valentina puntmann - Academia.edu (original) (raw)

Uploads

Papers by valentina puntmann

Research paper thumbnail of Atherosclerosis and oxidant stress: The end of the road for antioxidant vitamin treatment?

Cardiovascular Drugs and Therapy, 2007

Research paper thumbnail of These abstracts have been selected for VIEWING only as ePosters and in print. ePosters will be available on Screen A & B throughout the meeting, Print Posters at the times indicated below. Please refer to the PROGRAM for more details

Research paper thumbnail of Ischemic burden and clinical outcome: is one 'culprit' ischemic segment by dobutamine stress magnetic resonance predictive?

Research paper thumbnail of 130 Reproducibility of T1 and T2 Mapping in Health and Disease, and Assessment of T2 Variability Across the Normal Myocardium

Heart (British Cardiac Society)

ABSTRACT T1 and T2 mapping detect myocardial fibrosis and oedema respectively. T1 values show seg... more ABSTRACT T1 and T2 mapping detect myocardial fibrosis and oedema respectively. T1 values show segmental variation in mid ventricular SAX slice, making the identification of regional pathology difficult.We tested the reproducibility of T1 and T2 mapping in health and disease and regional variations of T2 values.

Research paper thumbnail of Prevalence of myocardial crypts in a large retrospective cohort study by cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance

Background: Myocardial crypts are discrete clefts or fissures in otherwise compacted myocardium o... more Background: Myocardial crypts are discrete clefts or fissures in otherwise compacted myocardium of the left ventricle (LV). Recent reports suggest a higher prevalence of crypts in patients with hypertrophic cardiomyopathy (HCM) and also within small samples of genotype positive but phenotype negative relatives. The presence of a crypt has been suggested to be a predictor of gene carrier status. However, the prevalence and clinical significance of crypts in the general population is unclear. We aimed to determine the prevalence of myocardial crypts in a large cohort of subjects using clinical cardiovascular magnetic resonance (CMR). Methods: Consecutive subjects referred for clinical CMR during a 12-month period (n = 1020, age 52.6 ± 17, males: 61%) were included. Crypts were defined as >50% invagination into normal myocardium and their overall prevalence, location and shape was investigated and compared between different patient groups. Results: The overall prevalence of crypts was 64/1020 (6.3%). In a predefined 'normal' control group the prevalence was lower (11/306, 3.6%, p = 0.031), but were equally prevalent in ischemic heart disease (12/236, 5.1%, p = n/s) and the combined non-ischemic cardiomyopathy (NICM) groups (24/373; 6.4%, p = n/s). Within the NICM group, crypts were significantly more common in HCM (9/76, 11.7%, p = 0.04) and hypertensive CM subjects (3/11, 27%, p = 0.03). In patients referred for CMR for family screening of inherited forms of CM, crypts were significantly more prevalent (10/41, 23%, p < 0.001), including a smaller group with a first degree relative with HCM (3/9, 33%, p = 0.01). Conclusion: Myocardial crypts are relatively common in the normal population, and increasingly common in HCM and hypertensive cardiomyopathy. Crypts are also more frequently seen in normal phenotype subjects referred because of a family history of an inherited cardiomyopathy and HCM specifically. It is uncertain what the significance of crypts are in this group, and because of variability in the imaging protocols used and their relative frequency within the normal population, should not be used to clinically stratify these patients. Prospective studies are required to confirm the clinical significance of myocardial crypts, as their significance remains unclear.

Research paper thumbnail of Native T1 in Discrimination of Acute and Convalescent Stages in Patients With Clinical Diagnosis of Myocarditis A Proposed Diagnostic Algorithm Using CMR

JACC. Cardiovascular imaging

OBJECTIVES We investigated whether T1 mapping by cardiac magnetic resonance (CMR) reflects the cl... more OBJECTIVES We investigated whether T1 mapping by cardiac magnetic resonance (CMR) reflects the clinical evolution of disease in myocarditis and supports its diagnosis independently of the disease stages.

Research paper thumbnail of Aortic stiffness in the presence of self-limiting and sustained systemic inflammation: comparison of acute myocarditis and chronic inflammatory diseases

Journal of Cardiovascular Magnetic Resonance, 2014

Research paper thumbnail of T1 values in discrimination between health and disease using different T1 sequences: comparison between 3'3'5-MOLLI, 3'5-MOLLI, shMOLLI and SASHA

Journal of Cardiovascular Magnetic Resonance, 2014

Research paper thumbnail of Myocardial T2 mapping for improved detection of inflammatory myocardial involvement in acute and chronic myocarditis

Journal of Cardiovascular Magnetic Resonance, 2014

Research paper thumbnail of Aortic Stiffness and Interstitial Myocardial Fibrosis by Native T1 Are Independently Associated With Left Ventricular Remodeling in Patients With Dilated Cardiomyopathy

Research paper thumbnail of Atherosclerosis and oxidant stress: The end of the road for antioxidant vitamin treatment?

Cardiovascular Drugs and Therapy, 2007

Research paper thumbnail of These abstracts have been selected for VIEWING only as ePosters and in print. ePosters will be available on Screen A & B throughout the meeting, Print Posters at the times indicated below. Please refer to the PROGRAM for more details

Research paper thumbnail of Ischemic burden and clinical outcome: is one 'culprit' ischemic segment by dobutamine stress magnetic resonance predictive?

Research paper thumbnail of 130 Reproducibility of T1 and T2 Mapping in Health and Disease, and Assessment of T2 Variability Across the Normal Myocardium

Heart (British Cardiac Society)

ABSTRACT T1 and T2 mapping detect myocardial fibrosis and oedema respectively. T1 values show seg... more ABSTRACT T1 and T2 mapping detect myocardial fibrosis and oedema respectively. T1 values show segmental variation in mid ventricular SAX slice, making the identification of regional pathology difficult.We tested the reproducibility of T1 and T2 mapping in health and disease and regional variations of T2 values.

Research paper thumbnail of Prevalence of myocardial crypts in a large retrospective cohort study by cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance

Background: Myocardial crypts are discrete clefts or fissures in otherwise compacted myocardium o... more Background: Myocardial crypts are discrete clefts or fissures in otherwise compacted myocardium of the left ventricle (LV). Recent reports suggest a higher prevalence of crypts in patients with hypertrophic cardiomyopathy (HCM) and also within small samples of genotype positive but phenotype negative relatives. The presence of a crypt has been suggested to be a predictor of gene carrier status. However, the prevalence and clinical significance of crypts in the general population is unclear. We aimed to determine the prevalence of myocardial crypts in a large cohort of subjects using clinical cardiovascular magnetic resonance (CMR). Methods: Consecutive subjects referred for clinical CMR during a 12-month period (n = 1020, age 52.6 ± 17, males: 61%) were included. Crypts were defined as >50% invagination into normal myocardium and their overall prevalence, location and shape was investigated and compared between different patient groups. Results: The overall prevalence of crypts was 64/1020 (6.3%). In a predefined 'normal' control group the prevalence was lower (11/306, 3.6%, p = 0.031), but were equally prevalent in ischemic heart disease (12/236, 5.1%, p = n/s) and the combined non-ischemic cardiomyopathy (NICM) groups (24/373; 6.4%, p = n/s). Within the NICM group, crypts were significantly more common in HCM (9/76, 11.7%, p = 0.04) and hypertensive CM subjects (3/11, 27%, p = 0.03). In patients referred for CMR for family screening of inherited forms of CM, crypts were significantly more prevalent (10/41, 23%, p < 0.001), including a smaller group with a first degree relative with HCM (3/9, 33%, p = 0.01). Conclusion: Myocardial crypts are relatively common in the normal population, and increasingly common in HCM and hypertensive cardiomyopathy. Crypts are also more frequently seen in normal phenotype subjects referred because of a family history of an inherited cardiomyopathy and HCM specifically. It is uncertain what the significance of crypts are in this group, and because of variability in the imaging protocols used and their relative frequency within the normal population, should not be used to clinically stratify these patients. Prospective studies are required to confirm the clinical significance of myocardial crypts, as their significance remains unclear.

Research paper thumbnail of Native T1 in Discrimination of Acute and Convalescent Stages in Patients With Clinical Diagnosis of Myocarditis A Proposed Diagnostic Algorithm Using CMR

JACC. Cardiovascular imaging

OBJECTIVES We investigated whether T1 mapping by cardiac magnetic resonance (CMR) reflects the cl... more OBJECTIVES We investigated whether T1 mapping by cardiac magnetic resonance (CMR) reflects the clinical evolution of disease in myocarditis and supports its diagnosis independently of the disease stages.

Research paper thumbnail of Aortic stiffness in the presence of self-limiting and sustained systemic inflammation: comparison of acute myocarditis and chronic inflammatory diseases

Journal of Cardiovascular Magnetic Resonance, 2014

Research paper thumbnail of T1 values in discrimination between health and disease using different T1 sequences: comparison between 3'3'5-MOLLI, 3'5-MOLLI, shMOLLI and SASHA

Journal of Cardiovascular Magnetic Resonance, 2014

Research paper thumbnail of Myocardial T2 mapping for improved detection of inflammatory myocardial involvement in acute and chronic myocarditis

Journal of Cardiovascular Magnetic Resonance, 2014

Research paper thumbnail of Aortic Stiffness and Interstitial Myocardial Fibrosis by Native T1 Are Independently Associated With Left Ventricular Remodeling in Patients With Dilated Cardiomyopathy