vijay raj - Academia.edu (original) (raw)

Papers by vijay raj

Arquivos Brasileiros de Cardiologia, 2021

A 17-year-old male was admitted for the management of multiple fractures after sustaining blunt t... more A 17-year-old male was admitted for the management of multiple fractures after sustaining blunt thoracic trauma. He was hemodynamically stable and without any cardiac symptoms. He was admitted with fracture of T4 end plate, manubrium and left first rib, right pulmonary contusion, left apical pneumothorax and pneumomediastinum. The patient underwent echocardiography and cardiac CT angiogram for the work up of aortic injury as the patient had new aortic regurgitation murmur, troponin rise and RBBB. He was found to have aortic root rupture, type A aortic dissection and acute severe aortic insufficiency. The patient underwent surgical aortic valve and root replacement with Bentall procedure with good outcome.

Albizzia lebbeck and Syzygium cumini are two natural plants with secondary metabolites and antiox... more Albizzia lebbeck and Syzygium cumini are two natural plants with secondary metabolites and antioxidant properties, which was shown to have a diabeto-protective effect in animal experiments. There were major reductions in the levels of endogenous antioxidant enzymes like superoxide dismutase, catalase and reduced glutathione after 30 days of experimental period with STZ suggesting the generation of free radicals in animals. The co-administration of aqueous, methanolic and methanolic fraction of aqueous extract of Albizzia lebbeck and Syzygium cumini significantly increased these antioxidant enzymes and reduced the elevated serum levels of malondialdehyde in the experimental animals. The established diabetoprotective actions of various extracts of Albizzia lebbeck and Syzygium cumini in experimental hepatic injury in rats widens the scope for further investigations in the field of research on other models either alone or in combination with other herbal molecules with proven diabeto-h...

European Journal of Pharmacology, 2021

Endothelial cell activation through nuclear factor-kappa-B (NFkB) and mitogen-activated protein k... more Endothelial cell activation through nuclear factor-kappa-B (NFkB) and mitogen-activated protein kinases leads to increased biosynthesis of pro-inflammatory mediators, cellular injury and vascular inflammation under lipopolysaccharide (LPS) exposure. Recent studies report that LPS up-regulated global methyltransferase activity. In this study, we observed that a combination treatment with metformin (MET) and cholecalciferol (VD) blocked the LPS-induced S-adenosylmethionine (SAM)-dependent methyltransferase (SDM) activity in Eahy926 cells. We found that LPS challenge (i) increased arginine methylation through up-regulated protein arginine methyltransferase-1 (PRMT1) mRNA, intracellular concentrations of asymmetric dimethylarginine (ADMA) and homocysteine (HCY); (ii) up-regulated cell senescence through mitigated sirtuin-1 (SIRT1) mRNA, nicotinamide adenine dinucleotide (NAD+) concentration, telomerase activity and total antioxidant capacity; and (iii) lead to endothelial dysfunction through compromised nitric oxide (NOx) production. However, these LPS-mediated cellular events in Eahy926 cells were restored by the synergistic effect of MET and VD. Taken together, this study identified that the dual compound effect inhibits LPS-induced protein arginine methylation, endothelial senescence and dysfunction through the components of epigenetic machinery, SIRT1 and PRMT1, which is a previously unidentified function of the test compounds. In silico results identified the presence of vitamin D response element (VDRE) sequence on PRMT1 suggesting that VDR could regulate PRMT1 gene expression. Further characterization of the cellular events associated with the dual compound challenge, using gene silencing approach or adenoviral constructs for SIRT1 and/or PRMT1 under inflammatory stress, could identify therapeutic strategies to address the endothelial consequences in vascular inflammation-mediated atherosclerosis.

Heart Failure Reviews, 2020

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Leukemia research reports, 2018

Doxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX... more Doxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX-cardiomyopathy are scarce. Here, we identify the effect of forskolin (FSK) on DOX-induced-asymmetric-dimethylarginine (ADMA) accumulation in monocytoid cells. DOX-challenge led to i) augmented cytotoxicity, reactive-oxygen-species (ROS) production and methyltransferase-enzyme-activity identified as ADMA and s-adenosylhomocysteine (SAH) accumulation (SAH-A). However, except cytotoxicity, other DOX effects were decreased by metformin and FSK. FSK, did not alter the DOX-induced cytotoxic effect, but, decreased SAH-A by >50% and a combination of three drugs restored physiological methyltransferase-enzyme-activity. Together, protective effect of FSK against DOX-induced SAH-A is associated with mitigated methyltransferase-activity, a one-of-a-kind report.

Water Science and Technology Library, 2017

Water is the remarkable natural resource which is essential for every form of life on the planet ... more Water is the remarkable natural resource which is essential for every form of life on the planet “Earth,” and nowadays India is facing major water scarcity problems. These problems are due to climate change and urbanization. As the urbanization is increasing, the percentage of impervious land is increasing which is leading to increase in urban runoff and lesser recharge of underlying aquifers, leading to water scarcity at local scale as runoff is not tapped and utilized. Watershed modeling is considered as one of the most important aspects of planning and development for natural resources for water conservation measures. Watershed modeling is useful for completing and implementing plans, programs, and projects to sustain and increase watershed utilities that directly affect the biotic and abiotic communities within watershed boundary. In this paper, we have taken Rajiv Gandhi South Campus (RGSC), Barkachha, which is the extension of Banaras Hindu University and facing serious water scarcity problems. Here, firstly runoff was N. Shivhare A.K. Rahul (&) S. Gaur P.K.S. Dikshit S.B. Dwivedi Department of Civil Engineering IIT(BHU), Varanasi 221005, UP, India e-mail: atulcivil.iitbhu@gmail.com N. Shivhare e-mail: nikitas.rs.civ15@itbhu.ac.in S. Gaur e-mail: shishir.gaur@gmail.com P.K.S. Dikshit e-mail: pksdikshit.civ@itbhu.ac.in S.B. Dwivedi e-mail: sbd.civ@itbhu.ac.in M.S. Chauhan Department of Civil Engineering, Chitkara University, Chandigarh 174103, HP, India e-mail: manvendra.hbti@gmail.com C.S.P. Ojha Department of Civil Engineering IIT, Roorkee 247667, Uttarakhand, India e-mail: cspojha@gmail.com © Springer International Publishing AG 2017 V. Garg et al. (eds.), Development of Water Resources in India, Water Science and Technology Library 75, DOI 10.1007/978-3-319-55125-8_1 3 calculated by SCS-CN method using 10 years of rainfall data, and then flow accumulation and sink map were created using DEM. Watershed investigation has been done to suggest some hydraulic structures using flow accumulation, sink map, and runoff data, for the study area, mainly to enhance the availability of water for agricultural activity and university development.

Pharmacological Research, 2017

Endothelial dysfunction (ED), an established response to cardiovascular risk factors, is characte... more Endothelial dysfunction (ED), an established response to cardiovascular risk factors, is characterized by increased levels of soluble molecules secreted by endothelial cells (EC). Evidence suggest that ED is an independent predictor of cardiac events and that it is associated with a deficiency in production or bioavailability of nitric oxide (NO) and/or an imbalance in the relative contribution of endothelium-derived relaxing and contracting factors. ED can be reversed by treating cardiovascular risk factors, hence, beyond ambiguity, ED contributes to initiation and progression of atherosclerotic disease. Majority of cardiovascular risk factors act by a common pathway, oxidative stress (OS), characterized by an imbalance in bioavailability of NO and reactive oxygen species (ROS). Enhanced ROS, through several mechanisms, alters competence of EC that leads to ED, reducing its potential to maintain homeostasis and resulting in development of cardiovascular disease (CVD). Influential mechanisms that have been implicated in the development of ED include (i) presence of elevated levels of NOS inhibitor, asymmetric dimethylarginine (ADMA) due to augmented enzyme activity of protein arginine methyl transferase-1 (PRMT1); (ii) decrease in NO generation by endothelial nitric oxide synthase (eNOS) uncoupling, or by reaction of NO with free radicals and (iii) impaired post translational modification of protein (PTM) such as eNOS, caveolin-1 (cav1) and sirtuin-1 (SIRT1). However, the inter-related mechanisms that concur to developing ED is yet to be understood. The events that possibly overlay include OS-induced sequestration of SIRT1 to caveolae facilitating cav1-SIRT1 association; potential increase in lysine acetylation of enzymes such as eNOS and PRMT1 leading to enhanced ADMA formation; imbalance in acetylation-methylation ratio (AMR); diminished NO generation and ED. Here we review current literature from research showing interdependent association between cav1-PRMT1-SIRT1 to the outcomes of experimental and clinical research aiming to preserve endothelial function with gene- or pharmaco-therapy.

Journal of Ferrocement, 1991

21st Design Automation Conference Proceedings, 1984

The purpose of this paper is to describe a method for translating an instruction set described in... more The purpose of this paper is to describe a method for translating an instruction set described in a high level language into a register-transfer structure of a microprocessor. The designer interacts with the translator through the constraints imposed on the design, and by giving the initial but not necessarily complete description of the structure. A microinstruction table, which specifies the

The Sixth International Conference on VLSI Design

Page 1. Algorithm-Based Concurrent Error Detection for FFT Networks * Choong Gun Oh, Hee Yong You... more Page 1. Algorithm-Based Concurrent Error Detection for FFT Networks * Choong Gun Oh, Hee Yong Youn, and Vijay E(. Raj Department of Computer Science Engineering The University of Texas at Arlington Arlington, Texas 7601 9-00 15 youn@cse.ut a.edu, 8 17-2 73-3602 ...

SPE Reservoir Evaluation & Engineering, 2014

Summary The 3D post-stack seismic attributes provide an intuitive and effective way of using seis... more Summary The 3D post-stack seismic attributes provide an intuitive and effective way of using seismic volumes for reservoir characterization and development, and further identification of exploration targets. Some of the seismic attributes can aid in the precise prediction of the geometry and heterogeneity of subsurface geological settings. These also can provide useful information on petrophysical and lithological properties when combined with well-log information. There exist numerous seismic attributes that provide a unique interpretation on some aspects of subsurface geology. Of these, the proper demarcation of structural features— such as location and edges of faults and salt domes, and their throw and extent—always has been of primary concern. In this paper, we propose new multiattribute seismic algorithms by using fractal dimension and 2D/3D continuous wavelet transform (CWT). The use of higher-dimensional wavelets incorporates information from the ensemble of traces and can c...

Proceedings of 4th Great Lakes Symposium on VLSI

Abstract Currently large digital systems consist of a control unit and many processing units. Muc... more Abstract Currently large digital systems consist of a control unit and many processing units. Much work has been done in partitioning large processing units (PUS) into multiple PUS. However, there is still a large control unit that must control each of these PUS. This results ...

1991., IEEE International Sympoisum on Circuits and Systems

The system described accepts as input a high level language behavioral description of a multiproc... more The system described accepts as input a high level language behavioral description of a multiprocessor computer system and outputs a specification for an array of parallel processors. The processors are then designed by the use of a high level architecture synthesis system. The behavioral description may contain loops nested to any depth. User specified constraints, limitations, and interconnection configurations may also be input