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Papers by virender saini

Annals of Thoracic Surgery, 1972

American Journal of Surgery, 1978

Annals of Thoracic Surgery, 1973

The use of continuous suturing in mitral valve replacement is discussed. Because of its advantage... more The use of continuous suturing in mitral valve replacement is discussed. Because of its advantages, the technique merits more widespread use. u suture k sing a continuous suture technique in mitral valve replacement simplifies the operative procedure, shortens bypass time, may diminish thromboembolic hazards by reducing the number of nots, and-at least in our experience-decreases the incidence of valve dehiscence and peribasilar leaks. In spite of all these advantages, the continuous suture technique has been harshly criticized and mostly abandoned [2]. T h e purpose of this communication is to describe a method for continuous suturing of the mitral prosthesis and to summarize the results in a series of clinical cases.

Annals of Thoracic Surgery, 1973

Femoral vein-to-artery partial and total cardiopulmonary bypass was employed in 117 patients. The... more Femoral vein-to-artery partial and total cardiopulmonary bypass was employed in 117 patients. The technique was utilized for (1) preoperative circulatory support in the presence of florid heart failure or shock; (2) circulatory support, cooling, and reinfusion of excessive blood losses from inadvertent but anticipated injury of a cardiac chamber or of great vessels during exposure of the heart; (3) elective intracardiac procedures through a left thoracotomy; and (4) partial cardiopulmonary bypass for operations on the .descending thoracic aorta. The femoral vein-to-artery peripheral cannulation provided satisfactory flows in most of these patients. Details of technique and indications in a wide variety of clinical situations are presented. artial and total cardiopulmonary bypass as well as mechanical circulatory support with the pump oxygenator is feasible by P cannulation of the femoral artery and vein alone [Z]. The availability of such a simple technique for cardiopulmonary bypass is not fully appreciated in the pertinent literature. For example, Flick and co-workers in 1971 reported a patient in whom institution of cardiopulmonary bypass prior to exposure of the heart was deemed essential since inadvertent entry into a pseudoaneurysm during sternotomy and exsanguination were thought to be distinct possibilities. The right atrium and inferior vena cava were cannulated from the periphery by a rather elaborate technique when a single catheter inserted through the femoral vein and into the inferior vena cava would have sufficed. Other workers also have suggested complicated approaches to peripheral cannulation [5, 7, 81.

New England Journal of Medicine, 1974

dial patch to achieve optimal coaptation and to correct AR . However, an optimal repair technique... more dial patch to achieve optimal coaptation and to correct AR . However, an optimal repair technique, which is associated with favorable leaflet-stress distribution and long repair durability, is yet to be established.

American Journal of Cardiology, 1974

This study assessed the pra and postoperative clinical, ECG, and cardiac catheterization data in ... more This study assessed the pra and postoperative clinical, ECG, and cardiac catheterization data in 110 patients with isolated pulmonary stenosis (P'S) operated between 1961 and 1972 using the inflow stasis technique. The patients ranged in age from 2 days to 36 years, and 11 (10%) were less than 1 year. Operative mortality was 3.6% (4/110), two deaths occurring in infants less than 1 week of age. Preoperative cardiac catheterization was performed in each patient and 69 (63%) had postoperative catheterization. The mean preoperative systolic gradient was 93 mm Hg and calculated pulmdnary valve area (PVA) 0.38 cm2lm2. Postoperatively, the mean gradient was 23 mm Hg and PVA 1.1 cm2/m2. Results were considered good in 78% ((30 mm Hg gradient), fair in 15% (30 -50 mm Hg gradient),and poor in 7% (>50 mm Hg gradient). Six of 7 patients with pulmonary valve dysplasia had unsatisfactory results, and we now recommend valvotomy on cardiopulmonary bypass when dysplastic PS is suspected. Four patients required reoperation for high residual gradient, 1 of whom had a dysplastic valve. Significant reduction in the QRS/T angle was the most characteristic ECG finding after surgery. Favorable operative results, low morbidity and mortality, and freedom from the problems of cardiopulmonary bypass are cited as reasons for use of this technique in the treatment of isolated pulmonary valvar stenosis.

Biotechnology Letters, 1992

A locally isolated oleaginous strain ofRhodotorula glutinis strain IIP-30 produced a growth assoc... more A locally isolated oleaginous strain ofRhodotorula glutinis strain IIP-30 produced a growth associated extracellular emulsifying agent while utilizing glucose during fed batch fermentation under nitrogen limitation at 30°C and pH 4. 0. Similar optimum conditions were also noted for intracellular lipid accumulation.

Biotechnology Letters, 1990

SCP producingCandida tropicalis, when grown in fed batch culture using n-hexadecane as carbon sub... more SCP producingCandida tropicalis, when grown in fed batch culture using n-hexadecane as carbon substrate, exhibited extracellular emulsifier production. The emulsifier showed activity against various hydrocarbons, maximum with aromatics and least with normal paraffins. Higher emulsification activity was noted in nitrogen-limiting growth conditions than in substrate- limiting conditions. The hot water extract of the cells also showed significant emulsification activity.

Journal of Industrial Microbiology & Biotechnology, 1995

Rhodotorula glutinis is known to produce fat when cultivated under nitrogen-limiting conditions. ... more Rhodotorula glutinis is known to produce fat when cultivated under nitrogen-limiting conditions. Economically, molasses is an ideal substrate, however, due to the presence of nitrogen in molasses, the lipid yield obtained is much lower than that obtained from glucose or sucrose. Higher yields were obtained using molasses in a fed batch fermentation supplemented with glucose or sucrose during the lipid accumulation phase. The fatty acids profile of the lipids thus produced, using a very simple and economical medium, was similar to that obtained from glucose and sucrose.

World Journal of Microbiology & Biotechnology, 1992

Maximum lipid production (66% w/w dry wt) inRhodotorula glutinis IIP-30 utilizing glucose in a fe... more Maximum lipid production (66% w/w dry wt) inRhodotorula glutinis IIP-30 utilizing glucose in a fed-batch fermentation under N-limiting conditions at 30°C, was at pH 4. At pH 3, 5 and 6, the lipid contents were 12%, 48% and 44%, respectively. There was only a small change in the fatty acid profile over the pH range examined, although the ergosterol content decreased by a third as the pH increased.

Biotechnology Letters, 1992

A locally isolated oleaginous strain ofRhodotorula glutinis strain IIP-30 produced a growth assoc... more A locally isolated oleaginous strain ofRhodotorula glutinis strain IIP-30 produced a growth associated extracellular emulsifying agent while utilizing glucose during fed batch fermentation under nitrogen limitation at 30°C and pH 4. 0. Similar optimum conditions were also noted for intracellular lipid accumulation.

Biotechnology Letters, 2002

Staphylococcus sp. strain S3/C desulfurized dibenzothiophene/n-hexadecane (3 mg ml−1) in a hydroc... more Staphylococcus sp. strain S3/C desulfurized dibenzothiophene/n-hexadecane (3 mg ml−1) in a hydrocarbon aqueous biphasic culture. The resting cells decreased the sulfur content of the hydrocarbon phase by 57% at 2.2 mg l−1 h−1 in the absence of any additional carbon and sulfur source.

American Journal of Anatomy, 1960

Annals of Thoracic Surgery, 1972

American Journal of Surgery, 1978

Annals of Thoracic Surgery, 1973

The use of continuous suturing in mitral valve replacement is discussed. Because of its advantage... more The use of continuous suturing in mitral valve replacement is discussed. Because of its advantages, the technique merits more widespread use. u suture k sing a continuous suture technique in mitral valve replacement simplifies the operative procedure, shortens bypass time, may diminish thromboembolic hazards by reducing the number of nots, and-at least in our experience-decreases the incidence of valve dehiscence and peribasilar leaks. In spite of all these advantages, the continuous suture technique has been harshly criticized and mostly abandoned [2]. T h e purpose of this communication is to describe a method for continuous suturing of the mitral prosthesis and to summarize the results in a series of clinical cases.

Annals of Thoracic Surgery, 1973

Femoral vein-to-artery partial and total cardiopulmonary bypass was employed in 117 patients. The... more Femoral vein-to-artery partial and total cardiopulmonary bypass was employed in 117 patients. The technique was utilized for (1) preoperative circulatory support in the presence of florid heart failure or shock; (2) circulatory support, cooling, and reinfusion of excessive blood losses from inadvertent but anticipated injury of a cardiac chamber or of great vessels during exposure of the heart; (3) elective intracardiac procedures through a left thoracotomy; and (4) partial cardiopulmonary bypass for operations on the .descending thoracic aorta. The femoral vein-to-artery peripheral cannulation provided satisfactory flows in most of these patients. Details of technique and indications in a wide variety of clinical situations are presented. artial and total cardiopulmonary bypass as well as mechanical circulatory support with the pump oxygenator is feasible by P cannulation of the femoral artery and vein alone [Z]. The availability of such a simple technique for cardiopulmonary bypass is not fully appreciated in the pertinent literature. For example, Flick and co-workers in 1971 reported a patient in whom institution of cardiopulmonary bypass prior to exposure of the heart was deemed essential since inadvertent entry into a pseudoaneurysm during sternotomy and exsanguination were thought to be distinct possibilities. The right atrium and inferior vena cava were cannulated from the periphery by a rather elaborate technique when a single catheter inserted through the femoral vein and into the inferior vena cava would have sufficed. Other workers also have suggested complicated approaches to peripheral cannulation [5, 7, 81.

New England Journal of Medicine, 1974

dial patch to achieve optimal coaptation and to correct AR . However, an optimal repair technique... more dial patch to achieve optimal coaptation and to correct AR . However, an optimal repair technique, which is associated with favorable leaflet-stress distribution and long repair durability, is yet to be established.

American Journal of Cardiology, 1974

This study assessed the pra and postoperative clinical, ECG, and cardiac catheterization data in ... more This study assessed the pra and postoperative clinical, ECG, and cardiac catheterization data in 110 patients with isolated pulmonary stenosis (P'S) operated between 1961 and 1972 using the inflow stasis technique. The patients ranged in age from 2 days to 36 years, and 11 (10%) were less than 1 year. Operative mortality was 3.6% (4/110), two deaths occurring in infants less than 1 week of age. Preoperative cardiac catheterization was performed in each patient and 69 (63%) had postoperative catheterization. The mean preoperative systolic gradient was 93 mm Hg and calculated pulmdnary valve area (PVA) 0.38 cm2lm2. Postoperatively, the mean gradient was 23 mm Hg and PVA 1.1 cm2/m2. Results were considered good in 78% ((30 mm Hg gradient), fair in 15% (30 -50 mm Hg gradient),and poor in 7% (>50 mm Hg gradient). Six of 7 patients with pulmonary valve dysplasia had unsatisfactory results, and we now recommend valvotomy on cardiopulmonary bypass when dysplastic PS is suspected. Four patients required reoperation for high residual gradient, 1 of whom had a dysplastic valve. Significant reduction in the QRS/T angle was the most characteristic ECG finding after surgery. Favorable operative results, low morbidity and mortality, and freedom from the problems of cardiopulmonary bypass are cited as reasons for use of this technique in the treatment of isolated pulmonary valvar stenosis.

Biotechnology Letters, 1992

A locally isolated oleaginous strain ofRhodotorula glutinis strain IIP-30 produced a growth assoc... more A locally isolated oleaginous strain ofRhodotorula glutinis strain IIP-30 produced a growth associated extracellular emulsifying agent while utilizing glucose during fed batch fermentation under nitrogen limitation at 30°C and pH 4. 0. Similar optimum conditions were also noted for intracellular lipid accumulation.

Biotechnology Letters, 1990

SCP producingCandida tropicalis, when grown in fed batch culture using n-hexadecane as carbon sub... more SCP producingCandida tropicalis, when grown in fed batch culture using n-hexadecane as carbon substrate, exhibited extracellular emulsifier production. The emulsifier showed activity against various hydrocarbons, maximum with aromatics and least with normal paraffins. Higher emulsification activity was noted in nitrogen-limiting growth conditions than in substrate- limiting conditions. The hot water extract of the cells also showed significant emulsification activity.

Journal of Industrial Microbiology & Biotechnology, 1995

Rhodotorula glutinis is known to produce fat when cultivated under nitrogen-limiting conditions. ... more Rhodotorula glutinis is known to produce fat when cultivated under nitrogen-limiting conditions. Economically, molasses is an ideal substrate, however, due to the presence of nitrogen in molasses, the lipid yield obtained is much lower than that obtained from glucose or sucrose. Higher yields were obtained using molasses in a fed batch fermentation supplemented with glucose or sucrose during the lipid accumulation phase. The fatty acids profile of the lipids thus produced, using a very simple and economical medium, was similar to that obtained from glucose and sucrose.

World Journal of Microbiology & Biotechnology, 1992

Maximum lipid production (66% w/w dry wt) inRhodotorula glutinis IIP-30 utilizing glucose in a fe... more Maximum lipid production (66% w/w dry wt) inRhodotorula glutinis IIP-30 utilizing glucose in a fed-batch fermentation under N-limiting conditions at 30°C, was at pH 4. At pH 3, 5 and 6, the lipid contents were 12%, 48% and 44%, respectively. There was only a small change in the fatty acid profile over the pH range examined, although the ergosterol content decreased by a third as the pH increased.

Biotechnology Letters, 1992

A locally isolated oleaginous strain ofRhodotorula glutinis strain IIP-30 produced a growth assoc... more A locally isolated oleaginous strain ofRhodotorula glutinis strain IIP-30 produced a growth associated extracellular emulsifying agent while utilizing glucose during fed batch fermentation under nitrogen limitation at 30°C and pH 4. 0. Similar optimum conditions were also noted for intracellular lipid accumulation.

Biotechnology Letters, 2002

Staphylococcus sp. strain S3/C desulfurized dibenzothiophene/n-hexadecane (3 mg ml−1) in a hydroc... more Staphylococcus sp. strain S3/C desulfurized dibenzothiophene/n-hexadecane (3 mg ml−1) in a hydrocarbon aqueous biphasic culture. The resting cells decreased the sulfur content of the hydrocarbon phase by 57% at 2.2 mg l−1 h−1 in the absence of any additional carbon and sulfur source.

American Journal of Anatomy, 1960