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Papers by urvi khambhati

Research paper thumbnail of A Rare Case Report of Spontaneous Disassembly of Bipolar Hip Prosthesis in Elderly Patient

Journal of Orthopaedic Case Reports, 2020

Introduction: Hip fracture is an established health problem, especially in the elderly population... more Introduction: Hip fracture is an established health problem, especially in the elderly population and, its incidence is dramatically rising in the globe. The standard protocol of management in the elderly population for end-stage hip diseases and unstable femur fracture is bipolar hemiarthroplasty. Common complications of hip replacement include infection, fracture, dislocation, venous thrombosis, nerve palsy, chronic pain, and implant failure. In the literature, there are very few reported cases of disassembly of the implant in hemi replacement arthroplasty. Case Report: We, hereby, present a case of the spontaneous disassembly of the bipolar hip prosthesis, which was timely recognized and treated adequately in an elderly patient. Conclusion: The use of the cemented bipolar prosthesis can also lead to disassembly of the implant components and thereby the need for open reduction. Identification of the distinction between dislocation of head and disassembly of the prosthetic componen...

Research paper thumbnail of Understanding scale-up and quality risks on the interface between primary and secondary development

Research paper thumbnail of Does matrilin-3 gene polymorphism and primary knee osteoarthritis have a association in Indian population?

Journal of Orthopaedics and Spine, 2020

INTRODUCTION: Osteoarthritis (OA) is estimated to be the fourth-leading cause of disability. Resu... more INTRODUCTION: Osteoarthritis (OA) is estimated to be the fourth-leading cause of disability. Results from several studies have shown that OA is inherited and may vary by joint site. Twin family and studies have estimated the heritable component of OA to be between 50% and 65% with larger genetic influences for hand and hip OA than for knee OA. In view of the possible role of matrilin-3 (MATN-3) gene in primary OA, a number of studies during the past few years have evaluated the role of MATN-3 polymorphism in OA in various countries. SUBJECTS AND METHODS: The study was conducted in the Department of Orthopedics and Department of Bio-Technology in ERA's Lucknow Medical College and Hospital, Lucknow. Necessary blood (complete blood count, erythrocyte sedimentation rate, C reactive protein, rheumatoid arthritis factor, serum uric acid) and X-ray of the bilateral knee in investigations anteroposterior and lateral view on standing for confirmation of the diagnosis. Cases will be diagnosed with OA based on the Kellgren-LawrenceKL) Grading System. Five millimeters of venous blood will be drawn and poured in ethylenediaminetetraacetic acid-containing tubes. The DNA samples will be isolated from peripheral blood lymphocytes by the standard phenol extraction method. MATN-3 genotyping done from the blood. RESULTS: Statistically, the difference between the two groups was not significant (P = 0.603). No significant difference in genotype was observed among different KL-grades (P = 0.945). CONCLUSION: The findings of the present study showed that MATN-3 polymorphism does not seem to be associated with primary knee OA in the Indian population.

Research paper thumbnail of Radio imaging features of hip tuberculosis; journey from ancient to modern concept, and its mimickers

International Journal of Radiology and Diagnostic Imaging, 2020

Hip tuberculosis (TB) is second to the spine and only hence, the majority of cases visit the medi... more Hip tuberculosis (TB) is second to the spine and only hence, the majority of cases visit the medical clinic annually. In the early stages of hip TB, there is a diagnostic perplexity when plain X-rays are negative. Currently, diagnostic modalities have advanced compared to ancient times and, radio imaging features have become the backbone in proper diagnosis. When the disease has progressed gradually, definite radiological changes reveal on plain X-ray with the advent of time. Advanced diagnostic facilities such as ultrasonography (USG), magnetic resonance imaging (MRI), computed tomography (CT) scan as well as, nuclear medicine (in some instance), is universally established. Many radiologists referred hip TB as a double-edged sword in clinical practice as making a false diagnosis is potentially as harmful as missing the diagnosis in genuine cases. The incorrect diagnosis of hip TB results in the futile treatment as well as, the toxic side effects due to administered antitubercular drugs. A range of clinical situations mimics hip TB such as pyogenic arthritis (septic arthritis), transient synovitis, juvenile rheumatoid arthritis, and so on. Without radio imaging findings, it is extremely troublesome to make an accurate diagnosis. This review delineates radio imaging feature of hip TB and its mimickers, as well as, by the time, advancements in radio imaging concept of hip TB.

Research paper thumbnail of A rare case report of osteochondroma on dorsal surface of scapula

International Journal of Orthopaedics Sciences, 2019

Osteochondroma is one of the most common cartilage-capped outgrowth and it grows underneath the p... more Osteochondroma is one of the most common cartilage-capped outgrowth and it grows underneath the periosteum through ossification of the cartilage. Most common age of presentation is noted in second decade of life near long bones of knee joint which are distal end of femur and proximal end of tibia. Osteochondroma as seen radiologically are of two types: sessile and pedunculated seen as outgrowth from scapula. Occurrence of osteochondroma in scapula and in 1 st decade of life is very rare It mainly causes cosmetic disfigurement and pain due to fracture, malignant transformation or pseudowinging or compression of neural or vascular structures. Here presenting a rare case report of osteochondroma on dorsal surface of scapula treated with complete surgical excision and functional improvement of the patient.

Research paper thumbnail of Associations of computed tomography imaging findings and Glasgow coma scale in head trauma patients: A cross-sectional, observational study

International Journal of Radiology and Diagnostic Imaging, 2020

This cross-sectional, observational study was undertaken to find out the association between Glas... more This cross-sectional, observational study was undertaken to find out the association between Glasgow coma scale (GCS) with computed tomography (CT) findings in patients with head trauma (HT). Materials and Methods: In total, 100 participants were enrolled randomly during the period of December 2016 to December 2017. Patients having a history of HT who were advised for brain CT scan were included in the study. In each patient, GCS scoring was noted and, brain CT scans were performed without any medium of contrast. Results: Mean age of patients was 34.39± 18.31 years. Male: female ratio was 2.6:1. Adults' age group was more commonly involved, with 62% of cases seen in 18-45 years of age group. The most prevalent cause of HT was a road traffic accident in 64% cases, followed by physical assaults in 20% and falls from height in16%. According to GCS, the distribution of patients was estimated to be 44% with mild HT (GCS 13-15), 46% with moderate HT (GCS 9-12) and 10% with severe HT (GCS 3-8). GCS scoring and CT findings (extra-axial hematoma, subarachnoid haemorrhage, fracture of skull bones, contusion, hemosinus, midline shift and pattern of three or more findings) were significantly associated. There was a significant difference in the average GCS of events with a single lesion (M=13.62, SD=0.49) and multiple lesions (M=10.48, SD=1.88); P<0.0001. In addition, the average GCS of the events with multiple lesions and multiple lesions events together with midline shift (7.85±1.61) was also statistically significant (P<0.0001). Conclusion: There was a significant association between GCS and CT findings in HT cases. The existence of multiple lesions with midline shift in CT scan findings was accompanied with low GCS score, whereas, patients with single lesion had a greater level of GCS.

Research paper thumbnail of A Rare Case Report of Spontaneous Disassembly of Bipolar Hip Prosthesis in Elderly Patient

Journal of Orthopaedic Case Reports, 2020

Introduction: Hip fracture is an established health problem, especially in the elderly population... more Introduction: Hip fracture is an established health problem, especially in the elderly population and, its incidence is dramatically rising in the globe. The standard protocol of management in the elderly population for end-stage hip diseases and unstable femur fracture is bipolar hemiarthroplasty. Common complications of hip replacement include infection, fracture, dislocation, venous thrombosis, nerve palsy, chronic pain, and implant failure. In the literature, there are very few reported cases of disassembly of the implant in hemi replacement arthroplasty. Case Report: We, hereby, present a case of the spontaneous disassembly of the bipolar hip prosthesis, which was timely recognized and treated adequately in an elderly patient. Conclusion: The use of the cemented bipolar prosthesis can also lead to disassembly of the implant components and thereby the need for open reduction. Identification of the distinction between dislocation of head and disassembly of the prosthetic componen...

Research paper thumbnail of Understanding scale-up and quality risks on the interface between primary and secondary development

Research paper thumbnail of Does matrilin-3 gene polymorphism and primary knee osteoarthritis have a association in Indian population?

Journal of Orthopaedics and Spine, 2020

INTRODUCTION: Osteoarthritis (OA) is estimated to be the fourth-leading cause of disability. Resu... more INTRODUCTION: Osteoarthritis (OA) is estimated to be the fourth-leading cause of disability. Results from several studies have shown that OA is inherited and may vary by joint site. Twin family and studies have estimated the heritable component of OA to be between 50% and 65% with larger genetic influences for hand and hip OA than for knee OA. In view of the possible role of matrilin-3 (MATN-3) gene in primary OA, a number of studies during the past few years have evaluated the role of MATN-3 polymorphism in OA in various countries. SUBJECTS AND METHODS: The study was conducted in the Department of Orthopedics and Department of Bio-Technology in ERA's Lucknow Medical College and Hospital, Lucknow. Necessary blood (complete blood count, erythrocyte sedimentation rate, C reactive protein, rheumatoid arthritis factor, serum uric acid) and X-ray of the bilateral knee in investigations anteroposterior and lateral view on standing for confirmation of the diagnosis. Cases will be diagnosed with OA based on the Kellgren-LawrenceKL) Grading System. Five millimeters of venous blood will be drawn and poured in ethylenediaminetetraacetic acid-containing tubes. The DNA samples will be isolated from peripheral blood lymphocytes by the standard phenol extraction method. MATN-3 genotyping done from the blood. RESULTS: Statistically, the difference between the two groups was not significant (P = 0.603). No significant difference in genotype was observed among different KL-grades (P = 0.945). CONCLUSION: The findings of the present study showed that MATN-3 polymorphism does not seem to be associated with primary knee OA in the Indian population.

Research paper thumbnail of Radio imaging features of hip tuberculosis; journey from ancient to modern concept, and its mimickers

International Journal of Radiology and Diagnostic Imaging, 2020

Hip tuberculosis (TB) is second to the spine and only hence, the majority of cases visit the medi... more Hip tuberculosis (TB) is second to the spine and only hence, the majority of cases visit the medical clinic annually. In the early stages of hip TB, there is a diagnostic perplexity when plain X-rays are negative. Currently, diagnostic modalities have advanced compared to ancient times and, radio imaging features have become the backbone in proper diagnosis. When the disease has progressed gradually, definite radiological changes reveal on plain X-ray with the advent of time. Advanced diagnostic facilities such as ultrasonography (USG), magnetic resonance imaging (MRI), computed tomography (CT) scan as well as, nuclear medicine (in some instance), is universally established. Many radiologists referred hip TB as a double-edged sword in clinical practice as making a false diagnosis is potentially as harmful as missing the diagnosis in genuine cases. The incorrect diagnosis of hip TB results in the futile treatment as well as, the toxic side effects due to administered antitubercular drugs. A range of clinical situations mimics hip TB such as pyogenic arthritis (septic arthritis), transient synovitis, juvenile rheumatoid arthritis, and so on. Without radio imaging findings, it is extremely troublesome to make an accurate diagnosis. This review delineates radio imaging feature of hip TB and its mimickers, as well as, by the time, advancements in radio imaging concept of hip TB.

Research paper thumbnail of A rare case report of osteochondroma on dorsal surface of scapula

International Journal of Orthopaedics Sciences, 2019

Osteochondroma is one of the most common cartilage-capped outgrowth and it grows underneath the p... more Osteochondroma is one of the most common cartilage-capped outgrowth and it grows underneath the periosteum through ossification of the cartilage. Most common age of presentation is noted in second decade of life near long bones of knee joint which are distal end of femur and proximal end of tibia. Osteochondroma as seen radiologically are of two types: sessile and pedunculated seen as outgrowth from scapula. Occurrence of osteochondroma in scapula and in 1 st decade of life is very rare It mainly causes cosmetic disfigurement and pain due to fracture, malignant transformation or pseudowinging or compression of neural or vascular structures. Here presenting a rare case report of osteochondroma on dorsal surface of scapula treated with complete surgical excision and functional improvement of the patient.

Research paper thumbnail of Associations of computed tomography imaging findings and Glasgow coma scale in head trauma patients: A cross-sectional, observational study

International Journal of Radiology and Diagnostic Imaging, 2020

This cross-sectional, observational study was undertaken to find out the association between Glas... more This cross-sectional, observational study was undertaken to find out the association between Glasgow coma scale (GCS) with computed tomography (CT) findings in patients with head trauma (HT). Materials and Methods: In total, 100 participants were enrolled randomly during the period of December 2016 to December 2017. Patients having a history of HT who were advised for brain CT scan were included in the study. In each patient, GCS scoring was noted and, brain CT scans were performed without any medium of contrast. Results: Mean age of patients was 34.39± 18.31 years. Male: female ratio was 2.6:1. Adults' age group was more commonly involved, with 62% of cases seen in 18-45 years of age group. The most prevalent cause of HT was a road traffic accident in 64% cases, followed by physical assaults in 20% and falls from height in16%. According to GCS, the distribution of patients was estimated to be 44% with mild HT (GCS 13-15), 46% with moderate HT (GCS 9-12) and 10% with severe HT (GCS 3-8). GCS scoring and CT findings (extra-axial hematoma, subarachnoid haemorrhage, fracture of skull bones, contusion, hemosinus, midline shift and pattern of three or more findings) were significantly associated. There was a significant difference in the average GCS of events with a single lesion (M=13.62, SD=0.49) and multiple lesions (M=10.48, SD=1.88); P<0.0001. In addition, the average GCS of the events with multiple lesions and multiple lesions events together with midline shift (7.85±1.61) was also statistically significant (P<0.0001). Conclusion: There was a significant association between GCS and CT findings in HT cases. The existence of multiple lesions with midline shift in CT scan findings was accompanied with low GCS score, whereas, patients with single lesion had a greater level of GCS.