it is estimated that 39% of 520 new approved drugs (between 1983 and 1994), 5080% of antibacterial and anticancer drugs were derived from natural product. 3 The increased interest in the use of natural products is for a number of reasons, the perception that such products are safe, ecofriendly, low cost, readily available and of little or no side effects. The use of natural products has led in many drug discoveries as they provided chemical building blocks used in their synthesis or used as new drugs in their unmodified state. 4