uday kumar - Academia.edu (original) (raw)
Papers by uday kumar
The American journal of geriatric cardiology
Primarily a disease of the elderly, heart failure continues to be an ever-increasing health care ... more Primarily a disease of the elderly, heart failure continues to be an ever-increasing health care problem given the growth in the number of individuals over age 65. Although there have been many advances in the pharmacologic management of heart failure, there continues to be a significant number of patients with persistent symptoms despite maximal therapy and it is likely that this group of patients will only continue to increase in number. Given this, significant research has gone into exploring new modalities, such as device therapies, to treat heart failure. Of these, ventricular resynchronization has emerged as one of the most promising. This review will examine the most important aspects of ventricular resynchronization therapy including: the significance of ventricular dyssynchrony, the role of traditional pacemakers, the effects on contractile function and reverse remodeling, and the currently accepted indications for resynchronization devices. Additionally, various aspects of...
Surgical Management of Congestive Heart Failure, 2005
Page 1. 6 Pacing in Heart Failure Uday N. Kumar, AID, Teresa De Marco, MD, andLeslie A. Saxon, AI... more Page 1. 6 Pacing in Heart Failure Uday N. Kumar, AID, Teresa De Marco, MD, andLeslie A. Saxon, AID CONTENTS INTRODUCTION STANDARD DUAL-CHAMBER PACING IN DILATED CARDIOMYOPATHY PACING IN ATRIAL ...
The Process of Innovating Medical Technologies, 2009
The Process of Innovating Medical Technologies, 2009
The Process of Innovating Medical Technologies, 2009
The Process of Innovating Medical Technologies, 2009
International Journal of System Assurance Engineering and Management, 2010
Reliability prediction of machinery is crucial to schedule overhauls, spare parts replacement and... more Reliability prediction of machinery is crucial to schedule overhauls, spare parts replacement and maintenance interventions. Many AI tools have been used in order to provide these predictions for the industry. Support vector regression (SVR) is a nonlinear regression technique extended from support vector machine. SVR can fit data flexibly and it has a wide variety of applications. This paper utilizes SVR combining time series to predict the next failure time based on historical failure data. To solve the parameter selection problem a method has been proposed. This method approximates the widely used leave-one-out method. To bound the prediction error, a confidence interval is proposed based on the non-homogeneous poisson process. A numerical case from the mining industry is presented to demonstrate the developed approach.
International Symposium on Electromagnetic Compatibility - EMC EUROPE, 2012
Several studies in Sweden have looked into railway electromagnetic interference (EMI) either to d... more Several studies in Sweden have looked into railway electromagnetic interference (EMI) either to discover the source of the interference or to determine if the equipment in the system is performing properly. The movement of rolling stock along an electrified track produces certain EMI events. Transient electromagnetic fields are produced in the signalling system when the train leaves the neutral section of the overhead power line and enters the powered section. These transient EM fields are mainly produced by the engine. The track's infrastructure system has been tested for EMI events, but this phenomenon affects the surrounding environment as well, up to at least 10 meters from the track. The infrastructure is designed so that the return current from locomotives should go through the running rails, but occasionally the ground acts as a conductor, transmitting current to areas that are distant from the rail. The paper reviews the status of Swedish railways with respect to electromagnetic compatibility. This TREND project is a joint project with 7 FP EU.
Future medicinal chemistry, 2013
InhA is a promising and attractive target in antimycobacterial drug development. InhA is involved... more InhA is a promising and attractive target in antimycobacterial drug development. InhA is involved in the reduction of long-chain trans-2-enoyl-ACP in the type II fatty acid biosynthesis pathway of Mycobacterium tuberculosis. Recent studies have demonstrated that InhA is one of the targets for the second line antitubercular drug ethionamide. In the current study, we have generated quantitative pharmacophore models using known InhA inhibitors and validated using a large test set. The validated pharmacophore model was used as a query to screen an in-house database of 400,000 compounds and retrieved 25,000 hits. These hits were further ranked based on its shape and feature similarity with potent InhA inhibitor using rapid overlay of chemical structures (OpenEye™) and subsequent hits were subjected for docking. Based on the pharmacophore, rapid overlay of chemical structures model and docking interactions, 32 compounds with more than eight chemotypes were selected, purchased and assayed ...
2008 Annual Reliability and Maintainability Symposium, 2008
Life Cycle Cost (LCC) is used as a cost effective decision support for maintenance of railway tra... more Life Cycle Cost (LCC) is used as a cost effective decision support for maintenance of railway track infrastructure. However, a fair degree of uncertainty associated with the estimation of LCC is due to the statistical characteristics of Reliability, Availability and Maintainability (RAM) parameters. This paper illustrates a methodology for estimation of uncertainty linked with LCC, by a combination of Design
2011 IEEE International Conference on Quality and Reliability, 2011
In practice, both maintenance engineers on site and maintenance managers should have a clear idea... more In practice, both maintenance engineers on site and maintenance managers should have a clear idea of how the maintenance plans are being carried out, and they will be improved continuously in the future. In this paper, the House of Maintenance Management (HOMM) is proposed to describe that what should be included in, for maintenance management. With HOMM, a continuous improvement
Journal of Quality in Maintenance Engineering, 2010
Purpose – The purpose of this paper is to present issues and challenges of scheduled maintenance ... more Purpose – The purpose of this paper is to present issues and challenges of scheduled maintenance task development within the maintenance review board (MRB) process, and to find potential areas of improvement in the application of the MSG-3 methodology for aircraft systems. Design/methodology/approach – The issues and challenges as well as potential areas of improvement have been identified through a
Journal of Quality in Maintenance Engineering, 2005
Purpose With continuous technological development in the twenty-first century, the industry and... more Purpose With continuous technological development in the twenty-first century, the industry and industrial systems have become complex and making their availability more critical. In this context, the product support and its related issues such as spare parts play an important ...
Journal of Quality in Maintenance Engineering, 2006
... Tore Markeset, University of Stavanger, Stavanger, Norway. Uday Kumar, Luleå University of Te... more ... Tore Markeset, University of Stavanger, Stavanger, Norway. Uday Kumar, Luleå University of Technology, Luleå, Sweden. Acknowledgements. ... They emphasized the importance of face-to-face meetings where problems were discussed and attempted resolved. ...
Journal of Quality in Maintenance Engineering, 2003
Abstract: Most industrial customers are looking for products that meet the functional performance... more Abstract: Most industrial customers are looking for products that meet the functional performance needs and have predictable life cycle cost (LCC). Due to design problems and poor product support, these systems are not able to meet the customers' requirements. ...
Journal of Quality in Maintenance Engineering, 2003
Product design and service delivery both affect service performance, and therefore a product supp... more Product design and service delivery both affect service performance, and therefore a product support strategy must be defined during design stage, in terms of these two dimensions, to ensure the delivery of "promised product performance" to customers. Furthermore, product support strategy should not only be focused around product, or its operating characteristics, but also on assisting customers with services that enhance product use and add additional value to their business processes. This paper examines various issues such as reliability, availability, maintainability, and supportability (RAMS), etc., which directly or indirectly affect product support, maintenance needs and related costs on the basis of a case study conducted in a manufacturing company. The main purpose of the study was to analyse the critical issues related to the product support and service delivery strategy as being practised by the company, and to suggest means for improvements. On the basis of the case study, the paper presents an approach for design and development of product support and maintenance concepts for industrial systems in a multinational environment. The paper emphasizes that the strategy for product support should not be centred only on "product", but should also take into account important issues such as the service delivery capability of the manufacturers, service suppliers, the capability of users' maintenance organization, etc.
Journal of Molecular Graphics and Modelling, 2010
Bacillus anthracis is a causative organism of anthrax. The main reason to use anthrax as a biowea... more Bacillus anthracis is a causative organism of anthrax. The main reason to use anthrax as a bioweapon is the combination of the spore's durability and the lethal toxaemia of the vegetative stage. In anthrax infection, lethal factor (LF) is playing crucial role in causing cell death, by inhibiting pathways that rely on this kinase family. The combination of vaccine and antibiotics is preferred as an effective treatment for this target. Till date, no small molecule inhibitor is identified as a drug on the target. In this study, we have performed pharmacophore modeling and docking studies to identify a novel small molecule inhibitor to target the Anthrax LF. The best pharmacophore model is used to screen ∼2 M drug-like small molecule database and yielded 2543 hits. Docking studies of the pharmacophore hits on to the active site of Anthrax LF resulted 120 structurally diverse hits. Out of 120 hits, based on synthetic feasibility, 17 hits are selected for further synthesis and pharmacological screening. In due course, we will publish the updated results.
International Journal of Reliability, Quality and Safety Engineering, 2013
ABSTRACT The testing-development phase has been carried out in a given control environment. Howev... more ABSTRACT The testing-development phase has been carried out in a given control environment. However, the product will be used in different operating environment by different end-users, which is unknown to the developer. The operating environment may range from a very clean one up to a harsh environment. These uncertain operating environments will impact to the reliability and performance of the software which may differ from the testing phase reliability. We consider that the effect of environment on reliability has a fuzzy nature. The fuzzy effects of the field environments can be captured by a unit-free environmental factor. To overcome this problem, the fuzzy probabilistic theory may be used in the processing of stochastic parameters, taking into account their fuzzy nature. The proposed model is based on Weibull distribution. The aim of this paper is to introduce a fuzzy field environment (FFE) reliability model that covers both the testing and operating phases in the development cycle. Illustration examples of the proposed model have been validated on data collected from two industries.
The American journal of geriatric cardiology
Primarily a disease of the elderly, heart failure continues to be an ever-increasing health care ... more Primarily a disease of the elderly, heart failure continues to be an ever-increasing health care problem given the growth in the number of individuals over age 65. Although there have been many advances in the pharmacologic management of heart failure, there continues to be a significant number of patients with persistent symptoms despite maximal therapy and it is likely that this group of patients will only continue to increase in number. Given this, significant research has gone into exploring new modalities, such as device therapies, to treat heart failure. Of these, ventricular resynchronization has emerged as one of the most promising. This review will examine the most important aspects of ventricular resynchronization therapy including: the significance of ventricular dyssynchrony, the role of traditional pacemakers, the effects on contractile function and reverse remodeling, and the currently accepted indications for resynchronization devices. Additionally, various aspects of...
Surgical Management of Congestive Heart Failure, 2005
Page 1. 6 Pacing in Heart Failure Uday N. Kumar, AID, Teresa De Marco, MD, andLeslie A. Saxon, AI... more Page 1. 6 Pacing in Heart Failure Uday N. Kumar, AID, Teresa De Marco, MD, andLeslie A. Saxon, AID CONTENTS INTRODUCTION STANDARD DUAL-CHAMBER PACING IN DILATED CARDIOMYOPATHY PACING IN ATRIAL ...
The Process of Innovating Medical Technologies, 2009
The Process of Innovating Medical Technologies, 2009
The Process of Innovating Medical Technologies, 2009
The Process of Innovating Medical Technologies, 2009
International Journal of System Assurance Engineering and Management, 2010
Reliability prediction of machinery is crucial to schedule overhauls, spare parts replacement and... more Reliability prediction of machinery is crucial to schedule overhauls, spare parts replacement and maintenance interventions. Many AI tools have been used in order to provide these predictions for the industry. Support vector regression (SVR) is a nonlinear regression technique extended from support vector machine. SVR can fit data flexibly and it has a wide variety of applications. This paper utilizes SVR combining time series to predict the next failure time based on historical failure data. To solve the parameter selection problem a method has been proposed. This method approximates the widely used leave-one-out method. To bound the prediction error, a confidence interval is proposed based on the non-homogeneous poisson process. A numerical case from the mining industry is presented to demonstrate the developed approach.
International Symposium on Electromagnetic Compatibility - EMC EUROPE, 2012
Several studies in Sweden have looked into railway electromagnetic interference (EMI) either to d... more Several studies in Sweden have looked into railway electromagnetic interference (EMI) either to discover the source of the interference or to determine if the equipment in the system is performing properly. The movement of rolling stock along an electrified track produces certain EMI events. Transient electromagnetic fields are produced in the signalling system when the train leaves the neutral section of the overhead power line and enters the powered section. These transient EM fields are mainly produced by the engine. The track's infrastructure system has been tested for EMI events, but this phenomenon affects the surrounding environment as well, up to at least 10 meters from the track. The infrastructure is designed so that the return current from locomotives should go through the running rails, but occasionally the ground acts as a conductor, transmitting current to areas that are distant from the rail. The paper reviews the status of Swedish railways with respect to electromagnetic compatibility. This TREND project is a joint project with 7 FP EU.
Future medicinal chemistry, 2013
InhA is a promising and attractive target in antimycobacterial drug development. InhA is involved... more InhA is a promising and attractive target in antimycobacterial drug development. InhA is involved in the reduction of long-chain trans-2-enoyl-ACP in the type II fatty acid biosynthesis pathway of Mycobacterium tuberculosis. Recent studies have demonstrated that InhA is one of the targets for the second line antitubercular drug ethionamide. In the current study, we have generated quantitative pharmacophore models using known InhA inhibitors and validated using a large test set. The validated pharmacophore model was used as a query to screen an in-house database of 400,000 compounds and retrieved 25,000 hits. These hits were further ranked based on its shape and feature similarity with potent InhA inhibitor using rapid overlay of chemical structures (OpenEye™) and subsequent hits were subjected for docking. Based on the pharmacophore, rapid overlay of chemical structures model and docking interactions, 32 compounds with more than eight chemotypes were selected, purchased and assayed ...
2008 Annual Reliability and Maintainability Symposium, 2008
Life Cycle Cost (LCC) is used as a cost effective decision support for maintenance of railway tra... more Life Cycle Cost (LCC) is used as a cost effective decision support for maintenance of railway track infrastructure. However, a fair degree of uncertainty associated with the estimation of LCC is due to the statistical characteristics of Reliability, Availability and Maintainability (RAM) parameters. This paper illustrates a methodology for estimation of uncertainty linked with LCC, by a combination of Design
2011 IEEE International Conference on Quality and Reliability, 2011
In practice, both maintenance engineers on site and maintenance managers should have a clear idea... more In practice, both maintenance engineers on site and maintenance managers should have a clear idea of how the maintenance plans are being carried out, and they will be improved continuously in the future. In this paper, the House of Maintenance Management (HOMM) is proposed to describe that what should be included in, for maintenance management. With HOMM, a continuous improvement
Journal of Quality in Maintenance Engineering, 2010
Purpose – The purpose of this paper is to present issues and challenges of scheduled maintenance ... more Purpose – The purpose of this paper is to present issues and challenges of scheduled maintenance task development within the maintenance review board (MRB) process, and to find potential areas of improvement in the application of the MSG-3 methodology for aircraft systems. Design/methodology/approach – The issues and challenges as well as potential areas of improvement have been identified through a
Journal of Quality in Maintenance Engineering, 2005
Purpose With continuous technological development in the twenty-first century, the industry and... more Purpose With continuous technological development in the twenty-first century, the industry and industrial systems have become complex and making their availability more critical. In this context, the product support and its related issues such as spare parts play an important ...
Journal of Quality in Maintenance Engineering, 2006
... Tore Markeset, University of Stavanger, Stavanger, Norway. Uday Kumar, Luleå University of Te... more ... Tore Markeset, University of Stavanger, Stavanger, Norway. Uday Kumar, Luleå University of Technology, Luleå, Sweden. Acknowledgements. ... They emphasized the importance of face-to-face meetings where problems were discussed and attempted resolved. ...
Journal of Quality in Maintenance Engineering, 2003
Abstract: Most industrial customers are looking for products that meet the functional performance... more Abstract: Most industrial customers are looking for products that meet the functional performance needs and have predictable life cycle cost (LCC). Due to design problems and poor product support, these systems are not able to meet the customers' requirements. ...
Journal of Quality in Maintenance Engineering, 2003
Product design and service delivery both affect service performance, and therefore a product supp... more Product design and service delivery both affect service performance, and therefore a product support strategy must be defined during design stage, in terms of these two dimensions, to ensure the delivery of "promised product performance" to customers. Furthermore, product support strategy should not only be focused around product, or its operating characteristics, but also on assisting customers with services that enhance product use and add additional value to their business processes. This paper examines various issues such as reliability, availability, maintainability, and supportability (RAMS), etc., which directly or indirectly affect product support, maintenance needs and related costs on the basis of a case study conducted in a manufacturing company. The main purpose of the study was to analyse the critical issues related to the product support and service delivery strategy as being practised by the company, and to suggest means for improvements. On the basis of the case study, the paper presents an approach for design and development of product support and maintenance concepts for industrial systems in a multinational environment. The paper emphasizes that the strategy for product support should not be centred only on "product", but should also take into account important issues such as the service delivery capability of the manufacturers, service suppliers, the capability of users' maintenance organization, etc.
Journal of Molecular Graphics and Modelling, 2010
Bacillus anthracis is a causative organism of anthrax. The main reason to use anthrax as a biowea... more Bacillus anthracis is a causative organism of anthrax. The main reason to use anthrax as a bioweapon is the combination of the spore's durability and the lethal toxaemia of the vegetative stage. In anthrax infection, lethal factor (LF) is playing crucial role in causing cell death, by inhibiting pathways that rely on this kinase family. The combination of vaccine and antibiotics is preferred as an effective treatment for this target. Till date, no small molecule inhibitor is identified as a drug on the target. In this study, we have performed pharmacophore modeling and docking studies to identify a novel small molecule inhibitor to target the Anthrax LF. The best pharmacophore model is used to screen ∼2 M drug-like small molecule database and yielded 2543 hits. Docking studies of the pharmacophore hits on to the active site of Anthrax LF resulted 120 structurally diverse hits. Out of 120 hits, based on synthetic feasibility, 17 hits are selected for further synthesis and pharmacological screening. In due course, we will publish the updated results.
International Journal of Reliability, Quality and Safety Engineering, 2013
ABSTRACT The testing-development phase has been carried out in a given control environment. Howev... more ABSTRACT The testing-development phase has been carried out in a given control environment. However, the product will be used in different operating environment by different end-users, which is unknown to the developer. The operating environment may range from a very clean one up to a harsh environment. These uncertain operating environments will impact to the reliability and performance of the software which may differ from the testing phase reliability. We consider that the effect of environment on reliability has a fuzzy nature. The fuzzy effects of the field environments can be captured by a unit-free environmental factor. To overcome this problem, the fuzzy probabilistic theory may be used in the processing of stochastic parameters, taking into account their fuzzy nature. The proposed model is based on Weibull distribution. The aim of this paper is to introduce a fuzzy field environment (FFE) reliability model that covers both the testing and operating phases in the development cycle. Illustration examples of the proposed model have been validated on data collected from two industries.