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Papers by vanitha rani

Journal of Pharmacovigilance, Nov 29, 2014

Indian Journal of Pharmacy Practice, 2009

To study the cardiac and non-cardiac safety of amiodarone and measure the efficacy of amiodarone ... more To study the cardiac and non-cardiac safety of amiodarone and measure the efficacy of amiodarone in restoring and maintaining sinus rhythm. 35 patients on amiodarone therapy were examined for its safety and efficacy during a period of 6-months. The dosing schedule of amiodarone in the study population was as follows: I.V. loading doses of 150-300 mg bolus over 30 minutes, followed by 1 mg per minute for 6 hours, followed by daily oral maintenance dose of 100-400 mg; I.V. + oral loading dose of 800-2320 mg per day, to a total dose of up to 10 gm, followed by daily oral maintenance dose of 100-400 mg; Oral loading dose of 200 mg T.D.S. for 5 days followed by 200 mg B.D. for 5 days and a daily oral maintenance dose of 100-200 mg O.D. Out of 35 patients, only 2 patients developed severe ADR (hypothyroidism) and discontinued amiodarone therapy. Amiodarone could restore rhythm in 15 (83.33%) out of 18 patients with Ventricular Tachyarrhythmias (VT) and in 10 (83.33%) patients out of 12 patients with Atrial Fibrillation (AF). In other types of arrhythmias (Supraventricular Tachycardia (SVT), Ventricular Tachycardia (VT), Ventricular Premature Complexes (VPCs) & Supraventricular Premature Complexes (SVPCs), amiodarone could restore rhythm in 5 (100%) out of 5 patients. Amiodarone was found to be safe and effective in treating all types of arrhythmias.

Blood stream infections range from self-limiting infections to life-threatening sepsis causing si... more Blood stream infections range from self-limiting infections to life-threatening sepsis causing significant mortality and morbidity worldwide and require rapid and aggressive anti-microbial treatment. Rational and correct use of antibiotics requires understanding of common pathogens and drug resistance patterns in a community. A retrospective study was conducted to identify the microbial profile in the blood culture isolates and their antibiotic susceptibility patterns in a tertiary care teaching hospital. The reports of specimens submitted for blood culture during the period of January to December 2009 to the microbiology laboratory were obtained, the positive cultures were identified, and data on the microbial species and their antibiotic sensitivity patterns were collected. There were 3442 blood culture samples, of which 289 (8.39%) were identified to be culture positive (174 (60.2%) males and 115 (39.7%) females; mean age 43.9 ± 24.08 years). Of 289 positive cultures, 277 (96.19%) showed bacterial growth, 106 (37.7%) were gram-positive and 168 (59.1%) gram-negative. Candida species were isolated from 12 (4.15%) specimens. Staphylococcus aureus and E. coli were the most common bacterial organisms identified to cause blood stream infections. Staphylococcus aureus was found to be highly sensitive to vancomycin (86.61%) linezolid and ciprofloxacin (60.16%); resistant to ampicillin, erythromycin and cephalosporins. E-coli was highly sensitive to amikacin (86.8%) and piperacillin + tazobactum (77%); resistant to ampicillin and cephalosporins. Specific antibiotic utilization strategies like antibiotic restriction, combination therapy and usage according to the standard antimicrobial susceptibility testing may help to decrease or prevent the emergence of resistance and incidence of blood stream infections.

International journal of pharma and bio sciences, 2014

Although streptokinase and tissue plasminogen activators tenecteplase, reteplase and alteplase ar... more Although streptokinase and tissue plasminogen activators tenecteplase, reteplase and alteplase are in clinical use for Acute ST-segment elevated myocardial infarction (STEMI), their efficacy in reducing mortality and safety remains less explored. A study was conducted in 90 patients of either sex (30 patients each in streptokinase (SK), tenecteplase (TNK) and reteplase (RTP) groups), aged above 18 years, admitted with acute STEMI in the Intensive Coronary Care Unit to assess the efficacy and safety of fibrinolytics. Data on efficacy and safety parameters before and after the initiation of therapy were obtained from patient medical records and were assessed. Based on the efficacy parameters, 27 patients in SK and RTP group each and 26 in TNP group had more than 50 % resolution; no early peaking in 3 patients each in SK and RTP & one in TNK group; reperfusion arrhythmia was noted in one patient each in SK & TNK; but no arrhythmias in RTP group; symptoms relief < 50% in 5 patients i...

International Journal of Medical and Health Sciences, 2015

Background: Malnutrition and anorexia are frequent complications in patients on maintenance hemod... more Background: Malnutrition and anorexia are frequent complications in patients on maintenance hemodialysis (MHD) significantly affecting their quality of life, resulting in high morbidity and mortality. A study was conducted to assess the association between anorexia, nutritional status and quality of life. Materials and methods: 90 patients (55 males and 35 females; age range of 25 to 73 years; mean age 52.62 ± 11.7 years) undergoing twice/thrice weekly MHD for six months and above were assessed for self reported appetite using first three questions of Appetite and Diet Assessment tool (ADAT). Anthropometry and Subjective global assessment – Dialysis Malnutrition Scale (SGA-DMS) to were used to assess the nutritional status, and Health survey for dialysis patients Short Form (SF) -36 questionnaire to assess the health related quality of life. Results: Based on SGA-DMS, 54.4 % were moderate to severely malnourished, 31% were mild to moderately malnourished and 14.4% were well nourishe...

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

The global incidence of breast cancer and associated mortality is rising annually despite advance... more The global incidence of breast cancer and associated mortality is rising annually despite advanced diagnostic aids and treatment methods. This is due to the failure and difficulty in detecting the disease at an early stage. Due to an increase in the breast cancer mortality rate, biomarkers associated with early and prompt detection are being extensively studied, owing to their sensitivity, specificity, cost-effectiveness, and minimally invasive or non invasive analysis. Among those carbohydrate antigens, carcinoembryonic antigens, and circulating tumour cells are the most commonly observed serum biomarkers in the detection of cancer. In recent years, extensive research is carried out on cell adhesion molecules and their role in the process of cell adhesion which is essential for the development and homeostasis in multicellular organisms. These cell adhesion molecules accelerate appropriate cell response and intercellular communication. Activated Leucocyte Cell Adhesion Molecule (ALC...

Diabetes Research and Clinical Practice

Indian Journal of Pharmacy Practice, 2009

Stroke is one of the major challenges facing medicine with a scaring statistics of being the thir... more Stroke is one of the major challenges facing medicine with a scaring statistics of being the third leading cause of mortality world wide after heart disease and cancer, and primary cause of serious long term disability. Identification . and management of risk factors remains pivotal in reducing morbidity and mortality from stroke A retrospective study was conducted with the objective of identifying various risk factors for stroke and assess the role of the risk factors for stroke in the South Indian population. A total of 120 patients with completed stroke or cerebrovascular accident were taken up for the study. The mean age of the patients was 62.6 ± 14.46 (range 25 to 90 years). There were 83 (69.02%) males (mean age 61.3±26.9) and 37 (30.83%) females (mean age 63.25±17). 32.5% patients (25 males & 14 females) were in the age group of 65-75 years. Out of 120 patients, 104 patients (86.7%) were hypertensive. Of these, 83 (79.8%) had a past history of hypertension with a mean systol...

Asian Journal of Pharmaceutical and Clinical Research, 2017

Objective: Acenocoumarol is anoral anticoagulant with narrow therapeutic index, and the ideal d... more Objective: Acenocoumarol is anoral anticoagulant with narrow therapeutic index, and the ideal dose of anticoagulation lies between International normalized ratio (INR) values of 2.0 and 3.5. Lack of monitoring and knowledge on acenocoumarol therapy may compromise patient’s safety resulting in under- or over-anticoagulation. A study was conducted to monitor for the safety of anticoagulation therapy, achievement of goal INR levels and to assess the impact of pharmacist led anticoagulation monitoring and patient education on the rational use of acenocoumarol in patients admitted in cardiology wards with thromboembolic disorders.Methods: The study was conducted in 70 patients; data collection was done, prescriptions were analyzed for drug-drug interactions and adverse drug reactions (ADRs). Patients’ knowledge on acenocoumarol therapy was assessed using a self-developed questionnaire at the baseline, then were subjected to a detailed patient education and on an average each patient re...

Journal of Young Pharmacists, 2019

International Journal of Pharmacy and Pharmaceutical Sciences, 2019

Objective: A study was conducted to analyse the applicability of the tools of inventory control o... more Objective: A study was conducted to analyse the applicability of the tools of inventory control of drugs, and the awareness of hospital pharmacists on the inventory tools in the central pharmacy of a tertiary care hospital. Methods: Always Better Control (ABC) and High Moderate Low (HML) analysis were carried out for 4057 drugs purchased in the central pharmacy during the financial year of 2017-2018. The drugs were classified as A, B and C category based on their annual usage value and as Category High (H), Moderate (M) and low (L) drugs based on their unit price respectively. The knowledge of the 80 hospital pharmacists on the tools of inventory control was assessed using a structured questionnaire. Results: Based on ABC analysis, of 4057 drugs, 330 drugs were classified under “A” category accounting to 8.13% of the total number of drugs purchased which was 70.91 % of total annual consumption in money value. The category “B” consisted of 667 drugs accounting to 16.44% of the total ...

International Journal of Pharma and Bio Sciences, 2019

Atypical antipsychotics are commonly prescribed for psychosis and metabolic Syndrome has a strong... more Atypical antipsychotics are commonly prescribed for psychosis and metabolic Syndrome has a strong relationship with atypical antipsychotic usage. A prospective study was done to assess the incidence of metabolic syndrome and its components in Psychiatric patients on atypical antipsychotics. Blood pressure, body weight, Body Mass Index and waist circumference were calculated and a 5 ml of venous blood was collected at baseline, and for 12 weeks it was follow up to determine the fasting lipid profile and blood glucose levels. Difference in values, from baseline to follow up was assessed using statistical tools. Metabolic syndrome was assessed using International Diabetes Federation criteria. Of 96 patients, 53 were male and 43 were female. Majority (40%) were in the age range of 26 to 35 years. Patients were given Olanzapine, Quetiapine, Risperidone per oral as monotherapy and Risperidone with Olanzapine or Quetiapine as combination therapy per orally. Changes observed from baseline to follow up included weight gain (89%), increase in BMI (78%), waist circumference (91%), FBS (60%), triglycerides (95%) and decreased HDL (65%) but no changes were observed in blood pressure. Olanzapine was found to cause weight gain both as single (32%) and in combined therapy (15%). Increased waist circumference was observed with all the three drugs. The study identified 5% of patients with metabolic syndrome as per criteria. Duration of antipsychotic usage had a positive correlation with alterations in the metabolic components. Gender had no statistically significant influence over the risk for metabolic syndrome. Early identification of metabolic syndrome and therapeutic intervention in Psychiatric patients on atypical antipsychotics may reduce long term morbidity.

Journal of Hepatology, 2015

The aim of the study was to investigate the incidence and factors linked with nonalcoholic fatty ... more The aim of the study was to investigate the incidence and factors linked with nonalcoholic fatty liver disease (NAFLD) among type-2 diabetes mellitus (T2DM) patients in Warangal, Telangana, India. It was an observational, cohort crosssectional study; a target sample of 100 T2DM patients was recruited from a single study site of Warangal. Detailed medical history was obtained and laboratory examinations and ultrasound imaging were carried out to evaluate the NAFLD. The overall incidence of NAFLD was 80%. The risk of NAFLD was significantly high in subjects with uncontrolled blood glucose levels, abnormal waist circumference, increased aspartate aminotransferase (AST), and elevated triglyceride levels (p < 0.05). In our study subjects, the consumption of alcohol is the predominant risk factor (Odds ratio: 6.652; 95% confident interval: 1.86-23.74 and p = 0.00*) significantly causing NAFLD among the study subjects. Grade-1 and 2 fatty livers are typically associated with elevated AST levels and a high incidence was observed in men.

The Journal of Alternative and Complementary Medicine, 2011

Indian Journal of Pharmaceutical Sciences, 2011

Janardhan, et al.: Malnutrition in Hemodialysis Malnutrition is widely prevalent among patients o... more Janardhan, et al.: Malnutrition in Hemodialysis Malnutrition is widely prevalent among patients on hemodialysis. Malnutrition can be estimated using a fully quantitative scoring system Subjective Global Assessment-Dialysis Malnutrition Score which is simple, reliable and dynamic. The primary objective of the study was to assess the severity of malnutrition in patients with end stage renal disease and undergoing hemodialysis in a tertiary care teaching hospital in Chennai, using Subjective Global Assessment-Dialysis Malnutrition Score and correlate it with standard indicators of malnutrition like anthropometric and biochemical parameters of the study population by Pearson's correlation. Anthropometric assessment included height, body weight, triceps skin fold thickness, mid arm circumference, mid arm muscle circumference % and biochemical parameters included serum albumin, transferrin, ferritin, total protein, total cholesterol, blood urea nitrogen and creatinine. Based on the scores, of the 66 patients, 91% were moderately malnourished. There was a significant negative correlation between modified Subjective Global Assessment-Dialysis Malnutrition Score and anthropometric measures such as triceps skin fold thickness, mid arm circumference, mid arm muscle circumference; biochemical markers such as albumin, transferrin and ferritin. The data obtained from this study confirm that a high degree of malnutrition was prevalent in patients on hemodialysis, as shown by anthropometric assessment, biochemical markers of malnutrition and Subjective Global Assessment-Dialysis Malnutrition Score. Nutritional status as determined by Subjective Global Assessment-Dialysis Malnutrition Score is a useful and reliable index for identifying patients at risk for malnutrition and it correlates well with anthropometric and biochemical assessment. may be integrated in regular assessment of malnutrition in patients on maintenance hemodialysis.

Journal of Postgraduate Medicine, 2011

Indian Journal of Pharmaceutical Sciences, 2009

*Values are mean±SEM, n=5 in each group. p<0.001 as compared to control group.

To assess the incidence of ADRs and their causal relationship to chemotherapeutic agents and to e... more To assess the incidence of ADRs and their causal relationship to chemotherapeutic agents and to evaluate the severity and preventability of the ADRs. Patients above 18 years of age, on cancer chemotherapy were included. ADRs experienced by patients were identified and categorized using National Cancer Institute Common Terminology Criteria version 3.0 Questionnaire. The causality assessment of suspected ADRs was done using WHO and Naranjo's scales, severity assessment of ADRs using Hartwig and Siegel scale and preventability of ADRs using Schumock and Thornton scale. Results: The study was conducted in 109 patients (46 males, 63 females; mean age 53.75±12.75 years). Majority of the patients had breast cancer. Dry mouth and taste disturbances, were major ADRs found in 82.50% patients, dermatological ADRs alopecia, eczema and acne in 68.80%, hematological ADRs in 52.20%, and the least were the constitutional symptoms and renal ADRs (9.10% each). Causality assessment of ADRs using ...

Objective: To evaluate the medication knowledge of the patients on maintenance hemodialysis, thei... more Objective: To evaluate the medication knowledge of the patients on maintenance hemodialysis, their adherence to drug therapy and to assess the effect of patient counselling in improving their medication knowledge and adherence. Methods: Data was obtained from the patients by medical history interview and review of their medical records. The medication knowledge was assessed using Medication knowledge assessment questionnaire (MKAQ) and their medication adherence behaviour using Brief Medication questionnaire (BMQ). Patients were counseled both verbally and by distribution of education leaflets regarding their disease, dialysis procedure, the drugs, diet and fluid restrictions on regular dialysis days and the effect of patient counselling in improving their medication knowledge and adherence was assessed using the respective questionnaires at the baseline, after 6 and 12 weeks. The mean scores were subjected to statistical analysis. Results: 85 patients (57 males and 28 females; mean...

Background:A key to the success of asthma and Chronic obstructive pulmonary disease treatment is ... more Background:A key to the success of asthma and Chronic obstructive pulmonary disease treatment is proper inhalational technique. A study was conducted to evaluate the knowledge on inhaler usage and to assess the impact of continuous education on the improvement of inhaler use in Asthma and COPD patients. Materials and Methods:110 patients prescribed with inhalation medications were divided randomly into Group I and Group II as 55 patients in each. On their first visit, both were asked to demonstrate the inhalation technique and were educated on the proper use of inhalers. Group I was subjected to extensive follow up every 15 days for three months. Group II was followed up after three months of their first visit. Both groups were subjected to spirometry during the first and last visits and Peak Expiratory Flow Rate during every visit. The relationship between knowledge of inhalation therapy and health status was assessed by a self developed and validated questionnaire and the results ...

Journal of Pharmacovigilance, Nov 29, 2014

Indian Journal of Pharmacy Practice, 2009

To study the cardiac and non-cardiac safety of amiodarone and measure the efficacy of amiodarone ... more To study the cardiac and non-cardiac safety of amiodarone and measure the efficacy of amiodarone in restoring and maintaining sinus rhythm. 35 patients on amiodarone therapy were examined for its safety and efficacy during a period of 6-months. The dosing schedule of amiodarone in the study population was as follows: I.V. loading doses of 150-300 mg bolus over 30 minutes, followed by 1 mg per minute for 6 hours, followed by daily oral maintenance dose of 100-400 mg; I.V. + oral loading dose of 800-2320 mg per day, to a total dose of up to 10 gm, followed by daily oral maintenance dose of 100-400 mg; Oral loading dose of 200 mg T.D.S. for 5 days followed by 200 mg B.D. for 5 days and a daily oral maintenance dose of 100-200 mg O.D. Out of 35 patients, only 2 patients developed severe ADR (hypothyroidism) and discontinued amiodarone therapy. Amiodarone could restore rhythm in 15 (83.33%) out of 18 patients with Ventricular Tachyarrhythmias (VT) and in 10 (83.33%) patients out of 12 patients with Atrial Fibrillation (AF). In other types of arrhythmias (Supraventricular Tachycardia (SVT), Ventricular Tachycardia (VT), Ventricular Premature Complexes (VPCs) & Supraventricular Premature Complexes (SVPCs), amiodarone could restore rhythm in 5 (100%) out of 5 patients. Amiodarone was found to be safe and effective in treating all types of arrhythmias.

Blood stream infections range from self-limiting infections to life-threatening sepsis causing si... more Blood stream infections range from self-limiting infections to life-threatening sepsis causing significant mortality and morbidity worldwide and require rapid and aggressive anti-microbial treatment. Rational and correct use of antibiotics requires understanding of common pathogens and drug resistance patterns in a community. A retrospective study was conducted to identify the microbial profile in the blood culture isolates and their antibiotic susceptibility patterns in a tertiary care teaching hospital. The reports of specimens submitted for blood culture during the period of January to December 2009 to the microbiology laboratory were obtained, the positive cultures were identified, and data on the microbial species and their antibiotic sensitivity patterns were collected. There were 3442 blood culture samples, of which 289 (8.39%) were identified to be culture positive (174 (60.2%) males and 115 (39.7%) females; mean age 43.9 ± 24.08 years). Of 289 positive cultures, 277 (96.19%) showed bacterial growth, 106 (37.7%) were gram-positive and 168 (59.1%) gram-negative. Candida species were isolated from 12 (4.15%) specimens. Staphylococcus aureus and E. coli were the most common bacterial organisms identified to cause blood stream infections. Staphylococcus aureus was found to be highly sensitive to vancomycin (86.61%) linezolid and ciprofloxacin (60.16%); resistant to ampicillin, erythromycin and cephalosporins. E-coli was highly sensitive to amikacin (86.8%) and piperacillin + tazobactum (77%); resistant to ampicillin and cephalosporins. Specific antibiotic utilization strategies like antibiotic restriction, combination therapy and usage according to the standard antimicrobial susceptibility testing may help to decrease or prevent the emergence of resistance and incidence of blood stream infections.

International journal of pharma and bio sciences, 2014

Although streptokinase and tissue plasminogen activators tenecteplase, reteplase and alteplase ar... more Although streptokinase and tissue plasminogen activators tenecteplase, reteplase and alteplase are in clinical use for Acute ST-segment elevated myocardial infarction (STEMI), their efficacy in reducing mortality and safety remains less explored. A study was conducted in 90 patients of either sex (30 patients each in streptokinase (SK), tenecteplase (TNK) and reteplase (RTP) groups), aged above 18 years, admitted with acute STEMI in the Intensive Coronary Care Unit to assess the efficacy and safety of fibrinolytics. Data on efficacy and safety parameters before and after the initiation of therapy were obtained from patient medical records and were assessed. Based on the efficacy parameters, 27 patients in SK and RTP group each and 26 in TNP group had more than 50 % resolution; no early peaking in 3 patients each in SK and RTP & one in TNK group; reperfusion arrhythmia was noted in one patient each in SK & TNK; but no arrhythmias in RTP group; symptoms relief < 50% in 5 patients i...

International Journal of Medical and Health Sciences, 2015

Background: Malnutrition and anorexia are frequent complications in patients on maintenance hemod... more Background: Malnutrition and anorexia are frequent complications in patients on maintenance hemodialysis (MHD) significantly affecting their quality of life, resulting in high morbidity and mortality. A study was conducted to assess the association between anorexia, nutritional status and quality of life. Materials and methods: 90 patients (55 males and 35 females; age range of 25 to 73 years; mean age 52.62 ± 11.7 years) undergoing twice/thrice weekly MHD for six months and above were assessed for self reported appetite using first three questions of Appetite and Diet Assessment tool (ADAT). Anthropometry and Subjective global assessment – Dialysis Malnutrition Scale (SGA-DMS) to were used to assess the nutritional status, and Health survey for dialysis patients Short Form (SF) -36 questionnaire to assess the health related quality of life. Results: Based on SGA-DMS, 54.4 % were moderate to severely malnourished, 31% were mild to moderately malnourished and 14.4% were well nourishe...

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

The global incidence of breast cancer and associated mortality is rising annually despite advance... more The global incidence of breast cancer and associated mortality is rising annually despite advanced diagnostic aids and treatment methods. This is due to the failure and difficulty in detecting the disease at an early stage. Due to an increase in the breast cancer mortality rate, biomarkers associated with early and prompt detection are being extensively studied, owing to their sensitivity, specificity, cost-effectiveness, and minimally invasive or non invasive analysis. Among those carbohydrate antigens, carcinoembryonic antigens, and circulating tumour cells are the most commonly observed serum biomarkers in the detection of cancer. In recent years, extensive research is carried out on cell adhesion molecules and their role in the process of cell adhesion which is essential for the development and homeostasis in multicellular organisms. These cell adhesion molecules accelerate appropriate cell response and intercellular communication. Activated Leucocyte Cell Adhesion Molecule (ALC...

Diabetes Research and Clinical Practice

Indian Journal of Pharmacy Practice, 2009

Stroke is one of the major challenges facing medicine with a scaring statistics of being the thir... more Stroke is one of the major challenges facing medicine with a scaring statistics of being the third leading cause of mortality world wide after heart disease and cancer, and primary cause of serious long term disability. Identification . and management of risk factors remains pivotal in reducing morbidity and mortality from stroke A retrospective study was conducted with the objective of identifying various risk factors for stroke and assess the role of the risk factors for stroke in the South Indian population. A total of 120 patients with completed stroke or cerebrovascular accident were taken up for the study. The mean age of the patients was 62.6 ± 14.46 (range 25 to 90 years). There were 83 (69.02%) males (mean age 61.3±26.9) and 37 (30.83%) females (mean age 63.25±17). 32.5% patients (25 males & 14 females) were in the age group of 65-75 years. Out of 120 patients, 104 patients (86.7%) were hypertensive. Of these, 83 (79.8%) had a past history of hypertension with a mean systol...

Asian Journal of Pharmaceutical and Clinical Research, 2017

Objective: Acenocoumarol is anoral anticoagulant with narrow therapeutic index, and the ideal d... more Objective: Acenocoumarol is anoral anticoagulant with narrow therapeutic index, and the ideal dose of anticoagulation lies between International normalized ratio (INR) values of 2.0 and 3.5. Lack of monitoring and knowledge on acenocoumarol therapy may compromise patient’s safety resulting in under- or over-anticoagulation. A study was conducted to monitor for the safety of anticoagulation therapy, achievement of goal INR levels and to assess the impact of pharmacist led anticoagulation monitoring and patient education on the rational use of acenocoumarol in patients admitted in cardiology wards with thromboembolic disorders.Methods: The study was conducted in 70 patients; data collection was done, prescriptions were analyzed for drug-drug interactions and adverse drug reactions (ADRs). Patients’ knowledge on acenocoumarol therapy was assessed using a self-developed questionnaire at the baseline, then were subjected to a detailed patient education and on an average each patient re...

Journal of Young Pharmacists, 2019

International Journal of Pharmacy and Pharmaceutical Sciences, 2019

Objective: A study was conducted to analyse the applicability of the tools of inventory control o... more Objective: A study was conducted to analyse the applicability of the tools of inventory control of drugs, and the awareness of hospital pharmacists on the inventory tools in the central pharmacy of a tertiary care hospital. Methods: Always Better Control (ABC) and High Moderate Low (HML) analysis were carried out for 4057 drugs purchased in the central pharmacy during the financial year of 2017-2018. The drugs were classified as A, B and C category based on their annual usage value and as Category High (H), Moderate (M) and low (L) drugs based on their unit price respectively. The knowledge of the 80 hospital pharmacists on the tools of inventory control was assessed using a structured questionnaire. Results: Based on ABC analysis, of 4057 drugs, 330 drugs were classified under “A” category accounting to 8.13% of the total number of drugs purchased which was 70.91 % of total annual consumption in money value. The category “B” consisted of 667 drugs accounting to 16.44% of the total ...

International Journal of Pharma and Bio Sciences, 2019

Atypical antipsychotics are commonly prescribed for psychosis and metabolic Syndrome has a strong... more Atypical antipsychotics are commonly prescribed for psychosis and metabolic Syndrome has a strong relationship with atypical antipsychotic usage. A prospective study was done to assess the incidence of metabolic syndrome and its components in Psychiatric patients on atypical antipsychotics. Blood pressure, body weight, Body Mass Index and waist circumference were calculated and a 5 ml of venous blood was collected at baseline, and for 12 weeks it was follow up to determine the fasting lipid profile and blood glucose levels. Difference in values, from baseline to follow up was assessed using statistical tools. Metabolic syndrome was assessed using International Diabetes Federation criteria. Of 96 patients, 53 were male and 43 were female. Majority (40%) were in the age range of 26 to 35 years. Patients were given Olanzapine, Quetiapine, Risperidone per oral as monotherapy and Risperidone with Olanzapine or Quetiapine as combination therapy per orally. Changes observed from baseline to follow up included weight gain (89%), increase in BMI (78%), waist circumference (91%), FBS (60%), triglycerides (95%) and decreased HDL (65%) but no changes were observed in blood pressure. Olanzapine was found to cause weight gain both as single (32%) and in combined therapy (15%). Increased waist circumference was observed with all the three drugs. The study identified 5% of patients with metabolic syndrome as per criteria. Duration of antipsychotic usage had a positive correlation with alterations in the metabolic components. Gender had no statistically significant influence over the risk for metabolic syndrome. Early identification of metabolic syndrome and therapeutic intervention in Psychiatric patients on atypical antipsychotics may reduce long term morbidity.

Journal of Hepatology, 2015

The aim of the study was to investigate the incidence and factors linked with nonalcoholic fatty ... more The aim of the study was to investigate the incidence and factors linked with nonalcoholic fatty liver disease (NAFLD) among type-2 diabetes mellitus (T2DM) patients in Warangal, Telangana, India. It was an observational, cohort crosssectional study; a target sample of 100 T2DM patients was recruited from a single study site of Warangal. Detailed medical history was obtained and laboratory examinations and ultrasound imaging were carried out to evaluate the NAFLD. The overall incidence of NAFLD was 80%. The risk of NAFLD was significantly high in subjects with uncontrolled blood glucose levels, abnormal waist circumference, increased aspartate aminotransferase (AST), and elevated triglyceride levels (p < 0.05). In our study subjects, the consumption of alcohol is the predominant risk factor (Odds ratio: 6.652; 95% confident interval: 1.86-23.74 and p = 0.00*) significantly causing NAFLD among the study subjects. Grade-1 and 2 fatty livers are typically associated with elevated AST levels and a high incidence was observed in men.

The Journal of Alternative and Complementary Medicine, 2011

Indian Journal of Pharmaceutical Sciences, 2011

Janardhan, et al.: Malnutrition in Hemodialysis Malnutrition is widely prevalent among patients o... more Janardhan, et al.: Malnutrition in Hemodialysis Malnutrition is widely prevalent among patients on hemodialysis. Malnutrition can be estimated using a fully quantitative scoring system Subjective Global Assessment-Dialysis Malnutrition Score which is simple, reliable and dynamic. The primary objective of the study was to assess the severity of malnutrition in patients with end stage renal disease and undergoing hemodialysis in a tertiary care teaching hospital in Chennai, using Subjective Global Assessment-Dialysis Malnutrition Score and correlate it with standard indicators of malnutrition like anthropometric and biochemical parameters of the study population by Pearson's correlation. Anthropometric assessment included height, body weight, triceps skin fold thickness, mid arm circumference, mid arm muscle circumference % and biochemical parameters included serum albumin, transferrin, ferritin, total protein, total cholesterol, blood urea nitrogen and creatinine. Based on the scores, of the 66 patients, 91% were moderately malnourished. There was a significant negative correlation between modified Subjective Global Assessment-Dialysis Malnutrition Score and anthropometric measures such as triceps skin fold thickness, mid arm circumference, mid arm muscle circumference; biochemical markers such as albumin, transferrin and ferritin. The data obtained from this study confirm that a high degree of malnutrition was prevalent in patients on hemodialysis, as shown by anthropometric assessment, biochemical markers of malnutrition and Subjective Global Assessment-Dialysis Malnutrition Score. Nutritional status as determined by Subjective Global Assessment-Dialysis Malnutrition Score is a useful and reliable index for identifying patients at risk for malnutrition and it correlates well with anthropometric and biochemical assessment. may be integrated in regular assessment of malnutrition in patients on maintenance hemodialysis.

Journal of Postgraduate Medicine, 2011

Indian Journal of Pharmaceutical Sciences, 2009

*Values are mean±SEM, n=5 in each group. p<0.001 as compared to control group.

To assess the incidence of ADRs and their causal relationship to chemotherapeutic agents and to e... more To assess the incidence of ADRs and their causal relationship to chemotherapeutic agents and to evaluate the severity and preventability of the ADRs. Patients above 18 years of age, on cancer chemotherapy were included. ADRs experienced by patients were identified and categorized using National Cancer Institute Common Terminology Criteria version 3.0 Questionnaire. The causality assessment of suspected ADRs was done using WHO and Naranjo's scales, severity assessment of ADRs using Hartwig and Siegel scale and preventability of ADRs using Schumock and Thornton scale. Results: The study was conducted in 109 patients (46 males, 63 females; mean age 53.75±12.75 years). Majority of the patients had breast cancer. Dry mouth and taste disturbances, were major ADRs found in 82.50% patients, dermatological ADRs alopecia, eczema and acne in 68.80%, hematological ADRs in 52.20%, and the least were the constitutional symptoms and renal ADRs (9.10% each). Causality assessment of ADRs using ...

Objective: To evaluate the medication knowledge of the patients on maintenance hemodialysis, thei... more Objective: To evaluate the medication knowledge of the patients on maintenance hemodialysis, their adherence to drug therapy and to assess the effect of patient counselling in improving their medication knowledge and adherence. Methods: Data was obtained from the patients by medical history interview and review of their medical records. The medication knowledge was assessed using Medication knowledge assessment questionnaire (MKAQ) and their medication adherence behaviour using Brief Medication questionnaire (BMQ). Patients were counseled both verbally and by distribution of education leaflets regarding their disease, dialysis procedure, the drugs, diet and fluid restrictions on regular dialysis days and the effect of patient counselling in improving their medication knowledge and adherence was assessed using the respective questionnaires at the baseline, after 6 and 12 weeks. The mean scores were subjected to statistical analysis. Results: 85 patients (57 males and 28 females; mean...

Background:A key to the success of asthma and Chronic obstructive pulmonary disease treatment is ... more Background:A key to the success of asthma and Chronic obstructive pulmonary disease treatment is proper inhalational technique. A study was conducted to evaluate the knowledge on inhaler usage and to assess the impact of continuous education on the improvement of inhaler use in Asthma and COPD patients. Materials and Methods:110 patients prescribed with inhalation medications were divided randomly into Group I and Group II as 55 patients in each. On their first visit, both were asked to demonstrate the inhalation technique and were educated on the proper use of inhalers. Group I was subjected to extensive follow up every 15 days for three months. Group II was followed up after three months of their first visit. Both groups were subjected to spirometry during the first and last visits and Peak Expiratory Flow Rate during every visit. The relationship between knowledge of inhalation therapy and health status was assessed by a self developed and validated questionnaire and the results ...