valentin oprea - Academia.edu (original) (raw)
Papers by valentin oprea
Medicina
Abdominal cystic masses are diagnosed during the intrauterine period and have a relatively low in... more Abdominal cystic masses are diagnosed during the intrauterine period and have a relatively low incidence. Fetal ovarian cysts are the most common form diagnosed prenatally or immediately after birth. The pathophysiology of the development of these types of tumors is not fully elucidated, with ovarian hyperstimulation caused by maternal and placental hormones being the most accepted hypothesis. During intrauterine development, the diagnosis of fetal ovarian cysts is most often made accidentally during usual check-up ultrasounds corresponding to the first, second, and third trimesters of pregnancy. We conducted a scoping review with the aim to map the current knowledge regarding the treatment of fetal ovarian cysts diagnosed in the intrauterine period. Focusing on the articles published in the last 10 years in the specialized literature, we tried to identify a conceptualization regarding the surveillance and treatment of these anomalies.
The Journal of Surgery
ABSTRACT
Chirurgia (Bucharest, Romania : 1990)
Even they are considered inert and biocompatible, prosthetic materials induce a local inflammator... more Even they are considered inert and biocompatible, prosthetic materials induce a local inflammatory response with the host despite of their composition and structure. This reaction is responsible for most of the long-term complications of the prosthetic repair of abdominal wall defects. Unfortunately, most of the published studies are the results of animal experiments. Our study analyses the prosthetic materials extruded from humans for various reasons. 15 prosthetic samples extruded from human patients for various reasons were analyzed. This were prepared with standard colorations (eosin - hematoxilin), for collagen (rethiculyn, Syrius red) and immunohistochemical in order to count inflammatory cells, fibroblasts, collagen fibers, blood vessels. 10 polypropilene (Prolene) and 5 polyester (Mersilene) samples extruded from 11 male patients and 5 female patients with the age between 36 and 73 years old (average 57.46 +/- 9.7) have been studied. Average implantation period was 15.13 +/-...
2010 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR), 2010
This paper is devoted to investigate numerical optimization algorithms of the theory of deformabl... more This paper is devoted to investigate numerical optimization algorithms of the theory of deformable surfaces and to emphasize some of their computerized applications in medical image analysis and prosthetic surgery. After defining the 3D variational deformable model, both in static and dynamic form, an algorithm for finding the optimal deformable surface is presented, together with estimations for its approximation error and a condition for its convergence. Finally, a statistical modeling and a corresponding algorithm applied in surgery are presented.
Hernia, 2022
Data about abdominal wall function in patients with incisional hernias (IH) are limited. Abdomina... more Data about abdominal wall function in patients with incisional hernias (IH) are limited. Abdominal Wall Reconstruction (AWR) could be beneficial for the improvement of this function. The goal of the study was to evaluate if the abdominal wall function was restored after transversus abdominis muscle release (TAR). We performed a prospective case-control study of 59 patients with IH equal or larger than 10 cm in their width undergoing AWR via TAR with mesh reinforcement and complete linea alba restoration. With two simple physical tests-Trunk Raising (TR) and Double Leg Lowering (DLL), we clinically assessed, preoperatively, 1 month and 1 year postoperatively the functionality of the abdominal wall (flexion). Patients were compared with a control group (n = 57) with an intact abdominal wall undergoing visceral surgery through a midline laparotomy. There were no differences between the groups in terms of sex and mean age. In the study group, TR demonstrated an increase from 1.93 preoperatively to 2.44 at 1 month and 4.27, respectively, at 1 year postoperatively (p < 0.001). DLL was improved from 2.067 to 4.37 at 1 year postoperatively (p = 0.016). In the control group, surgery resulted in a decrease of truncal flexion. At 1 year postoperatively, the abdominal wall function for study group patients was almost identical with that the functionality of the control group featuring an intact abdominal wall (TR 4.26 vs 4.33 p = 0.532; DLL 4.42 vs 4.21 p = 0.193). AWR via TAR for large IH specifically improved long-term abdominal wall muscular function.
Hernia, 2021
Introduction Among many other techniques for Abdominal Wall Reconstruction (AWR), posterior compo... more Introduction Among many other techniques for Abdominal Wall Reconstruction (AWR), posterior component separation with Transversus Abdominis Release (TAR), continues to gain popularity and it is increasingly used with promising longterm results. Our goal was to evaluate the influence of TAR with mesh retromuscular reinforcement on the intra-abdominal pressure (IAP) and respiratory function in a series of patients with complex incisional hernias (IH). Methods Since November 2014 through February 2019, patients with TAR were identified in the Clinical Department of Surgery database and were retrospectively reviewed. Outcome measures include: demographics, pre-and perioperative details, preoperative and postoperative IAP and plateau pressure (PP). Results One-hundred-and-one consecutive TAR procedures (19.7% from all incisional hernia repairs) were analyzed. Mean age was 63 years with a mean Body Mass Index (BMI) of 31.85 kg/m 2 (25-51). Diabetes and Chronic Obstructive Pulmonary Disease (COPD) were the main major comorbidities. Mean hernia defect area was 247 cm 2 (104-528 cm 2). Conclusion TAR is a safe and sound procedure with acceptable modifications of the IAP morbidity and recurrence rate when correctly performed on the right patient.
Chirurgia (Bucharest, Romania : 1990)
forced repair of a giant abdominal wall defect end with unsatisfactory results despite developmen... more forced repair of a giant abdominal wall defect end with unsatisfactory results despite development of prosthetics materials. The enlargement of abdominal wall dimensions could be realized altogether other methods with the aid of pneumo-peritoneum. The aim of the study is to evaluate early results of the method used for patients with giant incisional hernias. between june 1998 - june 2013, 17 patients (4 males) with giant abdominal wall defects (incisional and inguinal hernias) were prepaired for radical surgery with pneumoperitoneum. Average age was 64.35 years. We reevaluated the standard constants of the pulmonary function,blood gases, and intra-vesical pressure in 3 moments: before the first gas insuflation, 24 hours before surgery and in the 7th daypost operatively. the method was free of accidents or incidents, no mortality was recorded. The respiratory function was significantly increased and also the intra-abdominal pressure. our results suggest that the method of progressive...
Indian Journal of Surgery
Closing the midline in patients with incisional hernias is the cornerstone for a functional recon... more Closing the midline in patients with incisional hernias is the cornerstone for a functional reconstruction with low morbidity, low recurrence rates, and good cosmetic results, which is the ideal outcome for every hernia surgeon. However, in patients with large hernias (usually over 10 cm width) or in loss of domain cases, this goal is difficult to achieve. Anterior component separation with or without mesh reinforcement has been the procedure of choice for these patients despite its high rate of wound complications. The goal of our study is to evaluate the opportunity and necessity of the anterior component separation in patients with complex incisional or ventral hernias (defects larger than 10 cm, infected meshes). Data of patients with large incisional/ventral hernia operated using anterior component separation technique in the past 10 years were re-visited and analyzed from hospital records between January 2012 and December 2020. Demographic data (age, gender, body mass index, A...
Background Umbilical and epigastric hernias are sometimes associated with rectus muscle divaricat... more Background Umbilical and epigastric hernias are sometimes associated with rectus muscle divarication. Isolated repair of the hernia defect can have a high recurrence rate and bad cosmetic results .With this condition the repair of both pathologies is mandatory. The goal of the study is to detail some technical aspects of the endoscopic retro-rectus mesh repair. Methods We present a small series of 15 patients operated for primary or incisional ventral hernias associated with rectus diastasis. The width of the defect was under 6 cm. The performed procedure was eRives repair. Results There were no perioperative complications or short term recurrences. Conclusions In our opinion eTEP access Rives Stoppa repair is the best choice for ventral hernias associating rectus diastasis. The technique has to be promoted for its cosmetic results, reproducibility and for acquiring the principles of modern hernia surgery. Key words: umbilical hernia, diastasis recti, extended-view totally extraperi...
Chirurgia, 2021
Background: The treatment of incisional hernias has radically changed over the last 50 years due ... more Background: The treatment of incisional hernias has radically changed over the last 50 years due to the introduction of mesh repair, which has been proven to be superior to tissue repairs in terms of recurrence. Severe complications such as bacterial contamination, enteral fistulas and severe visceral adhesions are the bane of mesh repair and lead to great challenges as far as treatment is concerned. Methods: From January 2009 to December 2018, we retrospectively collected operative and outcome data on reoperation following septic complications of incisional hernias (IH) mesh repair in 89 patients. For adjustment, comorbidities, mesh location, prognostic nutritional index (PNI) and operative time were included in an SPSS data analyzer. Results: in the referred interval 89 patients (29 males) met the inclusion criteria. The mean time for the onset of infections 15.04+-0.95 months and the number of previous abdominal interventions varied from 1 to 5. Wound infections were reported to ...
JSLS : Journal of the Society of Laparoscopic & Robotic Surgeons
Background: Both umbilical and epigastric hernias may be associated with rectus muscle divaricati... more Background: Both umbilical and epigastric hernias may be associated with rectus muscle divarication. In such cases, isolated repair of combined hernia defects can have high recurrence rates and poorer cosmetic outcomes, thus the repair of both pathologies ought to be favored. The goal of the study below is to provide detailed technical aspects of the endoscopic retro-rectus mesh repair. Methods: We chose a group of 16 patients who underwent the repair of ventral hernias associated with both primary and incisional rectus diastasis, using the extended-view of a totally extraperitoneal Rives-Stoppa repair (eRives) technique. All defects were < 6 cm in width. Our outcome measures perioperative complications and early recurrences. Results: The approach used in our study has led to zero cases of perioperative complications and only one early recurrence. Conclusions: We believe that the e-Rives repair is the optimal approach for ventral hernias associated with diastasis recti. This technique additionally produces favorable cosmetic outcomes that granted our results a well-deserved recognition in the medical literature.
International Journal of Abdominal Wall and Hernia Surgery
BACKGROUND: Incisional hernia (IH) is the most frequent complication of laparotomy with an increa... more BACKGROUND: Incisional hernia (IH) is the most frequent complication of laparotomy with an increasing incidence over time. A large amount of them present in complex forms with large defects or even loss of domain. There is still no consensus regarding the optimal surgical approach for this IHs. The posterior component separation with transversus abdominis release (TAR) alone or in combination with augmentation of the abdominal wall became the standard of repair in large IHs (LIH). No clear evidence that TAR alone can recreate the normal volume of the peritoneal cavity is available. We assessed if it is possible to reconstruct normal peritoneal volume (PV) by TAR. MATERIALS AND METHODS: In this retrospective study, data from LIH patients with midline defects equal or larger than 10 cm width, and computed tomography scans available before and 1-week after TAR with complete fascial closure were analyzed. Hernia sac volume (HSV), abdominal cavity volume (ACV), and (PV = HSV + ACV) were evaluated before surgery. Peritoneal index (PI) was calculated as HSV/PV ratio. PV was measured at 7 days post-TAR (PVTAR). The compliance of the abdominal wall (Cab) was calculated as the ratio between the difference of the PV before surgery and after TAR and the difference between preoperative intra-abdominal pressure (IAP) and postoperative IAP. RESULTS: 23 consecutive patients with a mean age of 64 years were included in the study. The mean value of the HSV was 3,775 cm3 and of the ACV 8377 cm3. PI varied between 0.22 and 0.4. A statistically insignificant difference was recorded between PV and PVTAR(P = 0.7). Patients with PI ≥0.3 had the volume of the peritoneal cavity lesser than patients with PI <0.3. The compliance of the abdominal wall was decreased for the patients with defects larger than 15 cm width and PI larger than 0.33. Urine output in the first postoperative day was smaller in the patients with PI larger than 0.3 with a statistically significant (P = 0.0002) difference and was highly correlated with the abdominal perfusion pressure (APP) and PI. CONCLUSIONS: TAR is able to recreate normal PV in LIH patients with PI <0.3. When PI is larger than 0.33, a permissive intraabdominal hypertension develops for 24 h with the reduction of the APP and of the urine output. In this condition, the augmentation of the abdominal wall could be considered as an option by preoperative administration of pneumoperitoneum and/or Botulin toxin.
Mathematics
The stability of receiver operating characteristic in context of random split used in development... more The stability of receiver operating characteristic in context of random split used in development and validation sets, as compared to the full models for three inflammatory ratios (neutrophil-to-lymphocyte (NLR), derived neutrophil-to-lymphocyte (dNLR) and platelet-to-lymphocyte (PLR) ratio) evaluated as predictors for metastasis in patients with colorectal cancer, was investigated. Data belonging to patients admitted with the diagnosis of colorectal cancer from January 2014 until September 2019 in a single hospital were used. There were 1688 patients eligible for the study, 418 in the metastatic stage. All investigated inflammatory ratios proved to be significant classification models on both the full models and on cross-validations (AUCs > 0.05). High variability of the cut-off values was observed in the unrestricted and restricted split (full models: 4.255 for NLR, 2.745 for dNLR and 255.56 for PLR; random splits: cut-off from 3.215 to 5.905 for NLR, from 2.625 to 3.575 for dN...
Medicina
Abdominal cystic masses are diagnosed during the intrauterine period and have a relatively low in... more Abdominal cystic masses are diagnosed during the intrauterine period and have a relatively low incidence. Fetal ovarian cysts are the most common form diagnosed prenatally or immediately after birth. The pathophysiology of the development of these types of tumors is not fully elucidated, with ovarian hyperstimulation caused by maternal and placental hormones being the most accepted hypothesis. During intrauterine development, the diagnosis of fetal ovarian cysts is most often made accidentally during usual check-up ultrasounds corresponding to the first, second, and third trimesters of pregnancy. We conducted a scoping review with the aim to map the current knowledge regarding the treatment of fetal ovarian cysts diagnosed in the intrauterine period. Focusing on the articles published in the last 10 years in the specialized literature, we tried to identify a conceptualization regarding the surveillance and treatment of these anomalies.
The Journal of Surgery
ABSTRACT
Chirurgia (Bucharest, Romania : 1990)
Even they are considered inert and biocompatible, prosthetic materials induce a local inflammator... more Even they are considered inert and biocompatible, prosthetic materials induce a local inflammatory response with the host despite of their composition and structure. This reaction is responsible for most of the long-term complications of the prosthetic repair of abdominal wall defects. Unfortunately, most of the published studies are the results of animal experiments. Our study analyses the prosthetic materials extruded from humans for various reasons. 15 prosthetic samples extruded from human patients for various reasons were analyzed. This were prepared with standard colorations (eosin - hematoxilin), for collagen (rethiculyn, Syrius red) and immunohistochemical in order to count inflammatory cells, fibroblasts, collagen fibers, blood vessels. 10 polypropilene (Prolene) and 5 polyester (Mersilene) samples extruded from 11 male patients and 5 female patients with the age between 36 and 73 years old (average 57.46 +/- 9.7) have been studied. Average implantation period was 15.13 +/-...
2010 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR), 2010
This paper is devoted to investigate numerical optimization algorithms of the theory of deformabl... more This paper is devoted to investigate numerical optimization algorithms of the theory of deformable surfaces and to emphasize some of their computerized applications in medical image analysis and prosthetic surgery. After defining the 3D variational deformable model, both in static and dynamic form, an algorithm for finding the optimal deformable surface is presented, together with estimations for its approximation error and a condition for its convergence. Finally, a statistical modeling and a corresponding algorithm applied in surgery are presented.
Hernia, 2022
Data about abdominal wall function in patients with incisional hernias (IH) are limited. Abdomina... more Data about abdominal wall function in patients with incisional hernias (IH) are limited. Abdominal Wall Reconstruction (AWR) could be beneficial for the improvement of this function. The goal of the study was to evaluate if the abdominal wall function was restored after transversus abdominis muscle release (TAR). We performed a prospective case-control study of 59 patients with IH equal or larger than 10 cm in their width undergoing AWR via TAR with mesh reinforcement and complete linea alba restoration. With two simple physical tests-Trunk Raising (TR) and Double Leg Lowering (DLL), we clinically assessed, preoperatively, 1 month and 1 year postoperatively the functionality of the abdominal wall (flexion). Patients were compared with a control group (n = 57) with an intact abdominal wall undergoing visceral surgery through a midline laparotomy. There were no differences between the groups in terms of sex and mean age. In the study group, TR demonstrated an increase from 1.93 preoperatively to 2.44 at 1 month and 4.27, respectively, at 1 year postoperatively (p < 0.001). DLL was improved from 2.067 to 4.37 at 1 year postoperatively (p = 0.016). In the control group, surgery resulted in a decrease of truncal flexion. At 1 year postoperatively, the abdominal wall function for study group patients was almost identical with that the functionality of the control group featuring an intact abdominal wall (TR 4.26 vs 4.33 p = 0.532; DLL 4.42 vs 4.21 p = 0.193). AWR via TAR for large IH specifically improved long-term abdominal wall muscular function.
Hernia, 2021
Introduction Among many other techniques for Abdominal Wall Reconstruction (AWR), posterior compo... more Introduction Among many other techniques for Abdominal Wall Reconstruction (AWR), posterior component separation with Transversus Abdominis Release (TAR), continues to gain popularity and it is increasingly used with promising longterm results. Our goal was to evaluate the influence of TAR with mesh retromuscular reinforcement on the intra-abdominal pressure (IAP) and respiratory function in a series of patients with complex incisional hernias (IH). Methods Since November 2014 through February 2019, patients with TAR were identified in the Clinical Department of Surgery database and were retrospectively reviewed. Outcome measures include: demographics, pre-and perioperative details, preoperative and postoperative IAP and plateau pressure (PP). Results One-hundred-and-one consecutive TAR procedures (19.7% from all incisional hernia repairs) were analyzed. Mean age was 63 years with a mean Body Mass Index (BMI) of 31.85 kg/m 2 (25-51). Diabetes and Chronic Obstructive Pulmonary Disease (COPD) were the main major comorbidities. Mean hernia defect area was 247 cm 2 (104-528 cm 2). Conclusion TAR is a safe and sound procedure with acceptable modifications of the IAP morbidity and recurrence rate when correctly performed on the right patient.
Chirurgia (Bucharest, Romania : 1990)
forced repair of a giant abdominal wall defect end with unsatisfactory results despite developmen... more forced repair of a giant abdominal wall defect end with unsatisfactory results despite development of prosthetics materials. The enlargement of abdominal wall dimensions could be realized altogether other methods with the aid of pneumo-peritoneum. The aim of the study is to evaluate early results of the method used for patients with giant incisional hernias. between june 1998 - june 2013, 17 patients (4 males) with giant abdominal wall defects (incisional and inguinal hernias) were prepaired for radical surgery with pneumoperitoneum. Average age was 64.35 years. We reevaluated the standard constants of the pulmonary function,blood gases, and intra-vesical pressure in 3 moments: before the first gas insuflation, 24 hours before surgery and in the 7th daypost operatively. the method was free of accidents or incidents, no mortality was recorded. The respiratory function was significantly increased and also the intra-abdominal pressure. our results suggest that the method of progressive...
Indian Journal of Surgery
Closing the midline in patients with incisional hernias is the cornerstone for a functional recon... more Closing the midline in patients with incisional hernias is the cornerstone for a functional reconstruction with low morbidity, low recurrence rates, and good cosmetic results, which is the ideal outcome for every hernia surgeon. However, in patients with large hernias (usually over 10 cm width) or in loss of domain cases, this goal is difficult to achieve. Anterior component separation with or without mesh reinforcement has been the procedure of choice for these patients despite its high rate of wound complications. The goal of our study is to evaluate the opportunity and necessity of the anterior component separation in patients with complex incisional or ventral hernias (defects larger than 10 cm, infected meshes). Data of patients with large incisional/ventral hernia operated using anterior component separation technique in the past 10 years were re-visited and analyzed from hospital records between January 2012 and December 2020. Demographic data (age, gender, body mass index, A...
Background Umbilical and epigastric hernias are sometimes associated with rectus muscle divaricat... more Background Umbilical and epigastric hernias are sometimes associated with rectus muscle divarication. Isolated repair of the hernia defect can have a high recurrence rate and bad cosmetic results .With this condition the repair of both pathologies is mandatory. The goal of the study is to detail some technical aspects of the endoscopic retro-rectus mesh repair. Methods We present a small series of 15 patients operated for primary or incisional ventral hernias associated with rectus diastasis. The width of the defect was under 6 cm. The performed procedure was eRives repair. Results There were no perioperative complications or short term recurrences. Conclusions In our opinion eTEP access Rives Stoppa repair is the best choice for ventral hernias associating rectus diastasis. The technique has to be promoted for its cosmetic results, reproducibility and for acquiring the principles of modern hernia surgery. Key words: umbilical hernia, diastasis recti, extended-view totally extraperi...
Chirurgia, 2021
Background: The treatment of incisional hernias has radically changed over the last 50 years due ... more Background: The treatment of incisional hernias has radically changed over the last 50 years due to the introduction of mesh repair, which has been proven to be superior to tissue repairs in terms of recurrence. Severe complications such as bacterial contamination, enteral fistulas and severe visceral adhesions are the bane of mesh repair and lead to great challenges as far as treatment is concerned. Methods: From January 2009 to December 2018, we retrospectively collected operative and outcome data on reoperation following septic complications of incisional hernias (IH) mesh repair in 89 patients. For adjustment, comorbidities, mesh location, prognostic nutritional index (PNI) and operative time were included in an SPSS data analyzer. Results: in the referred interval 89 patients (29 males) met the inclusion criteria. The mean time for the onset of infections 15.04+-0.95 months and the number of previous abdominal interventions varied from 1 to 5. Wound infections were reported to ...
JSLS : Journal of the Society of Laparoscopic & Robotic Surgeons
Background: Both umbilical and epigastric hernias may be associated with rectus muscle divaricati... more Background: Both umbilical and epigastric hernias may be associated with rectus muscle divarication. In such cases, isolated repair of combined hernia defects can have high recurrence rates and poorer cosmetic outcomes, thus the repair of both pathologies ought to be favored. The goal of the study below is to provide detailed technical aspects of the endoscopic retro-rectus mesh repair. Methods: We chose a group of 16 patients who underwent the repair of ventral hernias associated with both primary and incisional rectus diastasis, using the extended-view of a totally extraperitoneal Rives-Stoppa repair (eRives) technique. All defects were < 6 cm in width. Our outcome measures perioperative complications and early recurrences. Results: The approach used in our study has led to zero cases of perioperative complications and only one early recurrence. Conclusions: We believe that the e-Rives repair is the optimal approach for ventral hernias associated with diastasis recti. This technique additionally produces favorable cosmetic outcomes that granted our results a well-deserved recognition in the medical literature.
International Journal of Abdominal Wall and Hernia Surgery
BACKGROUND: Incisional hernia (IH) is the most frequent complication of laparotomy with an increa... more BACKGROUND: Incisional hernia (IH) is the most frequent complication of laparotomy with an increasing incidence over time. A large amount of them present in complex forms with large defects or even loss of domain. There is still no consensus regarding the optimal surgical approach for this IHs. The posterior component separation with transversus abdominis release (TAR) alone or in combination with augmentation of the abdominal wall became the standard of repair in large IHs (LIH). No clear evidence that TAR alone can recreate the normal volume of the peritoneal cavity is available. We assessed if it is possible to reconstruct normal peritoneal volume (PV) by TAR. MATERIALS AND METHODS: In this retrospective study, data from LIH patients with midline defects equal or larger than 10 cm width, and computed tomography scans available before and 1-week after TAR with complete fascial closure were analyzed. Hernia sac volume (HSV), abdominal cavity volume (ACV), and (PV = HSV + ACV) were evaluated before surgery. Peritoneal index (PI) was calculated as HSV/PV ratio. PV was measured at 7 days post-TAR (PVTAR). The compliance of the abdominal wall (Cab) was calculated as the ratio between the difference of the PV before surgery and after TAR and the difference between preoperative intra-abdominal pressure (IAP) and postoperative IAP. RESULTS: 23 consecutive patients with a mean age of 64 years were included in the study. The mean value of the HSV was 3,775 cm3 and of the ACV 8377 cm3. PI varied between 0.22 and 0.4. A statistically insignificant difference was recorded between PV and PVTAR(P = 0.7). Patients with PI ≥0.3 had the volume of the peritoneal cavity lesser than patients with PI <0.3. The compliance of the abdominal wall was decreased for the patients with defects larger than 15 cm width and PI larger than 0.33. Urine output in the first postoperative day was smaller in the patients with PI larger than 0.3 with a statistically significant (P = 0.0002) difference and was highly correlated with the abdominal perfusion pressure (APP) and PI. CONCLUSIONS: TAR is able to recreate normal PV in LIH patients with PI <0.3. When PI is larger than 0.33, a permissive intraabdominal hypertension develops for 24 h with the reduction of the APP and of the urine output. In this condition, the augmentation of the abdominal wall could be considered as an option by preoperative administration of pneumoperitoneum and/or Botulin toxin.
Mathematics
The stability of receiver operating characteristic in context of random split used in development... more The stability of receiver operating characteristic in context of random split used in development and validation sets, as compared to the full models for three inflammatory ratios (neutrophil-to-lymphocyte (NLR), derived neutrophil-to-lymphocyte (dNLR) and platelet-to-lymphocyte (PLR) ratio) evaluated as predictors for metastasis in patients with colorectal cancer, was investigated. Data belonging to patients admitted with the diagnosis of colorectal cancer from January 2014 until September 2019 in a single hospital were used. There were 1688 patients eligible for the study, 418 in the metastatic stage. All investigated inflammatory ratios proved to be significant classification models on both the full models and on cross-validations (AUCs > 0.05). High variability of the cut-off values was observed in the unrestricted and restricted split (full models: 4.255 for NLR, 2.745 for dNLR and 255.56 for PLR; random splits: cut-off from 3.215 to 5.905 for NLR, from 2.625 to 3.575 for dN...