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Research paper thumbnail of Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study

Diabetes Care, 2022

OBJECTIVE Finerenone significantly improved cardiorenal outcomes in patients with chronic kidney ... more OBJECTIVE Finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) in the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease trial. We explored whether baseline HbA1c level and insulin treatment influenced outcomes. RESEARCH DESIGN AND METHODS Patients with T2D, urine albumin-to-creatinine ratio (UACR) of 30–5,000 mg/g, estimated glomerular filtration rate (eGFR) of 25 to <75 mL/min/1.73 m2, and treated with optimized renin–angiotensin system blockade were randomly assigned to receive finerenone or placebo. Efficacy outcomes included kidney (kidney failure, sustained decrease ≥40% in eGFR from baseline, or renal death) and cardiovascular (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) composite endpoints. Patients were analyzed by baseline insulin use and by baseline HbA1c <7.5% (58 mmol/mol) or ≥7.5%. RESULTS...

Research paper thumbnail of Pre- and peri-operative characteristics, complications and outcomes of patients with biochemically silent pheochromocytomas; a case series

Research paper thumbnail of Thyroid Paraganglioma With Medullary Carcinoma: A Unique Combination in a Patient in Association With Multiple Endocrine Neoplasia Type 2B Syndrome With Prolonged Survival

Research paper thumbnail of Gastric monomorphic epitheliotropic intestinal T-cell lymphoma with bilateral adrenal metastases

Research paper thumbnail of Pre-, peri- and post-operative characteristics of biochemically silent pheochromocytomas: a case series

Research paper thumbnail of A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement

Leukemia Research Reports

Research paper thumbnail of Arare case of caucasian patient with insulin autoimmune syndrome induced by a-lipoic acid

Research paper thumbnail of A very rare case of extranodal lymphoma with adrenal and heart involvement

Endocrine Abstracts, 2021

Research paper thumbnail of A new highly sensitive and specific overnight combined screening and diagnostic test for primary aldosteronism

European Journal of Endocrinology, 2016

Context Primary aldosteronism (PA) is the most common cause of endocrine hypertension that is dia... more Context Primary aldosteronism (PA) is the most common cause of endocrine hypertension that is diagnosed following a two-step process: an initial screening test, based on the serum aldosterone-to-renin ratio (ARR), followed by a relatively laborious and time-consuming confirmatory test to document autonomous aldosterone (ALD) secretion. Objective The aim of this study is to develop a simple overnight test for the early and definite diagnosis of PA. Patients and methods Totally, 148 hypertensive patients underwent a fludrocortisone–dexamethasone suppression test (FDST) and the new overnight diagnostic test (DCVT) using pharmaceutical RAAS (renin–angiotensin–aldosterone system) blockade with dexamethasone, captopril and valsartan. Results Of the 148 patients, 45 were diagnosed as having PA and they all normalized their elevated blood pressure (BP) after administration of spironolactone or eplerenone. The remaining 103 patients were considered as having essential hypertension and served...

Research paper thumbnail of Plasma glucose levels and mortality in bacteremic ICU patients

Critical Care, 2006

Objective To examine the effects of short-term cyclic stretch on apoptosis in alveolar type II ce... more Objective To examine the effects of short-term cyclic stretch on apoptosis in alveolar type II cells (A549). To study in vitro the direct influence of alveolar type II cells on mechanical stretch. Methods A549 were treated with different doses of lipopolysaccharide (LPS), 0 ng/ml, 1 ng/ml, 10 ng/ml, 100 ng/ml, 1000 ng/ml, and then A549 were lengthened 5%, 15%, 30% using a FLEXCELL tension unit 4000, a vacuum-driven device that applies strain to cells, which were cultured in six-well plates coated with collagen-I, and 12 cycles/min for 4 hours. Apoptosis was measured using the flow cytometry method that measures annexin V and propidium iodide (PI) staining. The morphological changes of apoptotic cells were observed by transmission electron microscope. Results Apoptosis could be induced in alveolar type II cells (A549) by mechanical stretch. The percentage of annexin V + PI cells increased after being treated with cyclic stretch for 4 hours by 5%, 15%, 30% in all groups. The morphological features of apoptotic cells demonstrated by transmission electron microscope were as follows: shrinkage of the cell, chromatin condensation and aggregation under the nuclear membrane as a crescent or lump, membrane-encapsulated nuclear fragment or cell organ formed by invagination of the cell membrane, and apoptotic body formation followed by vacuolization. Conclusion Apoptosis induced by mechanical stretch and LPS is dose dependent. Mechanical stretch aggravates apoptosis especially in cells treated with LPS. Annexin V and PI double staining is a specific, sensitive, and quantitative method for analyzing apoptotic cells. It is also helpful to clarify the protective mechanism of low-volume ventilation in ARDS. Acknowledgement The study was funded by the 'One Hundred People' project of Shanghai Sanitary Bureau (03-77-20).

Research paper thumbnail of Ectopic Bioactive Luteinizing Hormone Secretion by a Pancreatic Endocrine Tumor, Manifested as Luteinized Granulosa-Thecal Cell Tumor of the Ovaries

The Journal of Clinical Endocrinology & Metabolism, 2005

Research paper thumbnail of Prevalence of autonomous cortisol and aldosterone secretion in patients with a single benign cortical adrenal adenoma after modification of the diagnostic tests

Research paper thumbnail of Plasma metanephrines and normetanephrines: Alternative indices of avs in a patient with primary aldosteronism and endogenous hypercortisolemia

Research paper thumbnail of Juxtaglomerular cell tumour of the kidney: a rare cause of resistant hypertension

Endocrinology, Diabetes & Metabolism Case Reports, 2022

Summary Juxtaglomerular cell tumour (JGCT) is an unusually encountered clinical entity. A 33-year... more Summary Juxtaglomerular cell tumour (JGCT) is an unusually encountered clinical entity. A 33-year-old man with severe long-standing hypertension and hypokalaemia is described. The patient also suffered from polyuria, polydipsia, nocturia and severe headaches. On admission, laboratory investigation revealed hypokalaemia, kaliuresis, high aldosterone and renin levels, and the abdomen CT identified a mass of 4 cm at the right kidney. Kidney function was normal. Following nephrectomy, the histological investigation revealed the presence of a JGCT. Immunostaining was positive for CD34 as well as for smooth muscle actin and vimentin. Following surgery, a marked control of his hypertension with calcium channel blockers and normalization of the serum potassium, renin or aldosterone levels were reached. According to our findings, JGCT could be included in the differential diagnosis of secondary hypertension as it consists of a curable cause. The association of JGCT with hypertension and hypo...

Research paper thumbnail of Prevalance of primary aldosteronism in hypertensive patients: epidemiological data from a tertiary centre

Endocrine Abstracts, 2018

Research paper thumbnail of Severe pheochromocytoma crisis, Type B, resulting in Takotsubo-like cardiomyopathy and fulminant refractory cardiogenic shock, successfully treated with extracorporeal membrane oxygenation (ECMO) but with fatal neurological sequelae for the patient

Endocrine Abstracts, 2018

Research paper thumbnail of Hyperparathyroidism in patients with overt and mild primary aldosteronism: Epidemiological data from a tertiary centre

Research paper thumbnail of Medullary thyroid carcinoma: a case report on the efficacy and safety of combined treatment with Vandetanib and Lanreotide Autogel

Research paper thumbnail of Renin: a possible novel marker for the efficacy of pharmacological treatment of primary aldosteronism

Research paper thumbnail of Expression ofestrogen-related receptors andepidermal growth factor receptorin normal adrenal cortex and adrenocortical tumors: A possible role of GPR30 and EGFR in adrenocortical malignancy

Research paper thumbnail of Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study

Diabetes Care, 2022

OBJECTIVE Finerenone significantly improved cardiorenal outcomes in patients with chronic kidney ... more OBJECTIVE Finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) in the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease trial. We explored whether baseline HbA1c level and insulin treatment influenced outcomes. RESEARCH DESIGN AND METHODS Patients with T2D, urine albumin-to-creatinine ratio (UACR) of 30–5,000 mg/g, estimated glomerular filtration rate (eGFR) of 25 to <75 mL/min/1.73 m2, and treated with optimized renin–angiotensin system blockade were randomly assigned to receive finerenone or placebo. Efficacy outcomes included kidney (kidney failure, sustained decrease ≥40% in eGFR from baseline, or renal death) and cardiovascular (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) composite endpoints. Patients were analyzed by baseline insulin use and by baseline HbA1c <7.5% (58 mmol/mol) or ≥7.5%. RESULTS...

Research paper thumbnail of Pre- and peri-operative characteristics, complications and outcomes of patients with biochemically silent pheochromocytomas; a case series

Research paper thumbnail of Thyroid Paraganglioma With Medullary Carcinoma: A Unique Combination in a Patient in Association With Multiple Endocrine Neoplasia Type 2B Syndrome With Prolonged Survival

Research paper thumbnail of Gastric monomorphic epitheliotropic intestinal T-cell lymphoma with bilateral adrenal metastases

Research paper thumbnail of Pre-, peri- and post-operative characteristics of biochemically silent pheochromocytomas: a case series

Research paper thumbnail of A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement

Leukemia Research Reports

Research paper thumbnail of Arare case of caucasian patient with insulin autoimmune syndrome induced by a-lipoic acid

Research paper thumbnail of A very rare case of extranodal lymphoma with adrenal and heart involvement

Endocrine Abstracts, 2021

Research paper thumbnail of A new highly sensitive and specific overnight combined screening and diagnostic test for primary aldosteronism

European Journal of Endocrinology, 2016

Context Primary aldosteronism (PA) is the most common cause of endocrine hypertension that is dia... more Context Primary aldosteronism (PA) is the most common cause of endocrine hypertension that is diagnosed following a two-step process: an initial screening test, based on the serum aldosterone-to-renin ratio (ARR), followed by a relatively laborious and time-consuming confirmatory test to document autonomous aldosterone (ALD) secretion. Objective The aim of this study is to develop a simple overnight test for the early and definite diagnosis of PA. Patients and methods Totally, 148 hypertensive patients underwent a fludrocortisone–dexamethasone suppression test (FDST) and the new overnight diagnostic test (DCVT) using pharmaceutical RAAS (renin–angiotensin–aldosterone system) blockade with dexamethasone, captopril and valsartan. Results Of the 148 patients, 45 were diagnosed as having PA and they all normalized their elevated blood pressure (BP) after administration of spironolactone or eplerenone. The remaining 103 patients were considered as having essential hypertension and served...

Research paper thumbnail of Plasma glucose levels and mortality in bacteremic ICU patients

Critical Care, 2006

Objective To examine the effects of short-term cyclic stretch on apoptosis in alveolar type II ce... more Objective To examine the effects of short-term cyclic stretch on apoptosis in alveolar type II cells (A549). To study in vitro the direct influence of alveolar type II cells on mechanical stretch. Methods A549 were treated with different doses of lipopolysaccharide (LPS), 0 ng/ml, 1 ng/ml, 10 ng/ml, 100 ng/ml, 1000 ng/ml, and then A549 were lengthened 5%, 15%, 30% using a FLEXCELL tension unit 4000, a vacuum-driven device that applies strain to cells, which were cultured in six-well plates coated with collagen-I, and 12 cycles/min for 4 hours. Apoptosis was measured using the flow cytometry method that measures annexin V and propidium iodide (PI) staining. The morphological changes of apoptotic cells were observed by transmission electron microscope. Results Apoptosis could be induced in alveolar type II cells (A549) by mechanical stretch. The percentage of annexin V + PI cells increased after being treated with cyclic stretch for 4 hours by 5%, 15%, 30% in all groups. The morphological features of apoptotic cells demonstrated by transmission electron microscope were as follows: shrinkage of the cell, chromatin condensation and aggregation under the nuclear membrane as a crescent or lump, membrane-encapsulated nuclear fragment or cell organ formed by invagination of the cell membrane, and apoptotic body formation followed by vacuolization. Conclusion Apoptosis induced by mechanical stretch and LPS is dose dependent. Mechanical stretch aggravates apoptosis especially in cells treated with LPS. Annexin V and PI double staining is a specific, sensitive, and quantitative method for analyzing apoptotic cells. It is also helpful to clarify the protective mechanism of low-volume ventilation in ARDS. Acknowledgement The study was funded by the 'One Hundred People' project of Shanghai Sanitary Bureau (03-77-20).

Research paper thumbnail of Ectopic Bioactive Luteinizing Hormone Secretion by a Pancreatic Endocrine Tumor, Manifested as Luteinized Granulosa-Thecal Cell Tumor of the Ovaries

The Journal of Clinical Endocrinology & Metabolism, 2005

Research paper thumbnail of Prevalence of autonomous cortisol and aldosterone secretion in patients with a single benign cortical adrenal adenoma after modification of the diagnostic tests

Research paper thumbnail of Plasma metanephrines and normetanephrines: Alternative indices of avs in a patient with primary aldosteronism and endogenous hypercortisolemia

Research paper thumbnail of Juxtaglomerular cell tumour of the kidney: a rare cause of resistant hypertension

Endocrinology, Diabetes & Metabolism Case Reports, 2022

Summary Juxtaglomerular cell tumour (JGCT) is an unusually encountered clinical entity. A 33-year... more Summary Juxtaglomerular cell tumour (JGCT) is an unusually encountered clinical entity. A 33-year-old man with severe long-standing hypertension and hypokalaemia is described. The patient also suffered from polyuria, polydipsia, nocturia and severe headaches. On admission, laboratory investigation revealed hypokalaemia, kaliuresis, high aldosterone and renin levels, and the abdomen CT identified a mass of 4 cm at the right kidney. Kidney function was normal. Following nephrectomy, the histological investigation revealed the presence of a JGCT. Immunostaining was positive for CD34 as well as for smooth muscle actin and vimentin. Following surgery, a marked control of his hypertension with calcium channel blockers and normalization of the serum potassium, renin or aldosterone levels were reached. According to our findings, JGCT could be included in the differential diagnosis of secondary hypertension as it consists of a curable cause. The association of JGCT with hypertension and hypo...

Research paper thumbnail of Prevalance of primary aldosteronism in hypertensive patients: epidemiological data from a tertiary centre

Endocrine Abstracts, 2018

Research paper thumbnail of Severe pheochromocytoma crisis, Type B, resulting in Takotsubo-like cardiomyopathy and fulminant refractory cardiogenic shock, successfully treated with extracorporeal membrane oxygenation (ECMO) but with fatal neurological sequelae for the patient

Endocrine Abstracts, 2018

Research paper thumbnail of Hyperparathyroidism in patients with overt and mild primary aldosteronism: Epidemiological data from a tertiary centre

Research paper thumbnail of Medullary thyroid carcinoma: a case report on the efficacy and safety of combined treatment with Vandetanib and Lanreotide Autogel

Research paper thumbnail of Renin: a possible novel marker for the efficacy of pharmacological treatment of primary aldosteronism

Research paper thumbnail of Expression ofestrogen-related receptors andepidermal growth factor receptorin normal adrenal cortex and adrenocortical tumors: A possible role of GPR30 and EGFR in adrenocortical malignancy