tülin Ergun - Academia.edu (original) (raw)

Papers by tülin Ergun

Research paper thumbnail of Does decision tree analysis predict oral ulcer activity-related factors in patients with Behçet's syndrome?

Clinical and Experimental Rheumatology, Oct 29, 2023

Research paper thumbnail of Interstitial Mycosis Fungoides With Lichen Sclerosus–Like Clinical and Histopathological Features

American Journal of Dermatopathology, Feb 1, 2016

Research paper thumbnail of AB0639 Common Femoral Vein Thickness Measurement as a diagnostic test in Incomplete Behçet’s Disease

Annals of the Rheumatic Diseases

BackgroundBehçet's disease (BD) is characterized by recurrent oral and/or genital aphthous ul... more BackgroundBehçet's disease (BD) is characterized by recurrent oral and/or genital aphthous ulcers accompanied by cutaneous, ocular, articular, gastrointestinal and central nervous system lesions. Diagnosing BD can be a clinical challenge in patients presenting with a limited number of organ manifestations, especially with single major organ involvement. We reported the first controlled doppler ultrasound study showing increased common femoral vein (CFV) thickness in BD (1). We recently also showed that increased CFV thickness is a distinctive feature of BD, rarely present in other inflammatory or vascular diseases such as ankylosing spondylitis, systemic vasculitides, venous insufficiency, and non-inflammatory DVT with a specificity higher than 80% for the cut-off value of ≥ 0.5 mm. We suggest that CFV thickness measurement is an easy, non-invasive diagnostic test for BD (2).ObjectivesIn this study, we aimed to assess the diagnostic performance of CFV thickness measurement in pa...

Research paper thumbnail of An unusual presentation of ocular rosacea

Arquivos Brasileiros de Oftalmologia, 2017

Research paper thumbnail of AB0895-HPR A Moderated Mediation Analysis for Poor Oral Health-Related Quality of Life in Patients with Behçet’s Disease

Annals of the Rheumatic Diseases, 2021

Since oral ulcer is a common clinical manifestation, oral health-related quality of life (OHRQoL)... more Since oral ulcer is a common clinical manifestation, oral health-related quality of life (OHRQoL) is affected by the presence of oral ulcer poorly in patients with Behcet’s disease (BD).The aim of the study was to examine associated factors for poor OHRQoL status to improve treatment outcomes in patients with BD.In this retrospective study, 339 BD patients (F/M: 179/160, mean age: 36,13±9,81 years) included. Data were collected by a structured questionnaire regarding treatment expectation, Oral Health Impact Profile-14 (OHIP-14) questionnaire for OHRQoL, oral ulcer activity, and disease severity score. Treatment expectation was coded by a 5-point Likert type scale (1: symptoms were completely cured vs 5: symptoms were worsened). OHIP-14 score was between “0 point (the best score)” and “56 points (the worst score)”. The disease severity score was calculated according to the organ involvement. Then, patients were categorised as mucocutaneous involvement (n=181) and severe organ involv...

Research paper thumbnail of FRI0156 Cytokine responses to streptococcus sanguis in patients with behcet’s disease

Annals of the Rheumatic Diseases, 2001

Background Atypical streptococcal infections (Streptoccocus Sanguis, Salivarius) are implicated i... more Background Atypical streptococcal infections (Streptoccocus Sanguis, Salivarius) are implicated in the pathogenesis of Behcet’s Disease (BD), a systemic vasculitis of unknown aetiology. Objectives This study aimed to investigate in mononuclear cell culture supernatants, in vitro cytokine responses to S. Sanguis in patients with BD compared to psoriasis (PS) and healthy controls (HC). Methods Twelve patients with BD (4F/8M, mean age: 33.6 years), 7 with PS (4F/3M, mean age: 38.2 years) and 10 HC (7F/3M, mean age: 27.5 years) were included in the study. IL-4, IL-10, and IFN-γ responses were measured in peripheral blood mononuclear cell culture supernatants by ELISA after 48 h stimulations with S. Sanguis (10 μg/ml) and PHA (20 μg/ml). Positive responses were defined as above mean+2SD of unstimulated samples from HC. Results Positive IL-10 responses to S. Sanguis were observed in 5/12 patients with BD (mean: 94 pg/ml), 2/7 with PS (76 pg/ml), and 3/10 with HC (57 pg/ml). IFN-γ response...

Research paper thumbnail of Editorial: Behçet's Disease: Epidemiology, Etiopathogenesis, Diagnosis and Treatment

Frontiers in Medicine, 2021

Research paper thumbnail of Alopecia universalis unresponsive to treatment with tofacinitib: report of a case with a brief review of the literature

Dermatology Online Journal, 2017

Research paper thumbnail of Femoral vein wall thickness measurement: A new diagnostic tool for Behçet’s disease

Rheumatology, 2020

Objectives Diagnosing Behçet’s disease (BD) is a challenge, especially in countries with a low pr... more Objectives Diagnosing Behçet’s disease (BD) is a challenge, especially in countries with a low prevalence. Recently, venous wall thickness (VWT) in lower extremities has been shown to be increased in BD patients. In this study, we aimed to investigate the diagnostic performance of common femoral vein (CFV) thickness measurement in BD and whether it can be used as a diagnostic tool. Methods . Patients with BD (n = 152), ankylosing spondylitis (n = 27), systemic vasculitides (n = 23), venous insufficiency (n = 29), antiphospholipid syndrome (APS; n = 43), deep vein thrombosis due to non-inflammatory causes (n = 25) and healthy controls (n = 51) were included in the study. Bilateral CFV thickness was measured with ultrasonography by a radiologist blinded to cases. Results Bilateral CFV thickness was significantly increased in BD compared with all control groups (P < 0.001 for all). The area under the receiver operating characteristic curve for bilateral CFV thicknesses in all compar...

Research paper thumbnail of Internalized Stigma in Pediatric Psoriasis: A Comparative Multicenter Study

Annals of Dermatology, 2020

Research paper thumbnail of Effect of Dental Follicle Mesenchymal Stem Cell on Th1 and Th2 Derived Naive T Cells in Atopic Dermatitis Patients

Clinical and Experimental Health Sciences, 2019

Objective: The purpose of our study is to investigate the immunomodulatory effects of Dental Foll... more Objective: The purpose of our study is to investigate the immunomodulatory effects of Dental Follicle Mesenchymal Stem Cells (DF-MSCs) on lymphocytes isolated from peripheral blood of AD patients, a Th2 disease and psoriasis, a Th1 / Th17 disease and compare them with healthy individuals in vitro.Methods: Patients with the AD (n = 9) and psoriasis (n = 6) who are followed up in Marmara University Pediatric Allergy and Immunology and Dermatology outpatient clinics and healthy subjects (n = 6) were included. Peripheral Blood Mononuclear Cells (PBMCs) were isolated from 20 ml of venous blood of all participants. Cells were cultured for 72 hours in the absence and presence of DF-MSCs with anti-CD3/anti-CD28 stimulation or without stimulation. At the end of this period, CD4+ and CD8+ T lymphocyte proliferation and cytokine levels from the culture supernatants were analyzed by flow cytometry.Results: In the presence of DF-MSCs, proliferation ratio was suppressed in both CD4+ and CD8+ cell...

Research paper thumbnail of 125. New major organ involvement is lower in young male behçet’s patients compared to retrospective series: five-year results of a prospective cohort

Research paper thumbnail of Expanding the differential diagnosis of raccoon eyes: sweet syndrome

Journal of the European Academy of Dermatology and Venereology, 2018

Research paper thumbnail of The assessment of contributing factors to oral ulcer presence in Behçet’s disease: Dietary and non-dietary factors

European Journal of Rheumatology, 2018

Research paper thumbnail of Internalized stigma in psoriasis: A multicenter study

The Journal of Dermatology, 2017

Internalized stigma is the adoption of negative attitudes and stereotypes of the society regardin... more Internalized stigma is the adoption of negative attitudes and stereotypes of the society regarding a person's illness. It causes decreased self‐esteem and life‐satisfaction, increased depression and suicidality, and difficulty in coping with the illness. The primary aim of this study was to investigate the internalized stigma state of psoriatic patients and to identify the factors influencing internalized stigma. The secondary aim was to identify the correlation of internalized stigma with quality of life and perceived health status. This multicentre, cross‐sectional study comprised 1485 patients. There was a significant positive correlation between mean values of Psoriasis Internalized Stigma Scale (PISS) and Psoriasis Area and Severity Index, Body Surface Area, Dermatological Life Quality Index and General Health Questionnaire‐12 (P < 0.001 in all). Lower percieved health score (P = 0.001), early onset psoriasis (P = 0.016), family history of psoriasis (P = 0.0034), being i...

Research paper thumbnail of Efficacy, safety and drug survival of conventional agents in pediatric psoriasis: A multicenter, cohort study

The Journal of Dermatology, 2016

Research paper thumbnail of Tumor necrosis factor-alpha inhibitors for the treatment of psoriasis patients with liver cirrhosis: A report of four cases with a literature review

Indian Journal of Dermatology, Venereology, and Leprology, 2017

Patients with psoriasis are at an increased risk of developing liver disease due to various facto... more Patients with psoriasis are at an increased risk of developing liver disease due to various factors. The existing data regarding the treatment of psoriasis patients with associated liver cirrhosis is limited. We report four patients of psoriasis with liver cirrhosis who were treated with TNF-alpha inhibitors for a mean duration of 35.4 months. Two patients were treated with etanercept, one with adalimumab and one was treated with both infliximab and etanercept. Three patients tolerated the treatment well without any deterioration of liver disease whereas one died of progressive liver disease. Although large-scale, controlled studies are needed, this case series provides insights regarding the long-term safety of TNF-alpha inhibitors in patients with psoriasis and liver cirrhosis.

Research paper thumbnail of Interstitial Mycosis Fungoides With Lichen Sclerosus-Like Clinical and Histopathological Features

The American Journal of dermatopathology, Jan 27, 2015

Mycosis fungoides (MF) simulates a variety of dermatologic disorders histopathologically and clin... more Mycosis fungoides (MF) simulates a variety of dermatologic disorders histopathologically and clinically, well deserving the designation of a great mimicker. Interstitial MF is a rare, but well-recognized histopathological variant resembling the interstitial form of granuloma annulare or the inflammatory phase of morphea. From a clinical standpoint, MF can have a wide array of manifestations, including an anecdotal presentation with lesions clinically suggestive of lichen sclerosus (LS). We herein report a 25-year-old man with a history of patch-stage MF who later developed widespread LS-like lesions histopathologically consistent with interstitial MF. In some biopsies, additional features resembling LS were discerned. We think that our case might represent a unique variant of interstitial MF presenting with LS-like lesions. The diagnostic challenge arising from this uncommon presentation is discussed together with review of the literature.

Research paper thumbnail of A new Mucocutaneous Activity Index for Behçet's disease

Clinical and experimental rheumatology

Patient-reported outcomes are increasingly accepted to be major domains in chronic disorders. The... more Patient-reported outcomes are increasingly accepted to be major domains in chronic disorders. The aim of this study was to develop a patient-derived disease activity index in Beh-çet's disease (BD). One hundred and seventy-seven BD patients (M/F: 69/108) were included in the study. Data were collected by clinical examination and a questionnaire regarding a Mucocutaneous Index (MI) with genital ulcer activity (GI), erythema nodosum activity (EI) and the composite index (CI) for oral ulcers, as subscales of it. Self-reported treatment evaluation was carried out as criterion validity. Patients whose symptoms completely disappeared or decreased significantly, were categorised as 'improved group', others were classified as 'non-improved group'. Among the study group, 79.7% of the patients (n=141) were active, whereas 20.3% were inactive (n=36). Scores of CI, GI, EI and MI score were 0±0 in inactive ones, whereas scores were 5.65±2.36 for CI, 0.81±2.34 for GI, 0.91±2.3...

Research paper thumbnail of TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts

Clinical and experimental rheumatology

The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be... more The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet's disease (BD) in a European-derived cohort, but not in Middle Eastern patients is investigated in two other populations. Two cohorts of BD patients and controls from Turkey (n=797) and Italy (n=633) were genotyped by sequence specific primer-polymerase chain reaction (SSP-PCR) or TaqMan q-PCR assays. Genotype and allele frequencies in TIRAP S180L (rs8177374) were not different between BD patients and controls in either ethnicity. Furthermore, a meta-analysis between the Turkish and the Italian BD cohorts did not reveal an association between this non-synonymous SNP in TIRAP and BD (meta-analysis OR=0.94, meta-analysis p=0.61, Q statistic heterogeneity p=0.11). TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.

Research paper thumbnail of Does decision tree analysis predict oral ulcer activity-related factors in patients with Behçet's syndrome?

Clinical and Experimental Rheumatology, Oct 29, 2023

Research paper thumbnail of Interstitial Mycosis Fungoides With Lichen Sclerosus–Like Clinical and Histopathological Features

American Journal of Dermatopathology, Feb 1, 2016

Research paper thumbnail of AB0639 Common Femoral Vein Thickness Measurement as a diagnostic test in Incomplete Behçet’s Disease

Annals of the Rheumatic Diseases

BackgroundBehçet's disease (BD) is characterized by recurrent oral and/or genital aphthous ul... more BackgroundBehçet's disease (BD) is characterized by recurrent oral and/or genital aphthous ulcers accompanied by cutaneous, ocular, articular, gastrointestinal and central nervous system lesions. Diagnosing BD can be a clinical challenge in patients presenting with a limited number of organ manifestations, especially with single major organ involvement. We reported the first controlled doppler ultrasound study showing increased common femoral vein (CFV) thickness in BD (1). We recently also showed that increased CFV thickness is a distinctive feature of BD, rarely present in other inflammatory or vascular diseases such as ankylosing spondylitis, systemic vasculitides, venous insufficiency, and non-inflammatory DVT with a specificity higher than 80% for the cut-off value of ≥ 0.5 mm. We suggest that CFV thickness measurement is an easy, non-invasive diagnostic test for BD (2).ObjectivesIn this study, we aimed to assess the diagnostic performance of CFV thickness measurement in pa...

Research paper thumbnail of An unusual presentation of ocular rosacea

Arquivos Brasileiros de Oftalmologia, 2017

Research paper thumbnail of AB0895-HPR A Moderated Mediation Analysis for Poor Oral Health-Related Quality of Life in Patients with Behçet’s Disease

Annals of the Rheumatic Diseases, 2021

Since oral ulcer is a common clinical manifestation, oral health-related quality of life (OHRQoL)... more Since oral ulcer is a common clinical manifestation, oral health-related quality of life (OHRQoL) is affected by the presence of oral ulcer poorly in patients with Behcet’s disease (BD).The aim of the study was to examine associated factors for poor OHRQoL status to improve treatment outcomes in patients with BD.In this retrospective study, 339 BD patients (F/M: 179/160, mean age: 36,13±9,81 years) included. Data were collected by a structured questionnaire regarding treatment expectation, Oral Health Impact Profile-14 (OHIP-14) questionnaire for OHRQoL, oral ulcer activity, and disease severity score. Treatment expectation was coded by a 5-point Likert type scale (1: symptoms were completely cured vs 5: symptoms were worsened). OHIP-14 score was between “0 point (the best score)” and “56 points (the worst score)”. The disease severity score was calculated according to the organ involvement. Then, patients were categorised as mucocutaneous involvement (n=181) and severe organ involv...

Research paper thumbnail of FRI0156 Cytokine responses to streptococcus sanguis in patients with behcet’s disease

Annals of the Rheumatic Diseases, 2001

Background Atypical streptococcal infections (Streptoccocus Sanguis, Salivarius) are implicated i... more Background Atypical streptococcal infections (Streptoccocus Sanguis, Salivarius) are implicated in the pathogenesis of Behcet’s Disease (BD), a systemic vasculitis of unknown aetiology. Objectives This study aimed to investigate in mononuclear cell culture supernatants, in vitro cytokine responses to S. Sanguis in patients with BD compared to psoriasis (PS) and healthy controls (HC). Methods Twelve patients with BD (4F/8M, mean age: 33.6 years), 7 with PS (4F/3M, mean age: 38.2 years) and 10 HC (7F/3M, mean age: 27.5 years) were included in the study. IL-4, IL-10, and IFN-γ responses were measured in peripheral blood mononuclear cell culture supernatants by ELISA after 48 h stimulations with S. Sanguis (10 μg/ml) and PHA (20 μg/ml). Positive responses were defined as above mean+2SD of unstimulated samples from HC. Results Positive IL-10 responses to S. Sanguis were observed in 5/12 patients with BD (mean: 94 pg/ml), 2/7 with PS (76 pg/ml), and 3/10 with HC (57 pg/ml). IFN-γ response...

Research paper thumbnail of Editorial: Behçet's Disease: Epidemiology, Etiopathogenesis, Diagnosis and Treatment

Frontiers in Medicine, 2021

Research paper thumbnail of Alopecia universalis unresponsive to treatment with tofacinitib: report of a case with a brief review of the literature

Dermatology Online Journal, 2017

Research paper thumbnail of Femoral vein wall thickness measurement: A new diagnostic tool for Behçet’s disease

Rheumatology, 2020

Objectives Diagnosing Behçet’s disease (BD) is a challenge, especially in countries with a low pr... more Objectives Diagnosing Behçet’s disease (BD) is a challenge, especially in countries with a low prevalence. Recently, venous wall thickness (VWT) in lower extremities has been shown to be increased in BD patients. In this study, we aimed to investigate the diagnostic performance of common femoral vein (CFV) thickness measurement in BD and whether it can be used as a diagnostic tool. Methods . Patients with BD (n = 152), ankylosing spondylitis (n = 27), systemic vasculitides (n = 23), venous insufficiency (n = 29), antiphospholipid syndrome (APS; n = 43), deep vein thrombosis due to non-inflammatory causes (n = 25) and healthy controls (n = 51) were included in the study. Bilateral CFV thickness was measured with ultrasonography by a radiologist blinded to cases. Results Bilateral CFV thickness was significantly increased in BD compared with all control groups (P < 0.001 for all). The area under the receiver operating characteristic curve for bilateral CFV thicknesses in all compar...

Research paper thumbnail of Internalized Stigma in Pediatric Psoriasis: A Comparative Multicenter Study

Annals of Dermatology, 2020

Research paper thumbnail of Effect of Dental Follicle Mesenchymal Stem Cell on Th1 and Th2 Derived Naive T Cells in Atopic Dermatitis Patients

Clinical and Experimental Health Sciences, 2019

Objective: The purpose of our study is to investigate the immunomodulatory effects of Dental Foll... more Objective: The purpose of our study is to investigate the immunomodulatory effects of Dental Follicle Mesenchymal Stem Cells (DF-MSCs) on lymphocytes isolated from peripheral blood of AD patients, a Th2 disease and psoriasis, a Th1 / Th17 disease and compare them with healthy individuals in vitro.Methods: Patients with the AD (n = 9) and psoriasis (n = 6) who are followed up in Marmara University Pediatric Allergy and Immunology and Dermatology outpatient clinics and healthy subjects (n = 6) were included. Peripheral Blood Mononuclear Cells (PBMCs) were isolated from 20 ml of venous blood of all participants. Cells were cultured for 72 hours in the absence and presence of DF-MSCs with anti-CD3/anti-CD28 stimulation or without stimulation. At the end of this period, CD4+ and CD8+ T lymphocyte proliferation and cytokine levels from the culture supernatants were analyzed by flow cytometry.Results: In the presence of DF-MSCs, proliferation ratio was suppressed in both CD4+ and CD8+ cell...

Research paper thumbnail of 125. New major organ involvement is lower in young male behçet’s patients compared to retrospective series: five-year results of a prospective cohort

Research paper thumbnail of Expanding the differential diagnosis of raccoon eyes: sweet syndrome

Journal of the European Academy of Dermatology and Venereology, 2018

Research paper thumbnail of The assessment of contributing factors to oral ulcer presence in Behçet’s disease: Dietary and non-dietary factors

European Journal of Rheumatology, 2018

Research paper thumbnail of Internalized stigma in psoriasis: A multicenter study

The Journal of Dermatology, 2017

Internalized stigma is the adoption of negative attitudes and stereotypes of the society regardin... more Internalized stigma is the adoption of negative attitudes and stereotypes of the society regarding a person's illness. It causes decreased self‐esteem and life‐satisfaction, increased depression and suicidality, and difficulty in coping with the illness. The primary aim of this study was to investigate the internalized stigma state of psoriatic patients and to identify the factors influencing internalized stigma. The secondary aim was to identify the correlation of internalized stigma with quality of life and perceived health status. This multicentre, cross‐sectional study comprised 1485 patients. There was a significant positive correlation between mean values of Psoriasis Internalized Stigma Scale (PISS) and Psoriasis Area and Severity Index, Body Surface Area, Dermatological Life Quality Index and General Health Questionnaire‐12 (P < 0.001 in all). Lower percieved health score (P = 0.001), early onset psoriasis (P = 0.016), family history of psoriasis (P = 0.0034), being i...

Research paper thumbnail of Efficacy, safety and drug survival of conventional agents in pediatric psoriasis: A multicenter, cohort study

The Journal of Dermatology, 2016

Research paper thumbnail of Tumor necrosis factor-alpha inhibitors for the treatment of psoriasis patients with liver cirrhosis: A report of four cases with a literature review

Indian Journal of Dermatology, Venereology, and Leprology, 2017

Patients with psoriasis are at an increased risk of developing liver disease due to various facto... more Patients with psoriasis are at an increased risk of developing liver disease due to various factors. The existing data regarding the treatment of psoriasis patients with associated liver cirrhosis is limited. We report four patients of psoriasis with liver cirrhosis who were treated with TNF-alpha inhibitors for a mean duration of 35.4 months. Two patients were treated with etanercept, one with adalimumab and one was treated with both infliximab and etanercept. Three patients tolerated the treatment well without any deterioration of liver disease whereas one died of progressive liver disease. Although large-scale, controlled studies are needed, this case series provides insights regarding the long-term safety of TNF-alpha inhibitors in patients with psoriasis and liver cirrhosis.

Research paper thumbnail of Interstitial Mycosis Fungoides With Lichen Sclerosus-Like Clinical and Histopathological Features

The American Journal of dermatopathology, Jan 27, 2015

Mycosis fungoides (MF) simulates a variety of dermatologic disorders histopathologically and clin... more Mycosis fungoides (MF) simulates a variety of dermatologic disorders histopathologically and clinically, well deserving the designation of a great mimicker. Interstitial MF is a rare, but well-recognized histopathological variant resembling the interstitial form of granuloma annulare or the inflammatory phase of morphea. From a clinical standpoint, MF can have a wide array of manifestations, including an anecdotal presentation with lesions clinically suggestive of lichen sclerosus (LS). We herein report a 25-year-old man with a history of patch-stage MF who later developed widespread LS-like lesions histopathologically consistent with interstitial MF. In some biopsies, additional features resembling LS were discerned. We think that our case might represent a unique variant of interstitial MF presenting with LS-like lesions. The diagnostic challenge arising from this uncommon presentation is discussed together with review of the literature.

Research paper thumbnail of A new Mucocutaneous Activity Index for Behçet's disease

Clinical and experimental rheumatology

Patient-reported outcomes are increasingly accepted to be major domains in chronic disorders. The... more Patient-reported outcomes are increasingly accepted to be major domains in chronic disorders. The aim of this study was to develop a patient-derived disease activity index in Beh-çet's disease (BD). One hundred and seventy-seven BD patients (M/F: 69/108) were included in the study. Data were collected by clinical examination and a questionnaire regarding a Mucocutaneous Index (MI) with genital ulcer activity (GI), erythema nodosum activity (EI) and the composite index (CI) for oral ulcers, as subscales of it. Self-reported treatment evaluation was carried out as criterion validity. Patients whose symptoms completely disappeared or decreased significantly, were categorised as 'improved group', others were classified as 'non-improved group'. Among the study group, 79.7% of the patients (n=141) were active, whereas 20.3% were inactive (n=36). Scores of CI, GI, EI and MI score were 0±0 in inactive ones, whereas scores were 5.65±2.36 for CI, 0.81±2.34 for GI, 0.91±2.3...

Research paper thumbnail of TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts

Clinical and experimental rheumatology

The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be... more The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet's disease (BD) in a European-derived cohort, but not in Middle Eastern patients is investigated in two other populations. Two cohorts of BD patients and controls from Turkey (n=797) and Italy (n=633) were genotyped by sequence specific primer-polymerase chain reaction (SSP-PCR) or TaqMan q-PCR assays. Genotype and allele frequencies in TIRAP S180L (rs8177374) were not different between BD patients and controls in either ethnicity. Furthermore, a meta-analysis between the Turkish and the Italian BD cohorts did not reveal an association between this non-synonymous SNP in TIRAP and BD (meta-analysis OR=0.94, meta-analysis p=0.61, Q statistic heterogeneity p=0.11). TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.