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Papers by unyime eshiet
American journal of pharmacotherapy and pharmaceutical sciences, May 28, 2024
American Journal of Pharmacotherapy and Pharmaceutical Sciences, Oct 30, 2023
Exploratory Research in Clinical and Social Pharmacy, Feb 29, 2024
Psychology, Health & Medicine
International journal of pharmaceutical sciences review and research, Dec 15, 2022
Hypertension has become a major comorbidity among people living with HIV (PLWH). However, studies... more Hypertension has become a major comorbidity among people living with HIV (PLWH). However, studies examining drug use in hypertensive PLWH are scant. This study assessed the pharmacological management of HIV-hypertension in hypertensive PLWH as well as the effects of prescribed drugs on control of both diseases. The study utilized the case notes of 182 hypertensive PLWH recruited into a randomized controlled trial in the
American Journal of Pharmacotherapy and Pharmaceutical Sciences, Nov 30, 2022
Epilepsy Research, 2021
BACKGROUND The impact of epilepsy on the quality of life of the patient can be considerably high ... more BACKGROUND The impact of epilepsy on the quality of life of the patient can be considerably high with far-reaching and life-long consequences. The goal of patient counseling and education is to achieve positive clinical outcomes and optimize the patient's health-related quality of life. OBJECTIVE To evaluate the impact of a pharmacist-led education and counselling interventions on the health-related quality of life of patients living with epilepsy. METHODS A randomized controlled trial was carried out on epilepsy patients attending the neurology/medical out-patient clinics of two tertiary hospitals. Patients in the intervention group were offered education and counselling services. The impact of the interventions on the patients' quality of life in epilepsy was evaluated using the QOLIE-10P questionnaire. The research protocol was approved by the Health Research Ethics Committees of the University of Uyo Teaching Hospital and University of Calabar Teaching Hospital (Reference numbers: UUTH/AD/S/96/VOL.XIV/571 & UCTH/HREC/33/454). RESULTS There was a statistically significant difference between the usual care (UC) and the pharmaceutical care (PC) group on the quality of life in epilepsy scores post-intervention. Comparisons between groups (UC versus PC) revealed that patients in the PC group had a significantly higher QOLIE score than those in the UC group at 3 months and 6 months - (Pre-intervention: 8.73 versus 7.91; t = 0.619; p = 0.537), (3 months: 9.74 versus 15.37; t = -3.34; p = 0.01), (6 months: 11.59 versus 17.01; t = -3.137; p = 0.01). CONCLUSION Pharmacist-led education and counselling interventions may significantly improve the quality of life of patients with epilepsy.
Asian Journal of Research and Reports in Urology, Aug 16, 2021
Background: Benign prostatic hyperplasia (BPH) is one of the most common conditions in aging men.... more Background: Benign prostatic hyperplasia (BPH) is one of the most common conditions in aging men. Although BPH is not life threatening, the clinical manifestations such as lower urinary tract symptoms (LUTS) reduce patients' quality of life. BPH is associated with high healthcare costs and is a burden on the patients' families and society. Objective: To assess the incidence, treatment pattern, and direct cost of management of BPH in a tertiary hospital, in Eastern Nigeria. Methods: A retrospective descriptive assessment of case notes of patients diagnosed with BPH between September 2017 and August 2019. The treatment pattern was assessed for 12 months. Costs were calculated for BPH-related clinical procedures and medications. Results: The incidence rate of BPH in this population is 6.7%. One-hundred and two case notes were retrieved and evaluated. About 50.4% of the patients visited the hospital between 2 to 4 times, with a mean visit of 4.4 times a year. Ninety
Background: Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed... more Background: Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed that Angiotensin converting enzyme inhibitors (ACEIs) were often the least prescribed. However, the appropriate use of ACEIs in the black population achieves good blood pressure control and provides additional long term cardioand renovascular protection benefits. Objective: To assess the current utilization pattern of antihypertensive medicines with specific emphasis on identifying possible shift in the frequency of use of ACEIs. Methods: A prospective cross-sectional assessment of the current utilization pattern of anti-hypertensive medicines was conducted among 300 randomly selected cohort at a 900-bed premier Teaching Hospital located in Ibadan, Southwestern Nigeria. The current utilization pattern was compared with the results of a study conducted at the same site and published 10 years ago. Results: Of the 300 random cohorts, a majority (79%) were females (237) with mean age 58.7 years (SD=2.81 years. Stage 2 hypertension was the most frequent diagnosis (54.3%). The utilization of ACEIs and long acting CCB (amlodipine) significantly increased from 8.6% and 21% (Ten years ago) to 29.93% and 36.68% respectively (p ˂ 0.0001). The use of thiazide diuretic and methyldopa declined significantly from 39.4% and 23.3% (Ten years ago) to 16.12% and 9.7% respectively (p ˂ 0.0001). Adverse drug reactions due to ACEIs were documented in 1.5% (3), while laboratory monitoring of serum potassium, urea and creatinine was conducted in only 37% (111) of cohort. Potentially harmful drug-drug interactions were identified in 25% (75) of cohorts, and the most frequent were ACEIs + NSAIDs (53.3%), ACEIs + amiloride / hydrochlorothiazide (22.6%). Conclusions: Anti-hypertensive medicines utilization has significantly shifted towards the increased use of ACEIs and long acting dihydropyridine CCBs. The use of thiazides and methyldopa has declined significantly. Physicians appeared more cognizant of the long term cardio-and renovascular benefits inherent in using ACEIs in a high cardiovascular risk group such as black hypertensive.
Irish Journal of Medical Science (1971 -), 2021
Background The involvement of pharmacists in the provision of specialised care to patients with e... more Background The involvement of pharmacists in the provision of specialised care to patients with epilepsy is poor. Objective To evaluate the impact of pharmaceutical care services on the clinical outcomes of epilepsy. Setting Two selected major referral epilepsy treatment centres in southern Nigeria were used for the study. Patients were recruited from the Neurology and Medical out-patient clinics of the hospitals. Method An open randomised controlled study was carried out on epilepsy patients receiving clinical care at the selected hospitals. Patients in the intervention group were offered pharmaceutical care services. The impact of the pharmaceutical care services on the clinical outcomes of epilepsy (seizure frequency and severity) was evaluated. Main Outcome Measure The effect of pharmaceutical care services on seizure frequency and severity in patients with epilepsy. Results There was a statistically significant difference between the usual care (UC) and the pharmaceutical care ...
The lack of skilled attendants has been identified as a major factor responsible for the rising m... more The lack of skilled attendants has been identified as a major factor responsible for the rising maternal and infant mortality rate. There is sufficient evidence that traditional birth attendant-provided maternal health care has negative impacts on maternal health. Despite the presence of modern healthcare facilities, there is a rising patronage of traditional birth homes. This study seeks to determine the extent of patronage as well as the factors influencing the patronage of traditional birth homes in Akwa Ibom, Nigeria. A descriptive, cross sectional survey using structured, validated, and pre-tested questionnaires to interview 1,000 randomly selected women of child bearing age in Akwa Ibom, Nigeria. The questionnaire consisted of questions on demographic details, frequency of patronage of traditional birth attendant services as well as reasons for patronizing traditional birth homes.76.5% of our respondents reported that they patronized the ante-natal and child delivery services ...
Journal of Advances in Medical and Pharmaceutical Sciences, Mar 21, 2020
Objective: To determine the relationship between illness perception, medication adherence and hea... more Objective: To determine the relationship between illness perception, medication adherence and health related quality of life in patients living with epilepsy. Design: A cross-sectional prospective survey among patients living with epilepsy recruited from two tertiary referral centers in Nigeria. Methods: Patients' illness perception, adherence to antiepileptic drugs, and health related quality of life were determined using the brief illness perception questionnaire (BIPQ), the eight-item Morisky medication adherence scale (MMAS-8), and the patient weighted quality of life in epilepsy instrument (QOLIE-10-P) respectively. Correlation and linear regression analysis were used to test the relationship between the assessment variables. Statistical significance was set at p < 0.05.
Nigerian Journal of Pharmacy
Journal of Central Nervous System Disease
Background: Carbamazepine and valproate are widely used in the treatment of epileptic seizures. H... more Background: Carbamazepine and valproate are widely used in the treatment of epileptic seizures. However, these agents exhibit certain adverse effects including hematopoietic disorders (carbamazepine) and severe hepatotoxicity (valproate). Purpose: To determine the extent of monitoring of the hematologic effects of carbamazepine as well as the extent of monitoring of the hepatic effects of valproate in patients with epilepsy receiving treatment with these agents. Method: A cross-sectional antiepileptic drug use study using case notes of patients with epilepsy managed at the neurologic clinics of 2 tertiary medical facilities in Nigeria between January and December 2017. Results: Carbamazepine was the most frequently prescribed antiepileptic drug (48.24%), followed by valproate (29.34%) and levetiracetam (9.24%). Pretreatment monitoring of hematologic effect was carried out in only 61.11% of patients placed on carbamazepine therapy while follow-up monitoring was done in 3.7% of these ...
Journal of Pharmaceutical Research International
Purpose: Adherence to the chronic pharmacotherapeutic regimen is poor resulting in negative thera... more Purpose: Adherence to the chronic pharmacotherapeutic regimen is poor resulting in negative therapeutic outcomes. Health education has been shown to improve the adherence of patients to their antiepileptic medication. The Pharmacist has the responsibility of providing patient education and counselling in the context of pharmaceutical care. The study aims to evaluate the efficacy of pharmaceutical care intervention on patients' adherence to prescribed self-administered antiepileptic medications. Method: An opened, randomised, controlled, longitudinal and two-arm parallel prospective study with a 6-month patient follow up period was carried out on patients with epilepsy recruited from the medical and neurology outpatient clinics of two tertiary hospitals. Patients in the intervention group were provided with pharmaceutical care services. The impact of the pharmaceutical care intervention was evaluated by using the eight-Item Morisky Medication Adherence Scale. Repeated measure ANOVA was used to test the difference in the mean adherence score of the control and intervention groups over the time of intervention. The Pillai's Trace F was the corrected statistical test of choice for the model estimate, while the estimated effect was assessed with Partial etha.
Journal of Pharmaceutical Research International
British Journal of Pharmaceutical Research, 2016
Pharmacy Practice, 2014
Background: Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed... more Background: Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed that Angiotensin converting enzyme inhibitors (ACEIs) were often the least prescribed. However, the appropriate use of ACEIs in the black population achieves good blood pressure control and provides additional long term cardioand renovascular protection benefits. Objective: To assess the current utilization pattern of antihypertensive medicines with specific emphasis on identifying possible shift in the frequency of use of ACEIs. Methods: A prospective cross-sectional assessment of the current utilization pattern of anti-hypertensive medicines was conducted among 300 randomly selected cohort at a 900-bed premier Teaching Hospital located in Ibadan, Southwestern Nigeria. The current utilization pattern was compared with the results of a study conducted at the same site and published 10 years ago. Results: Of the 300 random cohorts, a majority (79%) were females (237) with mean age 58.7 years (SD=2.81 years. Stage 2 hypertension was the most frequent diagnosis (54.3%). The utilization of ACEIs and long acting CCB (amlodipine) significantly increased from 8.6% and 21% (Ten years ago) to 29.93% and 36.68% respectively (p ˂ 0.0001). The use of thiazide diuretic and methyldopa declined significantly from 39.4% and 23.3% (Ten years ago) to 16.12% and 9.7% respectively (p ˂ 0.0001). Adverse drug reactions due to ACEIs were documented in 1.5% (3), while laboratory monitoring of serum potassium, urea and creatinine was conducted in only 37% (111) of cohort. Potentially harmful drug-drug interactions were identified in 25% (75) of cohorts, and the most frequent were ACEIs + NSAIDs (53.3%), ACEIs + amiloride / hydrochlorothiazide (22.6%). Conclusions: Anti-hypertensive medicines utilization has significantly shifted towards the increased use of ACEIs and long acting dihydropyridine CCBs. The use of thiazides and methyldopa has declined significantly. Physicians appeared more cognizant of the long term cardio-and renovascular benefits inherent in using ACEIs in a high cardiovascular risk group such as black hypertensive.
Seizure
To evaluate the efficacy of a pharmacist implemented educational treatment programme in improving... more To evaluate the efficacy of a pharmacist implemented educational treatment programme in improving knowledge and perception of epilepsy among people with the condition. Method: A randomized controlled study was conducted on patients with epilepsy recruited from the medical and neurology outpatient clinics of two tertiary hospitals. Patients in the intervention group were offered an educational treatment programme implemented by a clinical pharmacist. The impact of the educational intervention was evaluated by using an epilepsy knowledge scale and the brief illness perception questionnaire. Results: There was a statistical significant difference between the control and intervention group over time on the knowledge of epilepsy, as the knowledge of epilepsy among patients in the intervention group significantly increased; F (2154) = 150.15, p = 0.000, Partial η 2 = 0.661. Also, there was a statistical significant difference between the control and intervention group over time on the perception of epilepsy, as the perception of epilepsy among patients in the intervention group significantly improved; F (2, 154) = 12.386, p = 0.000, Partial η 2 = 0.138. Conclusion: The Pharmacist implemented educational intervention improved patients' knowledge and perception of epilepsy. This finding has revealed the potential positive impact of pharmacists' involvement in the management of epilepsy.
Pharmacy practice, 2014
Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed that Angiot... more Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed that Angiotensin converting enzyme inhibitors (ACEIs) were often the least prescribed. However, the appropriate use of ACEIs in the black population achieves good blood pressure control and provides additional long term cardio- and renovascular protection benefits. To assess the current utilization pattern of antihypertensive medicines with specific emphasis on identifying possible shift in the frequency of use of ACEIs. A prospective cross-sectional assessment of the current utilization pattern of anti-hypertensive medicines was conducted among 300 randomly selected cohort at a 900-bed premier Teaching Hospital located in Ibadan, Southwestern Nigeria. The current utilization pattern was compared with the results of a study conducted at the same site and published 10 years ago. Of the 300 random cohorts, a majority (79%) were females (237) with mean age 58.7 years (SD=2.81 years. Stage 2 hypertensi...
American journal of pharmacotherapy and pharmaceutical sciences, May 28, 2024
American Journal of Pharmacotherapy and Pharmaceutical Sciences, Oct 30, 2023
Exploratory Research in Clinical and Social Pharmacy, Feb 29, 2024
Psychology, Health & Medicine
International journal of pharmaceutical sciences review and research, Dec 15, 2022
Hypertension has become a major comorbidity among people living with HIV (PLWH). However, studies... more Hypertension has become a major comorbidity among people living with HIV (PLWH). However, studies examining drug use in hypertensive PLWH are scant. This study assessed the pharmacological management of HIV-hypertension in hypertensive PLWH as well as the effects of prescribed drugs on control of both diseases. The study utilized the case notes of 182 hypertensive PLWH recruited into a randomized controlled trial in the
American Journal of Pharmacotherapy and Pharmaceutical Sciences, Nov 30, 2022
Epilepsy Research, 2021
BACKGROUND The impact of epilepsy on the quality of life of the patient can be considerably high ... more BACKGROUND The impact of epilepsy on the quality of life of the patient can be considerably high with far-reaching and life-long consequences. The goal of patient counseling and education is to achieve positive clinical outcomes and optimize the patient's health-related quality of life. OBJECTIVE To evaluate the impact of a pharmacist-led education and counselling interventions on the health-related quality of life of patients living with epilepsy. METHODS A randomized controlled trial was carried out on epilepsy patients attending the neurology/medical out-patient clinics of two tertiary hospitals. Patients in the intervention group were offered education and counselling services. The impact of the interventions on the patients' quality of life in epilepsy was evaluated using the QOLIE-10P questionnaire. The research protocol was approved by the Health Research Ethics Committees of the University of Uyo Teaching Hospital and University of Calabar Teaching Hospital (Reference numbers: UUTH/AD/S/96/VOL.XIV/571 & UCTH/HREC/33/454). RESULTS There was a statistically significant difference between the usual care (UC) and the pharmaceutical care (PC) group on the quality of life in epilepsy scores post-intervention. Comparisons between groups (UC versus PC) revealed that patients in the PC group had a significantly higher QOLIE score than those in the UC group at 3 months and 6 months - (Pre-intervention: 8.73 versus 7.91; t = 0.619; p = 0.537), (3 months: 9.74 versus 15.37; t = -3.34; p = 0.01), (6 months: 11.59 versus 17.01; t = -3.137; p = 0.01). CONCLUSION Pharmacist-led education and counselling interventions may significantly improve the quality of life of patients with epilepsy.
Asian Journal of Research and Reports in Urology, Aug 16, 2021
Background: Benign prostatic hyperplasia (BPH) is one of the most common conditions in aging men.... more Background: Benign prostatic hyperplasia (BPH) is one of the most common conditions in aging men. Although BPH is not life threatening, the clinical manifestations such as lower urinary tract symptoms (LUTS) reduce patients' quality of life. BPH is associated with high healthcare costs and is a burden on the patients' families and society. Objective: To assess the incidence, treatment pattern, and direct cost of management of BPH in a tertiary hospital, in Eastern Nigeria. Methods: A retrospective descriptive assessment of case notes of patients diagnosed with BPH between September 2017 and August 2019. The treatment pattern was assessed for 12 months. Costs were calculated for BPH-related clinical procedures and medications. Results: The incidence rate of BPH in this population is 6.7%. One-hundred and two case notes were retrieved and evaluated. About 50.4% of the patients visited the hospital between 2 to 4 times, with a mean visit of 4.4 times a year. Ninety
Background: Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed... more Background: Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed that Angiotensin converting enzyme inhibitors (ACEIs) were often the least prescribed. However, the appropriate use of ACEIs in the black population achieves good blood pressure control and provides additional long term cardioand renovascular protection benefits. Objective: To assess the current utilization pattern of antihypertensive medicines with specific emphasis on identifying possible shift in the frequency of use of ACEIs. Methods: A prospective cross-sectional assessment of the current utilization pattern of anti-hypertensive medicines was conducted among 300 randomly selected cohort at a 900-bed premier Teaching Hospital located in Ibadan, Southwestern Nigeria. The current utilization pattern was compared with the results of a study conducted at the same site and published 10 years ago. Results: Of the 300 random cohorts, a majority (79%) were females (237) with mean age 58.7 years (SD=2.81 years. Stage 2 hypertension was the most frequent diagnosis (54.3%). The utilization of ACEIs and long acting CCB (amlodipine) significantly increased from 8.6% and 21% (Ten years ago) to 29.93% and 36.68% respectively (p ˂ 0.0001). The use of thiazide diuretic and methyldopa declined significantly from 39.4% and 23.3% (Ten years ago) to 16.12% and 9.7% respectively (p ˂ 0.0001). Adverse drug reactions due to ACEIs were documented in 1.5% (3), while laboratory monitoring of serum potassium, urea and creatinine was conducted in only 37% (111) of cohort. Potentially harmful drug-drug interactions were identified in 25% (75) of cohorts, and the most frequent were ACEIs + NSAIDs (53.3%), ACEIs + amiloride / hydrochlorothiazide (22.6%). Conclusions: Anti-hypertensive medicines utilization has significantly shifted towards the increased use of ACEIs and long acting dihydropyridine CCBs. The use of thiazides and methyldopa has declined significantly. Physicians appeared more cognizant of the long term cardio-and renovascular benefits inherent in using ACEIs in a high cardiovascular risk group such as black hypertensive.
Irish Journal of Medical Science (1971 -), 2021
Background The involvement of pharmacists in the provision of specialised care to patients with e... more Background The involvement of pharmacists in the provision of specialised care to patients with epilepsy is poor. Objective To evaluate the impact of pharmaceutical care services on the clinical outcomes of epilepsy. Setting Two selected major referral epilepsy treatment centres in southern Nigeria were used for the study. Patients were recruited from the Neurology and Medical out-patient clinics of the hospitals. Method An open randomised controlled study was carried out on epilepsy patients receiving clinical care at the selected hospitals. Patients in the intervention group were offered pharmaceutical care services. The impact of the pharmaceutical care services on the clinical outcomes of epilepsy (seizure frequency and severity) was evaluated. Main Outcome Measure The effect of pharmaceutical care services on seizure frequency and severity in patients with epilepsy. Results There was a statistically significant difference between the usual care (UC) and the pharmaceutical care ...
The lack of skilled attendants has been identified as a major factor responsible for the rising m... more The lack of skilled attendants has been identified as a major factor responsible for the rising maternal and infant mortality rate. There is sufficient evidence that traditional birth attendant-provided maternal health care has negative impacts on maternal health. Despite the presence of modern healthcare facilities, there is a rising patronage of traditional birth homes. This study seeks to determine the extent of patronage as well as the factors influencing the patronage of traditional birth homes in Akwa Ibom, Nigeria. A descriptive, cross sectional survey using structured, validated, and pre-tested questionnaires to interview 1,000 randomly selected women of child bearing age in Akwa Ibom, Nigeria. The questionnaire consisted of questions on demographic details, frequency of patronage of traditional birth attendant services as well as reasons for patronizing traditional birth homes.76.5% of our respondents reported that they patronized the ante-natal and child delivery services ...
Journal of Advances in Medical and Pharmaceutical Sciences, Mar 21, 2020
Objective: To determine the relationship between illness perception, medication adherence and hea... more Objective: To determine the relationship between illness perception, medication adherence and health related quality of life in patients living with epilepsy. Design: A cross-sectional prospective survey among patients living with epilepsy recruited from two tertiary referral centers in Nigeria. Methods: Patients' illness perception, adherence to antiepileptic drugs, and health related quality of life were determined using the brief illness perception questionnaire (BIPQ), the eight-item Morisky medication adherence scale (MMAS-8), and the patient weighted quality of life in epilepsy instrument (QOLIE-10-P) respectively. Correlation and linear regression analysis were used to test the relationship between the assessment variables. Statistical significance was set at p < 0.05.
Nigerian Journal of Pharmacy
Journal of Central Nervous System Disease
Background: Carbamazepine and valproate are widely used in the treatment of epileptic seizures. H... more Background: Carbamazepine and valproate are widely used in the treatment of epileptic seizures. However, these agents exhibit certain adverse effects including hematopoietic disorders (carbamazepine) and severe hepatotoxicity (valproate). Purpose: To determine the extent of monitoring of the hematologic effects of carbamazepine as well as the extent of monitoring of the hepatic effects of valproate in patients with epilepsy receiving treatment with these agents. Method: A cross-sectional antiepileptic drug use study using case notes of patients with epilepsy managed at the neurologic clinics of 2 tertiary medical facilities in Nigeria between January and December 2017. Results: Carbamazepine was the most frequently prescribed antiepileptic drug (48.24%), followed by valproate (29.34%) and levetiracetam (9.24%). Pretreatment monitoring of hematologic effect was carried out in only 61.11% of patients placed on carbamazepine therapy while follow-up monitoring was done in 3.7% of these ...
Journal of Pharmaceutical Research International
Purpose: Adherence to the chronic pharmacotherapeutic regimen is poor resulting in negative thera... more Purpose: Adherence to the chronic pharmacotherapeutic regimen is poor resulting in negative therapeutic outcomes. Health education has been shown to improve the adherence of patients to their antiepileptic medication. The Pharmacist has the responsibility of providing patient education and counselling in the context of pharmaceutical care. The study aims to evaluate the efficacy of pharmaceutical care intervention on patients' adherence to prescribed self-administered antiepileptic medications. Method: An opened, randomised, controlled, longitudinal and two-arm parallel prospective study with a 6-month patient follow up period was carried out on patients with epilepsy recruited from the medical and neurology outpatient clinics of two tertiary hospitals. Patients in the intervention group were provided with pharmaceutical care services. The impact of the pharmaceutical care intervention was evaluated by using the eight-Item Morisky Medication Adherence Scale. Repeated measure ANOVA was used to test the difference in the mean adherence score of the control and intervention groups over the time of intervention. The Pillai's Trace F was the corrected statistical test of choice for the model estimate, while the estimated effect was assessed with Partial etha.
Journal of Pharmaceutical Research International
British Journal of Pharmaceutical Research, 2016
Pharmacy Practice, 2014
Background: Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed... more Background: Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed that Angiotensin converting enzyme inhibitors (ACEIs) were often the least prescribed. However, the appropriate use of ACEIs in the black population achieves good blood pressure control and provides additional long term cardioand renovascular protection benefits. Objective: To assess the current utilization pattern of antihypertensive medicines with specific emphasis on identifying possible shift in the frequency of use of ACEIs. Methods: A prospective cross-sectional assessment of the current utilization pattern of anti-hypertensive medicines was conducted among 300 randomly selected cohort at a 900-bed premier Teaching Hospital located in Ibadan, Southwestern Nigeria. The current utilization pattern was compared with the results of a study conducted at the same site and published 10 years ago. Results: Of the 300 random cohorts, a majority (79%) were females (237) with mean age 58.7 years (SD=2.81 years. Stage 2 hypertension was the most frequent diagnosis (54.3%). The utilization of ACEIs and long acting CCB (amlodipine) significantly increased from 8.6% and 21% (Ten years ago) to 29.93% and 36.68% respectively (p ˂ 0.0001). The use of thiazide diuretic and methyldopa declined significantly from 39.4% and 23.3% (Ten years ago) to 16.12% and 9.7% respectively (p ˂ 0.0001). Adverse drug reactions due to ACEIs were documented in 1.5% (3), while laboratory monitoring of serum potassium, urea and creatinine was conducted in only 37% (111) of cohort. Potentially harmful drug-drug interactions were identified in 25% (75) of cohorts, and the most frequent were ACEIs + NSAIDs (53.3%), ACEIs + amiloride / hydrochlorothiazide (22.6%). Conclusions: Anti-hypertensive medicines utilization has significantly shifted towards the increased use of ACEIs and long acting dihydropyridine CCBs. The use of thiazides and methyldopa has declined significantly. Physicians appeared more cognizant of the long term cardio-and renovascular benefits inherent in using ACEIs in a high cardiovascular risk group such as black hypertensive.
Seizure
To evaluate the efficacy of a pharmacist implemented educational treatment programme in improving... more To evaluate the efficacy of a pharmacist implemented educational treatment programme in improving knowledge and perception of epilepsy among people with the condition. Method: A randomized controlled study was conducted on patients with epilepsy recruited from the medical and neurology outpatient clinics of two tertiary hospitals. Patients in the intervention group were offered an educational treatment programme implemented by a clinical pharmacist. The impact of the educational intervention was evaluated by using an epilepsy knowledge scale and the brief illness perception questionnaire. Results: There was a statistical significant difference between the control and intervention group over time on the knowledge of epilepsy, as the knowledge of epilepsy among patients in the intervention group significantly increased; F (2154) = 150.15, p = 0.000, Partial η 2 = 0.661. Also, there was a statistical significant difference between the control and intervention group over time on the perception of epilepsy, as the perception of epilepsy among patients in the intervention group significantly improved; F (2, 154) = 12.386, p = 0.000, Partial η 2 = 0.138. Conclusion: The Pharmacist implemented educational intervention improved patients' knowledge and perception of epilepsy. This finding has revealed the potential positive impact of pharmacists' involvement in the management of epilepsy.
Pharmacy practice, 2014
Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed that Angiot... more Previous studies of anti-hypertensive medicines utilization pattern in Nigeria showed that Angiotensin converting enzyme inhibitors (ACEIs) were often the least prescribed. However, the appropriate use of ACEIs in the black population achieves good blood pressure control and provides additional long term cardio- and renovascular protection benefits. To assess the current utilization pattern of antihypertensive medicines with specific emphasis on identifying possible shift in the frequency of use of ACEIs. A prospective cross-sectional assessment of the current utilization pattern of anti-hypertensive medicines was conducted among 300 randomly selected cohort at a 900-bed premier Teaching Hospital located in Ibadan, Southwestern Nigeria. The current utilization pattern was compared with the results of a study conducted at the same site and published 10 years ago. Of the 300 random cohorts, a majority (79%) were females (237) with mean age 58.7 years (SD=2.81 years. Stage 2 hypertensi...