Umer Bin Tariq - Academia.edu (original) (raw)
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Papers by Umer Bin Tariq
Current Pharmaceutical Design
Background: Although chemotherapy and radiotherapy are effective in cancer treatment, different a... more Background: Although chemotherapy and radiotherapy are effective in cancer treatment, different adverse effects induced by these therapeutic modalities (such as ototoxicity) restrict their clinical use. Co-treatment of melatonin may alleviate the chemotherapy/radiotherapy-induced ototoxicity. Objective: In the present study, the otoprotective potentials of melatonin against the ototoxicity induced by chemotherapy and radiotherapy were reviewed. Methods: According to the PRISMA guideline, a systematic search was carried out to identify all relevant studies on “the role of melatonin against ototoxic damage associated with chemotherapy and radiotherapy” in the different electronic databases up to September 2022. Sixty-seven articles were screened based on a predefined set of inclusion and exclusion criteria. Seven eligible studies were finally included in this review. Results: The in vitro findings showed that cisplatin chemotherapy significantly decreased the auditory cell viability c...
Current Problems in Cardiology
International Immunopharmacology
Nature reviews. Microbiology, Jan 8, 2015
Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of p... more Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.
Current Pharmaceutical Design
Background: Although chemotherapy and radiotherapy are effective in cancer treatment, different a... more Background: Although chemotherapy and radiotherapy are effective in cancer treatment, different adverse effects induced by these therapeutic modalities (such as ototoxicity) restrict their clinical use. Co-treatment of melatonin may alleviate the chemotherapy/radiotherapy-induced ototoxicity. Objective: In the present study, the otoprotective potentials of melatonin against the ototoxicity induced by chemotherapy and radiotherapy were reviewed. Methods: According to the PRISMA guideline, a systematic search was carried out to identify all relevant studies on “the role of melatonin against ototoxic damage associated with chemotherapy and radiotherapy” in the different electronic databases up to September 2022. Sixty-seven articles were screened based on a predefined set of inclusion and exclusion criteria. Seven eligible studies were finally included in this review. Results: The in vitro findings showed that cisplatin chemotherapy significantly decreased the auditory cell viability c...
Current Problems in Cardiology
International Immunopharmacology
Nature reviews. Microbiology, Jan 8, 2015
Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of p... more Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.