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Papers by vasavi gedela

Research paper thumbnail of Post-Operative Nausea vomiting, Granisetron, Odansetron

Research paper thumbnail of Prospective, Randomized, Double Blind Study to Compare the Efficacy and Safety of Granisetron Versus Ondansetron in Prevention of Post Operative Nausea and Vomiting in Patients Undergoing Elective Laparoscopic Cholecystectomy Under General Anaesthesia

Journal of Evolution of medical and Dental Sciences, 2015

OBJECTIVE: To compare the efficacy and safety of Granisetron versus Ondansetron in prevention of ... more OBJECTIVE: To compare the efficacy and safety of Granisetron versus Ondansetron in prevention of post-operative nausea and vomiting in patients undergoing elective Laparoscopic Cholecystectomy under general anaesthesia. MATERIALS AND METHODS: After the approval from IEC, the study was started and conducted over a period of two years i.e., from 2010-2012. Data was collected from 100 ASA I and II patients scheduled for laparoscopic cholecystectomy aged between 20-60 years at Government General Hospital, Kakinada. Both the study groups were selected from these patients. Written informed consent was taken from all patients. Preanesthetic medication was given with Ranitidine 150mg and Lorazepam 1mg, the night before and morning of surgery. Patients were randomly allocated into 2 groups. Group A Received Inj. Ondansetron 8mg diluted in 5ml of normal saline. Group B Received Inj. Granisetron 1mg diluted in 5ml of normal saline. INJ. Glycopyrolate 0.01mg/kg & INJ. Fentanyl (1-2μ/Kg) given i...

Research paper thumbnail of A comparative study of case-based learning with conventional teaching in undergraduate training of pharmacology

National Journal of Physiology, Pharmacy and Pharmacology, 2022

Research paper thumbnail of Diabetes a risk for antimicrobial resistance

Magnitude of diabetes mellitus is increasing globally at an alarming rate. About 150-170 million ... more Magnitude of diabetes mellitus is increasing globally at an alarming rate. About 150-170 million populations are suffering from this disease worldwide and the prevalence of diabetes will be double by 2025 as per WHO reports.1 Diabetic foot lesions are a major medical, social, and economic problem and are the leading cause of hospitalization for patients with diabetes. Infectious agents are associated with amputation of the infected foot if not treated promptly. Proper management of these infections requires appropriate antibiotic selection based on culture and antimicrobial susceptibility results; however, initial management comprises empirical antimicrobial therapy, which is often based on susceptibility data extrapolated from studies performed on general clinical isolates.2 Higher antibiotic resistance rates in diabetic patients compared with those without DM have been reported in some studies. In Indian outpatients with chronic wounds, most (70%) antibiotic-resistant bacteria wer...

Research paper thumbnail of A prospective double blind randomized comparative study of safety and efficacy of Tapentadol versus Tramadol in post-operative orthopaedic patients

International Journal of Basic & Clinical Pharmacology, Oct 25, 2017

The quest for pain relief, following surgery continues from beginning of the history of surgery. ... more The quest for pain relief, following surgery continues from beginning of the history of surgery. Autonomic nervous system is stimulated by pain leading to various stress responses which are deleterious to the patient. Postoperative analgesia is provided with NSAID's and Opiods in repeated doses. Ever since Friedrich Vilhelm Adam Serturner isolated Morphine from opium, many opioids like Pethidine, Pentazocine, Buprenorphine, Butorphanol, Alfentanil, Remifentanil, and Sufentanil etc each with its unique characteristics and potency were discovered. 1 The list is growing on. Opioids are the most effective analgesic agents available till date for the management of moderate to severe painful conditions. Opioids relieve pain both by raising the pain threshold at the spinal cord level and more importantly, by altering the brain's perception of pain. Patients on opioids are still aware of the presence of pain, but the sensation is not unpleasant. Tramadol is a synthetic analgesic of the amino cyclohexanol group with opioidlike effects. Tramadol is now specifically recommended in musculoskeletal pain guidelines and neuropathic pain guidelines because of its efficacy, safety, and tolerability. 2-4 It has no major organ toxicity, and its use necessarily ABSTRACT Background: Pain following surgery is an unwanted effect which is to be relieved for the better outcome of surgery and anaesthesia. The study was conducted to compare the efficacy and safety of Tapentadol with Tramadol for post-operative pain relief in orthopaedic surgeries. Methods: After approval of IEC, patients of either sex aged between 18-55 years who had undergone orthopaedic surgeries at Government General Hospital, Kakinada between February 2013 to January 2015 were selected for study. It is a prospective double blind randomised active controlled parallel group comparative study. Sample size is 80 who fulfilled all criteria but there are 6 who discontinued drug in Tramadol group, so 74 were analysed. Written informed consent was taken from all patients, screening, pre anaesthetic evaluation done. Tablet Alprazolam 0.5mg was given at 9PM on previous day of surgery. Both Tramadol and Tapentadol were given 100mg orally 6th hourly. Pain intensity was analysed by visual analogue scale. Sedation was assessed with Modified Wilson sedation scale. Safety and tolerability was assessed by side effects reported by patients.

Research paper thumbnail of Post-Operative Nausea vomiting, Granisetron, Odansetron

Research paper thumbnail of Prospective, Randomized, Double Blind Study to Compare the Efficacy and Safety of Granisetron Versus Ondansetron in Prevention of Post Operative Nausea and Vomiting in Patients Undergoing Elective Laparoscopic Cholecystectomy Under General Anaesthesia

Journal of Evolution of medical and Dental Sciences, 2015

OBJECTIVE: To compare the efficacy and safety of Granisetron versus Ondansetron in prevention of ... more OBJECTIVE: To compare the efficacy and safety of Granisetron versus Ondansetron in prevention of post-operative nausea and vomiting in patients undergoing elective Laparoscopic Cholecystectomy under general anaesthesia. MATERIALS AND METHODS: After the approval from IEC, the study was started and conducted over a period of two years i.e., from 2010-2012. Data was collected from 100 ASA I and II patients scheduled for laparoscopic cholecystectomy aged between 20-60 years at Government General Hospital, Kakinada. Both the study groups were selected from these patients. Written informed consent was taken from all patients. Preanesthetic medication was given with Ranitidine 150mg and Lorazepam 1mg, the night before and morning of surgery. Patients were randomly allocated into 2 groups. Group A Received Inj. Ondansetron 8mg diluted in 5ml of normal saline. Group B Received Inj. Granisetron 1mg diluted in 5ml of normal saline. INJ. Glycopyrolate 0.01mg/kg & INJ. Fentanyl (1-2μ/Kg) given i...

Research paper thumbnail of A comparative study of case-based learning with conventional teaching in undergraduate training of pharmacology

National Journal of Physiology, Pharmacy and Pharmacology, 2022

Research paper thumbnail of Diabetes a risk for antimicrobial resistance

Magnitude of diabetes mellitus is increasing globally at an alarming rate. About 150-170 million ... more Magnitude of diabetes mellitus is increasing globally at an alarming rate. About 150-170 million populations are suffering from this disease worldwide and the prevalence of diabetes will be double by 2025 as per WHO reports.1 Diabetic foot lesions are a major medical, social, and economic problem and are the leading cause of hospitalization for patients with diabetes. Infectious agents are associated with amputation of the infected foot if not treated promptly. Proper management of these infections requires appropriate antibiotic selection based on culture and antimicrobial susceptibility results; however, initial management comprises empirical antimicrobial therapy, which is often based on susceptibility data extrapolated from studies performed on general clinical isolates.2 Higher antibiotic resistance rates in diabetic patients compared with those without DM have been reported in some studies. In Indian outpatients with chronic wounds, most (70%) antibiotic-resistant bacteria wer...

Research paper thumbnail of A prospective double blind randomized comparative study of safety and efficacy of Tapentadol versus Tramadol in post-operative orthopaedic patients

International Journal of Basic & Clinical Pharmacology, Oct 25, 2017

The quest for pain relief, following surgery continues from beginning of the history of surgery. ... more The quest for pain relief, following surgery continues from beginning of the history of surgery. Autonomic nervous system is stimulated by pain leading to various stress responses which are deleterious to the patient. Postoperative analgesia is provided with NSAID's and Opiods in repeated doses. Ever since Friedrich Vilhelm Adam Serturner isolated Morphine from opium, many opioids like Pethidine, Pentazocine, Buprenorphine, Butorphanol, Alfentanil, Remifentanil, and Sufentanil etc each with its unique characteristics and potency were discovered. 1 The list is growing on. Opioids are the most effective analgesic agents available till date for the management of moderate to severe painful conditions. Opioids relieve pain both by raising the pain threshold at the spinal cord level and more importantly, by altering the brain's perception of pain. Patients on opioids are still aware of the presence of pain, but the sensation is not unpleasant. Tramadol is a synthetic analgesic of the amino cyclohexanol group with opioidlike effects. Tramadol is now specifically recommended in musculoskeletal pain guidelines and neuropathic pain guidelines because of its efficacy, safety, and tolerability. 2-4 It has no major organ toxicity, and its use necessarily ABSTRACT Background: Pain following surgery is an unwanted effect which is to be relieved for the better outcome of surgery and anaesthesia. The study was conducted to compare the efficacy and safety of Tapentadol with Tramadol for post-operative pain relief in orthopaedic surgeries. Methods: After approval of IEC, patients of either sex aged between 18-55 years who had undergone orthopaedic surgeries at Government General Hospital, Kakinada between February 2013 to January 2015 were selected for study. It is a prospective double blind randomised active controlled parallel group comparative study. Sample size is 80 who fulfilled all criteria but there are 6 who discontinued drug in Tramadol group, so 74 were analysed. Written informed consent was taken from all patients, screening, pre anaesthetic evaluation done. Tablet Alprazolam 0.5mg was given at 9PM on previous day of surgery. Both Tramadol and Tapentadol were given 100mg orally 6th hourly. Pain intensity was analysed by visual analogue scale. Sedation was assessed with Modified Wilson sedation scale. Safety and tolerability was assessed by side effects reported by patients.