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Papers by taha aslan

Acta Neurologica Belgica, Apr 5, 2023

Archives of Epilepsy

Objective: The purpose of this study is to compare demographical and cognitive features of patien... more Objective: The purpose of this study is to compare demographical and cognitive features of patients who have neurodegenerative diseases with or without seizures. Methods: This descriptive retrospective study included a total of 16 348 participants, 479 with seizures and 15 869 without seizures. Independent samples t-test and chi-square tests were used to compare age, education, Mini Mental State Examination, and gender of groups. Results: There was a significant difference between patients with seizures and without seizures in age [t(3764) = 2.815, P = .005]. It is found that patients with seizures (M = 67.51, standard deviation = 9.69) were significantly younger than patients without seizures (M = 70.37, standard deviation = 9.51). Conclusion: In all neurodegenerative diseases, especially Alzheimer's disease, at an early age and regardless of cognitive status, diagnosis of seizures at the first admission and subsequent follow-ups is of great importance in terms of the patient's quality of life, prognosis of the disease, and treatment options.

Journal of Multiple Sclerosis Research

Objective: It has been reported that estrogen may affect T helper (Th) 1 and Th-2 lymphocytes and... more Objective: It has been reported that estrogen may affect T helper (Th) 1 and Th-2 lymphocytes and the ratio of Th-1 to Th-2, which play an essential role in the immunopathogenesis of multiple sclerosis (MS). Therefore, hormonal changes during transitional periods, such as pregnancy and menopause, may affect the activity of the disease at different phases of the menstrual cycle. This study aimed to determine the association of MS in women with variables, such as menarche age, menstrual order, menopausal age, and disease-related factors, such as disability level and the number of relapses. Materials and Methods: This descriptive study enrolled 281 women with MS. The participants were evaluated using a simple and short survey by the researchers. A neurologist evaluated the Expanded Disability Status Scale (EDSS) score, the number of attacks, and disease duration. Results: Sixty-seven (23.8%) of 281 patients had entered menopause. There was no significant difference in the EDSS score of women with MS with or without menopause (p>0.05). Sixty patients (21.4%) had children after MS. There was no significant difference between the number of relapses before (1.87±1.46) and after having a child (3.15±3.59) (p>0.05). Additionally, the last EDSS score (2.46±2.07) was not different from the EDSS score after having a child (2.35±1.81) (p>0.05). It was found that 80.4% of the patients had a regular menstrual cycle, whereas 19.6% of them had an irregular cycle. The EDSS score was significantly higher in women with irregular menstrual cycles than in women with regular menstrual cycles (p<0.05). The age at menarche in the study group (13.07) was found to be earlier than the average age at menarche in Turkey (13.3) (p<0.05). Conclusion: This study suggested that menopause and childbearing may not affect disability level or the number of attacks in women with MS. Additionally, women with MS have an earlier age at menarche compared with the general population. Future studies should investigate earlier age at menarche as a possible risk factor in MS.

Clinical Neurology and Neurosurgery, 2021

OBJECTIVE Critical treatment and management have advanced over the recent decades, bringing many ... more OBJECTIVE Critical treatment and management have advanced over the recent decades, bringing many benefits but also causing increasing complication rates. Among these complications, neurological complications have an important place and may increase in mortality rates. The aim of our study was to find the causes of neurological consultations in the level 3 adult intensive care units (ICU). METHODS The study population consisted of patients who were requested to have neurology consultation in the level 3 Adult ICUs between April 2013 and April 2017. The records in the hospital automation system of patients required neurology consultation were evaluated retrospectively. RESULTS A total of 906 neurology consultations were requested in ICUs and 302 patients were included in this study. Altered consciousness and unconsciousness (32.1%), seizure (26.5%), management and treatment (15.9%) were the most common reasons for neurological consultations. Epileptic seizures (16.9%), status epilepticus (9.3%) and ischemic stroke (8.6%) were the most common final neurological diagnoses after consultation. Wernicke encephalopathy, posterior reversible encephalopathy syndrome, motor neuron disease, Creutzfeldt-Jakob disease, critical illness polyneuropathy and critical illness myopathy were less frequently diagnosed (< 1%). The diagnostic benefit was 83.1%. Treatment change following neurological consultation occurred in 56.6% of the patients. CONCLUSIONS In our study, spanning a period of 4 years, the most common diagnoses were epileptic seizure, status epilepticus, and ischemic stroke. More frequent complications, such as stroke and seizure, as well as less common complications such as Wernicke's encephalopathy and posterior reversible encephalopathy syndrome, should be intervened immediately. In case of consultation, neurologists should be able to manage neurological complications as a consultant physician in the early period and evaluate the ICU patient systematically and be familiar with the complexity of intubation, sedation and sometimes paralyzed intensive ICU patients who have had severely limited routine clinical evaluations.

Turkish Journal Of Neurology, 2019

Dear Editor, It has been estimated that about one-quarter of all intracerebral hemorrhage (ICH) c... more Dear Editor, It has been estimated that about one-quarter of all intracerebral hemorrhage (ICH) cases are thalamic hemorrhage, even though some studies give much lower estimations (1,2). Hypertension is the most important risk factor associated with thalamic hemorrhage (3). The mortality rate among patients with thalamic hemorrhage is substantially high and sensory deficits, oculomotor signs, and language disturbances (if the lesion is in the dominant hemisphere) are three of the most reported clinical signs of patients who survive (2,4). Despite the fact that the clinical presentation of thalamic hemorrhage can vary considerably, there is only one case report of a patient who presented with vision loss due to a thalamic hemorrhage (5). A 46-year-old male patient was admitted to the emergency department with sudden and incomplete vision loss. Prior medical history included hypertension and coronary artery disease. The patient was non-adherent to the previous treatments. His blood pressure was 220/140 mmHg at the time of admission to the emergency department. During his first neurologic examination, minor dysarthria was reported. He had mild paresis in the left upper extremity and his motor strength in the left lower extremity was 4/5. He had mild hypoesthesia in his left extremities. He had moderate nystagmus while looking right. Right thalamic ICH was reported in his computed tomography (CT) without perilesional edema (Figures 1, 2, 3). On the third day of his admission, apart from a minor hypoesthesia that persisted in the distal parts of his lower left extremity, he had complete remission. However, the patient Ad dress for Cor res pon den ce/Ya z›fl ma Ad re si:

Journal of Membrane Science, 2016

Nanofibers fabricated with electrospinning method have several prominent properties such as high ... more Nanofibers fabricated with electrospinning method have several prominent properties such as high specific surface area, high porosity and uniform pore size distribution in nanoscale or microscale. These unique features are vital for separation processes in water and wastewater treatment applications. In this study, we have developed a new type of nanofiber electrospun membrane for the first time by collecting nanofibers on a hollow braided rope. The nanofiber membranes were characterized with Scanning Electron Microscope images, pore size, contact angle and porosity measurements. Filtration performances of tubular nanofiber and a commercial hollow braided reinforced membrane were determined for both standard particle solutions and surface water under low vacuum pressures. The novel tubular nanofiber (TuEN) membranes exhibited high water fluxes in even low vacuum pressures, relatively high removal efficiencies of turbidity (% 95), total organic carbon (29 %) and UV 254 (45%) compared to other microfiltration membranes. We claim that the tubular nanofiber membrane will attract more attention in coming years in the fields of water and wastewater treatment.

Desalination and Water Treatment, 2016

AbstractForward osmosis or osmotic membrane bioreactor (FOMBR) has attracted great attention for ... more AbstractForward osmosis or osmotic membrane bioreactor (FOMBR) has attracted great attention for wastewater treatment and reuse since conceptually introduced as a process. It has been proposed to reduce the high energy consumption in the conventional MBR, has lower membrane fouling propensity, and produce higher quality water. Moreover, RO process can be used after FOMBR to reconcentrate the diluted DS to be used for FO again. Besides significant advantages, when compared to conventional MBRs; lower water flux, concentration polarization, and salt accumulation because of high retention of FO in the bioreactor still remains as major drawbacks and challenges of FOMBR systems that need to be solved. In the last few years, many advances in development of FOMBR are stated to overcome the drawbacks of the system. The researches focused on manufacturing of high performance FO membranes and orientation, utilizing various different draw solutions providing required osmotic pressure and minimum reverse salt flux, a...

Acta Neurologica Belgica, Apr 5, 2023

Archives of Epilepsy

Objective: The purpose of this study is to compare demographical and cognitive features of patien... more Objective: The purpose of this study is to compare demographical and cognitive features of patients who have neurodegenerative diseases with or without seizures. Methods: This descriptive retrospective study included a total of 16 348 participants, 479 with seizures and 15 869 without seizures. Independent samples t-test and chi-square tests were used to compare age, education, Mini Mental State Examination, and gender of groups. Results: There was a significant difference between patients with seizures and without seizures in age [t(3764) = 2.815, P = .005]. It is found that patients with seizures (M = 67.51, standard deviation = 9.69) were significantly younger than patients without seizures (M = 70.37, standard deviation = 9.51). Conclusion: In all neurodegenerative diseases, especially Alzheimer's disease, at an early age and regardless of cognitive status, diagnosis of seizures at the first admission and subsequent follow-ups is of great importance in terms of the patient's quality of life, prognosis of the disease, and treatment options.

Journal of Multiple Sclerosis Research

Objective: It has been reported that estrogen may affect T helper (Th) 1 and Th-2 lymphocytes and... more Objective: It has been reported that estrogen may affect T helper (Th) 1 and Th-2 lymphocytes and the ratio of Th-1 to Th-2, which play an essential role in the immunopathogenesis of multiple sclerosis (MS). Therefore, hormonal changes during transitional periods, such as pregnancy and menopause, may affect the activity of the disease at different phases of the menstrual cycle. This study aimed to determine the association of MS in women with variables, such as menarche age, menstrual order, menopausal age, and disease-related factors, such as disability level and the number of relapses. Materials and Methods: This descriptive study enrolled 281 women with MS. The participants were evaluated using a simple and short survey by the researchers. A neurologist evaluated the Expanded Disability Status Scale (EDSS) score, the number of attacks, and disease duration. Results: Sixty-seven (23.8%) of 281 patients had entered menopause. There was no significant difference in the EDSS score of women with MS with or without menopause (p>0.05). Sixty patients (21.4%) had children after MS. There was no significant difference between the number of relapses before (1.87±1.46) and after having a child (3.15±3.59) (p>0.05). Additionally, the last EDSS score (2.46±2.07) was not different from the EDSS score after having a child (2.35±1.81) (p>0.05). It was found that 80.4% of the patients had a regular menstrual cycle, whereas 19.6% of them had an irregular cycle. The EDSS score was significantly higher in women with irregular menstrual cycles than in women with regular menstrual cycles (p<0.05). The age at menarche in the study group (13.07) was found to be earlier than the average age at menarche in Turkey (13.3) (p<0.05). Conclusion: This study suggested that menopause and childbearing may not affect disability level or the number of attacks in women with MS. Additionally, women with MS have an earlier age at menarche compared with the general population. Future studies should investigate earlier age at menarche as a possible risk factor in MS.

Clinical Neurology and Neurosurgery, 2021

OBJECTIVE Critical treatment and management have advanced over the recent decades, bringing many ... more OBJECTIVE Critical treatment and management have advanced over the recent decades, bringing many benefits but also causing increasing complication rates. Among these complications, neurological complications have an important place and may increase in mortality rates. The aim of our study was to find the causes of neurological consultations in the level 3 adult intensive care units (ICU). METHODS The study population consisted of patients who were requested to have neurology consultation in the level 3 Adult ICUs between April 2013 and April 2017. The records in the hospital automation system of patients required neurology consultation were evaluated retrospectively. RESULTS A total of 906 neurology consultations were requested in ICUs and 302 patients were included in this study. Altered consciousness and unconsciousness (32.1%), seizure (26.5%), management and treatment (15.9%) were the most common reasons for neurological consultations. Epileptic seizures (16.9%), status epilepticus (9.3%) and ischemic stroke (8.6%) were the most common final neurological diagnoses after consultation. Wernicke encephalopathy, posterior reversible encephalopathy syndrome, motor neuron disease, Creutzfeldt-Jakob disease, critical illness polyneuropathy and critical illness myopathy were less frequently diagnosed (< 1%). The diagnostic benefit was 83.1%. Treatment change following neurological consultation occurred in 56.6% of the patients. CONCLUSIONS In our study, spanning a period of 4 years, the most common diagnoses were epileptic seizure, status epilepticus, and ischemic stroke. More frequent complications, such as stroke and seizure, as well as less common complications such as Wernicke's encephalopathy and posterior reversible encephalopathy syndrome, should be intervened immediately. In case of consultation, neurologists should be able to manage neurological complications as a consultant physician in the early period and evaluate the ICU patient systematically and be familiar with the complexity of intubation, sedation and sometimes paralyzed intensive ICU patients who have had severely limited routine clinical evaluations.

Turkish Journal Of Neurology, 2019

Dear Editor, It has been estimated that about one-quarter of all intracerebral hemorrhage (ICH) c... more Dear Editor, It has been estimated that about one-quarter of all intracerebral hemorrhage (ICH) cases are thalamic hemorrhage, even though some studies give much lower estimations (1,2). Hypertension is the most important risk factor associated with thalamic hemorrhage (3). The mortality rate among patients with thalamic hemorrhage is substantially high and sensory deficits, oculomotor signs, and language disturbances (if the lesion is in the dominant hemisphere) are three of the most reported clinical signs of patients who survive (2,4). Despite the fact that the clinical presentation of thalamic hemorrhage can vary considerably, there is only one case report of a patient who presented with vision loss due to a thalamic hemorrhage (5). A 46-year-old male patient was admitted to the emergency department with sudden and incomplete vision loss. Prior medical history included hypertension and coronary artery disease. The patient was non-adherent to the previous treatments. His blood pressure was 220/140 mmHg at the time of admission to the emergency department. During his first neurologic examination, minor dysarthria was reported. He had mild paresis in the left upper extremity and his motor strength in the left lower extremity was 4/5. He had mild hypoesthesia in his left extremities. He had moderate nystagmus while looking right. Right thalamic ICH was reported in his computed tomography (CT) without perilesional edema (Figures 1, 2, 3). On the third day of his admission, apart from a minor hypoesthesia that persisted in the distal parts of his lower left extremity, he had complete remission. However, the patient Ad dress for Cor res pon den ce/Ya z›fl ma Ad re si:

Journal of Membrane Science, 2016

Nanofibers fabricated with electrospinning method have several prominent properties such as high ... more Nanofibers fabricated with electrospinning method have several prominent properties such as high specific surface area, high porosity and uniform pore size distribution in nanoscale or microscale. These unique features are vital for separation processes in water and wastewater treatment applications. In this study, we have developed a new type of nanofiber electrospun membrane for the first time by collecting nanofibers on a hollow braided rope. The nanofiber membranes were characterized with Scanning Electron Microscope images, pore size, contact angle and porosity measurements. Filtration performances of tubular nanofiber and a commercial hollow braided reinforced membrane were determined for both standard particle solutions and surface water under low vacuum pressures. The novel tubular nanofiber (TuEN) membranes exhibited high water fluxes in even low vacuum pressures, relatively high removal efficiencies of turbidity (% 95), total organic carbon (29 %) and UV 254 (45%) compared to other microfiltration membranes. We claim that the tubular nanofiber membrane will attract more attention in coming years in the fields of water and wastewater treatment.

Desalination and Water Treatment, 2016

AbstractForward osmosis or osmotic membrane bioreactor (FOMBR) has attracted great attention for ... more AbstractForward osmosis or osmotic membrane bioreactor (FOMBR) has attracted great attention for wastewater treatment and reuse since conceptually introduced as a process. It has been proposed to reduce the high energy consumption in the conventional MBR, has lower membrane fouling propensity, and produce higher quality water. Moreover, RO process can be used after FOMBR to reconcentrate the diluted DS to be used for FO again. Besides significant advantages, when compared to conventional MBRs; lower water flux, concentration polarization, and salt accumulation because of high retention of FO in the bioreactor still remains as major drawbacks and challenges of FOMBR systems that need to be solved. In the last few years, many advances in development of FOMBR are stated to overcome the drawbacks of the system. The researches focused on manufacturing of high performance FO membranes and orientation, utilizing various different draw solutions providing required osmotic pressure and minimum reverse salt flux, a...